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The map label for this gene is mrdA [H]

Identifier: 118580957

GI number: 118580957

Start: 2758379

End: 2760307

Strand: Reverse

Name: mrdA [H]

Synonym: Ppro_2545

Alternate gene names: 118580957

Gene position: 2760307-2758379 (Counterclockwise)

Preceding gene: 118580958

Following gene: 118580956

Centisome position: 68.87

GC content: 63.45

Gene sequence:

>1929_bases
ATGAAAGAGAAACGTTTCGTCCGTGAATTCATGGAGATGAAGCAACGCACCGTTCTGCTCTCCTTCATGGTTGCCGCCAT
CTTCTTCCTGCTGCTGCTGCGCCTCTGGCACCTGCAGATATTGAACGCCGATGACTACCGCAGCAAGTCCGAGGACAACC
GGTTGCGCTTCGTGCCCATTGCCGCCTCCCGGGGCGCGATCATGGACCGCAACGCTACGGTGCTGGTCAGCAACCAGCCC
TCCTTCAGCCTGGCGGTCGTCCCCCAGGAGGTGAAGGACAAGGAGGCCCTGCTGGACCAGCTGGTCTCGCTTTTGGGGGT
CGACCGGGAGGAGCTTGCCGAGCGCTGGAAGAAGGGGCAGGGGAGGGCCAGATACTACCCGATCGTGCTGGCCGCCAACA
TCACCCGCGACCAGGTGGAGATCATCGAGGAGAACCATCTGCGTCTGCCGGGGGTGGAGATCGAGGTCAAGCCGGTGCGG
CAGTATGCCAGCGGAATGCTGGCTTCGCACCTGATGGGCTACATCGGCGAGGTTTCCGAGGACGAACTTTCCCGGAAGGG
GAACGAGGCATACAACCCCGGCGACTACATCGGCAAGAACGGTATAGAACGGGCCTGGGAGGCGGTGCTGCACGGCCGTG
ACGGCGGCCGGCAGCTTGAGGTGGATGCCCGCGGACGGGTCCTGCGGACCATCTCCGAGACTCAGCCCCTGGTGGGCAAC
AGCGTGGTGCTGACCATCGACGCCAGGATCCAGCAGGGGGCCGAGAGCGCCTTCGGTGAACAGGCGGGCGCAGCGGTGGC
CATGGATGTGAACAGCGGCGAGATCCTGGCCTTTGTCAGCAATCCGGGCTTTGATCCCGCCCTGTTCAGCGGCAAGATGC
CGCCGGATGTCTGGAAACAGTACCTGGAGGACAAGCGCCGTCCCCTGGAGAACAAGGCCCTGAGCGGCCAGTATCCCCCC
GGCTCCACCTTCAAGATCATCACCGCCCTGGCCGGCCTGGAGAACAATCTGGTCGATGAAAACAGCAGCGTCAGCTGCTC
CGGCGCCTACAGGATGGGGACCTCCACCTTCAAATGCTGGAACAGGCACGGCCACGGAAGCGTTAACCTGAAAAAGTCCC
TGCGTGAGTCGTGCGACGTCTATTACTACCATCTGGGAGAACGGCTGGGGGTGGACCGCATCGCCGCCACGGCCAGGCAA
TTCATGCTCGGCTCGCCCATGGGCATCGGCCTGAAGCACGAAAAAGGGGGGCTGATCCCCAGCATCGCCTGGAAGCAGAA
GCGCTTCGGGAAAGCGTGGATCCGCGGTGAAACCCCCTCGGTGTCCATCGGCCAGGGGTATGTGCTGATGACGCCTATTC
AGCTGGCCTCCATGATCGCCACTGTGGCTAACGAGGGGACGATCTACCGTCCCCAACTGGTGAAACGGATCGTCGATGCC
GATGGCAGGACGCTCAGGGAGTTCGGGCCGGAACGCATCGGAACCACCGGCATATCGGCGCGCAGCTTCCGCTTGGTGAA
ACAGGGGCTCTTCGCCGTGGTGAACGAGCGGGGCGGTACCGGCGGCGCGGCGCGTGTCGGCTATGTGACGGTGGCCGGAA
AGACCGGTACCTCCCAGGTCGTAAAGCTGCGCGACAGCCGGGGAGGAATCCCCTACCAGTATCGGGATCATGCCCTGTTC
GTGGCCTTTGCCCCCTTTGAGAAGCCGGAAATCGCCGTGGCGGTGGTCATCGAACATGGCGAGCACGGCGGTTCCGCCGC
CGCGCCCATCGCCGGGCGCATCATACGGACCTGGTACGAGACAAAGCATCCCCCCAAACCGGTGGCCCGCCCTGTGGCTG
AGAAAGAAACGGAGGCCGAAGAGGAGACGGACGAGGCTCCGGCGACGGAACAGCAGCCACACCCGGATGGGGAGGAACGC
AATGATTGA

Upstream 100 bases:

>100_bases
ACACCATGGCCTCCGGGCTCTTTCCCCACCTGCTGGTCAACGCCTTCGCGGCTTCGCTGGTTGCCCTGCTCCCCCTGTTC
TCATCGGAAGAGGAAGTTGC

Downstream 100 bases:

>100_bases
CCGCCGATTGTTCACCAACATCGACTGGACCCTGACCGCCCTGGCCCTGGTCATCTGCCTGGTGGGAATAGCCAACATCT
ACAGCGCCTCATTCTCCTAT

Product: peptidoglycan glycosyltransferase

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 642; Mature: 642

Protein sequence:

>642_residues
MKEKRFVREFMEMKQRTVLLSFMVAAIFFLLLLRLWHLQILNADDYRSKSEDNRLRFVPIAASRGAIMDRNATVLVSNQP
SFSLAVVPQEVKDKEALLDQLVSLLGVDREELAERWKKGQGRARYYPIVLAANITRDQVEIIEENHLRLPGVEIEVKPVR
QYASGMLASHLMGYIGEVSEDELSRKGNEAYNPGDYIGKNGIERAWEAVLHGRDGGRQLEVDARGRVLRTISETQPLVGN
SVVLTIDARIQQGAESAFGEQAGAAVAMDVNSGEILAFVSNPGFDPALFSGKMPPDVWKQYLEDKRRPLENKALSGQYPP
GSTFKIITALAGLENNLVDENSSVSCSGAYRMGTSTFKCWNRHGHGSVNLKKSLRESCDVYYYHLGERLGVDRIAATARQ
FMLGSPMGIGLKHEKGGLIPSIAWKQKRFGKAWIRGETPSVSIGQGYVLMTPIQLASMIATVANEGTIYRPQLVKRIVDA
DGRTLREFGPERIGTTGISARSFRLVKQGLFAVVNERGGTGGAARVGYVTVAGKTGTSQVVKLRDSRGGIPYQYRDHALF
VAFAPFEKPEIAVAVVIEHGEHGGSAAAPIAGRIIRTWYETKHPPKPVARPVAEKETEAEEETDEAPATEQQPHPDGEER
ND

Sequences:

>Translated_642_residues
MKEKRFVREFMEMKQRTVLLSFMVAAIFFLLLLRLWHLQILNADDYRSKSEDNRLRFVPIAASRGAIMDRNATVLVSNQP
SFSLAVVPQEVKDKEALLDQLVSLLGVDREELAERWKKGQGRARYYPIVLAANITRDQVEIIEENHLRLPGVEIEVKPVR
QYASGMLASHLMGYIGEVSEDELSRKGNEAYNPGDYIGKNGIERAWEAVLHGRDGGRQLEVDARGRVLRTISETQPLVGN
SVVLTIDARIQQGAESAFGEQAGAAVAMDVNSGEILAFVSNPGFDPALFSGKMPPDVWKQYLEDKRRPLENKALSGQYPP
GSTFKIITALAGLENNLVDENSSVSCSGAYRMGTSTFKCWNRHGHGSVNLKKSLRESCDVYYYHLGERLGVDRIAATARQ
FMLGSPMGIGLKHEKGGLIPSIAWKQKRFGKAWIRGETPSVSIGQGYVLMTPIQLASMIATVANEGTIYRPQLVKRIVDA
DGRTLREFGPERIGTTGISARSFRLVKQGLFAVVNERGGTGGAARVGYVTVAGKTGTSQVVKLRDSRGGIPYQYRDHALF
VAFAPFEKPEIAVAVVIEHGEHGGSAAAPIAGRIIRTWYETKHPPKPVARPVAEKETEAEEETDEAPATEQQPHPDGEER
ND
>Mature_642_residues
MKEKRFVREFMEMKQRTVLLSFMVAAIFFLLLLRLWHLQILNADDYRSKSEDNRLRFVPIAASRGAIMDRNATVLVSNQP
SFSLAVVPQEVKDKEALLDQLVSLLGVDREELAERWKKGQGRARYYPIVLAANITRDQVEIIEENHLRLPGVEIEVKPVR
QYASGMLASHLMGYIGEVSEDELSRKGNEAYNPGDYIGKNGIERAWEAVLHGRDGGRQLEVDARGRVLRTISETQPLVGN
SVVLTIDARIQQGAESAFGEQAGAAVAMDVNSGEILAFVSNPGFDPALFSGKMPPDVWKQYLEDKRRPLENKALSGQYPP
GSTFKIITALAGLENNLVDENSSVSCSGAYRMGTSTFKCWNRHGHGSVNLKKSLRESCDVYYYHLGERLGVDRIAATARQ
FMLGSPMGIGLKHEKGGLIPSIAWKQKRFGKAWIRGETPSVSIGQGYVLMTPIQLASMIATVANEGTIYRPQLVKRIVDA
DGRTLREFGPERIGTTGISARSFRLVKQGLFAVVNERGGTGGAARVGYVTVAGKTGTSQVVKLRDSRGGIPYQYRDHALF
VAFAPFEKPEIAVAVVIEHGEHGGSAAAPIAGRIIRTWYETKHPPKPVARPVAEKETEAEEETDEAPATEQQPHPDGEER
ND

Specific function: Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross- linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=594, Percent_Identity=33.6700336700337, Blast_Score=353, Evalue=1e-98,
Organism=Escherichia coli, GI1786272, Length=596, Percent_Identity=28.1879194630872, Blast_Score=166, Evalue=4e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460
- InterPro:   IPR017790 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 70866; Mature: 70866

Theoretical pI: Translated: 8.63; Mature: 8.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEKRFVREFMEMKQRTVLLSFMVAAIFFLLLLRLWHLQILNADDYRSKSEDNRLRFVPI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCEEEEEE
AASRGAIMDRNATVLVSNQPSFSLAVVPQEVKDKEALLDQLVSLLGVDREELAERWKKGQ
ECCCCCEECCCCEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCC
GRARYYPIVLAANITRDQVEIIEENHLRLPGVEIEVKPVRQYASGMLASHLMGYIGEVSE
CCCEEEEEEEEECCCHHHHHHHHCCCEECCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCH
DELSRKGNEAYNPGDYIGKNGIERAWEAVLHGRDGGRQLEVDARGRVLRTISETQPLVGN
HHHHHCCCCCCCCCHHCCCCHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHCCCCCCC
SVVLTIDARIQQGAESAFGEQAGAAVAMDVNSGEILAFVSNPGFDPALFSGKMPPDVWKQ
EEEEEEEHHHHHHHHHHHHHHCCCEEEEECCCCCEEEEECCCCCCHHHCCCCCCHHHHHH
YLEDKRRPLENKALSGQYPPGSTFKIITALAGLENNLVDENSSVSCSGAYRMGTSTFKCW
HHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCEEECCCEECCCCHHHHH
NRHGHGSVNLKKSLRESCDVYYYHLGERLGVDRIAATARQFMLGSPMGIGLKHEKGGLIP
CCCCCCCCCHHHHHHHHCCEEEEEHHHHHCHHHHHHHHHHHHCCCCCCCCEEECCCCCCC
SIAWKQKRFGKAWIRGETPSVSIGQGYVLMTPIQLASMIATVANEGTIYRPQLVKRIVDA
CHHHHHHHCCCCEECCCCCCEECCCCEEEECHHHHHHHHHHHHCCCCEECHHHHHHHHCC
DGRTLREFGPERIGTTGISARSFRLVKQGLFAVVNERGGTGGAARVGYVTVAGKTGTSQV
CCCCHHHCCCHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEECCCCCCHH
VKLRDSRGGIPYQYRDHALFVAFAPFEKPEIAVAVVIEHGEHGGSAAAPIAGRIIRTWYE
EEEECCCCCCCEEECCCEEEEEECCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHH
TKHPPKPVARPVAEKETEAEEETDEAPATEQQPHPDGEERND
CCCCCCHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKEKRFVREFMEMKQRTVLLSFMVAAIFFLLLLRLWHLQILNADDYRSKSEDNRLRFVPI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCEEEEEE
AASRGAIMDRNATVLVSNQPSFSLAVVPQEVKDKEALLDQLVSLLGVDREELAERWKKGQ
ECCCCCEECCCCEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCC
GRARYYPIVLAANITRDQVEIIEENHLRLPGVEIEVKPVRQYASGMLASHLMGYIGEVSE
CCCEEEEEEEEECCCHHHHHHHHCCCEECCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCH
DELSRKGNEAYNPGDYIGKNGIERAWEAVLHGRDGGRQLEVDARGRVLRTISETQPLVGN
HHHHHCCCCCCCCCHHCCCCHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHCCCCCCC
SVVLTIDARIQQGAESAFGEQAGAAVAMDVNSGEILAFVSNPGFDPALFSGKMPPDVWKQ
EEEEEEEHHHHHHHHHHHHHHCCCEEEEECCCCCEEEEECCCCCCHHHCCCCCCHHHHHH
YLEDKRRPLENKALSGQYPPGSTFKIITALAGLENNLVDENSSVSCSGAYRMGTSTFKCW
HHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCEEECCCEECCCCHHHHH
NRHGHGSVNLKKSLRESCDVYYYHLGERLGVDRIAATARQFMLGSPMGIGLKHEKGGLIP
CCCCCCCCCHHHHHHHHCCEEEEEHHHHHCHHHHHHHHHHHHCCCCCCCCEEECCCCCCC
SIAWKQKRFGKAWIRGETPSVSIGQGYVLMTPIQLASMIATVANEGTIYRPQLVKRIVDA
CHHHHHHHCCCCEECCCCCCEECCCCEEEECHHHHHHHHHHHHCCCCEECHHHHHHHHCC
DGRTLREFGPERIGTTGISARSFRLVKQGLFAVVNERGGTGGAARVGYVTVAGKTGTSQV
CCCCHHHCCCHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEECCCCCCHH
VKLRDSRGGIPYQYRDHALFVAFAPFEKPEIAVAVVIEHGEHGGSAAAPIAGRIIRTWYE
EEEECCCCCCCEEECCCEEEEEECCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHH
TKHPPKPVARPVAEKETEAEEETDEAPATEQQPHPDGEERND
CCCCCCHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]