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The map label for this gene is pyrC

Identifier: 118580940

GI number: 118580940

Start: 2740170

End: 2741444

Strand: Reverse

Name: pyrC

Synonym: Ppro_2528

Alternate gene names: 118580940

Gene position: 2741444-2740170 (Counterclockwise)

Preceding gene: 118580941

Following gene: 118580939

Centisome position: 68.4

GC content: 65.33

Gene sequence:

>1275_bases
ATGAACCTTCTGATACAAAACGGCCGGGTGATCGACCCCTCCCAGGGGCTGGACGAAGAGCTGGACCTGCTGGTGGAAAA
CGGTCTGGTGAGGGAGATGGGCAGGGGGCTCACGGCTCCGGCCGGTGTAGAAATAGTTGATGCGGCAGGATGCTGCGTGG
TTCCCGGACTGGTGGACATGCACGTGCATCTGCGCGAGCCGGGGCTGGAGTACAAGGAAGACATCGAGAGCGGCTCCCGG
GCGGCCGTGGCCGGTGGTTTCACCTCCATCGCCTGCATGCCCAACACCAAGCCGGTGATCGACAACAAGGCTCTTGCCCG
CTACGTCATCGCCAGGGGCAGGGAGGCCGGGTTGTGCAACGTCTTCCCCGTCGGCTGCCTCACCGCCGGATCCAAGGGGG
AGCGGCTGGCCGAGATGGGCGAACTCAAGGAGGCCGGCTGCGTGGCCGTGTCCGATGACGGCCGGCCGGTGGTCAACGCA
GAGCTGATGCGTCGTGCCCTGGAGTACGCCCGCGGCATGCAGATTCCGGTCATCTCCCATGCCGAGGATCTGTCGCTGGT
GGGGGAGGGGGTGATGAACGAGGGCTTCACCTCCACCGAGTTGGGGCTGAAGGGGATTCCCCGGGTAGCCGAGGACATCG
CCATTGCCCGCGACGTCATGCTGGCCGAGTACACCAATTCCCCCATCCACATCGCCCACGTCTCCACCAGCGGAGCGGTG
CGCATCATCCGCAACGCCAAGCTGCGGGGGGTGAGGGTGACCTGCGAGACCGCGCCGCACTACTTCACCCTGACCGACGA
CGCGGTGCGCGGCTACAACACCAACGCCAAGATGAACCCGCCGCTCAGGGAGGCCGACGACGTGGCGGCAATCAGGGCCG
GACTGAGCGACGGCACCATTGACGTCATCGCTACCGACCACGCCCCGCACCACCTGGACGAGAAGGACGTGGAGTTCAAC
GTCGCCGCAAACGGCATCATCGGCCTGGAAACGTCGCTTCCTTTGTCGCTGGCGCTGGTGGAGCAGGGGGTGCTGACCAT
GAGCCAGCTGGTGGAGCGCATGTCCTGTTGCCCCTCCCTGATCCTGGGGCTGGAGCGGGGAACGCTGGCAAAGGGCGCCG
TGGCCGACATTACCCTGATCGATCCGACTCTCCCGTGGGTCGTGGAGGCTGACAAGCTGGCCAGCAAATCCACGAATACT
CCCTGGATGGGACAGGAGATGAAGGGGGCTGCCGTTGCCACCATCGTGGCCGGCAGGGTGGTGTACAGGCGGTAA

Upstream 100 bases:

>100_bases
GAGCTGGAATAAACCGGTTCGTGGTTCAAGGTTCAGGGGGCGTGGATTAAACCTTGAGCCTCGAGCCTCGAACCTGGAAC
CAATATAATGAGGTGATGAC

Downstream 100 bases:

>100_bases
GAGATAACGCTCACGGGAAGTACGCGAAGATTGCAGGGGAACGCAGGATGATGAAGAGCGGTTTTCTTCGTGCGCTTCGT
GCCTTCGTGTGAGTCTGCTG

Product: dihydroorotase, multifunctional complex type

Products: NA

Alternate protein names: DHOase

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MNLLIQNGRVIDPSQGLDEELDLLVENGLVREMGRGLTAPAGVEIVDAAGCCVVPGLVDMHVHLREPGLEYKEDIESGSR
AAVAGGFTSIACMPNTKPVIDNKALARYVIARGREAGLCNVFPVGCLTAGSKGERLAEMGELKEAGCVAVSDDGRPVVNA
ELMRRALEYARGMQIPVISHAEDLSLVGEGVMNEGFTSTELGLKGIPRVAEDIAIARDVMLAEYTNSPIHIAHVSTSGAV
RIIRNAKLRGVRVTCETAPHYFTLTDDAVRGYNTNAKMNPPLREADDVAAIRAGLSDGTIDVIATDHAPHHLDEKDVEFN
VAANGIIGLETSLPLSLALVEQGVLTMSQLVERMSCCPSLILGLERGTLAKGAVADITLIDPTLPWVVEADKLASKSTNT
PWMGQEMKGAAVATIVAGRVVYRR

Sequences:

>Translated_424_residues
MNLLIQNGRVIDPSQGLDEELDLLVENGLVREMGRGLTAPAGVEIVDAAGCCVVPGLVDMHVHLREPGLEYKEDIESGSR
AAVAGGFTSIACMPNTKPVIDNKALARYVIARGREAGLCNVFPVGCLTAGSKGERLAEMGELKEAGCVAVSDDGRPVVNA
ELMRRALEYARGMQIPVISHAEDLSLVGEGVMNEGFTSTELGLKGIPRVAEDIAIARDVMLAEYTNSPIHIAHVSTSGAV
RIIRNAKLRGVRVTCETAPHYFTLTDDAVRGYNTNAKMNPPLREADDVAAIRAGLSDGTIDVIATDHAPHHLDEKDVEFN
VAANGIIGLETSLPLSLALVEQGVLTMSQLVERMSCCPSLILGLERGTLAKGAVADITLIDPTLPWVVEADKLASKSTNT
PWMGQEMKGAAVATIVAGRVVYRR
>Mature_424_residues
MNLLIQNGRVIDPSQGLDEELDLLVENGLVREMGRGLTAPAGVEIVDAAGCCVVPGLVDMHVHLREPGLEYKEDIESGSR
AAVAGGFTSIACMPNTKPVIDNKALARYVIARGREAGLCNVFPVGCLTAGSKGERLAEMGELKEAGCVAVSDDGRPVVNA
ELMRRALEYARGMQIPVISHAEDLSLVGEGVMNEGFTSTELGLKGIPRVAEDIAIARDVMLAEYTNSPIHIAHVSTSGAV
RIIRNAKLRGVRVTCETAPHYFTLTDDAVRGYNTNAKMNPPLREADDVAAIRAGLSDGTIDVIATDHAPHHLDEKDVEFN
VAANGIIGLETSLPLSLALVEQGVLTMSQLVERMSCCPSLILGLERGTLAKGAVADITLIDPTLPWVVEADKLASKSTNT
PWMGQEMKGAAVATIVAGRVVYRR

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily

Homologues:

Organism=Homo sapiens, GI18105007, Length=378, Percent_Identity=31.4814814814815, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI190194363, Length=443, Percent_Identity=26.410835214447, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI19923821, Length=456, Percent_Identity=26.0964912280702, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI4503051, Length=448, Percent_Identity=24.3303571428571, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI62422571, Length=448, Percent_Identity=24.3303571428571, Blast_Score=105, Evalue=8e-23,
Organism=Homo sapiens, GI4503375, Length=457, Percent_Identity=26.9146608315098, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI4503379, Length=445, Percent_Identity=23.1460674157303, Blast_Score=98, Evalue=1e-20,
Organism=Escherichia coli, GI1786722, Length=437, Percent_Identity=28.604118993135, Blast_Score=164, Evalue=9e-42,
Organism=Escherichia coli, GI87082175, Length=450, Percent_Identity=27.5555555555556, Blast_Score=137, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI193204318, Length=398, Percent_Identity=29.3969849246231, Blast_Score=141, Evalue=8e-34,
Organism=Caenorhabditis elegans, GI17539558, Length=455, Percent_Identity=26.3736263736264, Blast_Score=99, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI86575075, Length=439, Percent_Identity=23.0068337129841, Blast_Score=73, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6322218, Length=397, Percent_Identity=28.2115869017632, Blast_Score=117, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24642586, Length=375, Percent_Identity=30.1333333333333, Blast_Score=154, Evalue=8e-38,
Organism=Drosophila melanogaster, GI18859883, Length=414, Percent_Identity=27.536231884058, Blast_Score=83, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRC_PELPD (A1AS12)

Other databases:

- EMBL:   CP000482
- RefSeq:   YP_902190.1
- ProteinModelPortal:   A1AS12
- SMR:   A1AS12
- STRING:   A1AS12
- GeneID:   4571553
- GenomeReviews:   CP000482_GR
- KEGG:   ppd:Ppro_2528
- eggNOG:   COG0044
- HOGENOM:   HBG724623
- OMA:   GVMNEGE
- PhylomeDB:   A1AS12
- ProtClustDB:   CLSK828273
- HAMAP:   MF_00220_B
- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059
- TIGRFAMs:   TIGR00857

Pfam domain/function: PF01979 Amidohydro_1; SSF51338 Metalo_hydrolase

EC number: =3.5.2.3

Molecular weight: Translated: 45088; Mature: 45088

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS00482 DIHYDROOROTASE_1; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLLIQNGRVIDPSQGLDEELDLLVENGLVREMGRGLTAPAGVEIVDAAGCCVVPGLVDM
CCEEECCCEEECCCCCCCHHHHHHHHCCHHHHHCCCCCCCCCCEEEECCCCEECCCCEEE
HVHLREPGLEYKEDIESGSRAAVAGGFTSIACMPNTKPVIDNKALARYVIARGREAGLCN
EEEECCCCCHHHHHHCCCCCEEEECCCEEEEECCCCCCCCCCHHHHHHHHHCCCCCCCCE
VFPVGCLTAGSKGERLAEMGELKEAGCVAVSDDGRPVVNAELMRRALEYARGMQIPVISH
ECCCCEECCCCCCHHHHHHHHHHHCCEEEECCCCCEEECHHHHHHHHHHHCCCCCEEECC
AEDLSLVGEGVMNEGFTSTELGLKGIPRVAEDIAIARDVMLAEYTNSPIHIAHVSTSGAV
CHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHEECCCCCEEEEEECCCCCE
RIIRNAKLRGVRVTCETAPHYFTLTDDAVRGYNTNAKMNPPLREADDVAAIRAGLSDGTI
EEEECCCEEEEEEEEECCCCEEEECCHHHCCCCCCCCCCCCCCCHHHHHHHHCCCCCCEE
DVIATDHAPHHLDEKDVEFNVAANGIIGLETSLPLSLALVEQGVLTMSQLVERMSCCPSL
EEEEECCCCCCCCCCCEEEEEEECCEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHCHHH
ILGLERGTLAKGAVADITLIDPTLPWVVEADKLASKSTNTPWMGQEMKGAAVATIVAGRV
HHCCCCCCCCCCCEEEEEEECCCCCCEEEHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCC
VYRR
EECC
>Mature Secondary Structure
MNLLIQNGRVIDPSQGLDEELDLLVENGLVREMGRGLTAPAGVEIVDAAGCCVVPGLVDM
CCEEECCCEEECCCCCCCHHHHHHHHCCHHHHHCCCCCCCCCCEEEECCCCEECCCCEEE
HVHLREPGLEYKEDIESGSRAAVAGGFTSIACMPNTKPVIDNKALARYVIARGREAGLCN
EEEECCCCCHHHHHHCCCCCEEEECCCEEEEECCCCCCCCCCHHHHHHHHHCCCCCCCCE
VFPVGCLTAGSKGERLAEMGELKEAGCVAVSDDGRPVVNAELMRRALEYARGMQIPVISH
ECCCCEECCCCCCHHHHHHHHHHHCCEEEECCCCCEEECHHHHHHHHHHHCCCCCEEECC
AEDLSLVGEGVMNEGFTSTELGLKGIPRVAEDIAIARDVMLAEYTNSPIHIAHVSTSGAV
CHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHEECCCCCEEEEEECCCCCE
RIIRNAKLRGVRVTCETAPHYFTLTDDAVRGYNTNAKMNPPLREADDVAAIRAGLSDGTI
EEEECCCEEEEEEEEECCCCEEEECCHHHCCCCCCCCCCCCCCCHHHHHHHHCCCCCCEE
DVIATDHAPHHLDEKDVEFNVAANGIIGLETSLPLSLALVEQGVLTMSQLVERMSCCPSL
EEEEECCCCCCCCCCCEEEEEEECCEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHCHHH
ILGLERGTLAKGAVADITLIDPTLPWVVEADKLASKSTNTPWMGQEMKGAAVATIVAGRV
HHCCCCCCCCCCCEEEEEEECCCCCCEEEHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCC
VYRR
EECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA