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The map label for this gene is capL [H]

Identifier: 118580854

GI number: 118580854

Start: 2639452

End: 2640738

Strand: Reverse

Name: capL [H]

Synonym: Ppro_2441

Alternate gene names: 118580854

Gene position: 2640738-2639452 (Counterclockwise)

Preceding gene: 118580855

Following gene: 118580853

Centisome position: 65.89

GC content: 63.09

Gene sequence:

>1287_bases
ATGAAACAGGAACGGGTGATTTCGGTCGTCGGCCTGGGCTATGTCGGCCTGCCGGTGGCGGTGGCCTTTGGCGGGGTGCG
TCGCACCATCGGGTTCGATGTTAACCGGACACGCATCGATGAGCTGAAGGCAGGCTATGACCGTACCGACGAGGTCAGCG
AGGAGGAACTGCGCGCTGCCAGGATCGTCTTCACCGATTCCGTCGATGACCTGCGTACGGCCGATTTCCACATCGTGGCC
GTGCCGACGCCGGTTGACGAGGCCCACCGGCCTGACCTCTCCCTGATGCACCGGGCGTCGGAGACCGTTGGGCAGGCGCT
GAAAAAGGGGGATATCGTGGTCTACGAGTCCACGGTCTATCCCGGTGTTACGGAGGACGAGTGCGTGCCGATCCTGGAGC
GGGTCTCCGGCCTTGCCTGCGGCAGCGATTTTACGGTCGGCTACAGCCCCGAGCGGATCAACCCGGGTGACCGGGAGCAT
ACCTTCACCAGGATCAAGAAGGTCGTCTCCGGCCAGGACGACGCCACCCTGGAGATCGTCGCCCGGGTGTACGAATCGGT
GGTCACCGCCGGAGTCCATCGGGCCAGATCCATCAAGGTCGCCGAAGCGGCCAAGGTGATCGAGAATACCCAGCGCGACC
TGAACATCGCCCTGATGAACGAACTGGCACTGATCTTCGACCGTCTCGGCATCGACACCAACGATGTCCTGGAGGCGGCA
GGCACCAAGTGGAATTTTCTCAAGTTCAAGCCGGGGCTCGTGGGGGGACACTGCATCGGCGTAGATCCCTACTACCTGAC
CCACAAGTCGGAGAAGATCGGCTACATCCCCCAGGTTATCCTGGCCGGCCGCCGGATCAACGACGGCATGGGCAGGTTCG
TCGCCCAGCGCGCCATCCGGGAGATGATCCACTGCGGGCACAGCATCCGGGACAGCAGGGTGACCGTGCTGGGGCTTACC
TTCAAGGAGGACTGCCCCGACCTGCGCAATTCCAAGGTGATCGATATCATCCGGGAGCTGGAGGACTATGGCATCAGCGT
GCAGGTCTGCGATCCCCTGGCTGATCTAGGTGAGGCGCGCCATGAGTACGGGGTCAACCTGGTTGCCGTGGATGATCTGA
AGCCCGCCTGCGCCGTGGTGGTGGCCGTTGCCCATCGCCCGTTCCTGGAATGGGGGACGGACGAGATGCTCCGCCGCATG
GGCAAGAACCCGGTGTTGGTGGATGTGAAGGGGATCTATGACCAGGACGCCATGTCTGCCGCCGGCATACGGGTCTGGAG
GCTGTGA

Upstream 100 bases:

>100_bases
CCCCGAGTCCGCGGACGTTGCCGGGCTTTCTCCGGGAACTCCGCGCGCTCCGCGGCCATTTTTCGCTTTATCCCCATGGT
GGAGAACAAAGGAGTAGATG

Downstream 100 bases:

>100_bases
GGTGGGGAACAGGGAGTCGCCGCCTCCTGATCACTGCCCACTGCCCGCTGCCCGCTGAACGCTGAACGCTGAACGCTGAA
GGAATGACATGAACCGCTAC

Product: UDP-glucose/GDP-mannose dehydrogenase

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: NA

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MKQERVISVVGLGYVGLPVAVAFGGVRRTIGFDVNRTRIDELKAGYDRTDEVSEEELRAARIVFTDSVDDLRTADFHIVA
VPTPVDEAHRPDLSLMHRASETVGQALKKGDIVVYESTVYPGVTEDECVPILERVSGLACGSDFTVGYSPERINPGDREH
TFTRIKKVVSGQDDATLEIVARVYESVVTAGVHRARSIKVAEAAKVIENTQRDLNIALMNELALIFDRLGIDTNDVLEAA
GTKWNFLKFKPGLVGGHCIGVDPYYLTHKSEKIGYIPQVILAGRRINDGMGRFVAQRAIREMIHCGHSIRDSRVTVLGLT
FKEDCPDLRNSKVIDIIRELEDYGISVQVCDPLADLGEARHEYGVNLVAVDDLKPACAVVVAVAHRPFLEWGTDEMLRRM
GKNPVLVDVKGIYDQDAMSAAGIRVWRL

Sequences:

>Translated_428_residues
MKQERVISVVGLGYVGLPVAVAFGGVRRTIGFDVNRTRIDELKAGYDRTDEVSEEELRAARIVFTDSVDDLRTADFHIVA
VPTPVDEAHRPDLSLMHRASETVGQALKKGDIVVYESTVYPGVTEDECVPILERVSGLACGSDFTVGYSPERINPGDREH
TFTRIKKVVSGQDDATLEIVARVYESVVTAGVHRARSIKVAEAAKVIENTQRDLNIALMNELALIFDRLGIDTNDVLEAA
GTKWNFLKFKPGLVGGHCIGVDPYYLTHKSEKIGYIPQVILAGRRINDGMGRFVAQRAIREMIHCGHSIRDSRVTVLGLT
FKEDCPDLRNSKVIDIIRELEDYGISVQVCDPLADLGEARHEYGVNLVAVDDLKPACAVVVAVAHRPFLEWGTDEMLRRM
GKNPVLVDVKGIYDQDAMSAAGIRVWRL
>Mature_428_residues
MKQERVISVVGLGYVGLPVAVAFGGVRRTIGFDVNRTRIDELKAGYDRTDEVSEEELRAARIVFTDSVDDLRTADFHIVA
VPTPVDEAHRPDLSLMHRASETVGQALKKGDIVVYESTVYPGVTEDECVPILERVSGLACGSDFTVGYSPERINPGDREH
TFTRIKKVVSGQDDATLEIVARVYESVVTAGVHRARSIKVAEAAKVIENTQRDLNIALMNELALIFDRLGIDTNDVLEAA
GTKWNFLKFKPGLVGGHCIGVDPYYLTHKSEKIGYIPQVILAGRRINDGMGRFVAQRAIREMIHCGHSIRDSRVTVLGLT
FKEDCPDLRNSKVIDIIRELEDYGISVQVCDPLADLGEARHEYGVNLVAVDDLKPACAVVVAVAHRPFLEWGTDEMLRRM
GKNPVLVDVKGIYDQDAMSAAGIRVWRL

Specific function: Required for the biosynthesis of type 1 capsular polysaccharide [H]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI48994968, Length=357, Percent_Identity=29.6918767507003, Blast_Score=146, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17560350, Length=457, Percent_Identity=24.507658643326, Blast_Score=81, Evalue=9e-16,
Organism=Drosophila melanogaster, GI17136908, Length=373, Percent_Identity=22.2520107238606, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 47308; Mature: 47308

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQERVISVVGLGYVGLPVAVAFGGVRRTIGFDVNRTRIDELKAGYDRTDEVSEEELRAA
CCCHHEEEEECCCHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHCCCCCCCCCCHHHHHHE
RIVFTDSVDDLRTADFHIVAVPTPVDEAHRPDLSLMHRASETVGQALKKGDIVVYESTVY
EEEEECCCCHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCC
PGVTEDECVPILERVSGLACGSDFTVGYSPERINPGDREHTFTRIKKVVSGQDDATLEIV
CCCCCHHHHHHHHHHCCCCCCCCCEECCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHH
ARVYESVVTAGVHRARSIKVAEAAKVIENTQRDLNIALMNELALIFDRLGIDTNDVLEAA
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHC
GTKWNFLKFKPGLVGGHCIGVDPYYLTHKSEKIGYIPQVILAGRRINDGMGRFVAQRAIR
CCCEEEEEECCCCCCCEEECCCCEEEECCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHH
EMIHCGHSIRDSRVTVLGLTFKEDCPDLRNSKVIDIIRELEDYGISVQVCDPLADLGEAR
HHHHCCCCCCCCEEEEEEEEEHHCCCCCCCCHHHHHHHHHHHCCCEEEECCCHHHHHHHH
HEYGVNLVAVDDLKPACAVVVAVAHRPFLEWGTDEMLRRMGKNPVLVDVKGIYDQDAMSA
HHHCCEEEEECCCCHHHHHHHHHHHCCHHHCCHHHHHHHHCCCCEEEEECCCCCCHHHHH
AGIRVWRL
CCEEEECC
>Mature Secondary Structure
MKQERVISVVGLGYVGLPVAVAFGGVRRTIGFDVNRTRIDELKAGYDRTDEVSEEELRAA
CCCHHEEEEECCCHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHCCCCCCCCCCHHHHHHE
RIVFTDSVDDLRTADFHIVAVPTPVDEAHRPDLSLMHRASETVGQALKKGDIVVYESTVY
EEEEECCCCHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCC
PGVTEDECVPILERVSGLACGSDFTVGYSPERINPGDREHTFTRIKKVVSGQDDATLEIV
CCCCCHHHHHHHHHHCCCCCCCCCEECCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHH
ARVYESVVTAGVHRARSIKVAEAAKVIENTQRDLNIALMNELALIFDRLGIDTNDVLEAA
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHC
GTKWNFLKFKPGLVGGHCIGVDPYYLTHKSEKIGYIPQVILAGRRINDGMGRFVAQRAIR
CCCEEEEEECCCCCCCEEECCCCEEEECCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHH
EMIHCGHSIRDSRVTVLGLTFKEDCPDLRNSKVIDIIRELEDYGISVQVCDPLADLGEAR
HHHHCCCCCCCCEEEEEEEEEHHCCCCCCCCHHHHHHHHHHHCCCEEEECCCHHHHHHHH
HEYGVNLVAVDDLKPACAVVVAVAHRPFLEWGTDEMLRRMGKNPVLVDVKGIYDQDAMSA
HHHCCEEEEECCCCHHHHHHHHHHHCCHHHCCHHHHHHHHCCCCEEEEECCCCCCHHHHH
AGIRVWRL
CCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7961465 [H]