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The map label for this gene is atoC [H]

Identifier: 118580851

GI number: 118580851

Start: 2634788

End: 2636191

Strand: Reverse

Name: atoC [H]

Synonym: Ppro_2438

Alternate gene names: 118580851

Gene position: 2636191-2634788 (Counterclockwise)

Preceding gene: 118580852

Following gene: 118580847

Centisome position: 65.77

GC content: 63.11

Gene sequence:

>1404_bases
ATGCACATGGTAAAGATACTGATAATCGATGACGATCCCGATATCCGCCAGCAGCTGAAGTGGGGCTTGAGCGACGAGTA
CAGCGTCGTGCAGGCCGGCACGGTGCAGGAGGGGATCGTTGCCTTCAAGAAGCACCACCCCACGGTGGTGATCCTGGATC
TGGGCCTGCCCCCCTACGAGCACAGCTCGGAAGAGGGTTTCCGCGGCCTGGCGGCGCTTTTGGAGCTTAACCCGCACGTC
AAGATCATCATGCTGACCGGCAACAGCGAGCGGGAAAACGCCCTCAAGGCCATGCAGCTGGGGGCCTACGACTTTTATCC
CAAACCGCCTGTGCTGAACGAACTGAAGGTGATCATCGGCCGGGCGGTCCATGTGGCCGGCCTGGAGGAGCAGAACCGCA
CCCTGCAGCGCGCCGTGGAGATGAAGTCCATGGATCTGGGAGGCATGCTCGGCCAGTGTCCCGAGATGCAGACCATCTTC
GCCACCATCAAGAAGGTGGCCCCTTCGGATGTGTCCATACTGATCACCGGCGAGAACGGCACCGGCAAGGAGCTGGTAGC
CCAGGCCCTGCACGACGCCAGCCTGCGCAGGAAGGGGCCGTTCATCCCGATCAACTGCGGCGCGATCCCGGAGAATCTGC
TGGAGTCGGAACTCTTCGGCCACGAGCGGGGCGCCTTCACCGGCGCCCACACCACGGTCCAGGGCAAGCTGCAGTACGCC
AACAAGGGGACCCTGTTTCTGGACGAGATCGGCGAGCTGCCGGTCAACCTGCAGGTCAAGCTGCTGCGCTTCCTGCAGGA
AGGGGTGATCCAGCGGGTGGGCGGCAGGGTGGATATCCCGGTGGATACCCGCACGGTCTGCGCAACCAACGTGAACATCG
CCCAGGCCATCAAGGAGGGCAGGTTCCGTGAGGACCTGTACTACCGCATCAGCGTCATCTCCATCCACCTGCCCCCCTTG
CGGGAGCGGGGGGAGGATATCCTGCTTCTGGCCAACTATTTCCTGCGCATGTACAGCGACGAGCACAAGAAGAAGGTGCG
CCGCTTCAGCGCGGCCGCCGTCCACTTCCTGAAGAGCTACGAATGGCCGGGCAACGTGCGGGAACTGCGCAACCGGGTGC
AGCGGGCGATCATCATGAGCGATGCCTCGGTGGTCGAGCCGGATGATCTGGGATGCGAAATGGAGCTGCCTGAGTTTGAC
GAGGAAATCCGGCCGATCGTAACGCTGCGGGAGGCGCGGGACAAGGTGGAGCGGGAGTTGCTGGTGCAGGCCATGGACCG
CCAGAACGGCAACATCGCCAAGGCTGCCGAGGAGCTGGGTGTCAGCAGGCCGACCTTCTACGACATGATCAAGAAGCACG
GCCTGATGCCGCTGCACGGGGGTGAGAAGGGGGCCGACTCCTGA

Upstream 100 bases:

>100_bases
CGAAGTGGACAGTGAAGAGGGTGTGGGGACGACATTTACGATCTGGTTCAGCCAGGGGGGCGAAGGCGGTACCCCGGTCG
GCCATTGCTGACGAGGGACA

Downstream 100 bases:

>100_bases
TTACGGGCGGCGTTTGAAGCCTTCACGAGGGTGAGTCGATTACGAAAAAAGTGCCGGGAGAGTGGGTGTAAAGAAAACGA
TAATCAGCCGGGGGCGTTGC

Product: two component sigma54 specific Fis family transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 467; Mature: 467

Protein sequence:

>467_residues
MHMVKILIIDDDPDIRQQLKWGLSDEYSVVQAGTVQEGIVAFKKHHPTVVILDLGLPPYEHSSEEGFRGLAALLELNPHV
KIIMLTGNSERENALKAMQLGAYDFYPKPPVLNELKVIIGRAVHVAGLEEQNRTLQRAVEMKSMDLGGMLGQCPEMQTIF
ATIKKVAPSDVSILITGENGTGKELVAQALHDASLRRKGPFIPINCGAIPENLLESELFGHERGAFTGAHTTVQGKLQYA
NKGTLFLDEIGELPVNLQVKLLRFLQEGVIQRVGGRVDIPVDTRTVCATNVNIAQAIKEGRFREDLYYRISVISIHLPPL
RERGEDILLLANYFLRMYSDEHKKKVRRFSAAAVHFLKSYEWPGNVRELRNRVQRAIIMSDASVVEPDDLGCEMELPEFD
EEIRPIVTLREARDKVERELLVQAMDRQNGNIAKAAEELGVSRPTFYDMIKKHGLMPLHGGEKGADS

Sequences:

>Translated_467_residues
MHMVKILIIDDDPDIRQQLKWGLSDEYSVVQAGTVQEGIVAFKKHHPTVVILDLGLPPYEHSSEEGFRGLAALLELNPHV
KIIMLTGNSERENALKAMQLGAYDFYPKPPVLNELKVIIGRAVHVAGLEEQNRTLQRAVEMKSMDLGGMLGQCPEMQTIF
ATIKKVAPSDVSILITGENGTGKELVAQALHDASLRRKGPFIPINCGAIPENLLESELFGHERGAFTGAHTTVQGKLQYA
NKGTLFLDEIGELPVNLQVKLLRFLQEGVIQRVGGRVDIPVDTRTVCATNVNIAQAIKEGRFREDLYYRISVISIHLPPL
RERGEDILLLANYFLRMYSDEHKKKVRRFSAAAVHFLKSYEWPGNVRELRNRVQRAIIMSDASVVEPDDLGCEMELPEFD
EEIRPIVTLREARDKVERELLVQAMDRQNGNIAKAAEELGVSRPTFYDMIKKHGLMPLHGGEKGADS
>Mature_467_residues
MHMVKILIIDDDPDIRQQLKWGLSDEYSVVQAGTVQEGIVAFKKHHPTVVILDLGLPPYEHSSEEGFRGLAALLELNPHV
KIIMLTGNSERENALKAMQLGAYDFYPKPPVLNELKVIIGRAVHVAGLEEQNRTLQRAVEMKSMDLGGMLGQCPEMQTIF
ATIKKVAPSDVSILITGENGTGKELVAQALHDASLRRKGPFIPINCGAIPENLLESELFGHERGAFTGAHTTVQGKLQYA
NKGTLFLDEIGELPVNLQVKLLRFLQEGVIQRVGGRVDIPVDTRTVCATNVNIAQAIKEGRFREDLYYRISVISIHLPPL
RERGEDILLLANYFLRMYSDEHKKKVRRFSAAAVHFLKSYEWPGNVRELRNRVQRAIIMSDASVVEPDDLGCEMELPEFD
EEIRPIVTLREARDKVERELLVQAMDRQNGNIAKAAEELGVSRPTFYDMIKKHGLMPLHGGEKGADS

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=462, Percent_Identity=40.2597402597403, Blast_Score=350, Evalue=8e-98,
Organism=Escherichia coli, GI1790437, Length=453, Percent_Identity=36.644591611479, Blast_Score=301, Evalue=4e-83,
Organism=Escherichia coli, GI1788905, Length=451, Percent_Identity=39.0243902439024, Blast_Score=297, Evalue=1e-81,
Organism=Escherichia coli, GI1790299, Length=478, Percent_Identity=37.0292887029289, Blast_Score=296, Evalue=2e-81,
Organism=Escherichia coli, GI87082152, Length=337, Percent_Identity=42.1364985163205, Blast_Score=251, Evalue=7e-68,
Organism=Escherichia coli, GI87082117, Length=340, Percent_Identity=39.4117647058824, Blast_Score=251, Evalue=1e-67,
Organism=Escherichia coli, GI1789233, Length=358, Percent_Identity=39.6648044692737, Blast_Score=248, Evalue=6e-67,
Organism=Escherichia coli, GI1786524, Length=323, Percent_Identity=44.8916408668731, Blast_Score=247, Evalue=1e-66,
Organism=Escherichia coli, GI1789087, Length=334, Percent_Identity=39.5209580838323, Blast_Score=241, Evalue=5e-65,
Organism=Escherichia coli, GI87081872, Length=317, Percent_Identity=41.0094637223975, Blast_Score=224, Evalue=6e-60,
Organism=Escherichia coli, GI1787583, Length=349, Percent_Identity=35.243553008596, Blast_Score=218, Evalue=6e-58,
Organism=Escherichia coli, GI87081858, Length=303, Percent_Identity=30.03300330033, Blast_Score=149, Evalue=5e-37,
Organism=Escherichia coli, GI1789828, Length=269, Percent_Identity=33.0855018587361, Blast_Score=132, Evalue=6e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 52263; Mature: 52263

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHMVKILIIDDDPDIRQQLKWGLSDEYSVVQAGTVQEGIVAFKKHHPTVVILDLGLPPYE
CCEEEEEEECCCHHHHHHHHCCCCCCCCEEECCCHHHHHHHHHCCCCEEEEEECCCCCCC
HSSEEGFRGLAALLELNPHVKIIMLTGNSERENALKAMQLGAYDFYPKPPVLNELKVIIG
CCCCHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
RAVHVAGLEEQNRTLQRAVEMKSMDLGGMLGQCPEMQTIFATIKKVAPSDVSILITGENG
HHHHEECCCHHHHHHHHHHHHHHCCCCCHHCCCCCHHHHHHHHHHCCCCCEEEEEECCCC
TGKELVAQALHDASLRRKGPFIPINCGAIPENLLESELFGHERGAFTGAHTTVQGKLQYA
CHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEEEC
NKGTLFLDEIGELPVNLQVKLLRFLQEGVIQRVGGRVDIPVDTRTVCATNVNIAQAIKEG
CCCCEEEEHHCCCCCCHHHHHHHHHHHHHHHHCCCEEECCCCCCEEEECCCHHHHHHHHC
RFREDLYYRISVISIHLPPLRERGEDILLLANYFLRMYSDEHKKKVRRFSAAAVHFLKSY
CCHHCCEEEEEEEEEECCCHHHCCCCEEEHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHC
EWPGNVRELRNRVQRAIIMSDASVVEPDDLGCEMELPEFDEEIRPIVTLREARDKVEREL
CCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
LVQAMDRQNGNIAKAAEELGVSRPTFYDMIKKHGLMPLHGGEKGADS
HHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MHMVKILIIDDDPDIRQQLKWGLSDEYSVVQAGTVQEGIVAFKKHHPTVVILDLGLPPYE
CCEEEEEEECCCHHHHHHHHCCCCCCCCEEECCCHHHHHHHHHCCCCEEEEEECCCCCCC
HSSEEGFRGLAALLELNPHVKIIMLTGNSERENALKAMQLGAYDFYPKPPVLNELKVIIG
CCCCHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
RAVHVAGLEEQNRTLQRAVEMKSMDLGGMLGQCPEMQTIFATIKKVAPSDVSILITGENG
HHHHEECCCHHHHHHHHHHHHHHCCCCCHHCCCCCHHHHHHHHHHCCCCCEEEEEECCCC
TGKELVAQALHDASLRRKGPFIPINCGAIPENLLESELFGHERGAFTGAHTTVQGKLQYA
CHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEEEC
NKGTLFLDEIGELPVNLQVKLLRFLQEGVIQRVGGRVDIPVDTRTVCATNVNIAQAIKEG
CCCCEEEEHHCCCCCCHHHHHHHHHHHHHHHHCCCEEECCCCCCEEEECCCHHHHHHHHC
RFREDLYYRISVISIHLPPLRERGEDILLLANYFLRMYSDEHKKKVRRFSAAAVHFLKSY
CCHHCCEEEEEEEEEECCCHHHCCCCEEEHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHC
EWPGNVRELRNRVQRAIIMSDASVVEPDDLGCEMELPEFDEEIRPIVTLREARDKVEREL
CCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
LVQAMDRQNGNIAKAAEELGVSRPTFYDMIKKHGLMPLHGGEKGADS
HHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]