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The map label for this gene is relA [H]

Identifier: 118580813

GI number: 118580813

Start: 2596250

End: 2598403

Strand: Reverse

Name: relA [H]

Synonym: Ppro_2399

Alternate gene names: 118580813

Gene position: 2598403-2596250 (Counterclockwise)

Preceding gene: 118580814

Following gene: 118580812

Centisome position: 64.83

GC content: 60.17

Gene sequence:

>2154_bases
ATGATCAGGCTCAACGACATCCTCGACAAGGTGGCGTCCTATAACCCCACCGCCGACCTGAACCTCATCCGCAAGGCCTA
CGTCTACTGCGCCAAGGTCCATCAGGGCCAGACCCGCCTGTCGGGCGAACCGTACATCATTCACCCCATGGAAGTGGCCG
GTCTGCTGGCCGAGCTGCGTCTGGACGTGGCCAGCGTCATCACCGGCTTTCTGCACGATACCATCGAGGATACCCTGACC
ACCGCCGAGGAGCTGACCTCCCTGTTCGGCGATGAGGTCGCCACCCTGGTGGATGGCGTCACCAAAATTAGCAAGATCCA
TTTCAAGACCAAGGCCGAGAGCCAGGCCGAAAATTTCCGCAAGATGCTGCTGGCCATGTCCATCGACATCCGCGTGATCC
TGGTCAAACTGGCCGACCGTCTCCACAACATGCGTACCCTGGAGTTTCAGCCCGAGCTGAAGCAGCGTTCCATCGCCCAG
GAGACCATGGACATCTATGCCCCCATCGCCAATCGGCTGGGTATCTCCTGGATCAAGGTGGAGCTGGAGGATCTCTCCTT
CCGCTACCTCAATCCGGAGATCTATTTCGATCTGGCGCGCAAGATCTCCCTGAAGAAGCGGGAGCGAGAGGCCTATGTGT
CCGAGGCCAAGACCGTCATCGCCGACAAGCTGGGGCAGCACGGCATCAAGGGAGAGGTCTCGGGGCGCAGCAAGCATCTC
TACTCCATTTACCGCAAAATGCTGGCGCGCAACGTTGAGTTGGACGAAATCTACGACCTGATCGCCCTGCGCATCCTGGT
GGACGACGTGCGCGACTGCTACGAGGTGCTGGGGGTGATCCACTCGGCCTGGAAGCCGATCCCGGGGCGCTTCAAGGATT
ACATCGCCATGCCCAAGGGGAACATGTACCAGTCGCTGCACACGACGGTGATCGGGCCCCACGGCGACCGCATGGAGGTG
CAGATCCGCACCCACGAGATGCACAACGTAGCCGATGCCGGCATCGCGGCCCACTGGAAGTACAAGGAAGGCAAGGGGTA
CGACGAGAGGGACGTGAAGCGCTTCTCCTGGCTGCGCCAGCTCCTGGAGTGGCAGCAGGAGCTGCAGGACTCCCGTGAGT
TCATGGATTCGGTCAAGGTGGAGCTGTTCCCTGAGGAGGTCTACGTCTTTACCCCCCAGGGGGATGTGAAACCGTTCCCG
CGGGGGTCGACACCCATCGATTTCGCCTATGCGGTGCACTCCGATGTGGGGCACCGCTGCGTGGGGGCCAAGGTCAACGG
CAAGCTGGTGCCGCTGAAGTACGAGCTGAAGAACGGCGACATCGTGGAGGTGATTACTTCCCCCCACCACACCCCCAGCA
AGGACTGGCTCAAGATCGTCAAGAGCTCCCGTGCCCGCAACCGAATCCGGGCCTGGATCAAGACCGAGGAGCGCAAACAC
AGCATCGTGCTGGGCAGGGAAATCTGCGAGAAGGATTTCCGCAAATATTCGGTGAACCTGCAGAAGATCCAGAAGAGCGG
TGATTTCAAACGCATCGCCGGCGAATTCGGTTTCGCCGGTGATGATGACCTGCTGGCCGCGGTGGGGTATGGCAGGATAA
CCCCCAACCAGATCATCGGCAGGCTGCTGCCGGAGGGGAAACTCCAGGAAAGGACGGAGCGCAAGGAGTCGCGCCTGAGT
GCGGCCATCAATAAGCTCAGGGGCAAGACCACCTCCGAGGCGGTGGAGATCAGCGGCGTGGATGACGTGCTGGTCCGCTT
CGGCAAGTGCTGCAACCCGGTGCCGGGGGACGAGATCATCGGCTTCATCACCCGCGGCAAGGGGGTGACGGTGCATACGG
CCGACTGTAAGTTCGCCCTTGAGAGCGATCCGGAGCGGCGCATAGACGTGACCTGGAACCAGAGCAAAACCAGTGGCCTG
CCGGTCAGGATTCGCGTGGTCTGCCATGACGTTAAGGGGATTCTTGCCAACATTTCCCTGGCCATCGCCAACAGCGAGGC
AAATATCGTCAGTGCAATGATCCAAAGCACGGTGGACAAGCGGGGCGAGAACATCTTCGAGGTGAGCGTGGTCGACCTGG
CTCACCTGCAACGGGTTATGAACGCCCTGATGAAGGTCAAGGGTGTAATTACGGTGGAAAGGATGAAAAATTGA

Upstream 100 bases:

>100_bases
AACCGCTCAACCGGGAGAAGCCCGTCATCGCGACAGGCTTCTCCTTTTTTTTCCTTCCCCTGCTGTATCCACCACATTCT
TGTCAGGCGACTAACGGCAC

Downstream 100 bases:

>100_bases
AACTGGACGTGATATCGACGGATAAGGCGCCCGCAGCCATAGGACCCTATTCCCAGGCGGTGCGACTGGGGGATATTCTC
TTCTGTTCCGGCCAGATACC

Product: (p)ppGpp synthetase I SpoT/RelA

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; ppGpp synthase I [H]

Number of amino acids: Translated: 717; Mature: 717

Protein sequence:

>717_residues
MIRLNDILDKVASYNPTADLNLIRKAYVYCAKVHQGQTRLSGEPYIIHPMEVAGLLAELRLDVASVITGFLHDTIEDTLT
TAEELTSLFGDEVATLVDGVTKISKIHFKTKAESQAENFRKMLLAMSIDIRVILVKLADRLHNMRTLEFQPELKQRSIAQ
ETMDIYAPIANRLGISWIKVELEDLSFRYLNPEIYFDLARKISLKKREREAYVSEAKTVIADKLGQHGIKGEVSGRSKHL
YSIYRKMLARNVELDEIYDLIALRILVDDVRDCYEVLGVIHSAWKPIPGRFKDYIAMPKGNMYQSLHTTVIGPHGDRMEV
QIRTHEMHNVADAGIAAHWKYKEGKGYDERDVKRFSWLRQLLEWQQELQDSREFMDSVKVELFPEEVYVFTPQGDVKPFP
RGSTPIDFAYAVHSDVGHRCVGAKVNGKLVPLKYELKNGDIVEVITSPHHTPSKDWLKIVKSSRARNRIRAWIKTEERKH
SIVLGREICEKDFRKYSVNLQKIQKSGDFKRIAGEFGFAGDDDLLAAVGYGRITPNQIIGRLLPEGKLQERTERKESRLS
AAINKLRGKTTSEAVEISGVDDVLVRFGKCCNPVPGDEIIGFITRGKGVTVHTADCKFALESDPERRIDVTWNQSKTSGL
PVRIRVVCHDVKGILANISLAIANSEANIVSAMIQSTVDKRGENIFEVSVVDLAHLQRVMNALMKVKGVITVERMKN

Sequences:

>Translated_717_residues
MIRLNDILDKVASYNPTADLNLIRKAYVYCAKVHQGQTRLSGEPYIIHPMEVAGLLAELRLDVASVITGFLHDTIEDTLT
TAEELTSLFGDEVATLVDGVTKISKIHFKTKAESQAENFRKMLLAMSIDIRVILVKLADRLHNMRTLEFQPELKQRSIAQ
ETMDIYAPIANRLGISWIKVELEDLSFRYLNPEIYFDLARKISLKKREREAYVSEAKTVIADKLGQHGIKGEVSGRSKHL
YSIYRKMLARNVELDEIYDLIALRILVDDVRDCYEVLGVIHSAWKPIPGRFKDYIAMPKGNMYQSLHTTVIGPHGDRMEV
QIRTHEMHNVADAGIAAHWKYKEGKGYDERDVKRFSWLRQLLEWQQELQDSREFMDSVKVELFPEEVYVFTPQGDVKPFP
RGSTPIDFAYAVHSDVGHRCVGAKVNGKLVPLKYELKNGDIVEVITSPHHTPSKDWLKIVKSSRARNRIRAWIKTEERKH
SIVLGREICEKDFRKYSVNLQKIQKSGDFKRIAGEFGFAGDDDLLAAVGYGRITPNQIIGRLLPEGKLQERTERKESRLS
AAINKLRGKTTSEAVEISGVDDVLVRFGKCCNPVPGDEIIGFITRGKGVTVHTADCKFALESDPERRIDVTWNQSKTSGL
PVRIRVVCHDVKGILANISLAIANSEANIVSAMIQSTVDKRGENIFEVSVVDLAHLQRVMNALMKVKGVITVERMKN
>Mature_717_residues
MIRLNDILDKVASYNPTADLNLIRKAYVYCAKVHQGQTRLSGEPYIIHPMEVAGLLAELRLDVASVITGFLHDTIEDTLT
TAEELTSLFGDEVATLVDGVTKISKIHFKTKAESQAENFRKMLLAMSIDIRVILVKLADRLHNMRTLEFQPELKQRSIAQ
ETMDIYAPIANRLGISWIKVELEDLSFRYLNPEIYFDLARKISLKKREREAYVSEAKTVIADKLGQHGIKGEVSGRSKHL
YSIYRKMLARNVELDEIYDLIALRILVDDVRDCYEVLGVIHSAWKPIPGRFKDYIAMPKGNMYQSLHTTVIGPHGDRMEV
QIRTHEMHNVADAGIAAHWKYKEGKGYDERDVKRFSWLRQLLEWQQELQDSREFMDSVKVELFPEEVYVFTPQGDVKPFP
RGSTPIDFAYAVHSDVGHRCVGAKVNGKLVPLKYELKNGDIVEVITSPHHTPSKDWLKIVKSSRARNRIRAWIKTEERKH
SIVLGREICEKDFRKYSVNLQKIQKSGDFKRIAGEFGFAGDDDLLAAVGYGRITPNQIIGRLLPEGKLQERTERKESRLS
AAINKLRGKTTSEAVEISGVDDVLVRFGKCCNPVPGDEIIGFITRGKGVTVHTADCKFALESDPERRIDVTWNQSKTSGL
PVRIRVVCHDVKGILANISLAIANSEANIVSAMIQSTVDKRGENIFEVSVVDLAHLQRVMNALMKVKGVITVERMKN

Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which i

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HD domain [H]

Homologues:

Organism=Escherichia coli, GI1790082, Length=711, Percent_Identity=41.7721518987342, Blast_Score=558, Evalue=1e-160,
Organism=Escherichia coli, GI1789147, Length=719, Percent_Identity=36.9958275382476, Blast_Score=514, Evalue=1e-147,
Organism=Caenorhabditis elegans, GI25143118, Length=134, Percent_Identity=36.5671641791045, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR003607
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 81229; Mature: 81229

Theoretical pI: Translated: 8.98; Mature: 8.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRLNDILDKVASYNPTADLNLIRKAYVYCAKVHQGQTRLSGEPYIIHPMEVAGLLAELR
CCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEECHHHHHHHHHHHH
LDVASVITGFLHDTIEDTLTTAEELTSLFGDEVATLVDGVTKISKIHFKTKAESQAENFR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KMLLAMSIDIRVILVKLADRLHNMRTLEFQPELKQRSIAQETMDIYAPIANRLGISWIKV
HHHHHHHCHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCEEEEE
ELEDLSFRYLNPEIYFDLARKISLKKREREAYVSEAKTVIADKLGQHGIKGEVSGRSKHL
EEECCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHH
YSIYRKMLARNVELDEIYDLIALRILVDDVRDCYEVLGVIHSAWKPIPGRFKDYIAMPKG
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHEECCCC
NMYQSLHTTVIGPHGDRMEVQIRTHEMHNVADAGIAAHWKYKEGKGYDERDVKRFSWLRQ
CHHHHHHHEEECCCCCEEEEEEEECHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHH
LLEWQQELQDSREFMDSVKVELFPEEVYVFTPQGDVKPFPRGSTPIDFAYAVHSDVGHRC
HHHHHHHHHHHHHHHHHHCEEEEECEEEEECCCCCCCCCCCCCCCCEEHEEHHHCCCCEE
VGAKVNGKLVPLKYELKNGDIVEVITSPHHTPSKDWLKIVKSSRARNRIRAWIKTEERKH
ECCEECCEEEEEEEEECCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHH
SIVLGREICEKDFRKYSVNLQKIQKSGDFKRIAGEFGFAGDDDLLAAVGYGRITPNQIIG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCEEECCCCCCCHHHHHH
RLLPEGKLQERTERKESRLSAAINKLRGKTTSEAVEISGVDDVLVRFGKCCNPVPGDEII
HHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHCCCCCCCHHHE
GFITRGKGVTVHTADCKFALESDPERRIDVTWNQSKTSGLPVRIRVVCHDVKGILANISL
EEEECCCCEEEEECCCEEEECCCCCCEEEEEECCCCCCCCCEEEEEEEHHHHHHHHHEEE
AIANSEANIVSAMIQSTVDKRGENIFEVSVVDLAHLQRVMNALMKVKGVITVERMKN
EEECCCHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHCCEEEEECCC
>Mature Secondary Structure
MIRLNDILDKVASYNPTADLNLIRKAYVYCAKVHQGQTRLSGEPYIIHPMEVAGLLAELR
CCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEECHHHHHHHHHHHH
LDVASVITGFLHDTIEDTLTTAEELTSLFGDEVATLVDGVTKISKIHFKTKAESQAENFR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KMLLAMSIDIRVILVKLADRLHNMRTLEFQPELKQRSIAQETMDIYAPIANRLGISWIKV
HHHHHHHCHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCEEEEE
ELEDLSFRYLNPEIYFDLARKISLKKREREAYVSEAKTVIADKLGQHGIKGEVSGRSKHL
EEECCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHH
YSIYRKMLARNVELDEIYDLIALRILVDDVRDCYEVLGVIHSAWKPIPGRFKDYIAMPKG
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHEECCCC
NMYQSLHTTVIGPHGDRMEVQIRTHEMHNVADAGIAAHWKYKEGKGYDERDVKRFSWLRQ
CHHHHHHHEEECCCCCEEEEEEEECHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHH
LLEWQQELQDSREFMDSVKVELFPEEVYVFTPQGDVKPFPRGSTPIDFAYAVHSDVGHRC
HHHHHHHHHHHHHHHHHHCEEEEECEEEEECCCCCCCCCCCCCCCCEEHEEHHHCCCCEE
VGAKVNGKLVPLKYELKNGDIVEVITSPHHTPSKDWLKIVKSSRARNRIRAWIKTEERKH
ECCEECCEEEEEEEEECCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHH
SIVLGREICEKDFRKYSVNLQKIQKSGDFKRIAGEFGFAGDDDLLAAVGYGRITPNQIIG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCEEECCCCCCCHHHHHH
RLLPEGKLQERTERKESRLSAAINKLRGKTTSEAVEISGVDDVLVRFGKCCNPVPGDEII
HHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHCCCCCCCHHHE
GFITRGKGVTVHTADCKFALESDPERRIDVTWNQSKTSGLPVRIRVVCHDVKGILANISL
EEEECCCCEEEEECCCEEEECCCCCCEEEEEECCCCCCCCCEEEEEEEHHHHHHHHHEEE
AIANSEANIVSAMIQSTVDKRGENIFEVSVVDLAHLQRVMNALMKVKGVITVERMKN
EEECCCHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA