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The map label for this gene is aroE

Identifier: 118580774

GI number: 118580774

Start: 2553103

End: 2553936

Strand: Direct

Name: aroE

Synonym: Ppro_2359

Alternate gene names: 118580774

Gene position: 2553103-2553936 (Clockwise)

Preceding gene: 118580772

Following gene: 118580775

Centisome position: 63.7

GC content: 63.31

Gene sequence:

>834_bases
ATGAATCCATGTAGCACCCCCAGCCTGTATGGCGTCATCGGCTACCCCCTGGGGCACAGCTTGAGCCCGCTTCTCCACAA
CACCGCGTTTCGCGAACTGGGCATTCCCGGTGTTCTGCTGCCCTGGTCCATCGAGCCGGAGCGGCTTCCCGCCTTCATCC
AGTCGGTTCGACTGCTCAATATCCGCGGCGCCTGCGTCACGATCCCCCACAAGCAGAGCATCATCCCGCTTCTGGACCGG
GTAACCGACCGGGTCAAGGCGCTGGGTGCGGCGAACACGCTCTACTGGGATGGCGATCTCCTCTGCGGTGACAATACCGA
CATCCTGGGCTTCATGTCGCCGCTGCAGGCGGATCCACCGTCGGCGGAGCAGACAAGGGTTCTGGTGCTGGGGGCAGGCG
GTGTCGCCAGGGCAGCCGTGGCGGGCCTGAAGAGCCTGGGGCTGAACCAAATCACCATAACCGATATCGTGGATGCATCG
TCGGCAACCCTGGCAGAGACATTTGACCTGAAGACCATCCCCTGGTCCCAACGCAGCGAAGTCGACGCCCACATCCTGAT
CAACACCACTCCGCTGGGCATGAAGGGCAAGTTCGAGGAGGAGAGTCCCTACCCCACCGAAGCCCTGGCGGCTAGGCAGG
GCATTGCCTACGATATCGTCTATACCCCCTTCGTGACCCGTTTCCTGCGCGAGGCCCGGGCAGCCGGGTGGAAAACCATC
GGCGGCCTGGAGATGTTCATCTCCCAGGCTGACCACCAGTTCCTCACCTGGACCGGCAGGAACCTGCCGCAGGCCGCCAA
GCAGGCGGTGATTGACGCACTCACCGCCACGTAG

Upstream 100 bases:

>100_bases
CAGGCAACAATCCGGAATCACCGGACAATCGCTTTCAAGCGGGACGCGCCCTCCCTCTGCACGGAACAGCCCGCGCTCCC
CACCAACCCGGAGGCATATC

Downstream 100 bases:

>100_bases
CATCTCCTCAAGACGGAAAGGGAGTTATGAAAAAGATACTCGTCCTCAACGGCATCAACCTGAACATGTTCGGCAAACGC
GATCCCGCCCACTACGGAAC

Product: shikimate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 277; Mature: 277

Protein sequence:

>277_residues
MNPCSTPSLYGVIGYPLGHSLSPLLHNTAFRELGIPGVLLPWSIEPERLPAFIQSVRLLNIRGACVTIPHKQSIIPLLDR
VTDRVKALGAANTLYWDGDLLCGDNTDILGFMSPLQADPPSAEQTRVLVLGAGGVARAAVAGLKSLGLNQITITDIVDAS
SATLAETFDLKTIPWSQRSEVDAHILINTTPLGMKGKFEEESPYPTEALAARQGIAYDIVYTPFVTRFLREARAAGWKTI
GGLEMFISQADHQFLTWTGRNLPQAAKQAVIDALTAT

Sequences:

>Translated_277_residues
MNPCSTPSLYGVIGYPLGHSLSPLLHNTAFRELGIPGVLLPWSIEPERLPAFIQSVRLLNIRGACVTIPHKQSIIPLLDR
VTDRVKALGAANTLYWDGDLLCGDNTDILGFMSPLQADPPSAEQTRVLVLGAGGVARAAVAGLKSLGLNQITITDIVDAS
SATLAETFDLKTIPWSQRSEVDAHILINTTPLGMKGKFEEESPYPTEALAARQGIAYDIVYTPFVTRFLREARAAGWKTI
GGLEMFISQADHQFLTWTGRNLPQAAKQAVIDALTAT
>Mature_277_residues
MNPCSTPSLYGVIGYPLGHSLSPLLHNTAFRELGIPGVLLPWSIEPERLPAFIQSVRLLNIRGACVTIPHKQSIIPLLDR
VTDRVKALGAANTLYWDGDLLCGDNTDILGFMSPLQADPPSAEQTRVLVLGAGGVARAAVAGLKSLGLNQITITDIVDAS
SATLAETFDLKTIPWSQRSEVDAHILINTTPLGMKGKFEEESPYPTEALAARQGIAYDIVYTPFVTRFLREARAAGWKTI
GGLEMFISQADHQFLTWTGRNLPQAAKQAVIDALTAT

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1787983, Length=277, Percent_Identity=29.9638989169675, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1789675, Length=261, Percent_Identity=33.3333333333333, Blast_Score=97, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6320332, Length=288, Percent_Identity=31.25, Blast_Score=107, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROE_PELPD (A1ARJ6)

Other databases:

- EMBL:   CP000482
- RefSeq:   YP_902024.1
- ProteinModelPortal:   A1ARJ6
- SMR:   A1ARJ6
- STRING:   A1ARJ6
- GeneID:   4575054
- GenomeReviews:   CP000482_GR
- KEGG:   ppd:Ppro_2359
- eggNOG:   COG0169
- HOGENOM:   HBG553408
- OMA:   EMFISQA
- PhylomeDB:   A1ARJ6
- ProtClustDB:   CLSK2526637
- GO:   GO:0005737
- HAMAP:   MF_00222
- InterPro:   IPR016040
- InterPro:   IPR011342
- InterPro:   IPR013708
- InterPro:   IPR022893
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR00507

Pfam domain/function: PF01488 Shikimate_DH; PF08501 Shikimate_dh_N

EC number: =1.1.1.25

Molecular weight: Translated: 29916; Mature: 29916

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: NA

Important sites: ACT_SITE 71-71

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPCSTPSLYGVIGYPLGHSLSPLLHNTAFRELGIPGVLLPWSIEPERLPAFIQSVRLLN
CCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHEEE
IRGACVTIPHKQSIIPLLDRVTDRVKALGAANTLYWDGDLLCGDNTDILGFMSPLQADPP
ECCCEEECCCCCCHHHHHHHHHHHHHHHCCCCEEEECCEEEECCCCCCEEECCCCCCCCC
SAEQTRVLVLGAGGVARAAVAGLKSLGLNQITITDIVDASSATLAETFDLKTIPWSQRSE
CCCCCEEEEEECCCHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHCCCCCCCCCCCCC
VDAHILINTTPLGMKGKFEEESPYPTEALAARQGIAYDIVYTPFVTRFLREARAAGWKTI
CCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHCCCEEEEEHHHHHHHHHHHHHHCCCCHH
GGLEMFISQADHQFLTWTGRNLPQAAKQAVIDALTAT
HHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNPCSTPSLYGVIGYPLGHSLSPLLHNTAFRELGIPGVLLPWSIEPERLPAFIQSVRLLN
CCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHEEE
IRGACVTIPHKQSIIPLLDRVTDRVKALGAANTLYWDGDLLCGDNTDILGFMSPLQADPP
ECCCEEECCCCCCHHHHHHHHHHHHHHHCCCCEEEECCEEEECCCCCCEEECCCCCCCCC
SAEQTRVLVLGAGGVARAAVAGLKSLGLNQITITDIVDASSATLAETFDLKTIPWSQRSE
CCCCCEEEEEECCCHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHCCCCCCCCCCCCC
VDAHILINTTPLGMKGKFEEESPYPTEALAARQGIAYDIVYTPFVTRFLREARAAGWKTI
CCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHCCCEEEEEHHHHHHHHHHHHHHCCCCHH
GGLEMFISQADHQFLTWTGRNLPQAAKQAVIDALTAT
HHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA