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The map label for this gene is lepB [H]

Identifier: 118580745

GI number: 118580745

Start: 2516275

End: 2516940

Strand: Reverse

Name: lepB [H]

Synonym: Ppro_2330

Alternate gene names: 118580745

Gene position: 2516940-2516275 (Counterclockwise)

Preceding gene: 118580746

Following gene: 118580744

Centisome position: 62.8

GC content: 60.06

Gene sequence:

>666_bases
ATGCAAGAAAAAGTGGAAGCAGCTCAGAACGCTACCGTTCGGGAGGCTGAACAGGTCGTGAAAAAGAAGAGTATCGTCCG
CGAATATGCCGAGTCCATCATCATCGCCCTGCTCCTGGCGCTGGTCATCCGCACCTATCTGGTGCAGGCCTTCAAGATCC
CCTCCGGCTCCATGGAGGACACCTTGGCCATCGGCGACCATCTGCTGGTGAGCAAGTTCATCTACGGCACCAAGATTCCC
TTCACCGATTCCCAGATCATCAAGGTTCGCGACCCCCGCCAGGGGGACGTGATCGTGTTCGAGTATCCCGAAGATCCCAG
CAAGGACTTCATCAAGCGGGTGGTCGGCACCCCGGGTGACGTTGTGGAGGGGAGGGACAAGAAGGTCTACGTGAACGGCA
GGCTCTACCGGAACCCCCACGAGGTCCACAAGGAGCGGGAGATCATCCCCAAGGAGATGAACCCCCGGGACAGCTTCGGC
CCGGTGACCGTGCCGGCCAACTCCTATTTCGTCATGGGGGACAACCGCGACCGCTCCTACGACAGCCGCTTCTGGGGTTT
CGTTTCCCGCGACAAGATCAAGGGGCTGGCCTTCATCAAGTACTGGTCCTGGGACCGGGAGACGTTCCGGCCGCGCATGG
GCAGCATTGGCACGCTGATCGACTGA

Upstream 100 bases:

>100_bases
TTTCTGGCGATTCTCAAAGTGGAGTAGCGGGTCACAGCCAAAGAAAACAGTCAGGCGATTTGCGCATAGCTCGCGCGCCT
CCGCCCCAAGAGGAAGCAAC

Downstream 100 bases:

>100_bases
TCGCGGCAAGCCGGGCAGGGGACCCGCTCCCTTCCGCCTTGGTATGCGCCGCGAGTTCAACCTGAAAACGCGCTTCAGGT
TCCCGCGTTTTGGGTTCAGA

Product: signal peptidase I

Products: NA

Alternate protein names: SPase I; Leader peptidase I [H]

Number of amino acids: Translated: 221; Mature: 221

Protein sequence:

>221_residues
MQEKVEAAQNATVREAEQVVKKKSIVREYAESIIIALLLALVIRTYLVQAFKIPSGSMEDTLAIGDHLLVSKFIYGTKIP
FTDSQIIKVRDPRQGDVIVFEYPEDPSKDFIKRVVGTPGDVVEGRDKKVYVNGRLYRNPHEVHKEREIIPKEMNPRDSFG
PVTVPANSYFVMGDNRDRSYDSRFWGFVSRDKIKGLAFIKYWSWDRETFRPRMGSIGTLID

Sequences:

>Translated_221_residues
MQEKVEAAQNATVREAEQVVKKKSIVREYAESIIIALLLALVIRTYLVQAFKIPSGSMEDTLAIGDHLLVSKFIYGTKIP
FTDSQIIKVRDPRQGDVIVFEYPEDPSKDFIKRVVGTPGDVVEGRDKKVYVNGRLYRNPHEVHKEREIIPKEMNPRDSFG
PVTVPANSYFVMGDNRDRSYDSRFWGFVSRDKIKGLAFIKYWSWDRETFRPRMGSIGTLID
>Mature_221_residues
MQEKVEAAQNATVREAEQVVKKKSIVREYAESIIIALLLALVIRTYLVQAFKIPSGSMEDTLAIGDHLLVSKFIYGTKIP
FTDSQIIKVRDPRQGDVIVFEYPEDPSKDFIKRVVGTPGDVVEGRDKKVYVNGRLYRNPHEVHKEREIIPKEMNPRDSFG
PVTVPANSYFVMGDNRDRSYDSRFWGFVSRDKIKGLAFIKYWSWDRETFRPRMGSIGTLID

Specific function: Unknown

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family [H]

Homologues:

Organism=Escherichia coli, GI1788921, Length=95, Percent_Identity=48.4210526315789, Blast_Score=100, Evalue=7e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019757
- InterPro:   IPR019756
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056 [H]

Pfam domain/function: PF00717 Peptidase_S24 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 25404; Mature: 25404

Theoretical pI: Translated: 9.58; Mature: 9.58

Prosite motif: PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQEKVEAAQNATVREAEQVVKKKSIVREYAESIIIALLLALVIRTYLVQAFKIPSGSMED
CCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCH
TLAIGDHLLVSKFIYGTKIPFTDSQIIKVRDPRQGDVIVFEYPEDPSKDFIKRVVGTPGD
HHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCEEEEECCCCCHHHHHHHHHCCCCC
VVEGRDKKVYVNGRLYRNPHEVHKEREIIPKEMNPRDSFGPVTVPANSYFVMGDNRDRSY
CCCCCCCEEEECCEEECCHHHHHHHHHCCCCCCCCCCCCCCEEECCCCEEEEECCCCCCC
DSRFWGFVSRDKIKGLAFIKYWSWDRETFRPRMGSIGTLID
HHHHHCCCCHHHHCCEEEEEEECCCHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MQEKVEAAQNATVREAEQVVKKKSIVREYAESIIIALLLALVIRTYLVQAFKIPSGSMED
CCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCH
TLAIGDHLLVSKFIYGTKIPFTDSQIIKVRDPRQGDVIVFEYPEDPSKDFIKRVVGTPGD
HHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCEEEEECCCCCHHHHHHHHHCCCCC
VVEGRDKKVYVNGRLYRNPHEVHKEREIIPKEMNPRDSFGPVTVPANSYFVMGDNRDRSY
CCCCCCCEEEECCEEECCHHHHHHHHHCCCCCCCCCCCCCCEEECCCCEEEEECCCCCCC
DSRFWGFVSRDKIKGLAFIKYWSWDRETFRPRMGSIGTLID
HHHHHCCCCHHHHCCEEEEEEECCCHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1546969 [H]