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The map label for this gene is yqeC [H]

Identifier: 118580664

GI number: 118580664

Start: 2428259

End: 2429284

Strand: Direct

Name: yqeC [H]

Synonym: Ppro_2249

Alternate gene names: 118580664

Gene position: 2428259-2429284 (Clockwise)

Preceding gene: 118580663

Following gene: 118580665

Centisome position: 60.59

GC content: 67.06

Gene sequence:

>1026_bases
ATGCGCATGGGAATGATCGGAGTGGGGAGGATGGGCGGAGACATGGTGCGGAGGCTCTTGAAGGGCGGTCACGAGTGCGT
GGTCCACGCCCGCAGACCATCGTCCATGGAACCGCTGGTCAGAGAGGGGGCACTGGGGGCAGCGCCCCTGGCCGAACTGG
TCTCGCTGCTCCCGAAGCCGCGCGTGGTCTGGCTGATGATCCCGGCCGCCTCGGTGGACAGGGTCATCGCCGACATAGCG
CCGCTTCTCGACGCGGGCGACATTCTGATCGACGGCGGCAACTCCCACTACCACGACGACATCAGGCGTTGTGACGAACT
GCGCGACAGATCGATCCACTACCTGGATGTGGGCACCAGCGGCGGCGTCTGGGGGCTTGAGCGGGGCTACTGCCTGATGA
TCGGCGGTGAACGGGAAGCGGTGCAGTACCTGGACCCGCTCTTCGCCACCCTGGCCCCCGGCAGGGGCGCAGCCCCGGAC
AGTCCCGGCCGGAGCGACTCCGGCTCCAGTGCCGAAAGGGGCTACCTGCACTGCGGACCCAGCGGGGCCGGACATTTCGT
CAAGATGGTGCACAACGGCATCGAATACGGCATGATGGCCGCCTATGCCGAGGGGTTCAACATCCTGGCCCATGCCAACA
TCGGCAGCCAGGAGCGGGAGACGGATGCCGAGACAACGCCCCTGCGCGACCCGCGCCACTTCCGCTTTGAGCTGAACCTG
GCCGACATCGCCGAACTGTGGCGAAGGGGGAGCGTGGTTTCCTCCTGGCTTTTGGACCTCACCGCCAGGGCCTTGGCCGC
TGGCCAGGGGTTGGAGCGCTTCAGCGGACAGGTTTCCGACTCGGGCGAGGGGCGCTGGACCGTGGCCACGGCCATCGAGG
CAGGTGTCCCGGCACCGGTGCTTGCCACGGCGCTCTTCCAGCGTTTCAGCTCGCGCGGCGAGGCGGACTTCGCCGACCGC
CTCTTGTCGGCCATGCGCTACGAATTCGGCGGCCACCATGAAAAGAGCACATCAGGGGAGGGATAG

Upstream 100 bases:

>100_bases
TTGACGCCGGATCCCGGAACATCATTATGGCGGTATACTCTCCACGGTCGGGGGATGATCGACTGACCGACGCCAAGGAG
AGGGACAGGGAGGAAAAACC

Downstream 100 bases:

>100_bases
ATCATGCCGTCATCCAGAAAGCTGGACCCGACCATCATCGTGATCTTCGGCGGCGGGGGGGATCTGACCAGGCGCAAACT
CATTCCGGCGCTGCACAACC

Product: 6-phosphogluconate dehydrogenase-like protein

Products: D-ribulose 5-phosphate; CO2; NADPH

Alternate protein names: NA

Number of amino acids: Translated: 341; Mature: 341

Protein sequence:

>341_residues
MRMGMIGVGRMGGDMVRRLLKGGHECVVHARRPSSMEPLVREGALGAAPLAELVSLLPKPRVVWLMIPAASVDRVIADIA
PLLDAGDILIDGGNSHYHDDIRRCDELRDRSIHYLDVGTSGGVWGLERGYCLMIGGEREAVQYLDPLFATLAPGRGAAPD
SPGRSDSGSSAERGYLHCGPSGAGHFVKMVHNGIEYGMMAAYAEGFNILAHANIGSQERETDAETTPLRDPRHFRFELNL
ADIAELWRRGSVVSSWLLDLTARALAAGQGLERFSGQVSDSGEGRWTVATAIEAGVPAPVLATALFQRFSSRGEADFADR
LLSAMRYEFGGHHEKSTSGEG

Sequences:

>Translated_341_residues
MRMGMIGVGRMGGDMVRRLLKGGHECVVHARRPSSMEPLVREGALGAAPLAELVSLLPKPRVVWLMIPAASVDRVIADIA
PLLDAGDILIDGGNSHYHDDIRRCDELRDRSIHYLDVGTSGGVWGLERGYCLMIGGEREAVQYLDPLFATLAPGRGAAPD
SPGRSDSGSSAERGYLHCGPSGAGHFVKMVHNGIEYGMMAAYAEGFNILAHANIGSQERETDAETTPLRDPRHFRFELNL
ADIAELWRRGSVVSSWLLDLTARALAAGQGLERFSGQVSDSGEGRWTVATAIEAGVPAPVLATALFQRFSSRGEADFADR
LLSAMRYEFGGHHEKSTSGEG
>Mature_341_residues
MRMGMIGVGRMGGDMVRRLLKGGHECVVHARRPSSMEPLVREGALGAAPLAELVSLLPKPRVVWLMIPAASVDRVIADIA
PLLDAGDILIDGGNSHYHDDIRRCDELRDRSIHYLDVGTSGGVWGLERGYCLMIGGEREAVQYLDPLFATLAPGRGAAPD
SPGRSDSGSSAERGYLHCGPSGAGHFVKMVHNGIEYGMMAAYAEGFNILAHANIGSQERETDAETTPLRDPRHFRFELNL
ADIAELWRRGSVVSSWLLDLTARALAAGQGLERFSGQVSDSGEGRWTVATAIEAGVPAPVLATALFQRFSSRGEADFADR
LLSAMRYEFGGHHEKSTSGEG

Specific function: May act as NAD-dependent 6-P-gluconate dehydrogenase [H]

COG id: COG1023

COG function: function code G; Predicted 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=346, Percent_Identity=30.3468208092486, Blast_Score=135, Evalue=7e-32,
Organism=Escherichia coli, GI1788341, Length=321, Percent_Identity=28.9719626168224, Blast_Score=136, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17542558, Length=321, Percent_Identity=31.4641744548287, Blast_Score=132, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6321695, Length=334, Percent_Identity=32.6347305389222, Blast_Score=149, Evalue=5e-37,
Organism=Saccharomyces cerevisiae, GI6321977, Length=317, Percent_Identity=31.8611987381703, Blast_Score=137, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24639279, Length=316, Percent_Identity=31.3291139240506, Blast_Score=132, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR004849
- InterPro:   IPR006114
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: 1.1.1.44

Molecular weight: Translated: 36721; Mature: 36721

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRMGMIGVGRMGGDMVRRLLKGGHECVVHARRPSSMEPLVREGALGAAPLAELVSLLPKP
CCCCCEECCCCCHHHHHHHHHCCCEEEEECCCCCCCCHHHHHCCCCCCCHHHHHHHCCCC
RVVWLMIPAASVDRVIADIAPLLDAGDILIDGGNSHYHDDIRRCDELRDRSIHYLDVGTS
CEEEEEECCHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHCCEEEEEECCC
GGVWGLERGYCLMIGGEREAVQYLDPLFATLAPGRGAAPDSPGRSDSGSSAERGYLHCGP
CCCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEECC
SGAGHFVKMVHNGIEYGMMAAYAEGFNILAHANIGSQERETDAETTPLRDPRHFRFELNL
CCHHHHHHHHHHCHHHHHHHHHHCCCEEEEECCCCCCHHCCCCCCCCCCCCCCEEEEECH
ADIAELWRRGSVVSSWLLDLTARALAAGQGLERFSGQVSDSGEGRWTVATAIEAGVPAPV
HHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCEEEEEEHHCCCCHHH
LATALFQRFSSRGEADFADRLLSAMRYEFGGHHEKSTSGEG
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MRMGMIGVGRMGGDMVRRLLKGGHECVVHARRPSSMEPLVREGALGAAPLAELVSLLPKP
CCCCCEECCCCCHHHHHHHHHCCCEEEEECCCCCCCCHHHHHCCCCCCCHHHHHHHCCCC
RVVWLMIPAASVDRVIADIAPLLDAGDILIDGGNSHYHDDIRRCDELRDRSIHYLDVGTS
CEEEEEECCHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHCCEEEEEECCC
GGVWGLERGYCLMIGGEREAVQYLDPLFATLAPGRGAAPDSPGRSDSGSSAERGYLHCGP
CCCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEECC
SGAGHFVKMVHNGIEYGMMAAYAEGFNILAHANIGSQERETDAETTPLRDPRHFRFELNL
CCHHHHHHHHHHCHHHHHHHHHHCCCEEEEECCCCCCHHCCCCCCCCCCCCCCEEEEECH
ADIAELWRRGSVVSSWLLDLTARALAAGQGLERFSGQVSDSGEGRWTVATAIEAGVPAPV
HHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCEEEEEEHHCCCCHHH
LATALFQRFSSRGEADFADRLLSAMRYEFGGHHEKSTSGEG
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.05 {6-phosphogluconate}} 0.01 {6-phosphogluconate}} [C]

Substrates: 6-phospho-D-gluconate; NADP+

Specific reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]