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The map label for this gene is bioC [H]

Identifier: 118580507

GI number: 118580507

Start: 2250292

End: 2251128

Strand: Reverse

Name: bioC [H]

Synonym: Ppro_2091

Alternate gene names: 118580507

Gene position: 2251128-2250292 (Counterclockwise)

Preceding gene: 118580508

Following gene: 118580505

Centisome position: 56.17

GC content: 65.47

Gene sequence:

>837_bases
TTGAACAGGGTAGATGACAGAACGAGGATCGGCAGGGGATTCCACCGCCAGGCCGGCGAGTATGACCGACATGCGGTGGT
GCAGAAGCGGGTGGTGACCAACCTGACTCGTCTGGTGCAGTCGCACTGCGACGCGGCGCCGGGAAGCGCGCTGGATATCG
GCTGCGGCACCGGGGCCATGCTCTCCGCACTCGCCGGGCTCTATCCCACTGCCCGGCTCTGCGGTCTCGACCTGGCCTTC
AACATGGCGCTGCGCTCGGCCCAGCGTCTCGGCCCCGCTGCCATGCTGGTCAATGGCGATGCCGAATCCCTCCCCTTCGG
GAGCGCATGCTTCGATCTGGTGGTCTCCGCCTCCACGCTGCAGTGGGTTCAGCGGCTTGACAGTTGCTTCCGGGAATGTC
AGCGTGTGCTGGCGCCGGGCGGACTGCTCTGCGCGGCCTTCTTCGGAGGGAAAACATTGTGGGAGCTGCAGGAGAGCTAC
CGGGAGGCCCTGGCGGATCGCTTTTCCCGCGACGACTGCCGTGGAGGGCGCTTGCAGCGCTTCCGCAGTGCCACGGATGT
GCGTCAGGCCCTGGAGGGGCTGGGTTTCGACCAGGTGATGGTGGCGACCGAGATCGAGATGGAGTATCATCCCGATGTCC
CCGCTCTCTTGCGCTCCATCAAGGGGATCGGCGCAACCACTCCCGCACGCACAGGTACCGGTGGCGGGCTGGGATGGCGG
GGGTTGTTGACCGCCATGGCCGATACCTACCGTTCCCGTTTCCAGAGGGACGGCATGATCCCGGCCACCTATGAGGTGAT
GTACATCGTCGCCCGCAAGAGCGACGATATCCCCTGA

Upstream 100 bases:

>100_bases
GAATGCCGGCAGGTCGTTTTCGCCGGCTGCGGACATGCGCCCTTCTTGACCCGCTGCACTGAATTCAACGATGCAATCAC
GCGTTTCAGCAGGAGGATTT

Downstream 100 bases:

>100_bases
ACGGAGCCGTCAGTGCAGGTCATGGCCGGTGGCGGTCATGACCAGCTTGCCATGCTTGACCCCCTTGACGCCGATCAGCT
CGTCGGCGATCTTCTTGATC

Product: type 11 methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 278; Mature: 278

Protein sequence:

>278_residues
MNRVDDRTRIGRGFHRQAGEYDRHAVVQKRVVTNLTRLVQSHCDAAPGSALDIGCGTGAMLSALAGLYPTARLCGLDLAF
NMALRSAQRLGPAAMLVNGDAESLPFGSACFDLVVSASTLQWVQRLDSCFRECQRVLAPGGLLCAAFFGGKTLWELQESY
REALADRFSRDDCRGGRLQRFRSATDVRQALEGLGFDQVMVATEIEMEYHPDVPALLRSIKGIGATTPARTGTGGGLGWR
GLLTAMADTYRSRFQRDGMIPATYEVMYIVARKSDDIP

Sequences:

>Translated_278_residues
MNRVDDRTRIGRGFHRQAGEYDRHAVVQKRVVTNLTRLVQSHCDAAPGSALDIGCGTGAMLSALAGLYPTARLCGLDLAF
NMALRSAQRLGPAAMLVNGDAESLPFGSACFDLVVSASTLQWVQRLDSCFRECQRVLAPGGLLCAAFFGGKTLWELQESY
REALADRFSRDDCRGGRLQRFRSATDVRQALEGLGFDQVMVATEIEMEYHPDVPALLRSIKGIGATTPARTGTGGGLGWR
GLLTAMADTYRSRFQRDGMIPATYEVMYIVARKSDDIP
>Mature_278_residues
MNRVDDRTRIGRGFHRQAGEYDRHAVVQKRVVTNLTRLVQSHCDAAPGSALDIGCGTGAMLSALAGLYPTARLCGLDLAF
NMALRSAQRLGPAAMLVNGDAESLPFGSACFDLVVSASTLQWVQRLDSCFRECQRVLAPGGLLCAAFFGGKTLWELQESY
REALADRFSRDDCRGGRLQRFRSATDVRQALEGLGFDQVMVATEIEMEYHPDVPALLRSIKGIGATTPARTGTGGGLGWR
GLLTAMADTYRSRFQRDGMIPATYEVMYIVARKSDDIP

Specific function: BioC is involved in an early, but chemically unexplored, step in the conversion of pimelic acid to biotin [H]

COG id: COG0500

COG function: function code QR; SAM-dependent methyltransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily [H]

Homologues:

Organism=Homo sapiens, GI40018642, Length=229, Percent_Identity=32.3144104803493, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI86792933, Length=162, Percent_Identity=30.2469135802469, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI1786994, Length=255, Percent_Identity=26.6666666666667, Blast_Score=74, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17535003, Length=233, Percent_Identity=26.6094420600858, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI19922210, Length=230, Percent_Identity=28.695652173913, Blast_Score=77, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011814
- InterPro:   IPR013216 [H]

Pfam domain/function: PF08241 Methyltransf_11 [H]

EC number: NA

Molecular weight: Translated: 30345; Mature: 30345

Theoretical pI: Translated: 8.21; Mature: 8.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRVDDRTRIGRGFHRQAGEYDRHAVVQKRVVTNLTRLVQSHCDAAPGSALDIGCGTGAM
CCCCCHHHHHCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCHHH
LSALAGLYPTARLCGLDLAFNMALRSAQRLGPAAMLVNGDAESLPFGSACFDLVVSASTL
HHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHHHHH
QWVQRLDSCFRECQRVLAPGGLLCAAFFGGKTLWELQESYREALADRFSRDDCRGGRLQR
HHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
FRSATDVRQALEGLGFDQVMVATEIEMEYHPDVPALLRSIKGIGATTPARTGTGGGLGWR
HHHHHHHHHHHHHCCCCHHHHHEEECCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCHHH
GLLTAMADTYRSRFQRDGMIPATYEVMYIVARKSDDIP
HHHHHHHHHHHHHHHHCCCCCHHHHHHEEEECCCCCCC
>Mature Secondary Structure
MNRVDDRTRIGRGFHRQAGEYDRHAVVQKRVVTNLTRLVQSHCDAAPGSALDIGCGTGAM
CCCCCHHHHHCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCHHH
LSALAGLYPTARLCGLDLAFNMALRSAQRLGPAAMLVNGDAESLPFGSACFDLVVSASTL
HHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHHHHH
QWVQRLDSCFRECQRVLAPGGLLCAAFFGGKTLWELQESYREALADRFSRDDCRGGRLQR
HHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
FRSATDVRQALEGLGFDQVMVATEIEMEYHPDVPALLRSIKGIGATTPARTGTGGGLGWR
HHHHHHHHHHHHHCCCCHHHHHEEECCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCHHH
GLLTAMADTYRSRFQRDGMIPATYEVMYIVARKSDDIP
HHHHHHHHHHHHHHHHCCCCCHHHHHHEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8250549 [H]