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The map label for this gene is pyrH

Identifier: 118580462

GI number: 118580462

Start: 2195911

End: 2196630

Strand: Direct

Name: pyrH

Synonym: Ppro_2046

Alternate gene names: 118580462

Gene position: 2195911-2196630 (Clockwise)

Preceding gene: 118580461

Following gene: 118580463

Centisome position: 54.79

GC content: 61.81

Gene sequence:

>720_bases
ATGAGCAGGCCGAAATTCACCAGGGTATTGCTGAAGCTGTCGGGCGAGTCCCTTGCCGGCAGCCAGGGATATGGTATCGA
CCCAAAAACAATCACCACCATCGCCAGGGAAATCAAGGAAGTGGTTCAGCAGGGGGTGCAGCTTGCCCTGGTCATCGGCG
GCGGCAACATCTTCCGCGGCCTGGCGGCATCCTCCCAGGGAATGGACCGCGCCGGCGCCGACAACATGGGCATGCTGGCC
ACCATGATCAACTCCCTGGCCATGCAGGATGCCCTGGAGAAAATTGGCGTCGCCACCCGCGTCCAGTCGGCCATCGTCAT
GCAGCAGGTCGCCGAACCGTACATCCGCCGCCGGGCCATCCGCCACCTGGAGAAGGGGCGCGTGGTCATCTTCGGCGCCG
GCACCGGCAACCCCTACTTCACCACCGATACCGCCGCCAGCCTGCGGGCCATGGAGATCAGCGCCCAGGCCATCCTCAAG
GGGACCAAGGTGGACGGCGTCTATACGGCCGATCCGAAAAAAGACGCCACCGCCACCAAACTGCCCCGGCTTGCCTACAT
CGATGTCCTCAAACGGGGACTGCAGGTGATGGACGCCACCGCCACATCGCTCTGCATGGACAACAACCTGCCGATCATCG
TCTTCGATCTGACAACCGAGGGCAACATCATCAAGGTTATCAACGGCGAAGAGATCGGCACCATCGTACAAGGAGAATGA

Upstream 100 bases:

>100_bases
GCCGCCGAGGTGGCGGCAGCGGCCGGCCTCAAATAGCAGCCACAGCCGGCCGGAAATGGCCGGCTTTTTTTTATTCAGTA
CACACGGAACGGGAGAGAGC

Downstream 100 bases:

>100_bases
CCCCATGCCCAAAACCGTACTCAGCGACATGAAAACCCATATGGAAAAGACCGTCGCGGTTCTCAAGGCCGAATTCCAGA
AGGTCCGCACCGGCCGCGCC

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK

Number of amino acids: Translated: 239; Mature: 238

Protein sequence:

>239_residues
MSRPKFTRVLLKLSGESLAGSQGYGIDPKTITTIAREIKEVVQQGVQLALVIGGGNIFRGLAASSQGMDRAGADNMGMLA
TMINSLAMQDALEKIGVATRVQSAIVMQQVAEPYIRRRAIRHLEKGRVVIFGAGTGNPYFTTDTAASLRAMEISAQAILK
GTKVDGVYTADPKKDATATKLPRLAYIDVLKRGLQVMDATATSLCMDNNLPIIVFDLTTEGNIIKVINGEEIGTIVQGE

Sequences:

>Translated_239_residues
MSRPKFTRVLLKLSGESLAGSQGYGIDPKTITTIAREIKEVVQQGVQLALVIGGGNIFRGLAASSQGMDRAGADNMGMLA
TMINSLAMQDALEKIGVATRVQSAIVMQQVAEPYIRRRAIRHLEKGRVVIFGAGTGNPYFTTDTAASLRAMEISAQAILK
GTKVDGVYTADPKKDATATKLPRLAYIDVLKRGLQVMDATATSLCMDNNLPIIVFDLTTEGNIIKVINGEEIGTIVQGE
>Mature_238_residues
SRPKFTRVLLKLSGESLAGSQGYGIDPKTITTIAREIKEVVQQGVQLALVIGGGNIFRGLAASSQGMDRAGADNMGMLAT
MINSLAMQDALEKIGVATRVQSAIVMQQVAEPYIRRRAIRHLEKGRVVIFGAGTGNPYFTTDTAASLRAMEISAQAILKG
TKVDGVYTADPKKDATATKLPRLAYIDVLKRGLQVMDATATSLCMDNNLPIIVFDLTTEGNIIKVINGEEIGTIVQGE

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family

Homologues:

Organism=Escherichia coli, GI1786367, Length=235, Percent_Identity=50.6382978723404, Blast_Score=241, Evalue=2e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRH_PELPD (A1AQN4)

Other databases:

- EMBL:   CP000482
- RefSeq:   YP_901712.1
- ProteinModelPortal:   A1AQN4
- SMR:   A1AQN4
- STRING:   A1AQN4
- GeneID:   4574243
- GenomeReviews:   CP000482_GR
- KEGG:   ppd:Ppro_2046
- eggNOG:   COG0528
- HOGENOM:   HBG497552
- OMA:   RHMEKGR
- PhylomeDB:   A1AQN4
- ProtClustDB:   PRK00358
- GO:   GO:0005737
- HAMAP:   MF_01220_B
- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF005650
- TIGRFAMs:   TIGR02075

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.4.22

Molecular weight: Translated: 25540; Mature: 25409

Theoretical pI: Translated: 9.64; Mature: 9.64

Prosite motif: NA

Important sites: BINDING 54-54 BINDING 55-55 BINDING 59-59 BINDING 74-74 BINDING 162-162 BINDING 168-168 BINDING 171-171

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRPKFTRVLLKLSGESLAGSQGYGIDPKTITTIAREIKEVVQQGVQLALVIGGGNIFRG
CCCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCHHHHH
LAASSQGMDRAGADNMGMLATMINSLAMQDALEKIGVATRVQSAIVMQQVAEPYIRRRAI
HHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RHLEKGRVVIFGAGTGNPYFTTDTAASLRAMEISAQAILKGTKVDGVYTADPKKDATATK
HHHHCCCEEEEECCCCCCEEECCHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCHHHH
LPRLAYIDVLKRGLQVMDATATSLCMDNNLPIIVFDLTTEGNIIKVINGEEIGTIVQGE
CCHHHHHHHHHHHHHHHHHHHHHHEECCCCCEEEEEECCCCCEEEEECCCCCCEEECCC
>Mature Secondary Structure 
SRPKFTRVLLKLSGESLAGSQGYGIDPKTITTIAREIKEVVQQGVQLALVIGGGNIFRG
CCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCHHHHH
LAASSQGMDRAGADNMGMLATMINSLAMQDALEKIGVATRVQSAIVMQQVAEPYIRRRAI
HHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RHLEKGRVVIFGAGTGNPYFTTDTAASLRAMEISAQAILKGTKVDGVYTADPKKDATATK
HHHHCCCEEEEECCCCCCEEECCHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCHHHH
LPRLAYIDVLKRGLQVMDATATSLCMDNNLPIIVFDLTTEGNIIKVINGEEIGTIVQGE
CCHHHHHHHHHHHHHHHHHHHHHHEECCCCCEEEEEECCCCCEEEEECCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA