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The map label for this gene is zraR [H]

Identifier: 118580392

GI number: 118580392

Start: 2120452

End: 2121837

Strand: Reverse

Name: zraR [H]

Synonym: Ppro_1976

Alternate gene names: 118580392

Gene position: 2121837-2120452 (Counterclockwise)

Preceding gene: 118580393

Following gene: 118580383

Centisome position: 52.94

GC content: 65.3

Gene sequence:

>1386_bases
ATGACCGCTTCCCGGGCCAAAGGGGGAACGTCGAACCTGCTCTCTCCCACCGAGGCGATCCTGGAGAGCATCTCCGACGG
TGTCTTTACCGTTGACATGGAGTGGGTGATCACCTCCTTCAACCGGGCCGCCGAGGAGATCACCGGTGTGCCGCGCAGGG
AGGCCATCGGCCGCCGCTGCGGCGAGGTGTTCCGCTCCAGCATGTGCGGCGCTGACTGCGCGTTGCAGCGCACCCTCAAG
AACGGCAAGCCGGTGATCGGCAGGTCGGGCTACATCATCGACGCCGACGGCAACCGCATCCCGATCAGTATCTCCACCGC
CGTGCTGCGGGATGCCGATGGACGCGTAATCGGCGGGGCGGAAACCTTCCGCGACCTGTCCGAAGTGGAAACCCTGCGAC
GGGAGCTGGAGGGTAAGTTCAGCGTGGGGGATCTCTCCAGTCGCAGCCCGCTGATGCAGCGTATCTTCGAGATCCTGCCG
GCCATAGCCGCCAGCCCCAGCACGGTCATGCTGCTGGGGGAGACCGGCACCGGCAAGGAGGTCATGGCGCGCACGATCCA
CTCCTTGGGTTCCCACAGCCAAGGGCCGTTCATCGCGGTCAACTGCGGCGCCCTGCCCGATACCCTGCTGGAGTCGGAGC
TGTTCGGCTACAAGGCCGGCGCGTTCACCGGCGCCACCCGGGACAAACCGGGCCGTTTCGCCCTGGCCAGGGGAGGGACG
ATCTTTCTGGATGAGATCGGCGAAGTGAGCCCGGCCCTGCAGGTGCGCCTGCTGCGGGTGCTCCAGGAGCGGAGTTTCGA
GCCGCTGGGGGCGGTCACGTCCGAAACCAGCGACGCGCGGGTAATCGTGGCCACCAACAGGGATCTTGTCGAGCAGGTGC
GCAAGGGGCTCTTCCGGGAGGATCTGTACTATCGGGTGAACGTGGTGCGCATGGAACTTCCCCCCCTGCGCCGCAGGAAG
GAGGATATCCCCCTGCTGGTGAATCGCTTCATCGAGCGGTTCAACCACCTGCAGCTGAAATCGGTTCCGGGGATCTCCGC
CGAGGCGTTGTCGTTGCTCATGGCCCACGACTGGCCGGGAAACATCCGCGAGCTGGAGAATGCCATCGAGCGCGCCTTCA
TCCTCTGCAACGAGGGGCAGATCGGCATCGGCCACCTCTCCGAGGAACTGCGCGCCCACCGGGCAATGGCAGCGGAAGGC
GACGTGCGTTCAGCACACGACATCCTGGATGCCCAGGCTATTCTGGCCTCCCTCGAACGTAACAACTTCAACCGCCTGGC
TGCGGCCAGGGAACTGGGTATTCACAAGACGACCCTGTTTCGCAGGATGAAGCGGCTCGGCATCCCCCTCCCCGAGGAGG
ACGGTCGATCGCGGCATGCCACCTGA

Upstream 100 bases:

>100_bases
TCATCCCTGTCCCGACCGTTTCGGTCGCCACCGGGTGCAAACGTTTCCCGGATGGCCAGGGGGAGATCTCATCCCTCCGT
GGGCCGGATCGGAGCAGGTC

Downstream 100 bases:

>100_bases
CTGATTACTAAAAACAGACAGGGCCGGGAGATTGTCCCGGCCCTGTCTGTTTTTAGTTTCCAAACTCCCTGTCCCTTTGA
TCAGGCCAGGCTACTTTCAA

Product: sigma-54 dependent trancsriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 461; Mature: 460

Protein sequence:

>461_residues
MTASRAKGGTSNLLSPTEAILESISDGVFTVDMEWVITSFNRAAEEITGVPRREAIGRRCGEVFRSSMCGADCALQRTLK
NGKPVIGRSGYIIDADGNRIPISISTAVLRDADGRVIGGAETFRDLSEVETLRRELEGKFSVGDLSSRSPLMQRIFEILP
AIAASPSTVMLLGETGTGKEVMARTIHSLGSHSQGPFIAVNCGALPDTLLESELFGYKAGAFTGATRDKPGRFALARGGT
IFLDEIGEVSPALQVRLLRVLQERSFEPLGAVTSETSDARVIVATNRDLVEQVRKGLFREDLYYRVNVVRMELPPLRRRK
EDIPLLVNRFIERFNHLQLKSVPGISAEALSLLMAHDWPGNIRELENAIERAFILCNEGQIGIGHLSEELRAHRAMAAEG
DVRSAHDILDAQAILASLERNNFNRLAAARELGIHKTTLFRRMKRLGIPLPEEDGRSRHAT

Sequences:

>Translated_461_residues
MTASRAKGGTSNLLSPTEAILESISDGVFTVDMEWVITSFNRAAEEITGVPRREAIGRRCGEVFRSSMCGADCALQRTLK
NGKPVIGRSGYIIDADGNRIPISISTAVLRDADGRVIGGAETFRDLSEVETLRRELEGKFSVGDLSSRSPLMQRIFEILP
AIAASPSTVMLLGETGTGKEVMARTIHSLGSHSQGPFIAVNCGALPDTLLESELFGYKAGAFTGATRDKPGRFALARGGT
IFLDEIGEVSPALQVRLLRVLQERSFEPLGAVTSETSDARVIVATNRDLVEQVRKGLFREDLYYRVNVVRMELPPLRRRK
EDIPLLVNRFIERFNHLQLKSVPGISAEALSLLMAHDWPGNIRELENAIERAFILCNEGQIGIGHLSEELRAHRAMAAEG
DVRSAHDILDAQAILASLERNNFNRLAAARELGIHKTTLFRRMKRLGIPLPEEDGRSRHAT
>Mature_460_residues
TASRAKGGTSNLLSPTEAILESISDGVFTVDMEWVITSFNRAAEEITGVPRREAIGRRCGEVFRSSMCGADCALQRTLKN
GKPVIGRSGYIIDADGNRIPISISTAVLRDADGRVIGGAETFRDLSEVETLRRELEGKFSVGDLSSRSPLMQRIFEILPA
IAASPSTVMLLGETGTGKEVMARTIHSLGSHSQGPFIAVNCGALPDTLLESELFGYKAGAFTGATRDKPGRFALARGGTI
FLDEIGEVSPALQVRLLRVLQERSFEPLGAVTSETSDARVIVATNRDLVEQVRKGLFREDLYYRVNVVRMELPPLRRRKE
DIPLLVNRFIERFNHLQLKSVPGISAEALSLLMAHDWPGNIRELENAIERAFILCNEGQIGIGHLSEELRAHRAMAAEGD
VRSAHDILDAQAILASLERNNFNRLAAARELGIHKTTLFRRMKRLGIPLPEEDGRSRHAT

Specific function: Member of the two-component regulatory system zraS/zraR. When activated by zraS it acts in conjunction with sigma-54 to regulate the expression of zraP. Positively autoregulates the expression of the zraSR operon [H]

COG id: COG3829

COG function: function code KT; Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1790437, Length=299, Percent_Identity=45.819397993311, Blast_Score=273, Evalue=2e-74,
Organism=Escherichia coli, GI87082117, Length=358, Percent_Identity=41.8994413407821, Blast_Score=259, Evalue=2e-70,
Organism=Escherichia coli, GI1788550, Length=334, Percent_Identity=43.4131736526946, Blast_Score=256, Evalue=2e-69,
Organism=Escherichia coli, GI1789087, Length=315, Percent_Identity=44.1269841269841, Blast_Score=234, Evalue=7e-63,
Organism=Escherichia coli, GI1789233, Length=313, Percent_Identity=42.4920127795527, Blast_Score=231, Evalue=5e-62,
Organism=Escherichia coli, GI1788905, Length=299, Percent_Identity=41.8060200668896, Blast_Score=228, Evalue=8e-61,
Organism=Escherichia coli, GI1786524, Length=330, Percent_Identity=40.6060606060606, Blast_Score=210, Evalue=1e-55,
Organism=Escherichia coli, GI87082152, Length=314, Percent_Identity=40.1273885350318, Blast_Score=207, Evalue=1e-54,
Organism=Escherichia coli, GI1790299, Length=333, Percent_Identity=37.2372372372372, Blast_Score=205, Evalue=5e-54,
Organism=Escherichia coli, GI1787583, Length=372, Percent_Identity=32.7956989247312, Blast_Score=188, Evalue=8e-49,
Organism=Escherichia coli, GI87081872, Length=219, Percent_Identity=43.8356164383562, Blast_Score=184, Evalue=1e-47,
Organism=Escherichia coli, GI1789828, Length=279, Percent_Identity=35.1254480286738, Blast_Score=146, Evalue=3e-36,
Organism=Escherichia coli, GI87081858, Length=457, Percent_Identity=28.4463894967177, Blast_Score=141, Evalue=1e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 50618; Mature: 50486

Theoretical pI: Translated: 7.60; Mature: 7.60

Prosite motif: PS50112 PAS ; PS50113 PAC ; PS00675 SIGMA54_INTERACT_1 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTASRAKGGTSNLLSPTEAILESISDGVFTVDMEWVITSFNRAAEEITGVPRREAIGRRC
CCCCCCCCCCCCCCCHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHH
GEVFRSSMCGADCALQRTLKNGKPVIGRSGYIIDADGNRIPISISTAVLRDADGRVIGGA
HHHHHHHCCCHHHHHHHHHHCCCCEECCCCEEEECCCCEEEEEEHHHHHCCCCCCEECCH
ETFRDLSEVETLRRELEGKFSVGDLSSRSPLMQRIFEILPAIAASPSTVMLLGETGTGKE
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCHH
VMARTIHSLGSHSQGPFIAVNCGALPDTLLESELFGYKAGAFTGATRDKPGRFALARGGT
HHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCCE
IFLDEIGEVSPALQVRLLRVLQERSFEPLGAVTSETSDARVIVATNRDLVEQVRKGLFRE
EEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHH
DLYYRVNVVRMELPPLRRRKEDIPLLVNRFIERFNHLQLKSVPGISAEALSLLMAHDWPG
HHHEEEEEEEECCCCHHHCCCCCHHHHHHHHHHHCCCEECCCCCCCHHHHHHHHHCCCCC
NIRELENAIERAFILCNEGQIGIGHLSEELRAHRAMAAEGDVRSAHDILDAQAILASLER
CHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
NNFNRLAAARELGIHKTTLFRRMKRLGIPLPEEDGRSRHAT
CCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TASRAKGGTSNLLSPTEAILESISDGVFTVDMEWVITSFNRAAEEITGVPRREAIGRRC
CCCCCCCCCCCCCCHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHH
GEVFRSSMCGADCALQRTLKNGKPVIGRSGYIIDADGNRIPISISTAVLRDADGRVIGGA
HHHHHHHCCCHHHHHHHHHHCCCCEECCCCEEEECCCCEEEEEEHHHHHCCCCCCEECCH
ETFRDLSEVETLRRELEGKFSVGDLSSRSPLMQRIFEILPAIAASPSTVMLLGETGTGKE
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCHH
VMARTIHSLGSHSQGPFIAVNCGALPDTLLESELFGYKAGAFTGATRDKPGRFALARGGT
HHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCCE
IFLDEIGEVSPALQVRLLRVLQERSFEPLGAVTSETSDARVIVATNRDLVEQVRKGLFRE
EEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHH
DLYYRVNVVRMELPPLRRRKEDIPLLVNRFIERFNHLQLKSVPGISAEALSLLMAHDWPG
HHHEEEEEEEECCCCHHHCCCCCHHHHHHHHHHHCCCEECCCCCCCHHHHHHHHHCCCCC
NIRELENAIERAFILCNEGQIGIGHLSEELRAHRAMAAEGDVRSAHDILDAQAILASLER
CHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
NNFNRLAAARELGIHKTTLFRRMKRLGIPLPEEDGRSRHAT
CCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]