Click here to switch to the map view.

The map label for this gene is mccB [H]

Identifier: 118580250

GI number: 118580250

Start: 1970002

End: 1971153

Strand: Direct

Name: mccB [H]

Synonym: Ppro_1830

Alternate gene names: 118580250

Gene position: 1970002-1971153 (Clockwise)

Preceding gene: 118580249

Following gene: 118580251

Centisome position: 49.15

GC content: 63.8

Gene sequence:

>1152_bases
ATGAACATCGATACGCAGGCGGTCCAGACCGGACTGGAGTGGGACACGCGAACAGGGGCGCTCTCGATCCCCATCTACCA
GTCAGCCACCTTCCGGCATCCGGGGCTTGGCCAGAGCACCGGCTTCGACTACAGCCGCTCGGGCAACCCCACCCGCCTGG
CGCTGGAGCAGGGCATCGCCCGCATGGACGGCGGCTCCAGGGGCTTCGCCTTTTCCTCGGGCATGGCGGCCATCACCAGC
CTGCTGCTGCTCTTTCAGGAGGGGGATCACCTGGTGGTCACCGAAGACCTGTACGGCGGAACCTGTCGCCTGTTCGACAG
GATCTTCACCCGCTTCGGCCTCTCCTTCAGCTATGTGGATACCACCGACAGGGAGGAGGTGCTGGCGGCCATAACCCCTT
CCACCAAGGCGCTGTTCGTGGAGACGCTCACCAACCCGCTGCTTAAATTCGCCGACATCCCTGCCCTCTCCACCATCTGC
CACGAGCGGGGACTGCTGCTGATCGCCGACAACACCTTCCTGACCCCCTACCTGCTGCGTCCCCTGGAACGTGGGGCCGA
CATCACCGTCTACAGTGCCACCAAGTATCTGTCGGGCCACAACGACACGGTGGCCGGCCTGGCGGTTGTCAGGGATCCGC
AGTTGGCCGAACAGGTCTACTTCCACCAGAACTCGGCCGGGGCCGTGCTGGGACCACAGGACTCCTGGCTGGTGATCCGC
GGCATGAAGACTCTGGGGGTGCGCCTTGACCGGCAGCAGGAAAACGCCCTGAAGATCGCCCGCTGGCTGCAACGGCACCC
CCAGGTCACCAGGGTCCATTACCCCGGCCTGGAGGAGCACCCCGATCATGATCTGATCAGGCGCCATGCCCGGGGCTTCG
GCGCCATGATCGCCTTCGAGGTCGAAAGCCACAGCCTGGTGGAGCAGCTCCTGCTCAGGACCCAGCTGATCTCCTTTGCC
GAAAGCCTGGGTGGGGTGGAAACTCTGATGACCTTCCCCGAGGGGCAGACCCATGCGGACATTCCGCCGGAACTGCGTGC
CCGACTGGGCATCAACGACGTGCTGCTGCGCCTTTCGGTGGGCATCGAGAATGTTGACGATCTGATCGACGACCTGAACC
AGGCATTCAACAAGAGGGAGACAACCGTATGA

Upstream 100 bases:

>100_bases
TCTAGCGGAATCGTATGATTCCGGGAGATAAGGAAGAGAGCGGCATAGCGGTCCTCTTCCTCCCCGGAAGGGGATTTTTT
ATTATGGGGAGGTTTTCACC

Downstream 100 bases:

>100_bases
AGTTTTCCACAAAACTGATCCACAGCGGACAGACCCATGACCCGCTCACCGGAGCCCTGGGGGTACCGATCTACCAGACC
TCCACCTATCGCCAGCAGTC

Product: cystathionine gamma-synthase

Products: NA

Alternate protein names: Gamma-cystathionase; Homocysteine gamma-lyase [H]

Number of amino acids: Translated: 383; Mature: 383

Protein sequence:

>383_residues
MNIDTQAVQTGLEWDTRTGALSIPIYQSATFRHPGLGQSTGFDYSRSGNPTRLALEQGIARMDGGSRGFAFSSGMAAITS
LLLLFQEGDHLVVTEDLYGGTCRLFDRIFTRFGLSFSYVDTTDREEVLAAITPSTKALFVETLTNPLLKFADIPALSTIC
HERGLLLIADNTFLTPYLLRPLERGADITVYSATKYLSGHNDTVAGLAVVRDPQLAEQVYFHQNSAGAVLGPQDSWLVIR
GMKTLGVRLDRQQENALKIARWLQRHPQVTRVHYPGLEEHPDHDLIRRHARGFGAMIAFEVESHSLVEQLLLRTQLISFA
ESLGGVETLMTFPEGQTHADIPPELRARLGINDVLLRLSVGIENVDDLIDDLNQAFNKRETTV

Sequences:

>Translated_383_residues
MNIDTQAVQTGLEWDTRTGALSIPIYQSATFRHPGLGQSTGFDYSRSGNPTRLALEQGIARMDGGSRGFAFSSGMAAITS
LLLLFQEGDHLVVTEDLYGGTCRLFDRIFTRFGLSFSYVDTTDREEVLAAITPSTKALFVETLTNPLLKFADIPALSTIC
HERGLLLIADNTFLTPYLLRPLERGADITVYSATKYLSGHNDTVAGLAVVRDPQLAEQVYFHQNSAGAVLGPQDSWLVIR
GMKTLGVRLDRQQENALKIARWLQRHPQVTRVHYPGLEEHPDHDLIRRHARGFGAMIAFEVESHSLVEQLLLRTQLISFA
ESLGGVETLMTFPEGQTHADIPPELRARLGINDVLLRLSVGIENVDDLIDDLNQAFNKRETTV
>Mature_383_residues
MNIDTQAVQTGLEWDTRTGALSIPIYQSATFRHPGLGQSTGFDYSRSGNPTRLALEQGIARMDGGSRGFAFSSGMAAITS
LLLLFQEGDHLVVTEDLYGGTCRLFDRIFTRFGLSFSYVDTTDREEVLAAITPSTKALFVETLTNPLLKFADIPALSTIC
HERGLLLIADNTFLTPYLLRPLERGADITVYSATKYLSGHNDTVAGLAVVRDPQLAEQVYFHQNSAGAVLGPQDSWLVIR
GMKTLGVRLDRQQENALKIARWLQRHPQVTRVHYPGLEEHPDHDLIRRHARGFGAMIAFEVESHSLVEQLLLRTQLISFA
ESLGGVETLMTFPEGQTHADIPPELRARLGINDVLLRLSVGIENVDDLIDDLNQAFNKRETTV

Specific function: Catalyzes the conversion of cystathionine to cysteine, and homocysteine to sulfide [H]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=362, Percent_Identity=43.646408839779, Blast_Score=310, Evalue=2e-84,
Organism=Homo sapiens, GI299473759, Length=362, Percent_Identity=40.0552486187845, Blast_Score=263, Evalue=3e-70,
Organism=Homo sapiens, GI25453487, Length=361, Percent_Identity=38.781163434903, Blast_Score=253, Evalue=2e-67,
Organism=Escherichia coli, GI1790375, Length=377, Percent_Identity=39.7877984084881, Blast_Score=282, Evalue=2e-77,
Organism=Escherichia coli, GI1789383, Length=395, Percent_Identity=29.620253164557, Blast_Score=185, Evalue=5e-48,
Organism=Caenorhabditis elegans, GI17560056, Length=366, Percent_Identity=39.8907103825137, Blast_Score=281, Evalue=5e-76,
Organism=Caenorhabditis elegans, GI17538055, Length=366, Percent_Identity=38.5245901639344, Blast_Score=273, Evalue=2e-73,
Organism=Caenorhabditis elegans, GI71980708, Length=367, Percent_Identity=37.0572207084469, Blast_Score=249, Evalue=1e-66,
Organism=Saccharomyces cerevisiae, GI6319307, Length=383, Percent_Identity=38.1201044386423, Blast_Score=260, Evalue=2e-70,
Organism=Saccharomyces cerevisiae, GI6321254, Length=396, Percent_Identity=36.1111111111111, Blast_Score=221, Evalue=1e-58,
Organism=Saccharomyces cerevisiae, GI6323333, Length=433, Percent_Identity=31.8706697459584, Blast_Score=176, Evalue=7e-45,
Organism=Saccharomyces cerevisiae, GI6321170, Length=333, Percent_Identity=29.1291291291291, Blast_Score=153, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6321904, Length=395, Percent_Identity=26.5822784810127, Blast_Score=127, Evalue=3e-30,
Organism=Drosophila melanogaster, GI19922554, Length=376, Percent_Identity=41.4893617021277, Blast_Score=310, Evalue=8e-85,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.1; =4.4.1.2 [H]

Molecular weight: Translated: 42460; Mature: 42460

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIDTQAVQTGLEWDTRTGALSIPIYQSATFRHPGLGQSTGFDYSRSGNPTRLALEQGIA
CCCCHHHHHCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEHHHHHHHH
RMDGGSRGFAFSSGMAAITSLLLLFQEGDHLVVTEDLYGGTCRLFDRIFTRFGLSFSYVD
HCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHCCEEEEEC
TTDREEVLAAITPSTKALFVETLTNPLLKFADIPALSTICHERGLLLIADNTFLTPYLLR
CCCHHHEEEEECCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCCEEEEECCCCCCHHHHH
PLERGADITVYSATKYLSGHNDTVAGLAVVRDPQLAEQVYFHQNSAGAVLGPQDSWLVIR
HHHCCCCEEEEEHHHHHCCCCCCEEEEEEECCCHHHHHHHHCCCCCCCEECCCCCEEEEE
GMKTLGVRLDRQQENALKIARWLQRHPQVTRVHYPGLEEHPDHDLIRRHARGFGAMIAFE
CHHHHCEEECCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHCCCCEEEEEE
VESHSLVEQLLLRTQLISFAESLGGVETLMTFPEGQTHADIPPELRARLGINDVLLRLSV
ECHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCHHHHHHCCHHHHHHHHHC
GIENVDDLIDDLNQAFNKRETTV
CCCHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNIDTQAVQTGLEWDTRTGALSIPIYQSATFRHPGLGQSTGFDYSRSGNPTRLALEQGIA
CCCCHHHHHCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEHHHHHHHH
RMDGGSRGFAFSSGMAAITSLLLLFQEGDHLVVTEDLYGGTCRLFDRIFTRFGLSFSYVD
HCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHCCEEEEEC
TTDREEVLAAITPSTKALFVETLTNPLLKFADIPALSTICHERGLLLIADNTFLTPYLLR
CCCHHHEEEEECCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCCEEEEECCCCCCHHHHH
PLERGADITVYSATKYLSGHNDTVAGLAVVRDPQLAEQVYFHQNSAGAVLGPQDSWLVIR
HHHCCCCEEEEEHHHHHCCCCCCEEEEEEECCCHHHHHHHHCCCCCCCEECCCCCEEEEE
GMKTLGVRLDRQQENALKIARWLQRHPQVTRVHYPGLEEHPDHDLIRRHARGFGAMIAFE
CHHHHCEEECCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHCCCCEEEEEE
VESHSLVEQLLLRTQLISFAESLGGVETLMTFPEGQTHADIPPELRARLGINDVLLRLSV
ECHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCHHHHHHCCHHHHHHHHHC
GIENVDDLIDDLNQAFNKRETTV
CCCHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377 [H]