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The map label for this gene is metC [H]

Identifier: 118580251

GI number: 118580251

Start: 1971150

End: 1972295

Strand: Direct

Name: metC [H]

Synonym: Ppro_1831

Alternate gene names: 118580251

Gene position: 1971150-1972295 (Clockwise)

Preceding gene: 118580250

Following gene: 118580252

Centisome position: 49.18

GC content: 64.05

Gene sequence:

>1146_bases
ATGAAGTTTTCCACAAAACTGATCCACAGCGGACAGACCCATGACCCGCTCACCGGAGCCCTGGGGGTACCGATCTACCA
GACCTCCACCTATCGCCAGCAGTCGCTGGACCAGTTCGGCAAGTACGACTATGCCCGCTCCGACAACCCCACCCGTGAGG
CACTGGAAGAGGCGGTTGCCGCCCTGGAGGGAGGCAACCGCGGTTTCGCCTTCAGCTCGGGCATGGCGGCCATCTCCTCC
ACCCTGCTGATCTTCTCCCCCGGCGACCATCTGGTGGTCTGCGATGACGTCTACGGCGGGGCCTATCGGGTGCTGACCCA
GATCTTCAGCCGCCTCGGCATCCACTCCACCTTCGTGGATGCAACCAGCCTGGAGGCGATAGAGGCGGCAATCAAGCCTG
AAACCAGGGGGATCTACCTGGAAACCCCCTCAAACCCGTTGCTCAAGGTCACCGACCTGCGGGGGGTGGCGGAACTGGCC
CGTGACCGCGGCATCGTCACCCTGGTGGACAACACCTTCATGACCCCCTACCTGCAGCGTCCCCTGGAGCTGGGCTGCGA
TATCGTCCTGCACAGCGCCACCAAGTTCATAAACGGCCACAGCGACGTCATCTGCGGCCTAGCGGTGGTGAAGGACAGCG
AACTGGGGGAGCGCATCCGCTTCATCCAGAACGGCTTCGGCGCGATACCCGGCCCCCAGGACTGTTTCCTGACCCTGCGG
GGACTGAAAACCCTCAAGGTCAGGATGGACCAGAGCCAGAAGAGTGCCGCCGCCATCGTGGACTGGCTGGGGAGTCAGCA
GCGGGTCACCAGGATCCACTACCCCGGCCTCGCCGACCATCCCGGCTATGCCATCCAGCGCAGCCAGACCGATGGAGCGG
GGGCGGTCTTCTCCTTCGAGCTGGATTCGTTGGAGACCACCCGGCGCCTGCTGGAGCAGTCCCGGCTGTCCGCCTTTGCC
GTCAGCCTGGGAGGGGTGGAGAGCATCATCTCCTACCCCGCCAGGATGTCCCATGCGGCGGTTCCGCCGGAGGAGCGCAG
GCGCAAGGGGATCACGGACACCCTGGTGCGCCTCTCCGTGGGACTGGAGGACCCGGACGATCTGATCGCGGAGATGGACA
GCATATTCAAGAGTAATCCGGTATGA

Upstream 100 bases:

>100_bases
GCATCAACGACGTGCTGCTGCGCCTTTCGGTGGGCATCGAGAATGTTGACGATCTGATCGACGACCTGAACCAGGCATTC
AACAAGAGGGAGACAACCGT

Downstream 100 bases:

>100_bases
TCGATACATATTTTTTGACAAAAACAGAACCGTACCCTACAAGGGTACTACAGCGCATTCGCGATGATATTTCACGCGGC
TGTGGCTAGAAAAGGAGAGG

Product: cystathionine gamma-synthase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 381; Mature: 381

Protein sequence:

>381_residues
MKFSTKLIHSGQTHDPLTGALGVPIYQTSTYRQQSLDQFGKYDYARSDNPTREALEEAVAALEGGNRGFAFSSGMAAISS
TLLIFSPGDHLVVCDDVYGGAYRVLTQIFSRLGIHSTFVDATSLEAIEAAIKPETRGIYLETPSNPLLKVTDLRGVAELA
RDRGIVTLVDNTFMTPYLQRPLELGCDIVLHSATKFINGHSDVICGLAVVKDSELGERIRFIQNGFGAIPGPQDCFLTLR
GLKTLKVRMDQSQKSAAAIVDWLGSQQRVTRIHYPGLADHPGYAIQRSQTDGAGAVFSFELDSLETTRRLLEQSRLSAFA
VSLGGVESIISYPARMSHAAVPPEERRRKGITDTLVRLSVGLEDPDDLIAEMDSIFKSNPV

Sequences:

>Translated_381_residues
MKFSTKLIHSGQTHDPLTGALGVPIYQTSTYRQQSLDQFGKYDYARSDNPTREALEEAVAALEGGNRGFAFSSGMAAISS
TLLIFSPGDHLVVCDDVYGGAYRVLTQIFSRLGIHSTFVDATSLEAIEAAIKPETRGIYLETPSNPLLKVTDLRGVAELA
RDRGIVTLVDNTFMTPYLQRPLELGCDIVLHSATKFINGHSDVICGLAVVKDSELGERIRFIQNGFGAIPGPQDCFLTLR
GLKTLKVRMDQSQKSAAAIVDWLGSQQRVTRIHYPGLADHPGYAIQRSQTDGAGAVFSFELDSLETTRRLLEQSRLSAFA
VSLGGVESIISYPARMSHAAVPPEERRRKGITDTLVRLSVGLEDPDDLIAEMDSIFKSNPV
>Mature_381_residues
MKFSTKLIHSGQTHDPLTGALGVPIYQTSTYRQQSLDQFGKYDYARSDNPTREALEEAVAALEGGNRGFAFSSGMAAISS
TLLIFSPGDHLVVCDDVYGGAYRVLTQIFSRLGIHSTFVDATSLEAIEAAIKPETRGIYLETPSNPLLKVTDLRGVAELA
RDRGIVTLVDNTFMTPYLQRPLELGCDIVLHSATKFINGHSDVICGLAVVKDSELGERIRFIQNGFGAIPGPQDCFLTLR
GLKTLKVRMDQSQKSAAAIVDWLGSQQRVTRIHYPGLADHPGYAIQRSQTDGAGAVFSFELDSLETTRRLLEQSRLSAFA
VSLGGVESIISYPARMSHAAVPPEERRRKGITDTLVRLSVGLEDPDDLIAEMDSIFKSNPV

Specific function: Catalyzes the transformation of cystathionine into homocysteine. Also exhibits cysteine desulfhydrase activity in vitro, producing sulfide from cysteine [H]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=362, Percent_Identity=44.1988950276243, Blast_Score=318, Evalue=4e-87,
Organism=Homo sapiens, GI299473759, Length=362, Percent_Identity=40.6077348066298, Blast_Score=274, Evalue=1e-73,
Organism=Homo sapiens, GI25453487, Length=361, Percent_Identity=38.5041551246537, Blast_Score=251, Evalue=1e-66,
Organism=Escherichia coli, GI1790375, Length=379, Percent_Identity=42.2163588390501, Blast_Score=302, Evalue=3e-83,
Organism=Escherichia coli, GI1789383, Length=390, Percent_Identity=28.974358974359, Blast_Score=173, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI17560056, Length=366, Percent_Identity=43.9890710382514, Blast_Score=313, Evalue=7e-86,
Organism=Caenorhabditis elegans, GI17538055, Length=366, Percent_Identity=42.3497267759563, Blast_Score=303, Evalue=8e-83,
Organism=Caenorhabditis elegans, GI71980708, Length=371, Percent_Identity=36.1185983827493, Blast_Score=244, Evalue=5e-65,
Organism=Caenorhabditis elegans, GI193202265, Length=96, Percent_Identity=39.5833333333333, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6319307, Length=385, Percent_Identity=42.5974025974026, Blast_Score=314, Evalue=1e-86,
Organism=Saccharomyces cerevisiae, GI6321254, Length=399, Percent_Identity=33.8345864661654, Blast_Score=219, Evalue=6e-58,
Organism=Saccharomyces cerevisiae, GI6321170, Length=330, Percent_Identity=29.6969696969697, Blast_Score=164, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6323333, Length=433, Percent_Identity=29.5612009237875, Blast_Score=156, Evalue=5e-39,
Organism=Saccharomyces cerevisiae, GI6321904, Length=393, Percent_Identity=28.2442748091603, Blast_Score=134, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6322970, Length=367, Percent_Identity=25.3405994550409, Blast_Score=70, Evalue=4e-13,
Organism=Drosophila melanogaster, GI19922554, Length=375, Percent_Identity=44.5333333333333, Blast_Score=338, Evalue=3e-93,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 41579; Mature: 41579

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFSTKLIHSGQTHDPLTGALGVPIYQTSTYRQQSLDQFGKYDYARSDNPTREALEEAVA
CCCCCCHHCCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
ALEGGNRGFAFSSGMAAISSTLLIFSPGDHLVVCDDVYGGAYRVLTQIFSRLGIHSTFVD
HHCCCCCCCEECCCHHHHHCEEEEECCCCCEEEEECCCCHHHHHHHHHHHHHCCCHHHHC
ATSLEAIEAAIKPETRGIYLETPSNPLLKVTDLRGVAELARDRGIVTLVDNTFMTPYLQR
HHHHHHHHHHCCCCCCEEEEECCCCCCEEEECHHHHHHHHHCCCEEEEECCCCCCHHHHC
PLELGCDIVLHSATKFINGHSDVICGLAVVKDSELGERIRFIQNGFGAIPGPQDCFLTLR
HHHHCCCEEEHHHHHHHCCCCHHEEEEEEEECHHHHHHHHHHHCCCCCCCCCHHHHHHHH
GLKTLKVRMDQSQKSAAAIVDWLGSQQRVTRIHYPGLADHPGYAIQRSQTDGAGAVFSFE
CCEEEEEECCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCEEEECCCCCCCEEEEEE
LDSLETTRRLLEQSRLSAFAVSLGGVESIISYPARMSHAAVPPEERRRKGITDTLVRLSV
CHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCHHHHCCCCCCCHHHHHCCHHHHHHHHHC
GLEDPDDLIAEMDSIFKSNPV
CCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKFSTKLIHSGQTHDPLTGALGVPIYQTSTYRQQSLDQFGKYDYARSDNPTREALEEAVA
CCCCCCHHCCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
ALEGGNRGFAFSSGMAAISSTLLIFSPGDHLVVCDDVYGGAYRVLTQIFSRLGIHSTFVD
HHCCCCCCCEECCCHHHHHCEEEEECCCCCEEEEECCCCHHHHHHHHHHHHHCCCHHHHC
ATSLEAIEAAIKPETRGIYLETPSNPLLKVTDLRGVAELARDRGIVTLVDNTFMTPYLQR
HHHHHHHHHHCCCCCCEEEEECCCCCCEEEECHHHHHHHHHCCCEEEEECCCCCCHHHHC
PLELGCDIVLHSATKFINGHSDVICGLAVVKDSELGERIRFIQNGFGAIPGPQDCFLTLR
HHHHCCCEEEHHHHHHHCCCCHHEEEEEEEECHHHHHHHHHHHCCCCCCCCCHHHHHHHH
GLKTLKVRMDQSQKSAAAIVDWLGSQQRVTRIHYPGLADHPGYAIQRSQTDGAGAVFSFE
CCEEEEEECCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCEEEECCCCCCCEEEEEE
LDSLETTRRLLEQSRLSAFAVSLGGVESIISYPARMSHAAVPPEERRRKGITDTLVRLSV
CHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCHHHHCCCCCCCHHHHHCCHHHHHHHHHC
GLEDPDDLIAEMDSIFKSNPV
CCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]