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The map label for this gene is rnc [H]

Identifier: 118580198

GI number: 118580198

Start: 1906638

End: 1907342

Strand: Reverse

Name: rnc [H]

Synonym: Ppro_1778

Alternate gene names: 118580198

Gene position: 1907342-1906638 (Counterclockwise)

Preceding gene: 118580199

Following gene: 118580197

Centisome position: 47.59

GC content: 63.69

Gene sequence:

>705_bases
ATGGCGAGTGATCTCGCAGAACTGGAGCGGGAGATTGCGTATCGTTTTATCGATCAGGCCCCGCTGCTGCAGGCTCTGAC
CCATCCGTCGTTTGAGCATGAGCAGGCCGGGGGGGGCAACTACCAGCGACTGGAATTCCTGGGTGACGCGGTGCTGGGGA
TGGTGCTGGCCGAGATGCTGTTCAGGCGCTTTCCCGACAGCAACGAGGGGGTTCTCTCCCGGCTCAGGTCGCAGATTGCG
GACCAGGACACCCTGGCGGGCATTGCCCGCTCGTTCGGACTGGGCAGGTTCGTCCGCCTCGGCCGCGGAGAGGAGCAGGG
CGCCGGACGCAACAAGGACTCGATTCTGGCCGATGTGCTGGAGGCGCTGATCGCTGCGGTCTACCTGGACGGCGGTTTGA
AAGAGTCGCGCCGGCTGATCCAGCGGCTGTTCGTCGCAATCCTGGAGAGCCGTGGGGCAAGGCTTCGGTTCAACGACGCC
AAGAGCGAGCTACAGGAACTGCTCTCTGCAAGACGGCTGCCGTCCCCTGTCTACCGCCTGACCGGCGAATCAGGACCGCC
CCACGACCGTCTGTTCATTTTTCAGGTGCTGGTGGATGATGCCGTTGTGGGCGAAGGAGAGGGGCGCTCCAAAAAGATCG
CCCAGCAGGCGGCGGCGACGCAGGCACTGACGGCATTTTCAGCCCCTGCCAATGCATCCCCATGA

Upstream 100 bases:

>100_bases
TTGCGGACCATGGATCTGTTCGGCATGGGAGAGATGAAGGTCAGCGATTACGGTCTGCTGGAGGGACTGCTGGTAAGCTT
GGACGGAGGAGTCGGACGCT

Downstream 100 bases:

>100_bases
GCAGGATTACGGTCCCTTTTTTTATCAGCCACCAGGGGTGCCCGCACACCTGCGTTTTCTGCGATCAGCGCTCGATCTCC
GGCTCCAGTGGCACACTGCC

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 234; Mature: 233

Protein sequence:

>234_residues
MASDLAELEREIAYRFIDQAPLLQALTHPSFEHEQAGGGNYQRLEFLGDAVLGMVLAEMLFRRFPDSNEGVLSRLRSQIA
DQDTLAGIARSFGLGRFVRLGRGEEQGAGRNKDSILADVLEALIAAVYLDGGLKESRRLIQRLFVAILESRGARLRFNDA
KSELQELLSARRLPSPVYRLTGESGPPHDRLFIFQVLVDDAVVGEGEGRSKKIAQQAAATQALTAFSAPANASP

Sequences:

>Translated_234_residues
MASDLAELEREIAYRFIDQAPLLQALTHPSFEHEQAGGGNYQRLEFLGDAVLGMVLAEMLFRRFPDSNEGVLSRLRSQIA
DQDTLAGIARSFGLGRFVRLGRGEEQGAGRNKDSILADVLEALIAAVYLDGGLKESRRLIQRLFVAILESRGARLRFNDA
KSELQELLSARRLPSPVYRLTGESGPPHDRLFIFQVLVDDAVVGEGEGRSKKIAQQAAATQALTAFSAPANASP
>Mature_233_residues
ASDLAELEREIAYRFIDQAPLLQALTHPSFEHEQAGGGNYQRLEFLGDAVLGMVLAEMLFRRFPDSNEGVLSRLRSQIAD
QDTLAGIARSFGLGRFVRLGRGEEQGAGRNKDSILADVLEALIAAVYLDGGLKESRRLIQRLFVAILESRGARLRFNDAK
SELQELLSARRLPSPVYRLTGESGPPHDRLFIFQVLVDDAVVGEGEGRSKKIAQQAAATQALTAFSAPANASP

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030234, Length=234, Percent_Identity=32.0512820512821, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI155030236, Length=234, Percent_Identity=32.0512820512821, Blast_Score=102, Evalue=4e-22,
Organism=Escherichia coli, GI1788920, Length=207, Percent_Identity=40.0966183574879, Blast_Score=139, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17506883, Length=200, Percent_Identity=33.5, Blast_Score=101, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI193202651, Length=200, Percent_Identity=33.5, Blast_Score=101, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17552834, Length=264, Percent_Identity=28.030303030303, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17137682, Length=226, Percent_Identity=30.0884955752212, Blast_Score=94, Evalue=8e-20,
Organism=Drosophila melanogaster, GI22026807, Length=91, Percent_Identity=40.6593406593407, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 25577; Mature: 25446

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASDLAELEREIAYRFIDQAPLLQALTHPSFEHEQAGGGNYQRLEFLGDAVLGMVLAEML
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
FRRFPDSNEGVLSRLRSQIADQDTLAGIARSFGLGRFVRLGRGEEQGAGRNKDSILADVL
HHHCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHH
EALIAAVYLDGGLKESRRLIQRLFVAILESRGARLRFNDAKSELQELLSARRLPSPVYRL
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHCCCCHHHHH
TGESGPPHDRLFIFQVLVDDAVVGEGEGRSKKIAQQAAATQALTAFSAPANASP
CCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
ASDLAELEREIAYRFIDQAPLLQALTHPSFEHEQAGGGNYQRLEFLGDAVLGMVLAEML
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
FRRFPDSNEGVLSRLRSQIADQDTLAGIARSFGLGRFVRLGRGEEQGAGRNKDSILADVL
HHHCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHH
EALIAAVYLDGGLKESRRLIQRLFVAILESRGARLRFNDAKSELQELLSARRLPSPVYRL
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHCCCCHHHHH
TGESGPPHDRLFIFQVLVDDAVVGEGEGRSKKIAQQAAATQALTAFSAPANASP
CCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]