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The map label for this gene is purN [H]

Identifier: 118580193

GI number: 118580193

Start: 1902944

End: 1903564

Strand: Direct

Name: purN [H]

Synonym: Ppro_1773

Alternate gene names: 118580193

Gene position: 1902944-1903564 (Clockwise)

Preceding gene: 118580192

Following gene: 118580194

Centisome position: 47.48

GC content: 58.78

Gene sequence:

>621_bases
ATGTCAGTAGCAGAGCCGCTCACCCTGGCCGTCCTGGTGTCGGGAAATGGTTCCAACCTGCAGGCGATCATCGACCGTAT
CGAAGCTGGGGAGATACATGCCCGTATCGCCTGCGTGATCAGCAACGTTCACGGTGTTTTTGCCCTTGAGCGGGCACGGC
GGCACGGCATACCGACGGTTATCCATGCGAATGGCGCATTTGCCACGCGGCGGGAGTATGACAATGCCCTGGTGGAGGTG
CTGCGCACTCATCGGGTCGAACTGGTCGTTCTGGCCGGTTTTATGCGGATTCTCTCCGACGTGATGATAGGCGCCTTCCC
CGGCGCAGTCATCAACATCCACCCAGCGCTGCTCCCCGCCTTCCCCGGCCTGCACGCCCAGAAGCAGGCACTTGAGTACG
GAGTGAAATTTTCAGGCTGCACGGTCCATTTCGTGGACAACGGCACCGACACCGGTCCGATAATTCTCCAGGCTGTTGTT
CCGGTCATGCAGGACGACAGTGAAGAGTCACTTTCGCGACGCATCCTCCAGGAGGAACACCGCATTTTTCCCGAATCGAT
CAGGCTCTTCGCCGAGGGAAAGCTGTCGTTCCATGGCAGACAGGTGCGAATTAGCAGTTGA

Upstream 100 bases:

>100_bases
TGCTCGACCGCCTGAACGGCCTTGGCGAACATGCCTGGGTCATCGGAGAGATCACCGCCTGCCCGGAGAACAGCGACCCC
ACCCAACTCGTGGAGGGGTA

Downstream 100 bases:

>100_bases
TATTATTAGGTTGACACGCGGCAGTAATTGATGGTAAAAACTTCTCTTTAAAATCAATCAAATCAACGTATCCTACGTTT
ACATGGAGGTGCAGTTTGGC

Product: phosphoribosylglycinamide formyltransferase

Products: NA

Alternate protein names: 5'-phosphoribosylglycinamide transformylase; GAR transformylase; GART [H]

Number of amino acids: Translated: 206; Mature: 205

Protein sequence:

>206_residues
MSVAEPLTLAVLVSGNGSNLQAIIDRIEAGEIHARIACVISNVHGVFALERARRHGIPTVIHANGAFATRREYDNALVEV
LRTHRVELVVLAGFMRILSDVMIGAFPGAVINIHPALLPAFPGLHAQKQALEYGVKFSGCTVHFVDNGTDTGPIILQAVV
PVMQDDSEESLSRRILQEEHRIFPESIRLFAEGKLSFHGRQVRISS

Sequences:

>Translated_206_residues
MSVAEPLTLAVLVSGNGSNLQAIIDRIEAGEIHARIACVISNVHGVFALERARRHGIPTVIHANGAFATRREYDNALVEV
LRTHRVELVVLAGFMRILSDVMIGAFPGAVINIHPALLPAFPGLHAQKQALEYGVKFSGCTVHFVDNGTDTGPIILQAVV
PVMQDDSEESLSRRILQEEHRIFPESIRLFAEGKLSFHGRQVRISS
>Mature_205_residues
SVAEPLTLAVLVSGNGSNLQAIIDRIEAGEIHARIACVISNVHGVFALERARRHGIPTVIHANGAFATRREYDNALVEVL
RTHRVELVVLAGFMRILSDVMIGAFPGAVINIHPALLPAFPGLHAQKQALEYGVKFSGCTVHFVDNGTDTGPIILQAVVP
VMQDDSEESLSRRILQEEHRIFPESIRLFAEGKLSFHGRQVRISS

Specific function: De novo purine biosynthesis; third step. [C]

COG id: COG0299

COG function: function code F; Folate-dependent phosphoribosylglycinamide formyltransferase PurN

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GART family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=189, Percent_Identity=46.5608465608466, Blast_Score=170, Evalue=7e-43,
Organism=Homo sapiens, GI209869995, Length=189, Percent_Identity=46.5608465608466, Blast_Score=170, Evalue=7e-43,
Organism=Homo sapiens, GI209869993, Length=189, Percent_Identity=46.5608465608466, Blast_Score=170, Evalue=7e-43,
Organism=Escherichia coli, GI1788846, Length=192, Percent_Identity=46.875, Blast_Score=181, Evalue=3e-47,
Organism=Escherichia coli, GI1787483, Length=165, Percent_Identity=33.3333333333333, Blast_Score=94, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI17567511, Length=179, Percent_Identity=42.4581005586592, Blast_Score=144, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6320616, Length=195, Percent_Identity=27.6923076923077, Blast_Score=77, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24582400, Length=187, Percent_Identity=52.9411764705882, Blast_Score=200, Evalue=6e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002376
- InterPro:   IPR001555
- InterPro:   IPR004607 [H]

Pfam domain/function: PF00551 Formyl_trans_N [H]

EC number: =2.1.2.2 [H]

Molecular weight: Translated: 22499; Mature: 22368

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVAEPLTLAVLVSGNGSNLQAIIDRIEAGEIHARIACVISNVHGVFALERARRHGIPTV
CCCCCCEEEEEEEECCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
IHANGAFATRREYDNALVEVLRTHRVELVVLAGFMRILSDVMIGAFPGAVINIHPALLPA
EECCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHC
FPGLHAQKQALEYGVKFSGCTVHFVDNGTDTGPIILQAVVPVMQDDSEESLSRRILQEEH
CCCCCHHHHHHHHCCEECCEEEEEECCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHH
RIFPESIRLFAEGKLSFHGRQVRISS
CCCHHHHHEEECCCEEECCCEEEECC
>Mature Secondary Structure 
SVAEPLTLAVLVSGNGSNLQAIIDRIEAGEIHARIACVISNVHGVFALERARRHGIPTV
CCCCCEEEEEEEECCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
IHANGAFATRREYDNALVEVLRTHRVELVVLAGFMRILSDVMIGAFPGAVINIHPALLPA
EECCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHC
FPGLHAQKQALEYGVKFSGCTVHFVDNGTDTGPIILQAVVPVMQDDSEESLSRRILQEEH
CCCCCHHHHHHHHCCEECCEEEEEECCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHH
RIFPESIRLFAEGKLSFHGRQVRISS
CCCHHHHHEEECCCEEECCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3301838; 9205837; 9278503; 10954745; 2204419; 1522592; 1631098; 9698564; 10606510 [H]