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The map label for this gene is purM [H]

Identifier: 118580192

GI number: 118580192

Start: 1901892

End: 1902944

Strand: Direct

Name: purM [H]

Synonym: Ppro_1772

Alternate gene names: 118580192

Gene position: 1901892-1902944 (Clockwise)

Preceding gene: 118580190

Following gene: 118580193

Centisome position: 47.45

GC content: 58.5

Gene sequence:

>1053_bases
TTGAGCGATCAGAGAATCACCTACAAGGATGCAGGGGTAGATATCGCTGCGGGCAACAGTTTCGTCAATATGATCAAGCC
TTTGGTCAAATCGACCTTCCGTCCCGAAGTTATGGCGGAAATCGGGGGGTTTGGCGGGCTTTTTTCACTGAACACCACTA
AATACAAGAATCCCGTGCTCGTGTCGGGAACGGACGGTGTCGGCACGAAGCTGAAGATCGCCTTTATGGCCGATATGCAC
GAGACGGTGGGCATCGACCTGGTTGCCATGTGCGTCAACGACATCGTGGTCCAAGGCGCTGAGCCGCTCTTTTTCCTGGA
CTACCTGGCCACGGGACGTCTGCATCCCGAAAAAGGGGCCGCCATTGTCAAGGGGATTGCCGAGGGATGCAGGCAGGCGG
GCTGTGCCCTGATCGGCGGGGAAACAGCAGAGATGCCCGGCTTCTACTCCGACGATGAATACGATTTGGCCGGTTTCGCG
GTGGGCGTGGTAGATCGGGACAGAATTATCGACGGATCGGGCATCTCGGTGGGTAACCGCCTGATCGGTATTGCCTCCAG
CGGCTTGCACAGCAATGGCTACTCCTTGGCCAGAAAACTTGTCTTTGAACGCATGGGTCTTGCCATCGACGCCGAGTTTC
CCGGAACCGGCCGCACGGTCGCCGAGGAGCTGCTCACCCCGACCCGCATCTATGTCCGCTCCATTATGAACCTGCTCAAG
GATTACTCCATCAAGGGGATTGCCCACATAACCGGCGGCGGTCTTCTGGAAAACGTCCCCCGTGTACTGCCCAAGGGATG
CCGCGCTACCATGCACCTCTCCAGCTGGGAGCGCCCCCTGCTCTTCGATGTTCTGGCAGAGGCCGGAAATGTGGAGCGCG
ACGAGATGTACCGGACGTTTAATATGGGTATCGGCATGGTGTTGGCGGTTGCCGAGCAGGATTGCGATGACATGCTCGAC
CGCCTGAACGGCCTTGGCGAACATGCCTGGGTCATCGGAGAGATCACCGCCTGCCCGGAGAACAGCGACCCCACCCAACT
CGTGGAGGGGTAA

Upstream 100 bases:

>100_bases
ACGGGTAGCGGAAGGTGAAAATGAATTTTACCAGTTTGATAATTGACATTTTCCGGCCCTTGTTTTACAAAAGGTTTTTA
TCTGCAAGGGGGTACATGGT

Downstream 100 bases:

>100_bases
TGTCAGTAGCAGAGCCGCTCACCCTGGCCGTCCTGGTGTCGGGAAATGGTTCCAACCTGCAGGCGATCATCGACCGTATC
GAAGCTGGGGAGATACATGC

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 350; Mature: 349

Protein sequence:

>350_residues
MSDQRITYKDAGVDIAAGNSFVNMIKPLVKSTFRPEVMAEIGGFGGLFSLNTTKYKNPVLVSGTDGVGTKLKIAFMADMH
ETVGIDLVAMCVNDIVVQGAEPLFFLDYLATGRLHPEKGAAIVKGIAEGCRQAGCALIGGETAEMPGFYSDDEYDLAGFA
VGVVDRDRIIDGSGISVGNRLIGIASSGLHSNGYSLARKLVFERMGLAIDAEFPGTGRTVAEELLTPTRIYVRSIMNLLK
DYSIKGIAHITGGGLLENVPRVLPKGCRATMHLSSWERPLLFDVLAEAGNVERDEMYRTFNMGIGMVLAVAEQDCDDMLD
RLNGLGEHAWVIGEITACPENSDPTQLVEG

Sequences:

>Translated_350_residues
MSDQRITYKDAGVDIAAGNSFVNMIKPLVKSTFRPEVMAEIGGFGGLFSLNTTKYKNPVLVSGTDGVGTKLKIAFMADMH
ETVGIDLVAMCVNDIVVQGAEPLFFLDYLATGRLHPEKGAAIVKGIAEGCRQAGCALIGGETAEMPGFYSDDEYDLAGFA
VGVVDRDRIIDGSGISVGNRLIGIASSGLHSNGYSLARKLVFERMGLAIDAEFPGTGRTVAEELLTPTRIYVRSIMNLLK
DYSIKGIAHITGGGLLENVPRVLPKGCRATMHLSSWERPLLFDVLAEAGNVERDEMYRTFNMGIGMVLAVAEQDCDDMLD
RLNGLGEHAWVIGEITACPENSDPTQLVEG
>Mature_349_residues
SDQRITYKDAGVDIAAGNSFVNMIKPLVKSTFRPEVMAEIGGFGGLFSLNTTKYKNPVLVSGTDGVGTKLKIAFMADMHE
TVGIDLVAMCVNDIVVQGAEPLFFLDYLATGRLHPEKGAAIVKGIAEGCRQAGCALIGGETAEMPGFYSDDEYDLAGFAV
GVVDRDRIIDGSGISVGNRLIGIASSGLHSNGYSLARKLVFERMGLAIDAEFPGTGRTVAEELLTPTRIYVRSIMNLLKD
YSIKGIAHITGGGLLENVPRVLPKGCRATMHLSSWERPLLFDVLAEAGNVERDEMYRTFNMGIGMVLAVAEQDCDDMLDR
LNGLGEHAWVIGEITACPENSDPTQLVEG

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=342, Percent_Identity=51.1695906432749, Blast_Score=342, Evalue=3e-94,
Organism=Homo sapiens, GI209869995, Length=342, Percent_Identity=51.1695906432749, Blast_Score=342, Evalue=3e-94,
Organism=Homo sapiens, GI209869993, Length=342, Percent_Identity=51.1695906432749, Blast_Score=342, Evalue=3e-94,
Organism=Escherichia coli, GI1788845, Length=353, Percent_Identity=55.5240793201133, Blast_Score=377, Evalue=1e-106,
Organism=Caenorhabditis elegans, GI17567511, Length=343, Percent_Identity=42.2740524781341, Blast_Score=245, Evalue=3e-65,
Organism=Saccharomyces cerevisiae, GI6321203, Length=342, Percent_Identity=48.2456140350877, Blast_Score=318, Evalue=1e-87,
Organism=Drosophila melanogaster, GI24582400, Length=297, Percent_Identity=44.7811447811448, Blast_Score=244, Evalue=6e-65,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 37587; Mature: 37455

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: PS00359 RIBOSOMAL_L11

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDQRITYKDAGVDIAAGNSFVNMIKPLVKSTFRPEVMAEIGGFGGLFSLNTTKYKNPVL
CCCCEEEEECCCEEEECCCHHHHHHHHHHHHCCCHHHHHHHCCCCCEEECCCCCCCCCEE
VSGTDGVGTKLKIAFMADMHETVGIDLVAMCVNDIVVQGAEPLFFLDYLATGRLHPEKGA
EECCCCCCCEEEEEEEHHHHHHHCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCH
AIVKGIAEGCRQAGCALIGGETAEMPGFYSDDEYDLAGFAVGVVDRDRIIDGSGISVGNR
HHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCEEEEEEECCCCEECCCCCCCCCE
LIGIASSGLHSNGYSLARKLVFERMGLAIDAEFPGTGRTVAEELLTPTRIYVRSIMNLLK
EEEEECCCCCCCHHHHHHHHHHHHHCCEEECCCCCCCHHHHHHHCCHHHHHHHHHHHHHH
DYSIKGIAHITGGGLLENVPRVLPKGCRATMHLSSWERPLLFDVLAEAGNVERDEMYRTF
CCCCCCEEEECCCHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHCCCCCHHHHHHHH
NMGIGMVLAVAEQDCDDMLDRLNGLGEHAWVIGEITACPENSDPTQLVEG
HCCHHEEEHHHHCCHHHHHHHHHCCCCCEEEEEEEEECCCCCCCHHHCCC
>Mature Secondary Structure 
SDQRITYKDAGVDIAAGNSFVNMIKPLVKSTFRPEVMAEIGGFGGLFSLNTTKYKNPVL
CCCEEEEECCCEEEECCCHHHHHHHHHHHHCCCHHHHHHHCCCCCEEECCCCCCCCCEE
VSGTDGVGTKLKIAFMADMHETVGIDLVAMCVNDIVVQGAEPLFFLDYLATGRLHPEKGA
EECCCCCCCEEEEEEEHHHHHHHCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCH
AIVKGIAEGCRQAGCALIGGETAEMPGFYSDDEYDLAGFAVGVVDRDRIIDGSGISVGNR
HHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCEEEEEEECCCCEECCCCCCCCCE
LIGIASSGLHSNGYSLARKLVFERMGLAIDAEFPGTGRTVAEELLTPTRIYVRSIMNLLK
EEEEECCCCCCCHHHHHHHHHHHHHCCEEECCCCCCCHHHHHHHCCHHHHHHHHHHHHHH
DYSIKGIAHITGGGLLENVPRVLPKGCRATMHLSSWERPLLFDVLAEAGNVERDEMYRTF
CCCCCCEEEECCCHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHCCCCCHHHHHHHH
NMGIGMVLAVAEQDCDDMLDRLNGLGEHAWVIGEITACPENSDPTQLVEG
HCCHHEEEHHHHCCHHHHHHHHHCCCCCEEEEEEEEECCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA