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The map label for this gene is tmk

Identifier: 118580087

GI number: 118580087

Start: 1784458

End: 1785117

Strand: Reverse

Name: tmk

Synonym: Ppro_1665

Alternate gene names: 118580087

Gene position: 1785117-1784458 (Counterclockwise)

Preceding gene: 118580100

Following gene: 118580086

Centisome position: 44.54

GC content: 64.85

Gene sequence:

>660_bases
GTGGGATATTTCATAACCTTTGAAGGAATCGAGGGGAGCGGCAAGACCACCCAGATCGGGCTATTGGGCGAGCAACTGGA
GTCCCTGGGCTACTCGGTCGTCATGACACGGGAACCGGGTGGCTGCGCCATCTCCGACAAGATACGCTCCATCCTGCTGG
ATGCGGACAACAGCTCCATCTCCCCCATGACGGAGCTCTTGCTGTACGCCGCCGCCCGTGCCCAGCACGTGAGCGAAGTG
ATCATCCCGGCCCTGAAACAGGGGAACATCGTGCTGTGCGACCGCTTCAGCGACGCGACCCTGGCCTACCAGGGCAGCGG
CCGGGGCATTGCCAGGGAAAAGGTGGATACGCTCAACCAGCTGGCCTGCCAGTCCCTGCGCCCCGACCTGACGGTGCTGA
TCGACTGCGACGTGAGCGTCGGCCTGGAACGGGCGCGCCGACGCATCGAGACGGCCTCCGGCCCGCGCGAGGAGCGCTTC
GAGCTGGAGGCGCTGGAATTCCACCGCTCAGTGCGCGAGGCCTACCTGGAGCTCGCCCATGCCGAGCCGCAGCGGTTCAT
CACCGTTGACGGCAGCGGCGGAGTGGAGGAAATCTCCGAGGCCATCGTGGCCCAGGTCCTGCAGAACCGGCTCAACAACA
CCAGTCATGCCCTTCTCTGA

Upstream 100 bases:

>100_bases
TTGCGGTCGGAGCACGAGGCAAGAGAATGCCTGAAATCAGTTGCCAATTCCCGCCGGCTTACCTATAATTCAGCATTTCA
GAAAAGTGTGGGGTCATTTC

Downstream 100 bases:

>100_bases
CGTCCTGGGCCATGAGCGGATCGTGGATATCCTGCTCCGCTCGCTCCGCACGGGCAAGACGGCCCATGCCTACATCTTCG
AGGGCCCGTCGGGCTGCGGC

Product: dTMP kinase

Products: NA

Alternate protein names: dTMP kinase

Number of amino acids: Translated: 219; Mature: 218

Protein sequence:

>219_residues
MGYFITFEGIEGSGKTTQIGLLGEQLESLGYSVVMTREPGGCAISDKIRSILLDADNSSISPMTELLLYAAARAQHVSEV
IIPALKQGNIVLCDRFSDATLAYQGSGRGIAREKVDTLNQLACQSLRPDLTVLIDCDVSVGLERARRRIETASGPREERF
ELEALEFHRSVREAYLELAHAEPQRFITVDGSGGVEEISEAIVAQVLQNRLNNTSHALL

Sequences:

>Translated_219_residues
MGYFITFEGIEGSGKTTQIGLLGEQLESLGYSVVMTREPGGCAISDKIRSILLDADNSSISPMTELLLYAAARAQHVSEV
IIPALKQGNIVLCDRFSDATLAYQGSGRGIAREKVDTLNQLACQSLRPDLTVLIDCDVSVGLERARRRIETASGPREERF
ELEALEFHRSVREAYLELAHAEPQRFITVDGSGGVEEISEAIVAQVLQNRLNNTSHALL
>Mature_218_residues
GYFITFEGIEGSGKTTQIGLLGEQLESLGYSVVMTREPGGCAISDKIRSILLDADNSSISPMTELLLYAAARAQHVSEVI
IPALKQGNIVLCDRFSDATLAYQGSGRGIAREKVDTLNQLACQSLRPDLTVLIDCDVSVGLERARRRIETASGPREERFE
LEALEFHRSVREAYLELAHAEPQRFITVDGSGGVEEISEAIVAQVLQNRLNNTSHALL

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family

Homologues:

Organism=Escherichia coli, GI1787340, Length=203, Percent_Identity=41.3793103448276, Blast_Score=138, Evalue=3e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KTHY_PELPD (A1APK9)

Other databases:

- EMBL:   CP000482
- RefSeq:   YP_901337.1
- ProteinModelPortal:   A1APK9
- SMR:   A1APK9
- STRING:   A1APK9
- GeneID:   4572616
- GenomeReviews:   CP000482_GR
- KEGG:   ppd:Ppro_1665
- eggNOG:   COG0125
- HOGENOM:   HBG626009
- OMA:   LFITLEG
- PhylomeDB:   A1APK9
- ProtClustDB:   CLSK924585
- HAMAP:   MF_00165
- InterPro:   IPR018094
- PANTHER:   PTHR10344
- TIGRFAMs:   TIGR00041

Pfam domain/function: PF02223 Thymidylate_kin

EC number: =2.7.4.9

Molecular weight: Translated: 23919; Mature: 23788

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGYFITFEGIEGSGKTTQIGLLGEQLESLGYSVVMTREPGGCAISDKIRSILLDADNSSI
CCEEEEEECCCCCCCEEEEHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHEEECCCCCC
SPMTELLLYAAARAQHVSEVIIPALKQGNIVLCDRFSDATLAYQGSGRGIAREKVDTLNQ
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEECCCCCCHHHHHHHHHH
LACQSLRPDLTVLIDCDVSVGLERARRRIETASGPREERFELEALEFHRSVREAYLELAH
HHHHHCCCCEEEEEECCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
AEPQRFITVDGSGGVEEISEAIVAQVLQNRLNNTSHALL
CCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
GYFITFEGIEGSGKTTQIGLLGEQLESLGYSVVMTREPGGCAISDKIRSILLDADNSSI
CEEEEEECCCCCCCEEEEHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHEEECCCCCC
SPMTELLLYAAARAQHVSEVIIPALKQGNIVLCDRFSDATLAYQGSGRGIAREKVDTLNQ
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEECCCCCCHHHHHHHHHH
LACQSLRPDLTVLIDCDVSVGLERARRRIETASGPREERFELEALEFHRSVREAYLELAH
HHHHHCCCCEEEEEECCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
AEPQRFITVDGSGGVEEISEAIVAQVLQNRLNNTSHALL
CCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA