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The map label for this gene is zraR [H]

Identifier: 118580022

GI number: 118580022

Start: 1708271

End: 1709995

Strand: Direct

Name: zraR [H]

Synonym: Ppro_1599

Alternate gene names: 118580022

Gene position: 1708271-1709995 (Clockwise)

Preceding gene: 118580016

Following gene: 118580023

Centisome position: 42.62

GC content: 61.22

Gene sequence:

>1725_bases
ATGATTTCTGTTATGCAACCATCCAGCTTTCGCATACTGCTTGTTGACGATGAAGAGGGAATCCGTTTTACTCTGGGATG
CCTGCTGAAGAAGGAGGGCTTTCGGGTGGAGGTTGCTGCGGGGCGCGGTGAAGCTCTTGCCCTGCTGGCTGCCGCCCCTT
TTGATCTGGCCCTGGTGGATATCATGCTGGCCGGGGAGAGCGGCATCGGGCTTTTGGGCGATATAAAGAGTATGTACCCG
TCGACGCAGGTAATCATGATCACCGGCCGTCCCGAGGTGGATACCGCGGCGGAAGCGGTCCGGTTGGGGGCATTCGACTA
TCTCACCAAGCCGATCCGCCACGAAACCCTGATGGCGGTCAGCCGTCATGCCCTGAGCGCGAAGAAGATGAACGATGAGA
GGGAGCTGTATCGCGCCAATCTGGATGCCATCTTTCGCACCGTTACGGATTCCATCGTGATGGTGGACCGGGAGGGGTGT
CTGGCCCAGTTCAATGCGGCAGCGGGACATCTCTGCGGACTGAACGGCGATATGATCGGGATGGATCTGGCTGCCCTCAA
CCTGAGCTGTAACGGTATGTGCGCCGCCACCCTGCTGGAAACGCTGCGCCGCAATGTCCCCCAGGAATTGCGGCGATTCG
AGTGCCGCAACCGGGAGGGCAAGCCGCGCGTGGCCTCGTTTACCTCCACGCCGGTGGTGGATGCGGACGGAACGGTGGAT
GGCGCGGTGGCGGTCATCCGCGACGAGACGCGCCTGGTGGATCTGGAACGCTCCCTGCGTACCAGAAGCACATACCACAA
CATCGTCGGCAACTCGGCGCCCATGCAGCGCCTGTTCGCCCTGATCGAGGCGCTTGCCGACGTGCCGACCACGGTTCTGA
TCAACGGCGAGAGCGGAACCGGCAAGGAACTGGTGGCGGCCGCCCTGCACGCCACCGGCGCGCGTTCAGGAGGTCCGTTC
GTGAAGGTCAACTGCTCGGCCCTGTCCGAGTCGCTTTTGGAGAGTGAACTGTTCGGGCACGTGCGCGGGGCGTTTACCGG
CGCCATTGCCGACAAGGTCGGCCGTTTCCAGAAGGCCCACGGCGGAACGCTCTTCCTGGATGAGATCGGCGATATCTCGT
CTGCCGTGCAGATGCGGCTTCTGCGGGTCCTGCAGGAAAGCGAGTTCGAGCGGGTAGGGGAGTCTACGCCCCTCCGGGTG
GATGTGCGCATCATAGCCGCAACCAACCAGAATCTGGCCGATAAGGTCAGTCAGGGAACGTTCCGCCAGGATCTCTTCTA
CCGCCTGAATGTGGTCCGGGTGGTGCTGCCGGCGCTCAGGGAACGCCTGGACGACCTTGAACCGCTGGTGGCTCATTTTA
TTGCAAAGTTCAACGTCAAGTTCGGTCGGGACATTACCGGTGTGTCCAGTGATGCCATGGCTGTCTTCCACAGGCACGAC
TGGCCGGGCAATGTGCGTGAACTGGAGCATGCCATTGAGCATGCCAGCATTCTCTGCAAATCCGATATCATCTCCCTTTC
CGACCTTCCGCAGGATTTGCTCGATTCCCTGCGGGCCGACGACGCTTCCCCGGTTGATGCTCCTGTTGCCCCTTCTTCAC
GACCGCCTCTTACCCTGGAGGAGGCTCTGGTGATGACTGGCGGCAACAAGAGCCGCGCCGCCGACCTGCTGGGCATCAGC
CGACGCACGGTATACCGGCACCTGGAAGAGTGCCAATCAAAATAG

Upstream 100 bases:

>100_bases
CGTGATTGCGGGGGGATGGACAAATCAAGGGATATACGTATACTGACCGGTATGGCCTGACAGCTCCATCGGCTTACCGA
TATTTCCACTGAACGAGGTA

Downstream 100 bases:

>100_bases
TGGCGGCAGGGTGGTGAGCAGCGCCACCAAACCGGTTGCCAACAAGGCCGCCGCTATTTTTCGTATGGCAGCTTACGCTC
TGTTTCAAACAACATAAAAT

Product: sigma-54 dependent trancsriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 574; Mature: 574

Protein sequence:

>574_residues
MISVMQPSSFRILLVDDEEGIRFTLGCLLKKEGFRVEVAAGRGEALALLAAAPFDLALVDIMLAGESGIGLLGDIKSMYP
STQVIMITGRPEVDTAAEAVRLGAFDYLTKPIRHETLMAVSRHALSAKKMNDERELYRANLDAIFRTVTDSIVMVDREGC
LAQFNAAAGHLCGLNGDMIGMDLAALNLSCNGMCAATLLETLRRNVPQELRRFECRNREGKPRVASFTSTPVVDADGTVD
GAVAVIRDETRLVDLERSLRTRSTYHNIVGNSAPMQRLFALIEALADVPTTVLINGESGTGKELVAAALHATGARSGGPF
VKVNCSALSESLLESELFGHVRGAFTGAIADKVGRFQKAHGGTLFLDEIGDISSAVQMRLLRVLQESEFERVGESTPLRV
DVRIIAATNQNLADKVSQGTFRQDLFYRLNVVRVVLPALRERLDDLEPLVAHFIAKFNVKFGRDITGVSSDAMAVFHRHD
WPGNVRELEHAIEHASILCKSDIISLSDLPQDLLDSLRADDASPVDAPVAPSSRPPLTLEEALVMTGGNKSRAADLLGIS
RRTVYRHLEECQSK

Sequences:

>Translated_574_residues
MISVMQPSSFRILLVDDEEGIRFTLGCLLKKEGFRVEVAAGRGEALALLAAAPFDLALVDIMLAGESGIGLLGDIKSMYP
STQVIMITGRPEVDTAAEAVRLGAFDYLTKPIRHETLMAVSRHALSAKKMNDERELYRANLDAIFRTVTDSIVMVDREGC
LAQFNAAAGHLCGLNGDMIGMDLAALNLSCNGMCAATLLETLRRNVPQELRRFECRNREGKPRVASFTSTPVVDADGTVD
GAVAVIRDETRLVDLERSLRTRSTYHNIVGNSAPMQRLFALIEALADVPTTVLINGESGTGKELVAAALHATGARSGGPF
VKVNCSALSESLLESELFGHVRGAFTGAIADKVGRFQKAHGGTLFLDEIGDISSAVQMRLLRVLQESEFERVGESTPLRV
DVRIIAATNQNLADKVSQGTFRQDLFYRLNVVRVVLPALRERLDDLEPLVAHFIAKFNVKFGRDITGVSSDAMAVFHRHD
WPGNVRELEHAIEHASILCKSDIISLSDLPQDLLDSLRADDASPVDAPVAPSSRPPLTLEEALVMTGGNKSRAADLLGIS
RRTVYRHLEECQSK
>Mature_574_residues
MISVMQPSSFRILLVDDEEGIRFTLGCLLKKEGFRVEVAAGRGEALALLAAAPFDLALVDIMLAGESGIGLLGDIKSMYP
STQVIMITGRPEVDTAAEAVRLGAFDYLTKPIRHETLMAVSRHALSAKKMNDERELYRANLDAIFRTVTDSIVMVDREGC
LAQFNAAAGHLCGLNGDMIGMDLAALNLSCNGMCAATLLETLRRNVPQELRRFECRNREGKPRVASFTSTPVVDADGTVD
GAVAVIRDETRLVDLERSLRTRSTYHNIVGNSAPMQRLFALIEALADVPTTVLINGESGTGKELVAAALHATGARSGGPF
VKVNCSALSESLLESELFGHVRGAFTGAIADKVGRFQKAHGGTLFLDEIGDISSAVQMRLLRVLQESEFERVGESTPLRV
DVRIIAATNQNLADKVSQGTFRQDLFYRLNVVRVVLPALRERLDDLEPLVAHFIAKFNVKFGRDITGVSSDAMAVFHRHD
WPGNVRELEHAIEHASILCKSDIISLSDLPQDLLDSLRADDASPVDAPVAPSSRPPLTLEEALVMTGGNKSRAADLLGIS
RRTVYRHLEECQSK

Specific function: Member of the two-component regulatory system zraS/zraR. When activated by zraS it acts in conjunction with sigma-54 to regulate the expression of zraP. Positively autoregulates the expression of the zraSR operon [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1790437, Length=324, Percent_Identity=47.2222222222222, Blast_Score=282, Evalue=4e-77,
Organism=Escherichia coli, GI1788550, Length=326, Percent_Identity=44.7852760736196, Blast_Score=270, Evalue=1e-73,
Organism=Escherichia coli, GI1790299, Length=337, Percent_Identity=42.7299703264095, Blast_Score=255, Evalue=6e-69,
Organism=Escherichia coli, GI1789233, Length=323, Percent_Identity=40.5572755417957, Blast_Score=244, Evalue=8e-66,
Organism=Escherichia coli, GI1789087, Length=336, Percent_Identity=41.9642857142857, Blast_Score=236, Evalue=3e-63,
Organism=Escherichia coli, GI87082117, Length=240, Percent_Identity=49.5833333333333, Blast_Score=232, Evalue=4e-62,
Organism=Escherichia coli, GI1786524, Length=326, Percent_Identity=42.0245398773006, Blast_Score=229, Evalue=3e-61,
Organism=Escherichia coli, GI1788905, Length=304, Percent_Identity=41.7763157894737, Blast_Score=226, Evalue=2e-60,
Organism=Escherichia coli, GI87082152, Length=235, Percent_Identity=49.3617021276596, Blast_Score=223, Evalue=4e-59,
Organism=Escherichia coli, GI87081872, Length=311, Percent_Identity=39.871382636656, Blast_Score=200, Evalue=2e-52,
Organism=Escherichia coli, GI1787583, Length=291, Percent_Identity=39.1752577319588, Blast_Score=194, Evalue=1e-50,
Organism=Escherichia coli, GI87081858, Length=439, Percent_Identity=26.6514806378132, Blast_Score=142, Evalue=6e-35,
Organism=Escherichia coli, GI1789828, Length=306, Percent_Identity=31.6993464052288, Blast_Score=137, Evalue=3e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 62426; Mature: 62426

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: PS50113 PAC ; PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISVMQPSSFRILLVDDEEGIRFTLGCLLKKEGFRVEVAAGRGEALALLAAAPFDLALVD
CCCCCCCCCEEEEEEECCCCCEEEEEHHCCCCCCEEEEECCCCCEEEEEEECCCHHEEEE
IMLAGESGIGLLGDIKSMYPSTQVIMITGRPEVDTAAEAVRLGAFDYLTKPIRHETLMAV
HEEECCCCCCHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHH
SRHALSAKKMNDERELYRANLDAIFRTVTDSIVMVDREGCLAQFNAAAGHLCGLNGDMIG
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHCCCCCCEECCCCCEEE
MDLAALNLSCNGMCAATLLETLRRNVPQELRRFECRNREGKPRVASFTSTPVVDADGTVD
EEEEEEECCCCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCEEECCCCCCCCCCCCCC
GAVAVIRDETRLVDLERSLRTRSTYHNIVGNSAPMQRLFALIEALADVPTTVLINGESGT
CEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCC
GKELVAAALHATGARSGGPFVKVNCSALSESLLESELFGHVRGAFTGAIADKVGRFQKAH
CHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GGTLFLDEIGDISSAVQMRLLRVLQESEFERVGESTPLRVDVRIIAATNQNLADKVSQGT
CCEEEEHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEECCCCHHHHHHCCH
FRQDLFYRLNVVRVVLPALRERLDDLEPLVAHFIAKFNVKFGRDITGVSSDAMAVFHRHD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHEEEECCC
WPGNVRELEHAIEHASILCKSDIISLSDLPQDLLDSLRADDASPVDAPVAPSSRPPLTLE
CCCCHHHHHHHHHHHHHHHHHCCCCHHCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCHH
EALVMTGGNKSRAADLLGISRRTVYRHLEECQSK
HHHEEECCCHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MISVMQPSSFRILLVDDEEGIRFTLGCLLKKEGFRVEVAAGRGEALALLAAAPFDLALVD
CCCCCCCCCEEEEEEECCCCCEEEEEHHCCCCCCEEEEECCCCCEEEEEEECCCHHEEEE
IMLAGESGIGLLGDIKSMYPSTQVIMITGRPEVDTAAEAVRLGAFDYLTKPIRHETLMAV
HEEECCCCCCHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHH
SRHALSAKKMNDERELYRANLDAIFRTVTDSIVMVDREGCLAQFNAAAGHLCGLNGDMIG
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHCCCCCCEECCCCCEEE
MDLAALNLSCNGMCAATLLETLRRNVPQELRRFECRNREGKPRVASFTSTPVVDADGTVD
EEEEEEECCCCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCEEECCCCCCCCCCCCCC
GAVAVIRDETRLVDLERSLRTRSTYHNIVGNSAPMQRLFALIEALADVPTTVLINGESGT
CEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCC
GKELVAAALHATGARSGGPFVKVNCSALSESLLESELFGHVRGAFTGAIADKVGRFQKAH
CHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GGTLFLDEIGDISSAVQMRLLRVLQESEFERVGESTPLRVDVRIIAATNQNLADKVSQGT
CCEEEEHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEECCCCHHHHHHCCH
FRQDLFYRLNVVRVVLPALRERLDDLEPLVAHFIAKFNVKFGRDITGVSSDAMAVFHRHD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHEEEECCC
WPGNVRELEHAIEHASILCKSDIISLSDLPQDLLDSLRADDASPVDAPVAPSSRPPLTLE
CCCCHHHHHHHHHHHHHHHHHCCCCHHCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCHH
EALVMTGGNKSRAADLLGISRRTVYRHLEECQSK
HHHEEECCCHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]