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The map label for this gene is ppnK [H]

Identifier: 118580002

GI number: 118580002

Start: 1684896

End: 1685762

Strand: Reverse

Name: ppnK [H]

Synonym: Ppro_1579

Alternate gene names: 118580002

Gene position: 1685762-1684896 (Counterclockwise)

Preceding gene: 118580003

Following gene: 118580001

Centisome position: 42.06

GC content: 61.13

Gene sequence:

>867_bases
ATGAGCATGCACCTAAAATATGTCGCCATATTCGCCAAGGTACACGACCCCCGCTGCCAGGAAGTAGCCACCGAGCTGAT
CTCCTGGCTGGAACGGAAGAACTGCGTCCACCTGATCGAGGAGCACCTGGCCCGCCATCTCCTGCGTAACGACGGCATGA
CCCACGAGGAGATCCTGAGCCAGGCCGAGATGGTGGTGGTGCTGGGGGGGGACGGCACCCTGCTCTCCACGGCGCGCCTG
TTCTATGGCAAGGAGATCCCCATCCTGGGGATCAACCTGGGCAGCCTCGGTTTTCTGACCGAAGTCACCGTGGAGGCTCT
CTACGGCGAGCTTGAACTCTGCCTGACGGGAAACCAGCGCAGTTCCCGGCGCATGATGCTGGAGGTCAGCATCCTGCGCG
AGGGCAAGCCGATCGAGAAATGCCCTATCCTGAACGAGTTGGTGCTCAACAGGACCGGTATCCTGGCCCGCATCGTCAAC
CTGAAGACGAGAATCGGCAACCACATCCTGACCAATTTCAAGGCCGACGGACTGATCGTCTCCACCCCCACCGGCTCCAC
CGGCTATTCCATGTCCGCCGGCGGCCCGATCGTCCATCCCCAGGTGAGCTGCATCGCCATAACCCCCATCTGCCCACACT
CCCTGACCAACCGTCCCGTCGTGGTCCCGGATGAATCGGTCATCACCATCACCGTCACCTGTCCCCACGACGACAAGGTC
TACCTGACCCTGGACGGCCAGGTGGGCTTCGAGCTATTGCAGGGTGACACAGTGGAGGTGCGCAGGGCCCCCTCGATCAC
CAATCTGGCCGTACCCCGGAAACTGGATTACTTCGAGGTACTGCGGACCAAACTGAAGTGGGGATAA

Upstream 100 bases:

>100_bases
GAGGCGCCCTCGCATCAGAAGATGTATCAACCCCAAAACCAGCAACCAGCCACAGAGTTCTGTGGCTGGTTGCTCTTTCC
GGGATCAACGAGCAGCCAGC

Downstream 100 bases:

>100_bases
ATCGGTTCAATGCTCGCGGTTCAGGGTTCATGGTTGACGTCACTCATACCTCTGAACGTTGAACCTCGAACCACGAATCA
CATACCAGGTGTTATTATGC

Product: NAD(+) kinase

Products: NA

Alternate protein names: Poly(P)/ATP NAD kinase [H]

Number of amino acids: Translated: 288; Mature: 287

Protein sequence:

>288_residues
MSMHLKYVAIFAKVHDPRCQEVATELISWLERKNCVHLIEEHLARHLLRNDGMTHEEILSQAEMVVVLGGDGTLLSTARL
FYGKEIPILGINLGSLGFLTEVTVEALYGELELCLTGNQRSSRRMMLEVSILREGKPIEKCPILNELVLNRTGILARIVN
LKTRIGNHILTNFKADGLIVSTPTGSTGYSMSAGGPIVHPQVSCIAITPICPHSLTNRPVVVPDESVITITVTCPHDDKV
YLTLDGQVGFELLQGDTVEVRRAPSITNLAVPRKLDYFEVLRTKLKWG

Sequences:

>Translated_288_residues
MSMHLKYVAIFAKVHDPRCQEVATELISWLERKNCVHLIEEHLARHLLRNDGMTHEEILSQAEMVVVLGGDGTLLSTARL
FYGKEIPILGINLGSLGFLTEVTVEALYGELELCLTGNQRSSRRMMLEVSILREGKPIEKCPILNELVLNRTGILARIVN
LKTRIGNHILTNFKADGLIVSTPTGSTGYSMSAGGPIVHPQVSCIAITPICPHSLTNRPVVVPDESVITITVTCPHDDKV
YLTLDGQVGFELLQGDTVEVRRAPSITNLAVPRKLDYFEVLRTKLKWG
>Mature_287_residues
SMHLKYVAIFAKVHDPRCQEVATELISWLERKNCVHLIEEHLARHLLRNDGMTHEEILSQAEMVVVLGGDGTLLSTARLF
YGKEIPILGINLGSLGFLTEVTVEALYGELELCLTGNQRSSRRMMLEVSILREGKPIEKCPILNELVLNRTGILARIVNL
KTRIGNHILTNFKADGLIVSTPTGSTGYSMSAGGPIVHPQVSCIAITPICPHSLTNRPVVVPDESVITITVTCPHDDKVY
LTLDGQVGFELLQGDTVEVRRAPSITNLAVPRKLDYFEVLRTKLKWG

Specific function: Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus [H]

COG id: COG0061

COG function: function code G; Predicted sugar kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAD kinase family [H]

Homologues:

Organism=Homo sapiens, GI55743112, Length=263, Percent_Identity=33.4600760456274, Blast_Score=129, Evalue=2e-30,
Organism=Escherichia coli, GI1788968, Length=289, Percent_Identity=33.9100346020761, Blast_Score=163, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6320794, Length=242, Percent_Identity=34.7107438016529, Blast_Score=143, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6322509, Length=241, Percent_Identity=32.7800829875519, Blast_Score=134, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6325068, Length=280, Percent_Identity=30, Blast_Score=112, Evalue=6e-26,
Organism=Drosophila melanogaster, GI28573828, Length=316, Percent_Identity=31.6455696202532, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI28573826, Length=316, Percent_Identity=31.6455696202532, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI161077047, Length=316, Percent_Identity=31.6455696202532, Blast_Score=121, Evalue=5e-28,
Organism=Drosophila melanogaster, GI28573832, Length=316, Percent_Identity=31.6455696202532, Blast_Score=121, Evalue=6e-28,
Organism=Drosophila melanogaster, GI28573830, Length=316, Percent_Identity=31.6455696202532, Blast_Score=121, Evalue=6e-28,
Organism=Drosophila melanogaster, GI24653422, Length=280, Percent_Identity=30.7142857142857, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI20129957, Length=280, Percent_Identity=30.7142857142857, Blast_Score=106, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24653424, Length=280, Percent_Identity=30.7142857142857, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI281363321, Length=280, Percent_Identity=30.7142857142857, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI281363323, Length=280, Percent_Identity=30.7142857142857, Blast_Score=106, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016064
- InterPro:   IPR017438
- InterPro:   IPR017437
- InterPro:   IPR002504 [H]

Pfam domain/function: PF01513 NAD_kinase [H]

EC number: =2.7.1.23 [H]

Molecular weight: Translated: 31868; Mature: 31737

Theoretical pI: Translated: 7.04; Mature: 7.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSMHLKYVAIFAKVHDPRCQEVATELISWLERKNCVHLIEEHLARHLLRNDGMTHEEILS
CCCEEEEEEEEEECCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHC
QAEMVVVLGGDGTLLSTARLFYGKEIPILGINLGSLGFLTEVTVEALYGELELCLTGNQR
CCCEEEEECCCCCCHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHCCEEEEEECCCC
SSRRMMLEVSILREGKPIEKCPILNELVLNRTGILARIVNLKTRIGNHILTNFKADGLIV
CCCEEEEEEEECCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHCCHHEECCCCCCEEE
STPTGSTGYSMSAGGPIVHPQVSCIAITPICPHSLTNRPVVVPDESVITITVTCPHDDKV
ECCCCCCCCCCCCCCCEECCCEEEEEECCCCCCCCCCCCEEECCCCEEEEEEECCCCCEE
YLTLDGQVGFELLQGDTVEVRRAPSITNLAVPRKLDYFEVLRTKLKWG
EEEECCCCCEEEECCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHCCC
>Mature Secondary Structure 
SMHLKYVAIFAKVHDPRCQEVATELISWLERKNCVHLIEEHLARHLLRNDGMTHEEILS
CCEEEEEEEEEECCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHC
QAEMVVVLGGDGTLLSTARLFYGKEIPILGINLGSLGFLTEVTVEALYGELELCLTGNQR
CCCEEEEECCCCCCHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHCCEEEEEECCCC
SSRRMMLEVSILREGKPIEKCPILNELVLNRTGILARIVNLKTRIGNHILTNFKADGLIV
CCCEEEEEEEECCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHCCHHEECCCCCCEEE
STPTGSTGYSMSAGGPIVHPQVSCIAITPICPHSLTNRPVVVPDESVITITVTCPHDDKV
ECCCCCCCCCCCCCCCEECCCEEEEEECCCCCCCCCCCCEEECCCCEEEEEEECCCCCEE
YLTLDGQVGFELLQGDTVEVRRAPSITNLAVPRKLDYFEVLRTKLKWG
EEEECCCCCEEEECCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA