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The map label for this gene is moeA [C]

Identifier: 118579877

GI number: 118579877

Start: 1552289

End: 1554247

Strand: Reverse

Name: moeA [C]

Synonym: Ppro_1453

Alternate gene names: 118579877

Gene position: 1554247-1552289 (Counterclockwise)

Preceding gene: 118579878

Following gene: 118579876

Centisome position: 38.78

GC content: 67.23

Gene sequence:

>1959_bases
ATGAGCAAGAGCAGAAATTTTTTTCTGGAAAACATACCGCTGGACGAGGCCTGGAGCCGCTTCATCACGGCCATGGAGGA
GGTCTGGGCATGGGACGAGATGCCCGGCGAGGAGGTAGCCGTCGACGAGGCCCTGGGCCGCGTGACCGCCAAACCGGTCT
GGGCGGAGCTTTCCTCTCCCGCCTACCACGCCAGCGCCATGGACGGCTATGCCGTGCGTTCCACCGATACCATCGGCGCC
ATGGAGACGGCGCCCAAACGCCTGGCGATCGGCCCGGCCGGCCCGGCAACCTACGTGGATACCGGCGACCCGATTCCGGC
CTGGGCCGATGCCGTGATCATGATCGAGCAGACCCAGCACATCGACGAACCTGACGGCGGCGAATCAATCGAGATCCACG
CCGGCGTCGCCCCCTGGACGGCAGTCAGGCCCATGGGCGAGGACATGGTGGCCACCGAACTGGTGCTGCCGGCCAACCAT
CTGCTGAAACCGGTGGACCTGGGCGCCCTGGCGGGATGCGGTCACGCCTTCGTCAACGTGCGCCGCAAGCCGCGGGTGGC
GGTCATCCCCACCGGCACCGAACTGGTGACGGTGGAGCAGGCCCGCCGCTGTGGCCTGAAGTCGGGGGACATCATCGAAT
ACAACTCGCTGGTGCTCTCCTCCCAGGTGCGCCAGTGGGGCGGCATTCCGACCCGCTACCCGGTGGTGCCGGACGATTAC
GAGCTGATCAAGGCAACGGTGCTGGAGGCGGCCGCCGAGCACGACCTGGTGCTGGTCAATGCCGGCTCGTCGGCGGGGAG
CGAGGATTTCACCTCCAGTATCGTGGTGGAGCTGGGAAAACTGCTGGTTCACGGAGTTGCGGTACGCCCCGGCCACCCGG
TCATTCTCGGCATGATCGCCGGCTTCAACAGGCCGGTGATCGGCATTCCCGGCTATCCGGTTTCCTGCGCGCTGACCGGA
GAGACCTTTGTGGAGCCGCTCATCTCCCACTGGCTCGGGTTGCCGCCACGGGAGCAGCCCCGGATGCAGGCCTCCATCAC
CCGCAAGCTGCTCTCCCCCATCGGCGAAGACGAAACGGTGCGCGTTACCGTGGGGCGGGTGGGCGAGCGGGCCGTGGCAG
CACCACTGTCGCGCGGGGCCGGCGTGATCACCTCCTTGGTTCGCGCCGACGGGATCGTGCGCATACCGCGCTTTTCCGAA
GGGGTGGAGGCGGGTCAGGAGGTTACGGTGGAACTCTACCGCACTCCGGCCGAGGTCGAACGCACCCTGGTGCACATCGG
CAGCCACGACCTCTGCCTGGACCTGTTGGCCCAGTACCTGGCCGATTCCGGCCGCCGCTTCACCAGTGCCAACGCCGGCA
GCCTGGGAGGCCTGATGGCGCTGAAACGCGGGGACGCCCATCTGGCGGGCGCCCACCTGCTGGACCCGGCCACGGGGGAC
TACAACGTCTCCTACATACAGCAGTACCTGCCCGGTCTGCCGGTGGTGCTGCTGACCTTCATGCACCGCCAGCAGGGGCT
GATCGTCCCGCCGGGCAACCCCAAGGGGATCGGAGGGCTGGCGGATCTGACGCGGGAGGGACTGCGTTTCGTCAACCGCC
AGCGCGGTGCAGGCACGCGGGTGCTTCTGGACTACCACCTGGGCAAGCTGGGAATCGCTCCCCAGCAGATACTGGGGTAC
AAACGGGAGGAGTACACCCACATGGCGGTTGCCGTGGCGGTCCAGTCGGGGTTGGCCGACTGCGGCCTCGGCATTGCAGC
CGCCGCACGGGCGCTGGAGCTGGACTTCATCCCCCTGGAGATGGAGCGCTACGACCTGGTGATCCCCCGCATCCACTATG
AAAGCGACCTGCTCCGTCCGCTGCTGGAGCTGATCAACGGCCAGGAACTGCGCCGGGCCGTTGCCGAACTGCCCGGCTAC
GACACCAGCCACATGGGGGAGATCGCCGGCCAGTGGTAG

Upstream 100 bases:

>100_bases
TTCAGCCATGCGTTGACGATCGGATCCGCAGCGACGCATTGCAACGCGTCGCTGCGAAGAAACGTGCAATGGGCATGATA
TCCAATGGCAGGAGACGGCA

Downstream 100 bases:

>100_bases
GCGCTTTGACGTTTCTCTGTAACACATGGCCCCAAGGGGCACCAGACAACAGCTCTGCCATCAAAATCGTTCATTTTTGA
CACAATTATTAAAACCATTG

Product: putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 652; Mature: 651

Protein sequence:

>652_residues
MSKSRNFFLENIPLDEAWSRFITAMEEVWAWDEMPGEEVAVDEALGRVTAKPVWAELSSPAYHASAMDGYAVRSTDTIGA
METAPKRLAIGPAGPATYVDTGDPIPAWADAVIMIEQTQHIDEPDGGESIEIHAGVAPWTAVRPMGEDMVATELVLPANH
LLKPVDLGALAGCGHAFVNVRRKPRVAVIPTGTELVTVEQARRCGLKSGDIIEYNSLVLSSQVRQWGGIPTRYPVVPDDY
ELIKATVLEAAAEHDLVLVNAGSSAGSEDFTSSIVVELGKLLVHGVAVRPGHPVILGMIAGFNRPVIGIPGYPVSCALTG
ETFVEPLISHWLGLPPREQPRMQASITRKLLSPIGEDETVRVTVGRVGERAVAAPLSRGAGVITSLVRADGIVRIPRFSE
GVEAGQEVTVELYRTPAEVERTLVHIGSHDLCLDLLAQYLADSGRRFTSANAGSLGGLMALKRGDAHLAGAHLLDPATGD
YNVSYIQQYLPGLPVVLLTFMHRQQGLIVPPGNPKGIGGLADLTREGLRFVNRQRGAGTRVLLDYHLGKLGIAPQQILGY
KREEYTHMAVAVAVQSGLADCGLGIAAAARALELDFIPLEMERYDLVIPRIHYESDLLRPLLELINGQELRRAVAELPGY
DTSHMGEIAGQW

Sequences:

>Translated_652_residues
MSKSRNFFLENIPLDEAWSRFITAMEEVWAWDEMPGEEVAVDEALGRVTAKPVWAELSSPAYHASAMDGYAVRSTDTIGA
METAPKRLAIGPAGPATYVDTGDPIPAWADAVIMIEQTQHIDEPDGGESIEIHAGVAPWTAVRPMGEDMVATELVLPANH
LLKPVDLGALAGCGHAFVNVRRKPRVAVIPTGTELVTVEQARRCGLKSGDIIEYNSLVLSSQVRQWGGIPTRYPVVPDDY
ELIKATVLEAAAEHDLVLVNAGSSAGSEDFTSSIVVELGKLLVHGVAVRPGHPVILGMIAGFNRPVIGIPGYPVSCALTG
ETFVEPLISHWLGLPPREQPRMQASITRKLLSPIGEDETVRVTVGRVGERAVAAPLSRGAGVITSLVRADGIVRIPRFSE
GVEAGQEVTVELYRTPAEVERTLVHIGSHDLCLDLLAQYLADSGRRFTSANAGSLGGLMALKRGDAHLAGAHLLDPATGD
YNVSYIQQYLPGLPVVLLTFMHRQQGLIVPPGNPKGIGGLADLTREGLRFVNRQRGAGTRVLLDYHLGKLGIAPQQILGY
KREEYTHMAVAVAVQSGLADCGLGIAAAARALELDFIPLEMERYDLVIPRIHYESDLLRPLLELINGQELRRAVAELPGY
DTSHMGEIAGQW
>Mature_651_residues
SKSRNFFLENIPLDEAWSRFITAMEEVWAWDEMPGEEVAVDEALGRVTAKPVWAELSSPAYHASAMDGYAVRSTDTIGAM
ETAPKRLAIGPAGPATYVDTGDPIPAWADAVIMIEQTQHIDEPDGGESIEIHAGVAPWTAVRPMGEDMVATELVLPANHL
LKPVDLGALAGCGHAFVNVRRKPRVAVIPTGTELVTVEQARRCGLKSGDIIEYNSLVLSSQVRQWGGIPTRYPVVPDDYE
LIKATVLEAAAEHDLVLVNAGSSAGSEDFTSSIVVELGKLLVHGVAVRPGHPVILGMIAGFNRPVIGIPGYPVSCALTGE
TFVEPLISHWLGLPPREQPRMQASITRKLLSPIGEDETVRVTVGRVGERAVAAPLSRGAGVITSLVRADGIVRIPRFSEG
VEAGQEVTVELYRTPAEVERTLVHIGSHDLCLDLLAQYLADSGRRFTSANAGSLGGLMALKRGDAHLAGAHLLDPATGDY
NVSYIQQYLPGLPVVLLTFMHRQQGLIVPPGNPKGIGGLADLTREGLRFVNRQRGAGTRVLLDYHLGKLGIAPQQILGYK
REEYTHMAVAVAVQSGLADCGLGIAAAARALELDFIPLEMERYDLVIPRIHYESDLLRPLLELINGQELRRAVAELPGYD
TSHMGEIAGQW

Specific function: Involved In The Biosynthesis Of A Demolybdo-Cofactor (Molybdopterin), Necessary For Molybdo-Enzymes. Seems To Be Involved In A Step Of Activation Of Molybdenum In The Form Of Thiomolybdenum. [C]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=348, Percent_Identity=30.1724137931034, Blast_Score=125, Evalue=2e-28,
Organism=Homo sapiens, GI10880983, Length=348, Percent_Identity=30.1724137931034, Blast_Score=124, Evalue=2e-28,
Organism=Escherichia coli, GI1787049, Length=350, Percent_Identity=31.4285714285714, Blast_Score=149, Evalue=7e-37,
Organism=Caenorhabditis elegans, GI25147659, Length=358, Percent_Identity=27.6536312849162, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI17136978, Length=359, Percent_Identity=27.0194986072423, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24638841, Length=359, Percent_Identity=27.0194986072423, Blast_Score=108, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 70239; Mature: 70108

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKSRNFFLENIPLDEAWSRFITAMEEVWAWDEMPGEEVAVDEALGRVTAKPVWAELSSP
CCCCCCCEEECCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHCCCC
AYHASAMDGYAVRSTDTIGAMETAPKRLAIGPAGPATYVDTGDPIPAWADAVIMIEQTQH
CHHHHCCCCEEEECCCCCCCHHCCCCEEEECCCCCCCCCCCCCCCCCCCCEEEEEECHHC
IDEPDGGESIEIHAGVAPWTAVRPMGEDMVATELVLPANHLLKPVDLGALAGCGHAFVNV
CCCCCCCCEEEEECCCCCCHHHCCCCCCHHHHHEECCHHHHCCCCCCHHHHCCCHHHHHH
RRKPRVAVIPTGTELVTVEQARRCGLKSGDIIEYNSLVLSSQVRQWGGIPTRYPVVPDDY
CCCCEEEEEECCCEEEEHHHHHHCCCCCCCEEEHHHHHHHHHHHHHCCCCCCCCCCCCCH
ELIKATVLEAAAEHDLVLVNAGSSAGSEDFTSSIVVELGKLLVHGVAVRPGHPVILGMIA
HHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHCEEECCCCCEEEEEEC
GFNRPVIGIPGYPVSCALTGETFVEPLISHWLGLPPREQPRMQASITRKLLSPIGEDETV
CCCCCEEECCCCCEEEEECCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCEE
RVTVGRVGERAVAAPLSRGAGVITSLVRADGIVRIPRFSEGVEAGQEVTVELYRTPAEVE
EEEECCCCCHHHHHHHHCCHHHHHHHHHCCCEEECCCCCHHHCCCCEEEEEEECCHHHHH
RTLVHIGSHDLCLDLLAQYLADSGRRFTSANAGSLGGLMALKRGDAHLAGAHLLDPATGD
HHHHHCCCCHHHHHHHHHHHHCCCCEEECCCCCCCCCCCEEECCCCCCCCCEEECCCCCC
YNVSYIQQYLPGLPVVLLTFMHRQQGLIVPPGNPKGIGGLADLTREGLRFVNRQRGAGTR
CCHHHHHHHCCCCHHHHHHHHHHCCCEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCE
VLLDYHLGKLGIAPQQILGYKREEYTHMAVAVAVQSGLADCGLGIAAAARALELDFIPLE
EEEEECCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHCHHHCCCHHHHHHHHHEEEEEEEE
MERYDLVIPRIHYESDLLRPLLELINGQELRRAVAELPGYDTSHMGEIAGQW
CCCEEEEECEECCHHHHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHCCCC
>Mature Secondary Structure 
SKSRNFFLENIPLDEAWSRFITAMEEVWAWDEMPGEEVAVDEALGRVTAKPVWAELSSP
CCCCCCEEECCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHCCCC
AYHASAMDGYAVRSTDTIGAMETAPKRLAIGPAGPATYVDTGDPIPAWADAVIMIEQTQH
CHHHHCCCCEEEECCCCCCCHHCCCCEEEECCCCCCCCCCCCCCCCCCCCEEEEEECHHC
IDEPDGGESIEIHAGVAPWTAVRPMGEDMVATELVLPANHLLKPVDLGALAGCGHAFVNV
CCCCCCCCEEEEECCCCCCHHHCCCCCCHHHHHEECCHHHHCCCCCCHHHHCCCHHHHHH
RRKPRVAVIPTGTELVTVEQARRCGLKSGDIIEYNSLVLSSQVRQWGGIPTRYPVVPDDY
CCCCEEEEEECCCEEEEHHHHHHCCCCCCCEEEHHHHHHHHHHHHHCCCCCCCCCCCCCH
ELIKATVLEAAAEHDLVLVNAGSSAGSEDFTSSIVVELGKLLVHGVAVRPGHPVILGMIA
HHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHCEEECCCCCEEEEEEC
GFNRPVIGIPGYPVSCALTGETFVEPLISHWLGLPPREQPRMQASITRKLLSPIGEDETV
CCCCCEEECCCCCEEEEECCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCEE
RVTVGRVGERAVAAPLSRGAGVITSLVRADGIVRIPRFSEGVEAGQEVTVELYRTPAEVE
EEEECCCCCHHHHHHHHCCHHHHHHHHHCCCEEECCCCCHHHCCCCEEEEEEECCHHHHH
RTLVHIGSHDLCLDLLAQYLADSGRRFTSANAGSLGGLMALKRGDAHLAGAHLLDPATGD
HHHHHCCCCHHHHHHHHHHHHCCCCEEECCCCCCCCCCCEEECCCCCCCCCEEECCCCCC
YNVSYIQQYLPGLPVVLLTFMHRQQGLIVPPGNPKGIGGLADLTREGLRFVNRQRGAGTR
CCHHHHHHHCCCCHHHHHHHHHHCCCEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCE
VLLDYHLGKLGIAPQQILGYKREEYTHMAVAVAVQSGLADCGLGIAAAARALELDFIPLE
EEEEECCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHCHHHCCCHHHHHHHHHEEEEEEEE
MERYDLVIPRIHYESDLLRPLLELINGQELRRAVAELPGYDTSHMGEIAGQW
CCCEEEEECEECCHHHHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]