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The map label for this gene is moeA [C]

Identifier: 118579878

GI number: 118579878

Start: 1554348

End: 1555580

Strand: Reverse

Name: moeA [C]

Synonym: Ppro_1454

Alternate gene names: 118579878

Gene position: 1555580-1554348 (Counterclockwise)

Preceding gene: 118579881

Following gene: 118579877

Centisome position: 38.81

GC content: 66.91

Gene sequence:

>1233_bases
ATGCCTGAAATGTTTACGGTGCTTCCCCCCGCGGATGCGCTCAGACTCTTGTTCGACCAACTCCCCCCGGAGATCCGGCT
GGAAACGGTTTCCACTCTGGAGGCCCTCGACCGGGCCCTGGCGGAGAACCTGCTGGCCCCCTCATCCCTCCCTTCCTTTC
CCCGCTGCACCATGGACGGCTATGCCGTGCTCGCCGAAGACACCTTCGGCGCAAGCGAATCTCTGCCGGCATACCTGACC
CTGATCGGCGAGGCGCCCATGGGCCGGGCCTGCCCCCTGACGGTGGCTTCCGGCCAGGCGGTCGCCGTCTACACCGGGGG
CATGCTCCCGGCTGGCGCCGATGCGGTGGTGATGGTGGAGCGGACACAGAAACTGGACGATGCCACCATCGAGGTGCTGC
GCTCCGTGGCAACGGGCGAAAACCTGGTCGAGGTGGGAGAGGACGTCAGGGAGGGAGATTCCCTGTTCCAGGCCGGGCAC
CTGCTCAGGCCCCAGGACCTGGGCGGCCTGACCGCCCTGGGCATCACCAGCCTTAAGGTGGCTGCCCGTCCACGGGTGGC
GATCATCTCCACCGGCGACGAGGTCATCCCTCCCGACCGGAGCCCCGCCCCCGGCCAGATACGGGATGTGAACAGCTACA
CCATCTCGGCCCTGGTTTCCCGGGCAGGCGGCATCCCGCTCCAACGGGGGATCATCCCCGACGACTTCGATGCGCTGCTC
TCTGCGGCCAGATCGGCACTGGAAGAGGCAGACTGCCTGGTGGTCTCGGCCGGTTCATCGGTTTCCACCCGCGACCTGAC
GGCGGATGTAATCAACAGACTGGGCGCACCGGGCGTGCTGGTGCACGGCATCGCCCTGCGGCCGGGCAAGCCGGCCATCC
TGGGCGTCTGCGACGGCAAGCCGGTGATCGGCCTGCCGGGCAACCCGGTCAGCGCCATGGTTGTGGCTGACCTGTTTCTG
GGTCCCCTGCTGCGCAGGATACAGGGGGTAGGCCACGCGCCTCTGCGGCGGCGCGTGGGAGCGACGCTCACCCACAACAT
CCCCTCGGCGCCGGGGCGCGAGGACTACGTTCAGGTCAGGCTGGCCGACCGGGACGGACGGCTGTGGGCCGAACCGGTCT
TCGGCAAATCCAACCTGATCTACACCATGATCAACTCCGATGGCATGGTATGCGTACCGCTCAACTCCAGCGGACTGTAC
CGGGACGAAACAGTCGAGGTTGAGCTGTTCTAA

Upstream 100 bases:

>100_bases
GGCTTCAAGGGGGCGGGAAACCCGGAACCACCGCCCATGCCTCCCGGGGAGGGGCGCAGCCCGAACCAGATATCCCGAAC
ACGAGGAGCAAGGAGTCCCG

Downstream 100 bases:

>100_bases
TTCAGCCATGCGTTGACGATCGGATCCGCAGCGACGCATTGCAACGCGTCGCTGCGAAGAAACGTGCAATGGGCATGATA
TCCAATGGCAGGAGACGGCA

Product: molybdenum cofactor synthesis domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 410; Mature: 409

Protein sequence:

>410_residues
MPEMFTVLPPADALRLLFDQLPPEIRLETVSTLEALDRALAENLLAPSSLPSFPRCTMDGYAVLAEDTFGASESLPAYLT
LIGEAPMGRACPLTVASGQAVAVYTGGMLPAGADAVVMVERTQKLDDATIEVLRSVATGENLVEVGEDVREGDSLFQAGH
LLRPQDLGGLTALGITSLKVAARPRVAIISTGDEVIPPDRSPAPGQIRDVNSYTISALVSRAGGIPLQRGIIPDDFDALL
SAARSALEEADCLVVSAGSSVSTRDLTADVINRLGAPGVLVHGIALRPGKPAILGVCDGKPVIGLPGNPVSAMVVADLFL
GPLLRRIQGVGHAPLRRRVGATLTHNIPSAPGREDYVQVRLADRDGRLWAEPVFGKSNLIYTMINSDGMVCVPLNSSGLY
RDETVEVELF

Sequences:

>Translated_410_residues
MPEMFTVLPPADALRLLFDQLPPEIRLETVSTLEALDRALAENLLAPSSLPSFPRCTMDGYAVLAEDTFGASESLPAYLT
LIGEAPMGRACPLTVASGQAVAVYTGGMLPAGADAVVMVERTQKLDDATIEVLRSVATGENLVEVGEDVREGDSLFQAGH
LLRPQDLGGLTALGITSLKVAARPRVAIISTGDEVIPPDRSPAPGQIRDVNSYTISALVSRAGGIPLQRGIIPDDFDALL
SAARSALEEADCLVVSAGSSVSTRDLTADVINRLGAPGVLVHGIALRPGKPAILGVCDGKPVIGLPGNPVSAMVVADLFL
GPLLRRIQGVGHAPLRRRVGATLTHNIPSAPGREDYVQVRLADRDGRLWAEPVFGKSNLIYTMINSDGMVCVPLNSSGLY
RDETVEVELF
>Mature_409_residues
PEMFTVLPPADALRLLFDQLPPEIRLETVSTLEALDRALAENLLAPSSLPSFPRCTMDGYAVLAEDTFGASESLPAYLTL
IGEAPMGRACPLTVASGQAVAVYTGGMLPAGADAVVMVERTQKLDDATIEVLRSVATGENLVEVGEDVREGDSLFQAGHL
LRPQDLGGLTALGITSLKVAARPRVAIISTGDEVIPPDRSPAPGQIRDVNSYTISALVSRAGGIPLQRGIIPDDFDALLS
AARSALEEADCLVVSAGSSVSTRDLTADVINRLGAPGVLVHGIALRPGKPAILGVCDGKPVIGLPGNPVSAMVVADLFLG
PLLRRIQGVGHAPLRRRVGATLTHNIPSAPGREDYVQVRLADRDGRLWAEPVFGKSNLIYTMINSDGMVCVPLNSSGLYR
DETVEVELF

Specific function: Involved In The Biosynthesis Of A Demolybdo-Cofactor (Molybdopterin), Necessary For Molybdo-Enzymes. Seems To Be Involved In A Step Of Activation Of Molybdenum In The Form Of Thiomolybdenum. [C]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=405, Percent_Identity=30.3703703703704, Blast_Score=173, Evalue=2e-43,
Organism=Homo sapiens, GI10880983, Length=405, Percent_Identity=30.3703703703704, Blast_Score=173, Evalue=2e-43,
Organism=Escherichia coli, GI1787049, Length=357, Percent_Identity=31.6526610644258, Blast_Score=158, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI25147659, Length=321, Percent_Identity=31.1526479750779, Blast_Score=141, Evalue=7e-34,
Organism=Caenorhabditis elegans, GI17562606, Length=375, Percent_Identity=24.8, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI17136978, Length=404, Percent_Identity=26.4851485148515, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI24638841, Length=404, Percent_Identity=26.4851485148515, Blast_Score=115, Evalue=5e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 43177; Mature: 43046

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEMFTVLPPADALRLLFDQLPPEIRLETVSTLEALDRALAENLLAPSSLPSFPRCTMDG
CCCCEEECCCHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
YAVLAEDTFGASESLPAYLTLIGEAPMGRACPLTVASGQAVAVYTGGMLPAGADAVVMVE
EEEEEECCCCCCCCCCEEEEEECCCCCCCCCEEEEECCCEEEEEECCCCCCCCCEEEEEE
RTQKLDDATIEVLRSVATGENLVEVGEDVREGDSLFQAGHLLRPQDLGGLTALGITSLKV
CHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCHHEEEE
AARPRVAIISTGDEVIPPDRSPAPGQIRDVNSYTISALVSRAGGIPLQRGIIPDDFDALL
ECCCCEEEEECCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHCCCCCCCCCCCCCHHHHH
SAARSALEEADCLVVSAGSSVSTRDLTADVINRLGAPGVLVHGIALRPGKPAILGVCDGK
HHHHHHHHHCCEEEEECCCCCCCHHHHHHHHHHCCCCCEEEEEEEECCCCCEEEEEECCC
PVIGLPGNPVSAMVVADLFLGPLLRRIQGVGHAPLRRRVGATLTHNIPSAPGREDYVQVR
EEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCEEECCCCCCCCCCCEEEEE
LADRDGRLWAEPVFGKSNLIYTMINSDGMVCVPLNSSGLYRDETVEVELF
EECCCCCEEECCCCCCCCEEEEEECCCCEEEEEECCCCCCCCCEEEEEEC
>Mature Secondary Structure 
PEMFTVLPPADALRLLFDQLPPEIRLETVSTLEALDRALAENLLAPSSLPSFPRCTMDG
CCCEEECCCHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
YAVLAEDTFGASESLPAYLTLIGEAPMGRACPLTVASGQAVAVYTGGMLPAGADAVVMVE
EEEEEECCCCCCCCCCEEEEEECCCCCCCCCEEEEECCCEEEEEECCCCCCCCCEEEEEE
RTQKLDDATIEVLRSVATGENLVEVGEDVREGDSLFQAGHLLRPQDLGGLTALGITSLKV
CHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCHHEEEE
AARPRVAIISTGDEVIPPDRSPAPGQIRDVNSYTISALVSRAGGIPLQRGIIPDDFDALL
ECCCCEEEEECCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHCCCCCCCCCCCCCHHHHH
SAARSALEEADCLVVSAGSSVSTRDLTADVINRLGAPGVLVHGIALRPGKPAILGVCDGK
HHHHHHHHHCCEEEEECCCCCCCHHHHHHHHHHCCCCCEEEEEEEECCCCCEEEEEECCC
PVIGLPGNPVSAMVVADLFLGPLLRRIQGVGHAPLRRRVGATLTHNIPSAPGREDYVQVR
EEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCEEECCCCCCCCCCCEEEEE
LADRDGRLWAEPVFGKSNLIYTMINSDGMVCVPLNSSGLYRDETVEVELF
EECCCCCEEECCCCCCCCEEEEEECCCCEEEEEECCCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]