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The map label for this gene is prsA [H]

Identifier: 118579840

GI number: 118579840

Start: 1511729

End: 1512787

Strand: Reverse

Name: prsA [H]

Synonym: Ppro_1416

Alternate gene names: 118579840

Gene position: 1512787-1511729 (Counterclockwise)

Preceding gene: 118579841

Following gene: 118579833

Centisome position: 37.74

GC content: 59.96

Gene sequence:

>1059_bases
ATGCCCGCAAAAGTGTGCTATAGCTCCCCTATTCTTTCCCCAAAGGAGATCTCCATGAACAGACGAACAATCGCCCTGCG
TCTCGCCCTGATGGCGGCGCTTTTCGGTTTCAGCACCCCATCATCGGCAGCCGACGCCAAGCCGGCAAAGACTCCCGCAG
CCAGCGCGCAACAACAGAAAGACGTGGTGGCGCGGGTGAATGGGAAACCGGTCTATGCCCGTGAACTGGAACGGGTCAAG
AAGGCGCTCCTTGCCGGCCGGCCGAACCAGCAGATCCCCAGCGAGCACCAGAAGGAGTTCGACAAAATGGCGCTCAACCA
ACTGACCTCGGCCGAACTGCTCTACCAGGCGGGCGAGAAGTTGGACACCAAGGATATCGACAAACAGGTTGAGGCCAAGA
TGAGCCAGGGCAAGGCCAGGTTCGCCACGACCGAGGAGTTCCAGAAGGCCATCGCCGGACTGGGCATGAACGAGAGCGAC
CTGCGCGAATACACGCGCCGCGACGCCGTCATCGCCAATTTCGTCCAGCAGACCTTTGCTTCCAAGGTGACGGTCAGCGA
CGAGGAGAGCAGGAAGTTCTACGACGAGAACCAGGACAAATTCAAGCAGAGCGAGTCGGTCAGGGCCAGCCACATCCTGA
TCGGCGTGGACCCCAAGGCCGATCCCGAGATCAGGAAGAAGGCACGGGAGAAGGCGGAAAAGCTGCGCAAGGAACTGGCG
GGAGGGGCGGACTTCGCCACCCTGGCACGGGAGAATTCCACCTGCCCCAGCAGCCAGCAGGGAGGGGATCTGGGCTTCTT
CCCCAGAGGGCAGATGGTCCCCCCCTTCGAGCAGGCAGCCTTCAGCCTCAAGCAGGGTGAGGTCAGCGACGTGGTGGAAA
CCCAGTTCGGATACCACATCATCAAGCAGATGGGCCACAAGAACGCCGAGACCGTTTCCTACGCCGACGCCAAGGCACGT
ATCGTCGACTACCTGAAAAATCAGAAGGTAAATTCGGCGATCACCGCCTATCTGGACGATGCGCGCAAAACCTCCAAGAT
CGAGACGTACCTGAAGTAG

Upstream 100 bases:

>100_bases
GCCGCTGCTGGTACGTCGCCAGGACGGAGCGTACACGGCCGAAGCCGGCCGCATACTGGGGGAAACGCCCTGAGTGGCTT
CGGCGCCCCTTTCCCTTTGC

Downstream 100 bases:

>100_bases
CGCACCCGCCCAGCCCATGAAAACGCAAACGGCCGGCCCGGAACAATCCGGGCCGGCCGTTTGCGCTTCTCAAGCCTGAC
TACCTGCGCCAGGGGGAGTG

Product: PpiC-type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 352; Mature: 351

Protein sequence:

>352_residues
MPAKVCYSSPILSPKEISMNRRTIALRLALMAALFGFSTPSSAADAKPAKTPAASAQQQKDVVARVNGKPVYARELERVK
KALLAGRPNQQIPSEHQKEFDKMALNQLTSAELLYQAGEKLDTKDIDKQVEAKMSQGKARFATTEEFQKAIAGLGMNESD
LREYTRRDAVIANFVQQTFASKVTVSDEESRKFYDENQDKFKQSESVRASHILIGVDPKADPEIRKKAREKAEKLRKELA
GGADFATLARENSTCPSSQQGGDLGFFPRGQMVPPFEQAAFSLKQGEVSDVVETQFGYHIIKQMGHKNAETVSYADAKAR
IVDYLKNQKVNSAITAYLDDARKTSKIETYLK

Sequences:

>Translated_352_residues
MPAKVCYSSPILSPKEISMNRRTIALRLALMAALFGFSTPSSAADAKPAKTPAASAQQQKDVVARVNGKPVYARELERVK
KALLAGRPNQQIPSEHQKEFDKMALNQLTSAELLYQAGEKLDTKDIDKQVEAKMSQGKARFATTEEFQKAIAGLGMNESD
LREYTRRDAVIANFVQQTFASKVTVSDEESRKFYDENQDKFKQSESVRASHILIGVDPKADPEIRKKAREKAEKLRKELA
GGADFATLARENSTCPSSQQGGDLGFFPRGQMVPPFEQAAFSLKQGEVSDVVETQFGYHIIKQMGHKNAETVSYADAKAR
IVDYLKNQKVNSAITAYLDDARKTSKIETYLK
>Mature_351_residues
PAKVCYSSPILSPKEISMNRRTIALRLALMAALFGFSTPSSAADAKPAKTPAASAQQQKDVVARVNGKPVYARELERVKK
ALLAGRPNQQIPSEHQKEFDKMALNQLTSAELLYQAGEKLDTKDIDKQVEAKMSQGKARFATTEEFQKAIAGLGMNESDL
REYTRRDAVIANFVQQTFASKVTVSDEESRKFYDENQDKFKQSESVRASHILIGVDPKADPEIRKKAREKAEKLRKELAG
GADFATLARENSTCPSSQQGGDLGFFPRGQMVPPFEQAAFSLKQGEVSDVVETQFGYHIIKQMGHKNAETVSYADAKARI
VDYLKNQKVNSAITAYLDDARKTSKIETYLK

Specific function: Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins [H]

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Cell membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PpiC domain [H]

Homologues:

Organism=Homo sapiens, GI5453898, Length=105, Percent_Identity=40.9523809523809, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1790211, Length=82, Percent_Identity=46.3414634146341, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1786238, Length=226, Percent_Identity=23.8938053097345, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17537729, Length=111, Percent_Identity=37.8378378378378, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6322478, Length=61, Percent_Identity=59.0163934426229, Blast_Score=82, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023059
- InterPro:   IPR000297
- InterPro:   IPR023058
- InterPro:   IPR015391
- InterPro:   IPR008880 [H]

Pfam domain/function: PF00639 Rotamase; PF09312 SurA_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 39066; Mature: 38934

Theoretical pI: Translated: 9.77; Mature: 9.77

Prosite motif: PS01096 PPIC_PPIASE_1 ; PS50198 PPIC_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAKVCYSSPILSPKEISMNRRTIALRLALMAALFGFSTPSSAADAKPAKTPAASAQQQK
CCCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHH
DVVARVNGKPVYARELERVKKALLAGRPNQQIPSEHQKEFDKMALNQLTSAELLYQAGEK
HHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
LDTKDIDKQVEAKMSQGKARFATTEEFQKAIAGLGMNESDLREYTRRDAVIANFVQQTFA
CCHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
SKVTVSDEESRKFYDENQDKFKQSESVRASHILIGVDPKADPEIRKKAREKAEKLRKELA
HCCCCCCHHHHHHHCCCHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHC
GGADFATLARENSTCPSSQQGGDLGFFPRGQMVPPFEQAAFSLKQGEVSDVVETQFGYHI
CCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHH
IKQMGHKNAETVSYADAKARIVDYLKNQKVNSAITAYLDDARKTSKIETYLK
HHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PAKVCYSSPILSPKEISMNRRTIALRLALMAALFGFSTPSSAADAKPAKTPAASAQQQK
CCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHH
DVVARVNGKPVYARELERVKKALLAGRPNQQIPSEHQKEFDKMALNQLTSAELLYQAGEK
HHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
LDTKDIDKQVEAKMSQGKARFATTEEFQKAIAGLGMNESDLREYTRRDAVIANFVQQTFA
CCHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
SKVTVSDEESRKFYDENQDKFKQSESVRASHILIGVDPKADPEIRKKAREKAEKLRKELA
HCCCCCCHHHHHHHCCCHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHC
GGADFATLARENSTCPSSQQGGDLGFFPRGQMVPPFEQAAFSLKQGEVSDVVETQFGYHI
CCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHH
IKQMGHKNAETVSYADAKARIVDYLKNQKVNSAITAYLDDARKTSKIETYLK
HHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]