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The map label for this gene is hisS

Identifier: 118579805

GI number: 118579805

Start: 1469711

End: 1470955

Strand: Direct

Name: hisS

Synonym: Ppro_1381

Alternate gene names: 118579805

Gene position: 1469711-1470955 (Clockwise)

Preceding gene: 118579804

Following gene: 118579808

Centisome position: 36.67

GC content: 65.14

Gene sequence:

>1245_bases
ATGGCCATCACGGCAATCAAGGGTTGTAACGATATCCTGCCGGAGGAGTCCGGCAGATGGCAGTACATCGAGCAGGCCGC
TCGCCGCATCTTCGAACGCAACGGCTTTTCCGAGATTCGCGTACCGATCATGGAGAAGACCGAGCTGTTCTGCCGCTCCA
TCGGCGACACCAGCGACATCGTGGAAAAGGAGATGTACACCTTCACCGACAAGGGGGAGAACAGCGTCACCCTGCGTCCC
GAGGGAACCGCCGGTGTCATGCGCGCCTACATCGAGCACAAGATGCACGCCCAGGACCCGCTGGCCAAGCTGTACTACCT
GGGCCCCATGTTCCGCTACGAGCGCCCCCAGAAGGGGCGCTACCGCCAGTTCCACCAGATTGGCGCCGAGGTCACTGGCG
TCACCGACCCGCTGGTGGATGCCCAGGTGCTGAACATGCTCTGCGCCTTTTTTCACGAGATCGGCCTGGACGAGCCGACC
CTGCAGATCAACTCCCTGGGCTGCCCCGACTGCCGCCCCGCCTACCGCGCGGCGCTGATGGAGTTTCTTCAGGGGAGGCT
GGACCGGCTCTGCGACGACTGCAAGCGGCGCTTCACGGTCAACCCGCTGCGCACCCTGGACTGCAAGTCGGCAGGCTGCG
CCGAGGCCACGAAAGGGGCGCCGGCCATGCTGGATCATCTCTGCACCGCCTGCGACGACCACTTCAGCAGCGTCAAGCGC
TACCTGGACCTAACCGGCAGCCGCTACAGCATCAACCCGCGCATGGTCAGGGGGCTTGACTACTACACCCGCACCACCTT
CGAGCTGGTCACCGGGCTTCTGGGCGCCCAGTCGGCCGTGGCCGCCGGCGGTCGCTACGACGGCCTGATCTCCCAGCTGG
GTGGGCCTTCCATCCCCGGCATCGGTTTCGCCATGGGGGTGGAGCGGGTGGCGTTGCTCTTGGGCGAGCGCGACTTCTCC
CGCAGACCGGACCTGTTCATCGCCACCATGGGGGCTGGCCAGCGTGACAAGGCCTTCTGCCTGTTGACGAAGCTGCAGAA
TCAGGGCATCCGAGTGGAGATGGATTACGAAGGGAAGAGCCTGAAGAGCCAGATGCGCCGGGCCGACAAGCTGCGGGCGC
GCTTCAGCGTGGTCATCGGAGAGAACGAGCTGGCCACGGGGCGGGCCAGCTTCAAGCGCATGGAGGACGGCGTGCAGAAC
GAGGCGGCGTTGGAGGCTGACGACATCGTGACGCTGCTCGCCTAG

Upstream 100 bases:

>100_bases
TACACCGGCAAGGGGCGCGGAAAAAACTGCGTTGTCCGCTTCACCAAGACCTCCTGATTTTCCCGTTTTTCCCCCACATC
ACATCAGATCGAGGAATTCT

Downstream 100 bases:

>100_bases
GAAAAAGCCGGATATACTCTTCAAACCGAAAACGGGCAGCCTGATAGCAGGCTGCCCGTTTTCGTGTCACCCTAGGTGTA
AAATTACAAAACTGCCTTCA

Product: histidyl-tRNA synthetase

Products: NA

Alternate protein names: Histidine--tRNA ligase; HisRS

Number of amino acids: Translated: 414; Mature: 413

Protein sequence:

>414_residues
MAITAIKGCNDILPEESGRWQYIEQAARRIFERNGFSEIRVPIMEKTELFCRSIGDTSDIVEKEMYTFTDKGENSVTLRP
EGTAGVMRAYIEHKMHAQDPLAKLYYLGPMFRYERPQKGRYRQFHQIGAEVTGVTDPLVDAQVLNMLCAFFHEIGLDEPT
LQINSLGCPDCRPAYRAALMEFLQGRLDRLCDDCKRRFTVNPLRTLDCKSAGCAEATKGAPAMLDHLCTACDDHFSSVKR
YLDLTGSRYSINPRMVRGLDYYTRTTFELVTGLLGAQSAVAAGGRYDGLISQLGGPSIPGIGFAMGVERVALLLGERDFS
RRPDLFIATMGAGQRDKAFCLLTKLQNQGIRVEMDYEGKSLKSQMRRADKLRARFSVVIGENELATGRASFKRMEDGVQN
EAALEADDIVTLLA

Sequences:

>Translated_414_residues
MAITAIKGCNDILPEESGRWQYIEQAARRIFERNGFSEIRVPIMEKTELFCRSIGDTSDIVEKEMYTFTDKGENSVTLRP
EGTAGVMRAYIEHKMHAQDPLAKLYYLGPMFRYERPQKGRYRQFHQIGAEVTGVTDPLVDAQVLNMLCAFFHEIGLDEPT
LQINSLGCPDCRPAYRAALMEFLQGRLDRLCDDCKRRFTVNPLRTLDCKSAGCAEATKGAPAMLDHLCTACDDHFSSVKR
YLDLTGSRYSINPRMVRGLDYYTRTTFELVTGLLGAQSAVAAGGRYDGLISQLGGPSIPGIGFAMGVERVALLLGERDFS
RRPDLFIATMGAGQRDKAFCLLTKLQNQGIRVEMDYEGKSLKSQMRRADKLRARFSVVIGENELATGRASFKRMEDGVQN
EAALEADDIVTLLA
>Mature_413_residues
AITAIKGCNDILPEESGRWQYIEQAARRIFERNGFSEIRVPIMEKTELFCRSIGDTSDIVEKEMYTFTDKGENSVTLRPE
GTAGVMRAYIEHKMHAQDPLAKLYYLGPMFRYERPQKGRYRQFHQIGAEVTGVTDPLVDAQVLNMLCAFFHEIGLDEPTL
QINSLGCPDCRPAYRAALMEFLQGRLDRLCDDCKRRFTVNPLRTLDCKSAGCAEATKGAPAMLDHLCTACDDHFSSVKRY
LDLTGSRYSINPRMVRGLDYYTRTTFELVTGLLGAQSAVAAGGRYDGLISQLGGPSIPGIGFAMGVERVALLLGERDFSR
RPDLFIATMGAGQRDKAFCLLTKLQNQGIRVEMDYEGKSLKSQMRRADKLRARFSVVIGENELATGRASFKRMEDGVQNE
AALEADDIVTLLA

Specific function: Unknown

COG id: COG0124

COG function: function code J; Histidyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI15029520, Length=456, Percent_Identity=25, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI6996014, Length=454, Percent_Identity=24.0088105726872, Blast_Score=100, Evalue=3e-21,
Organism=Escherichia coli, GI1788861, Length=409, Percent_Identity=45.9657701711491, Blast_Score=368, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI71993686, Length=456, Percent_Identity=21.4912280701754, Blast_Score=78, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI71993693, Length=456, Percent_Identity=21.4912280701754, Blast_Score=78, Evalue=9e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYH_PELPD (A1ANS7)

Other databases:

- EMBL:   CP000482
- RefSeq:   YP_901055.1
- ProteinModelPortal:   A1ANS7
- SMR:   A1ANS7
- STRING:   A1ANS7
- GeneID:   4574527
- GenomeReviews:   CP000482_GR
- KEGG:   ppd:Ppro_1381
- eggNOG:   COG0124
- HOGENOM:   HBG616575
- OMA:   VFEWVTT
- PhylomeDB:   A1ANS7
- ProtClustDB:   PRK00037
- GO:   GO:0005737
- HAMAP:   MF_00127
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR015807
- InterPro:   IPR004516
- Gene3D:   G3DSA:3.40.50.800
- PANTHER:   PTHR11476
- PIRSF:   PIRSF001549
- TIGRFAMs:   TIGR00442

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b; SSF52954 Anticodon_bd

EC number: =6.1.1.21

Molecular weight: Translated: 46255; Mature: 46123

Theoretical pI: Translated: 7.03; Mature: 7.03

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAITAIKGCNDILPEESGRWQYIEQAARRIFERNGFSEIRVPIMEKTELFCRSIGDTSDI
CCEEEECCCHHCCCCCCCCHHHHHHHHHHHHHHCCCCCEECCHHHHHHHHHHHCCCHHHH
VEKEMYTFTDKGENSVTLRPEGTAGVMRAYIEHKMHAQDPLAKLYYLGPMFRYERPQKGR
HHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCHHHHHHHHCHHHHCCCCCCCH
YRQFHQIGAEVTGVTDPLVDAQVLNMLCAFFHEIGLDEPTLQINSLGCPDCRPAYRAALM
HHHHHHHCCHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCHHHHHHHH
EFLQGRLDRLCDDCKRRFTVNPLRTLDCKSAGCAEATKGAPAMLDHLCTACDDHFSSVKR
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHH
YLDLTGSRYSINPRMVRGLDYYTRTTFELVTGLLGAQSAVAAGGRYDGLISQLGGPSIPG
HHHCCCCEEECCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCC
IGFAMGVERVALLLGERDFSRRPDLFIATMGAGQRDKAFCLLTKLQNQGIRVEMDYEGKS
CHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHCCCEEEEECCCCHH
LKSQMRRADKLRARFSVVIGENELATGRASFKRMEDGVQNEAALEADDIVTLLA
HHHHHHHHHHHHHHEEEEECCCCCCCHHHHHHHHHHCCCCCHHCCHHHHHHHCC
>Mature Secondary Structure 
AITAIKGCNDILPEESGRWQYIEQAARRIFERNGFSEIRVPIMEKTELFCRSIGDTSDI
CEEEECCCHHCCCCCCCCHHHHHHHHHHHHHHCCCCCEECCHHHHHHHHHHHCCCHHHH
VEKEMYTFTDKGENSVTLRPEGTAGVMRAYIEHKMHAQDPLAKLYYLGPMFRYERPQKGR
HHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCHHHHHHHHCHHHHCCCCCCCH
YRQFHQIGAEVTGVTDPLVDAQVLNMLCAFFHEIGLDEPTLQINSLGCPDCRPAYRAALM
HHHHHHHCCHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCHHHHHHHH
EFLQGRLDRLCDDCKRRFTVNPLRTLDCKSAGCAEATKGAPAMLDHLCTACDDHFSSVKR
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHH
YLDLTGSRYSINPRMVRGLDYYTRTTFELVTGLLGAQSAVAAGGRYDGLISQLGGPSIPG
HHHCCCCEEECCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCC
IGFAMGVERVALLLGERDFSRRPDLFIATMGAGQRDKAFCLLTKLQNQGIRVEMDYEGKS
CHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHCCCEEEEECCCCHH
LKSQMRRADKLRARFSVVIGENELATGRASFKRMEDGVQNEAALEADDIVTLLA
HHHHHHHHHHHHHHEEEEECCCCCCCHHHHHHHHHHCCCCCHHCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA