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The map label for this gene is trpF

Identifier: 118579720

GI number: 118579720

Start: 1361478

End: 1362107

Strand: Reverse

Name: trpF

Synonym: Ppro_1292

Alternate gene names: 118579720

Gene position: 1362107-1361478 (Counterclockwise)

Preceding gene: 118579721

Following gene: 118579719

Centisome position: 33.98

GC content: 61.43

Gene sequence:

>630_bases
ATGATCAAAGTAAAAATCTGCGGTATAACCAACCTGGAAGACGCCCTGCTGGCGGTGGACGCTGGCGCCGACGCCCTCGG
TTTCGTCTTCTGCGAAGCATCCCCCCGCTCCGTCACCCCCGAGCAGGCAGCCAGCATCATCCGTCAGCTCCCCCCCTTCA
TCCAGACCATCGGCCTGTTCGTCAACGAGCCACTGGCCGTGATCAACCAGACTGCTGACGCATGCGGTCTGGATATTGTC
CAGTTGCACGGCGAGGAAGCCCCGCAGTTCTGCGCCGGAGTCAAGCGCCGCGTCATCAAGGCGCTGCGGGTCAGGGACGA
GTCCAGCCTGGAACCAATGACATCGTACCGCGTCTCCGCTTTCCTTCTGGACGCCTGGTCTCCCTCCGCCCATGGAGGTA
CCGGCCGCACCTTCAACTGGGACATCGCTGCAGGCGCGGCGGCAAAGAACCGGATTGTTCTCGCGGGTGGCCTGACTGCG
GACAACATCGCCGCCGCCATCCGCAAGGTTCACCCCTACGGCGTGGACGTGTCCAGCGGAGTCGAAGCCGCTCCGGGCAA
AAAGGATGCTGTAAAGATCAGAGAGTTTATCAGAATAGCGAAGGAGACCCGCAGTGAATCTACCCGATAA

Upstream 100 bases:

>100_bases
CAGTCACTGGAGCGTCTGCCCAAAGTACAGCTGTAACCGGAACCGGGGATCCGTCTCTTTTTTACGGGTCCCCGGTCTCG
CCTCACCGGTCCTATCATAC

Downstream 100 bases:

>100_bases
AAAAGGCCATTTCGGTGAATTTGGCGGACGGTACGTTCCGGAGACACTCATGCCGGCCCTGCTGGAACTGGAACAGGCCT
ACAAGCACTACCGCCGCGAC

Product: N-(5'-phosphoribosyl)anthranilate isomerase

Products: NA

Alternate protein names: PRAI

Number of amino acids: Translated: 209; Mature: 209

Protein sequence:

>209_residues
MIKVKICGITNLEDALLAVDAGADALGFVFCEASPRSVTPEQAASIIRQLPPFIQTIGLFVNEPLAVINQTADACGLDIV
QLHGEEAPQFCAGVKRRVIKALRVRDESSLEPMTSYRVSAFLLDAWSPSAHGGTGRTFNWDIAAGAAAKNRIVLAGGLTA
DNIAAAIRKVHPYGVDVSSGVEAAPGKKDAVKIREFIRIAKETRSESTR

Sequences:

>Translated_209_residues
MIKVKICGITNLEDALLAVDAGADALGFVFCEASPRSVTPEQAASIIRQLPPFIQTIGLFVNEPLAVINQTADACGLDIV
QLHGEEAPQFCAGVKRRVIKALRVRDESSLEPMTSYRVSAFLLDAWSPSAHGGTGRTFNWDIAAGAAAKNRIVLAGGLTA
DNIAAAIRKVHPYGVDVSSGVEAAPGKKDAVKIREFIRIAKETRSESTR
>Mature_209_residues
MIKVKICGITNLEDALLAVDAGADALGFVFCEASPRSVTPEQAASIIRQLPPFIQTIGLFVNEPLAVINQTADACGLDIV
QLHGEEAPQFCAGVKRRVIKALRVRDESSLEPMTSYRVSAFLLDAWSPSAHGGTGRTFNWDIAAGAAAKNRIVLAGGLTA
DNIAAAIRKVHPYGVDVSSGVEAAPGKKDAVKIREFIRIAKETRSESTR

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0135

COG function: function code E; Phosphoribosylanthranilate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpF family

Homologues:

Organism=Escherichia coli, GI87081863, Length=192, Percent_Identity=35.4166666666667, Blast_Score=96, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6320210, Length=218, Percent_Identity=32.5688073394495, Blast_Score=88, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPF_PELPD (A1ANJ2)

Other databases:

- EMBL:   CP000482
- RefSeq:   YP_900970.1
- ProteinModelPortal:   A1ANJ2
- SMR:   A1ANJ2
- STRING:   A1ANJ2
- GeneID:   4573169
- GenomeReviews:   CP000482_GR
- KEGG:   ppd:Ppro_1292
- eggNOG:   COG0135
- HOGENOM:   HBG554803
- OMA:   SKICGIT
- PhylomeDB:   A1ANJ2
- ProtClustDB:   PRK01222
- HAMAP:   MF_00135_B
- InterPro:   IPR013785
- InterPro:   IPR001240
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00697 PRAI; SSF51366 RibP_bind_barrel

EC number: =5.3.1.24

Molecular weight: Translated: 22255; Mature: 22255

Theoretical pI: Translated: 7.95; Mature: 7.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKVKICGITNLEDALLAVDAGADALGFVFCEASPRSVTPEQAASIIRQLPPFIQTIGLF
CEEEEEECCCCCCHHHEEECCCCCEEEEEEECCCCCCCCHHHHHHHHHHCCHHHHHHHHH
VNEPLAVINQTADACGLDIVQLHGEEAPQFCAGVKRRVIKALRVRDESSLEPMTSYRVSA
HCCCHHHHHCCHHHHCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
FLLDAWSPSAHGGTGRTFNWDIAAGAAAKNRIVLAGGLTADNIAAAIRKVHPYGVDVSSG
EEEECCCCCCCCCCCCEEEEEEECCCCCCCCEEEECCCCHHHHHHHHHHHCCCCCCCCCC
VEAAPGKKDAVKIREFIRIAKETRSESTR
CCCCCCCHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MIKVKICGITNLEDALLAVDAGADALGFVFCEASPRSVTPEQAASIIRQLPPFIQTIGLF
CEEEEEECCCCCCHHHEEECCCCCEEEEEEECCCCCCCCHHHHHHHHHHCCHHHHHHHHH
VNEPLAVINQTADACGLDIVQLHGEEAPQFCAGVKRRVIKALRVRDESSLEPMTSYRVSA
HCCCHHHHHCCHHHHCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
FLLDAWSPSAHGGTGRTFNWDIAAGAAAKNRIVLAGGLTADNIAAAIRKVHPYGVDVSSG
EEEECCCCCCCCCCCCEEEEEEECCCCCCCCEEEECCCCHHHHHHHHHHHCCCCCCCCCC
VEAAPGKKDAVKIREFIRIAKETRSESTR
CCCCCCCHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA