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The map label for this gene is bhbA [H]

Identifier: 118579714

GI number: 118579714

Start: 1347961

End: 1350144

Strand: Reverse

Name: bhbA [H]

Synonym: Ppro_1285

Alternate gene names: 118579714

Gene position: 1350144-1347961 (Counterclockwise)

Preceding gene: 118579718

Following gene: 118579713

Centisome position: 33.69

GC content: 60.9

Gene sequence:

>2184_bases
ATGGCGGAAGCTGACGTAACGGTCGATATAACCAAGATCGACACGGACAGGGGATTCTTCGACGAATTCACGTTCCCGGA
CTACGAAACATGGAAGGAAGAGGTGATCAAGGCATTGAAGGGCGCTCCCTTTGATAAGGTCATGTTCACCTCGACCTATG
AGGGGCTGACCATCAACCCGATCTACTCTGCCGACGATATCAAGGGACTGCCCCATCTGGAATCGCGCCCGGGGTATGTT
CCCTATGTGCGGAGTACGCACGTGGGCGGTTATCTTGAAAAACCGTGGTTCATCTGCCAGGAGCTGCTCGTGTCCCTGCC
CGAGGAGTTCAACAGCGAGGCGCTTTTTGACACGAGCCGCGGCCAGACCATGTTGAATCTGGTACTGGACCGGCCGACAA
AAAAGGGGCTTGATCCCGCGGAGGCCGAGACCGGTGAGGTGGGCAAGCGGGGCCTATCCCTTGCATCGGTCAGTGACCTG
AAGCGGGCGTTCAAGGGGCTCGACCTGGCAAGCCTTCCCCTGCTCTGCAACACCGGAGCCACAGCCCTCCCCCTGACAGC
CCTTCTTGCCGCCGCCCTGGAGAGCGACGGAGTTCCCCTGAAGCGATTCAAGGGGTGCGTCGGCTGCGACCCCCTTGCCG
AACTGGTCAACGAGGGAGCCTTACGAATTGCTCTCCCCGTGGCCTATGATGCCATGTGCCAGGTTACATCCTGGGCCATA
CAGAACATGCCGGGGCTCGAGACCATATTCATCCAGGGTCATCCCTACCACGACGCCGGGGCAAGCTCCACGGAAGAAGT
GGCCTTTGCCCTCGCCACGGCTGCCGAATATCTCCGCGAAATGCTGACCCGCGGCCTGGCCGTCAACGACATCACCCCCC
GCATGCGCTTCGGCTTTTCCCTCGGCTCCAACTTCTTCGTCGAAATCGCCAAACTGCGCGCGGCGCGCATCCTCTGGAAC
CAGGTCGTGGCTGCCTTCGGAGGGAGCGAGCAGGCCCGGAAGATGCGTATCCACGGCCGCACCTCGGCCTACAACAAGAC
CGTCTGCGATCCCCATGTCAACATGCTGCGCATCACCAGCGAAGGTTTTTCCGGCGCGGTGGGGGGCGTGGACAGCATGC
ACCTGGCCCCCTTCGACGAACCGGTGCGGGTTCCGGACCGCTTCTCGCGGCGCATCGCCCGCAACGCCCAGATCATCCTT
CAGGAAGAGGCACGCTTCACCATACCGATCGACATGGGGGGCGGCTCATACTTCATCGAGAAGATGACCGACGAGTTTGC
CCGCGCAACATGGGCGCTCTTCCAGGAGATCGAGGGCATGGGGGGGATGACTGCCGCCATAGCCAACAGCCATCCCCAGA
AAAGAGCCGCCGCCACGGCAGCCAGCCGCGCCAAACGCATCGCCACCCGCCAGGACGTCATCCTGGGAACGAACATGTAC
GCCAACATTACGGAGAAGAAGCTGGAGATTCCCGAGATTGACTTGGCAGGTATCAGGCAGCAGCGCATGGACGCCGTTGC
CGATTACCGCATGAAACACGCCAGCACCTCGCTTGCCGAGCAGTTGACCGCCCTATCCAATTCCATCAGGGACAACGCGG
ACCAGACCATGGCTACGGCCATGGAGGCAGCCAAGAACGGAGCGACCCTGGGCGACATTACATCGCTTTTGGTCCAGATG
GGCGGGCAGCCTGAAACAGCCCGACCGCTTCACATCCACCGCGCATCCGAGCCGTTCGAGGAGTTGCGCCGTTTCTCCGA
CGAGCACCTGGTAAAAACGGGAAAACGCATGTCCATCTTTCTGGCCAACATGGGTCCCATCCCGCAGCACAAGCCGCGGG
CCGATTTTTCCTGCGGCTTCTTCGAGGTGGCCGGTTTCGAGATGCTGAACAACGAGGGGTTCGCCACATCCCAGGAAGCT
GCCGAGGCGGCCCTGGCATCGGGCACGGCCGTCACGGTGATCTGCTCCACGGACGCCACCTATCCGGAATACGTGCCGAC
CCTTGCCACAATCATAAAGGCTGCAAAACCGGAGATGACAATAATCGTTGCGGGCAAGCAGCCGCCGGACTTGGAGCAGG
AGTTCCGGGCCGCCGGCGTGGATGACTTCATCCATGTGCGGACCAACTGTTACGAGATGAACAGCAATCTGCAGTGCCGC
TACAGGGAGGTTACACAAGCATGA

Upstream 100 bases:

>100_bases
GCGCCGGCTCGGTGCAAGGCTGCGGCCGGACTCGCCCCCATGATATGAGCAGATGACATGCGCGTGTACGAAAACGCGAA
AACAAGGAGGAAGAGATCAC

Downstream 100 bases:

>100_bases
GTTCATTCCCGAATTTCAAGGATATTGCCTACGAACCGCACAGGAAGGTCGTGGACACACAGACCTGGCAGAAGGAGTTC
ACAGAGTCCGTCGGAGAACC

Product: methylmalonyl-CoA mutase, large subunit

Products: NA

Alternate protein names: MCM [H]

Number of amino acids: Translated: 727; Mature: 726

Protein sequence:

>727_residues
MAEADVTVDITKIDTDRGFFDEFTFPDYETWKEEVIKALKGAPFDKVMFTSTYEGLTINPIYSADDIKGLPHLESRPGYV
PYVRSTHVGGYLEKPWFICQELLVSLPEEFNSEALFDTSRGQTMLNLVLDRPTKKGLDPAEAETGEVGKRGLSLASVSDL
KRAFKGLDLASLPLLCNTGATALPLTALLAAALESDGVPLKRFKGCVGCDPLAELVNEGALRIALPVAYDAMCQVTSWAI
QNMPGLETIFIQGHPYHDAGASSTEEVAFALATAAEYLREMLTRGLAVNDITPRMRFGFSLGSNFFVEIAKLRAARILWN
QVVAAFGGSEQARKMRIHGRTSAYNKTVCDPHVNMLRITSEGFSGAVGGVDSMHLAPFDEPVRVPDRFSRRIARNAQIIL
QEEARFTIPIDMGGGSYFIEKMTDEFARATWALFQEIEGMGGMTAAIANSHPQKRAAATAASRAKRIATRQDVILGTNMY
ANITEKKLEIPEIDLAGIRQQRMDAVADYRMKHASTSLAEQLTALSNSIRDNADQTMATAMEAAKNGATLGDITSLLVQM
GGQPETARPLHIHRASEPFEELRRFSDEHLVKTGKRMSIFLANMGPIPQHKPRADFSCGFFEVAGFEMLNNEGFATSQEA
AEAALASGTAVTVICSTDATYPEYVPTLATIIKAAKPEMTIIVAGKQPPDLEQEFRAAGVDDFIHVRTNCYEMNSNLQCR
YREVTQA

Sequences:

>Translated_727_residues
MAEADVTVDITKIDTDRGFFDEFTFPDYETWKEEVIKALKGAPFDKVMFTSTYEGLTINPIYSADDIKGLPHLESRPGYV
PYVRSTHVGGYLEKPWFICQELLVSLPEEFNSEALFDTSRGQTMLNLVLDRPTKKGLDPAEAETGEVGKRGLSLASVSDL
KRAFKGLDLASLPLLCNTGATALPLTALLAAALESDGVPLKRFKGCVGCDPLAELVNEGALRIALPVAYDAMCQVTSWAI
QNMPGLETIFIQGHPYHDAGASSTEEVAFALATAAEYLREMLTRGLAVNDITPRMRFGFSLGSNFFVEIAKLRAARILWN
QVVAAFGGSEQARKMRIHGRTSAYNKTVCDPHVNMLRITSEGFSGAVGGVDSMHLAPFDEPVRVPDRFSRRIARNAQIIL
QEEARFTIPIDMGGGSYFIEKMTDEFARATWALFQEIEGMGGMTAAIANSHPQKRAAATAASRAKRIATRQDVILGTNMY
ANITEKKLEIPEIDLAGIRQQRMDAVADYRMKHASTSLAEQLTALSNSIRDNADQTMATAMEAAKNGATLGDITSLLVQM
GGQPETARPLHIHRASEPFEELRRFSDEHLVKTGKRMSIFLANMGPIPQHKPRADFSCGFFEVAGFEMLNNEGFATSQEA
AEAALASGTAVTVICSTDATYPEYVPTLATIIKAAKPEMTIIVAGKQPPDLEQEFRAAGVDDFIHVRTNCYEMNSNLQCR
YREVTQA
>Mature_726_residues
AEADVTVDITKIDTDRGFFDEFTFPDYETWKEEVIKALKGAPFDKVMFTSTYEGLTINPIYSADDIKGLPHLESRPGYVP
YVRSTHVGGYLEKPWFICQELLVSLPEEFNSEALFDTSRGQTMLNLVLDRPTKKGLDPAEAETGEVGKRGLSLASVSDLK
RAFKGLDLASLPLLCNTGATALPLTALLAAALESDGVPLKRFKGCVGCDPLAELVNEGALRIALPVAYDAMCQVTSWAIQ
NMPGLETIFIQGHPYHDAGASSTEEVAFALATAAEYLREMLTRGLAVNDITPRMRFGFSLGSNFFVEIAKLRAARILWNQ
VVAAFGGSEQARKMRIHGRTSAYNKTVCDPHVNMLRITSEGFSGAVGGVDSMHLAPFDEPVRVPDRFSRRIARNAQIILQ
EEARFTIPIDMGGGSYFIEKMTDEFARATWALFQEIEGMGGMTAAIANSHPQKRAAATAASRAKRIATRQDVILGTNMYA
NITEKKLEIPEIDLAGIRQQRMDAVADYRMKHASTSLAEQLTALSNSIRDNADQTMATAMEAAKNGATLGDITSLLVQMG
GQPETARPLHIHRASEPFEELRRFSDEHLVKTGKRMSIFLANMGPIPQHKPRADFSCGFFEVAGFEMLNNEGFATSQEAA
EAALASGTAVTVICSTDATYPEYVPTLATIIKAAKPEMTIIVAGKQPPDLEQEFRAAGVDDFIHVRTNCYEMNSNLQCRY
REVTQA

Specific function: Catalyzes the interconversion of succinyl-CoA and methylmalonyl-CoA during the polyhydroxyalkanoate degradation pathway [H]

COG id: COG1884

COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 B12-binding domain [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=675, Percent_Identity=28.8888888888889, Blast_Score=282, Evalue=7e-76,
Organism=Escherichia coli, GI1789284, Length=660, Percent_Identity=29.8484848484848, Blast_Score=290, Evalue=3e-79,
Organism=Caenorhabditis elegans, GI25144500, Length=691, Percent_Identity=29.3777134587554, Blast_Score=293, Evalue=2e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006159
- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR006098 [H]

Pfam domain/function: PF02310 B12-binding; PF01642 MM_CoA_mutase [H]

EC number: =5.4.99.2 [H]

Molecular weight: Translated: 79676; Mature: 79544

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEADVTVDITKIDTDRGFFDEFTFPDYETWKEEVIKALKGAPFDKVMFTSTYEGLTINP
CCCCCEEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCEEECC
IYSADDIKGLPHLESRPGYVPYVRSTHVGGYLEKPWFICQELLVSLPEEFNSEALFDTSR
CCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHCCHHCCCCEEEECCC
GQTMLNLVLDRPTKKGLDPAEAETGEVGKRGLSLASVSDLKRAFKGLDLASLPLLCNTGA
CCEEEHHHHCCCCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHCCCCCCCCEEECCCC
TALPLTALLAAALESDGVPLKRFKGCVGCDPLAELVNEGALRIALPVAYDAMCQVTSWAI
HHHHHHHHHHHHHHCCCCCHHHHCCCCCCCHHHHHHCCCCEEEEEEHHHHHHHHHHHHHH
QNMPGLETIFIQGHPYHDAGASSTEEVAFALATAAEYLREMLTRGLAVNDITPRMRFGFS
HCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEECCCCCHHHCCCC
LGSNFFVEIAKLRAARILWNQVVAAFGGSEQARKMRIHGRTSAYNKTVCDPHVNMLRITS
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHEEECCCCCCCCCCCCCCCCCEEEEEC
EGFSGAVGGVDSMHLAPFDEPVRVPDRFSRRIARNAQIILQEEARFTIPIDMGGGSYFIE
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCEEEEEECCEEEEEEECCCCHHHHH
KMTDEFARATWALFQEIEGMGGMTAAIANSHPQKRAAATAASRAKRIATRQDVILGTNMY
HHHHHHHHHHHHHHHHHHCCCCEEEHHHCCCCHHHHHHHHHHHHHHHHHHCCEEECCCCE
ANITEKKLEIPEIDLAGIRQQRMDAVADYRMKHASTSLAEQLTALSNSIRDNADQTMATA
ECCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
MEAAKNGATLGDITSLLVQMGGQPETARPLHIHRASEPFEELRRFSDEHLVKTGKRMSIF
HHHHHCCCCHHHHHHHHHHHCCCCCCCCCEEEECCCCHHHHHHHCCHHHHHHCCCCEEEE
LANMGPIPQHKPRADFSCGFFEVAGFEMLNNEGFATSQEAAEAALASGTAVTVICSTDAT
EECCCCCCCCCCCCCCCCCHHHHHCHHHCCCCCCCCCHHHHHHHHHCCCEEEEEEECCCC
YPEYVPTLATIIKAAKPEMTIIVAGKQPPDLEQEFRAAGVDDFIHVRTNCYEMNSNLQCR
CHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHCCCCHHEEEEHHEEECCCCCEEE
YREVTQA
HHHHCCC
>Mature Secondary Structure 
AEADVTVDITKIDTDRGFFDEFTFPDYETWKEEVIKALKGAPFDKVMFTSTYEGLTINP
CCCCEEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCEEECC
IYSADDIKGLPHLESRPGYVPYVRSTHVGGYLEKPWFICQELLVSLPEEFNSEALFDTSR
CCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHCCHHCCCCEEEECCC
GQTMLNLVLDRPTKKGLDPAEAETGEVGKRGLSLASVSDLKRAFKGLDLASLPLLCNTGA
CCEEEHHHHCCCCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHCCCCCCCCEEECCCC
TALPLTALLAAALESDGVPLKRFKGCVGCDPLAELVNEGALRIALPVAYDAMCQVTSWAI
HHHHHHHHHHHHHHCCCCCHHHHCCCCCCCHHHHHHCCCCEEEEEEHHHHHHHHHHHHHH
QNMPGLETIFIQGHPYHDAGASSTEEVAFALATAAEYLREMLTRGLAVNDITPRMRFGFS
HCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEECCCCCHHHCCCC
LGSNFFVEIAKLRAARILWNQVVAAFGGSEQARKMRIHGRTSAYNKTVCDPHVNMLRITS
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHEEECCCCCCCCCCCCCCCCCEEEEEC
EGFSGAVGGVDSMHLAPFDEPVRVPDRFSRRIARNAQIILQEEARFTIPIDMGGGSYFIE
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCEEEEEECCEEEEEEECCCCHHHHH
KMTDEFARATWALFQEIEGMGGMTAAIANSHPQKRAAATAASRAKRIATRQDVILGTNMY
HHHHHHHHHHHHHHHHHHCCCCEEEHHHCCCCHHHHHHHHHHHHHHHHHHCCEEECCCCE
ANITEKKLEIPEIDLAGIRQQRMDAVADYRMKHASTSLAEQLTALSNSIRDNADQTMATA
ECCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
MEAAKNGATLGDITSLLVQMGGQPETARPLHIHRASEPFEELRRFSDEHLVKTGKRMSIF
HHHHHCCCCHHHHHHHHHHHCCCCCCCCCEEEECCCCHHHHHHHCCHHHHHHCCCCEEEE
LANMGPIPQHKPRADFSCGFFEVAGFEMLNNEGFATSQEAAEAALASGTAVTVICSTDAT
EECCCCCCCCCCCCCCCCCHHHHHCHHHCCCCCCCCCHHHHHHHHHCCCEEEEEEECCCC
YPEYVPTLATIIKAAKPEMTIIVAGKQPPDLEQEFRAAGVDDFIHVRTNCYEMNSNLQCR
CHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHCCCCHHEEEEHHEEECCCCCEEE
YREVTQA
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9889346; 11481431 [H]