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The map label for this gene is mutB [H]

Identifier: 118579713

GI number: 118579713

Start: 1345793

End: 1347964

Strand: Reverse

Name: mutB [H]

Synonym: Ppro_1284

Alternate gene names: 118579713

Gene position: 1347964-1345793 (Counterclockwise)

Preceding gene: 118579714

Following gene: 118579712

Centisome position: 33.63

GC content: 62.71

Gene sequence:

>2172_bases
ATGAGTTCATTCCCGAATTTCAAGGATATTGCCTACGAACCGCACAGGAAGGTCGTGGACACACAGACCTGGCAGAAGGA
GTTCACAGAGTCCGTCGGAGAACCGCCGATCTGGATGACCAACGAGCAGATCCCGGTCAAGGCGCTCTACACCGAGGAGG
ACATCAAGGGCATCGAGCACATCGGATCCACCGCCGGTATCGCCCCCAACCTGCGTGGCCCCTACCCCACCATGTACGTG
CAGCGCCCCTGGACGATCCGCCAGTACGCCGGTTTCTCCACCGCCGAGGAGAGCAACGCCTTCTACCGCCGCAACCTGGC
CATGGGGCAGAAAGGGCTCTCGGTGGCCTTCGACCTGGCCACCCACCGCGGCTATGACTCGGACCATCCCCGGGTGGTGG
GAGATGTGGGCAAGGCCGGGGTTGCCGTCGACTCCATCCTGGACGCCGAGATCCTCTTTTCCGGCATCCCGCTGAACAAG
ATGTCCGTCTCCATGACCATGAACGGCGCGGTCCTGCCGGTTCTGGCCTTCTACATCGTGGCCGGTCTGGAGCAGGGGGC
GCAGCTGGACGAGCTGTCCGGCACGATCCAGAACGACATCCTCAAGGAGTTCATGGTGCGCAACACCTACATCTATGGGC
CGGAAGGCTCCATGCGCATCATCGGCGACATCTTTGAGTACACATCCAAATACATGCCCAAGTTCAACAGCATAAGCATC
TCCGGCTATCACATGCAGGAAGCCGGCGCCACCGCCGACATCGAGCTGGCCTACACCATCGCCGACGGCCTGGAATACAT
CCGCACCGGCATCACCGCCGGCCTGGAGGTGGACAAATTCGCGCCGCGTCTCTCCTTCTTCTGGGCCGAGGGGATGAACT
ACTTCATGGAGGTCTCCAAACTGCGTGCCGGTCGACTTTTGTGGGCCAAACTGCTCAAGCAATTCAACCCGAAGAATCCA
AAATCCCTGGCCCTGCGCACCCATTCTCAGACCTCGGGGTGGAGCCTCACGGAACAGGATCCCTTTAACAACGTCACCCG
CACCTGCCTGGAGGCAATGGCAGCCACCCTGGGGCACACCCAGTCGCTGCACACCAACGCCCTGGACGAGGCCATCGCCC
TGCCCACCGACTTCTCGGCCCGCATCGCCCGCAACACCCAGATTTACCTGCAGAGCGAAACTTCCATCTGCAAGGCAATC
GACCCCTGGGGCGGCTCCTACTACGTGGAATGGCTGACCGACCAGCTGCGCAAGAAGGCCTGGGCGCACATCGTGGAGGT
GGAGTCCCTGGGAGGCATGGCCAAGGCCATTGAGACTGGCCTGCCCAAGATGCGCATCGAAGAGGCGGCGGCCCGCAAAC
AGGCCAGGATCGACTCCAAGGCCGAGCCGATCATCGGCGTCAACAAGTTCCGGCTGGAGCAGGAGGATCCCATCGACATC
CTCTCCATCGACAACACTGCCGTACGCGAATCCCAGATCGCCCGACTGAAGAAGCTGCGCGCCGAACGGGACAACGCCAA
GGTCCAGGGAATCCTGGAGGCCATAACCAGGGCGGCCGAATCCCGGGAGAACGGCAACCTGCTGGAGCTGGCGGTGGAGG
CTGCCAAGGCGCGGGCCAGCCTGGGCGAGATATCCGACGCCATGGAGAAAGTCTATCCCCGCCACAAGGCGGTCATCCGC
TCCATCTCCGGAATCTACAGCTCCGAGTACGCTGAAAACGAAGAGGTGCAGGAGGTACAGCGCATGTGCGCCGAGTTCGA
GGAGCAGGAGGGGCGGCGGCCCCGCATCCTGGTGGCCAAGATGGGACAGGACGGCCACGACCGGGGCGCCAAGGTCATCG
CCACCGCCTTCTCCGACCTGGGGTTTGATGTGGATGTGGGTCCGCTGTTCCAGACTCCGGAAGAGACGGCCGACATGGCG
GTGGAGAACGACGTGCACGTGGTCGGCTTCAGCTCATTGGCAGCCGGGCACAAGACCCTGCTTCCCCAGCTGGTGGAGGA
GCTCAGGAAGCGGGGACGGGGCGATATCCTGGTGCAGATCGGCGGCGTCATCCCGGCCCAGGACTACCAGTACCTGTACG
ACCACGGCGCCGACCTGATCTTCGGACCCGGCACGGTCATCCCCATCGCGGCCAGGAAGACCCTGGAGCTGCTCAAGAAA
CGACTGGCATGA

Upstream 100 bases:

>100_bases
AGTTCCGGGCCGCCGGCGTGGATGACTTCATCCATGTGCGGACCAACTGTTACGAGATGAACAGCAATCTGCAGTGCCGC
TACAGGGAGGTTACACAAGC

Downstream 100 bases:

>100_bases
AACGGGACGGCACGGACAAAAGCCGGCCCGAATGGGTACCGGAACAGGCGGGCGCCGGCGACGGCTTCACCACCCACGTC
ATGGAGGGGATCCACAGCCT

Product: methylmalonyl-CoA mutase

Products: NA

Alternate protein names: MCM-alpha [H]

Number of amino acids: Translated: 723; Mature: 722

Protein sequence:

>723_residues
MSSFPNFKDIAYEPHRKVVDTQTWQKEFTESVGEPPIWMTNEQIPVKALYTEEDIKGIEHIGSTAGIAPNLRGPYPTMYV
QRPWTIRQYAGFSTAEESNAFYRRNLAMGQKGLSVAFDLATHRGYDSDHPRVVGDVGKAGVAVDSILDAEILFSGIPLNK
MSVSMTMNGAVLPVLAFYIVAGLEQGAQLDELSGTIQNDILKEFMVRNTYIYGPEGSMRIIGDIFEYTSKYMPKFNSISI
SGYHMQEAGATADIELAYTIADGLEYIRTGITAGLEVDKFAPRLSFFWAEGMNYFMEVSKLRAGRLLWAKLLKQFNPKNP
KSLALRTHSQTSGWSLTEQDPFNNVTRTCLEAMAATLGHTQSLHTNALDEAIALPTDFSARIARNTQIYLQSETSICKAI
DPWGGSYYVEWLTDQLRKKAWAHIVEVESLGGMAKAIETGLPKMRIEEAAARKQARIDSKAEPIIGVNKFRLEQEDPIDI
LSIDNTAVRESQIARLKKLRAERDNAKVQGILEAITRAAESRENGNLLELAVEAAKARASLGEISDAMEKVYPRHKAVIR
SISGIYSSEYAENEEVQEVQRMCAEFEEQEGRRPRILVAKMGQDGHDRGAKVIATAFSDLGFDVDVGPLFQTPEETADMA
VENDVHVVGFSSLAAGHKTLLPQLVEELRKRGRGDILVQIGGVIPAQDYQYLYDHGADLIFGPGTVIPIAARKTLELLKK
RLA

Sequences:

>Translated_723_residues
MSSFPNFKDIAYEPHRKVVDTQTWQKEFTESVGEPPIWMTNEQIPVKALYTEEDIKGIEHIGSTAGIAPNLRGPYPTMYV
QRPWTIRQYAGFSTAEESNAFYRRNLAMGQKGLSVAFDLATHRGYDSDHPRVVGDVGKAGVAVDSILDAEILFSGIPLNK
MSVSMTMNGAVLPVLAFYIVAGLEQGAQLDELSGTIQNDILKEFMVRNTYIYGPEGSMRIIGDIFEYTSKYMPKFNSISI
SGYHMQEAGATADIELAYTIADGLEYIRTGITAGLEVDKFAPRLSFFWAEGMNYFMEVSKLRAGRLLWAKLLKQFNPKNP
KSLALRTHSQTSGWSLTEQDPFNNVTRTCLEAMAATLGHTQSLHTNALDEAIALPTDFSARIARNTQIYLQSETSICKAI
DPWGGSYYVEWLTDQLRKKAWAHIVEVESLGGMAKAIETGLPKMRIEEAAARKQARIDSKAEPIIGVNKFRLEQEDPIDI
LSIDNTAVRESQIARLKKLRAERDNAKVQGILEAITRAAESRENGNLLELAVEAAKARASLGEISDAMEKVYPRHKAVIR
SISGIYSSEYAENEEVQEVQRMCAEFEEQEGRRPRILVAKMGQDGHDRGAKVIATAFSDLGFDVDVGPLFQTPEETADMA
VENDVHVVGFSSLAAGHKTLLPQLVEELRKRGRGDILVQIGGVIPAQDYQYLYDHGADLIFGPGTVIPIAARKTLELLKK
RLA
>Mature_722_residues
SSFPNFKDIAYEPHRKVVDTQTWQKEFTESVGEPPIWMTNEQIPVKALYTEEDIKGIEHIGSTAGIAPNLRGPYPTMYVQ
RPWTIRQYAGFSTAEESNAFYRRNLAMGQKGLSVAFDLATHRGYDSDHPRVVGDVGKAGVAVDSILDAEILFSGIPLNKM
SVSMTMNGAVLPVLAFYIVAGLEQGAQLDELSGTIQNDILKEFMVRNTYIYGPEGSMRIIGDIFEYTSKYMPKFNSISIS
GYHMQEAGATADIELAYTIADGLEYIRTGITAGLEVDKFAPRLSFFWAEGMNYFMEVSKLRAGRLLWAKLLKQFNPKNPK
SLALRTHSQTSGWSLTEQDPFNNVTRTCLEAMAATLGHTQSLHTNALDEAIALPTDFSARIARNTQIYLQSETSICKAID
PWGGSYYVEWLTDQLRKKAWAHIVEVESLGGMAKAIETGLPKMRIEEAAARKQARIDSKAEPIIGVNKFRLEQEDPIDIL
SIDNTAVRESQIARLKKLRAERDNAKVQGILEAITRAAESRENGNLLELAVEAAKARASLGEISDAMEKVYPRHKAVIRS
ISGIYSSEYAENEEVQEVQRMCAEFEEQEGRRPRILVAKMGQDGHDRGAKVIATAFSDLGFDVDVGPLFQTPEETADMAV
ENDVHVVGFSSLAAGHKTLLPQLVEELRKRGRGDILVQIGGVIPAQDYQYLYDHGADLIFGPGTVIPIAARKTLELLKKR
LA

Specific function: Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates [H]

COG id: COG1884

COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 B12-binding domain [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=687, Percent_Identity=63.6098981077147, Blast_Score=909, Evalue=0.0,
Organism=Escherichia coli, GI1789284, Length=711, Percent_Identity=60.337552742616, Blast_Score=852, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25144500, Length=688, Percent_Identity=64.6802325581395, Blast_Score=916, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006159
- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR006098 [H]

Pfam domain/function: PF02310 B12-binding; PF01642 MM_CoA_mutase [H]

EC number: =5.4.99.2 [H]

Molecular weight: Translated: 80256; Mature: 80125

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSFPNFKDIAYEPHRKVVDTQTWQKEFTESVGEPPIWMTNEQIPVKALYTEEDIKGIEH
CCCCCCCHHCCCCCCHHHHCHHHHHHHHHHHCCCCCEEECCCCCCEEEECCHHHHHHHHH
IGSTAGIAPNLRGPYPTMYVQRPWTIRQYAGFSTAEESNAFYRRNLAMGQKGLSVAFDLA
CCCCCCCCCCCCCCCCEEEEECCCCHHHHCCCCCCHHCCHHHHHHHHHCCCCCEEEEEHH
THRGYDSDHPRVVGDVGKAGVAVDSILDAEILFSGIPLNKMSVSMTMNGAVLPVLAFYIV
HHCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEECCHHHHHHHHHHH
AGLEQGAQLDELSGTIQNDILKEFMVRNTYIYGPEGSMRIIGDIFEYTSKYMPKFNSISI
HHHHCCCCHHHHHHHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHHHCCCCCCEEE
SGYHMQEAGATADIELAYTIADGLEYIRTGITAGLEVDKFAPRLSFFWAEGMNYFMEVSK
ECEEECCCCCCCEEEEEEEHHHHHHHHHHHHHCCCCHHHHCHHHHHHHHHHHHHHHHHHH
LRAGRLLWAKLLKQFNPKNPKSLALRTHSQTSGWSLTEQDPFNNVTRTCLEAMAATLGHT
HHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCC
QSLHTNALDEAIALPTDFSARIARNTQIYLQSETSICKAIDPWGGSYYVEWLTDQLRKKA
HHHHHHHHHHHHCCCCCCHHHHCCCCEEEEECCCCHHHHCCCCCCCCHHHHHHHHHHHHH
WAHIVEVESLGGMAKAIETGLPKMRIEEAAARKQARIDSKAEPIIGVNKFRLEQEDPIDI
HHHHHHHHHHCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHEECCCCCCEEE
LSIDNTAVRESQIARLKKLRAERDNAKVQGILEAITRAAESRENGNLLELAVEAAKARAS
EECCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
LGEISDAMEKVYPRHKAVIRSISGIYSSEYAENEEVQEVQRMCAEFEEQEGRRPRILVAK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEE
MGQDGHDRGAKVIATAFSDLGFDVDVGPLFQTPEETADMAVENDVHVVGFSSLAAGHKTL
CCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCCEEEEEHHHHHCCHHHH
LPQLVEELRKRGRGDILVQIGGVIPAQDYQYLYDHGADLIFGPGTVIPIAARKTLELLKK
HHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHCCCCEEECCCCEEEHHHHHHHHHHHH
RLA
HCC
>Mature Secondary Structure 
SSFPNFKDIAYEPHRKVVDTQTWQKEFTESVGEPPIWMTNEQIPVKALYTEEDIKGIEH
CCCCCCHHCCCCCCHHHHCHHHHHHHHHHHCCCCCEEECCCCCCEEEECCHHHHHHHHH
IGSTAGIAPNLRGPYPTMYVQRPWTIRQYAGFSTAEESNAFYRRNLAMGQKGLSVAFDLA
CCCCCCCCCCCCCCCCEEEEECCCCHHHHCCCCCCHHCCHHHHHHHHHCCCCCEEEEEHH
THRGYDSDHPRVVGDVGKAGVAVDSILDAEILFSGIPLNKMSVSMTMNGAVLPVLAFYIV
HHCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEECCHHHHHHHHHHH
AGLEQGAQLDELSGTIQNDILKEFMVRNTYIYGPEGSMRIIGDIFEYTSKYMPKFNSISI
HHHHCCCCHHHHHHHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHHHCCCCCCEEE
SGYHMQEAGATADIELAYTIADGLEYIRTGITAGLEVDKFAPRLSFFWAEGMNYFMEVSK
ECEEECCCCCCCEEEEEEEHHHHHHHHHHHHHCCCCHHHHCHHHHHHHHHHHHHHHHHHH
LRAGRLLWAKLLKQFNPKNPKSLALRTHSQTSGWSLTEQDPFNNVTRTCLEAMAATLGHT
HHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCC
QSLHTNALDEAIALPTDFSARIARNTQIYLQSETSICKAIDPWGGSYYVEWLTDQLRKKA
HHHHHHHHHHHHCCCCCCHHHHCCCCEEEEECCCCHHHHCCCCCCCCHHHHHHHHHHHHH
WAHIVEVESLGGMAKAIETGLPKMRIEEAAARKQARIDSKAEPIIGVNKFRLEQEDPIDI
HHHHHHHHHHCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHEECCCCCCEEE
LSIDNTAVRESQIARLKKLRAERDNAKVQGILEAITRAAESRENGNLLELAVEAAKARAS
EECCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
LGEISDAMEKVYPRHKAVIRSISGIYSSEYAENEEVQEVQRMCAEFEEQEGRRPRILVAK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEE
MGQDGHDRGAKVIATAFSDLGFDVDVGPLFQTPEETADMAVENDVHVVGFSSLAAGHKTL
CCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCCEEEEEHHHHHCCHHHH
LPQLVEELRKRGRGDILVQIGGVIPAQDYQYLYDHGADLIFGPGTVIPIAARKTLELLKK
HHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHCCCCEEECCCCEEEHHHHHHHHHHHH
RLA
HCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8566763; 12949112 [H]