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The map label for this gene is dxs2 [H]

Identifier: 118579621

GI number: 118579621

Start: 1242841

End: 1244715

Strand: Direct

Name: dxs2 [H]

Synonym: Ppro_1191

Alternate gene names: 118579621

Gene position: 1242841-1244715 (Clockwise)

Preceding gene: 118579620

Following gene: 118579622

Centisome position: 31.01

GC content: 62.51

Gene sequence:

>1875_bases
ATGTATCAGTATTTGAACCATATAGATTCACCCGATGATTTGAAGAAGCTGAAGCCGGAGCATCTGCTGGATCTGGCGGC
CGAGGTGCGCCGCTTCCTGCTGGAGAAGGTCTCTGTCACCGGCGGCCATCTGGGGTCCAACCTGGGCACGGTGGAACTCT
CCATCGCGCTGCTGTACTGCTTCGACTCGCCCAACGACAAGATCATCTGGGACGTGGGGCACCAGGCCTATACCCACAAG
ATCCTCACCGGCAGGAGGGACCGCTTCCACACCCAGCGCCAGTACAAGGGGCTCTCCGGTTTTCCCAAGCGCTCCGAGTC
CGAGCATGACGCTTTCGGGGTGGGGCACTCATCCACCTCCATCTCCGCGGCCTTGGGGATGGCGGCGGCGGCCGATCTGG
CTGGCGCGAAAAACCACGCCATCGCCGTCATCGGTGACGGATCCCTGACCGGTGGCATGGCCTTCGAGGCGCTGAACCAG
GCCGGCCATCTCAAGAAGGACCTGATCGTTATCTTGAACGACAACGAGATGTCCATCTCCAAAAACGTGGGGGCCTTTTC
TTCGTTCATCTCCCGCAAGATGACCGGCAGATACTTCCGCGACCTGAAGAAGGAGATGCAGGGGCTTTTGCGCAACATTC
CGGCCATCGGCTCCGACATCCTGCACTTTGCCCGGCGGGCCGAGAATTCGCTGAAGAGCTTCCTGACGCCGGGGTCGCTG
TTCGAAGCGTTGGGTTTCGACTATCTGGGGCCGCTGGATGGTCACGACCTGCCCCAGCTGATCGAGGTGTTCAACAACAT
CAACCAGCTGGACGGTCCGCTGCTGGTGCATGTCATGACCACCAAGGGCAAGGGGTACAAGCCGGCCGAGGAAAACCCGG
ACAAGTTCCACGGCGTGGGGCCCTTCGACATCGTCACCGGCAAGGCGACGTCCTCTACCTCGGCCAGGAGCTACACGGAG
CTGTTTGGCGAGGCCATGGTGGATCTGGCAGAGCAGGATCCCCGGGTCGTGGCCATTACCGCCGCCATGCGCGACGGCAC
CGGGTTGAAGACCTTCTCCGAGCGCTTTCCCAAACGCTTCTTCGACGTGGGGATCGCCGAACAGCACGCCATGACCTTCG
CCGCCGGCCTGGCAGCCGACGGTTTCCGTCCGGTAACCGCCATCTATTCCACCTTCGTACAGCGCGCCTATGACCAGGTC
TTTCACGACATCTGTCTGCAGAAGCTGCCGGTGACCATCGCCATGGACCGCGCCGGCCTGGTGGGGGACGACGGCCCGAC
CCACCATGGAGTGATGGACTACTCCTTTCTGCGCCACATCCCCGGACTGGCCCTGATGGCGCCCAAGGACGAGAACGAGC
TTCGCCACATGCTCAAGACCGCCGTCACGAGCGGCGTTCCCATCTCCCTGCGCTATCCGCGCGGCGCGGGTATGGGGGTG
GAGCTGGACAGGGATCTGAAGACCCTGGATATCGGCAGGGGAGAGCTTTTGATGGAGGGGAGCGACATCTGCCTGATTGC
CATCGGCTCCACGGTCTATCCGGCGCTCCAGGCCGCCCATTCCCTGCAAGGGCTGGGGGTGCGGGTTGGGGTGGTCAATG
CCCGTTTCATCAAGCCGCTGGATGCCGAGTTGATCCTCTCCGTTGCCGGTTCGTGCGGCCGGATCATGACCGTGGAGGAG
AACCTGCTGCAGGGAGGATTCGGCAGCGCGGTCCTGGAACTGCTCAACGACAACAACATGCAGGATGTGATCGTCAGGCG
CCTCGGCATACCCGACCGTTTCGTGGAGCATGGCTCCCAGGCGCGGCTGCGCCAGGATCTGGGCATCGATGCCGAGGGGA
TCGCCGCGGCTGCCCTGGCGTTTCTCAAACAGTAG

Upstream 100 bases:

>100_bases
GGTTCAGGGCCAACCGGTATGCGTGACGTCAGCCGGCGATTGCTCGCAACCACTGCCGATTGAAACGCGCCCGACTGGCC
TGTGATGGAGAAACAGTAAA

Downstream 100 bases:

>100_bases
GCCGCGGGCACGTATGCTATCAGCCAGGGGAACATCGACTCCCCTGCCTTTGAAACAGGGACGGCATCAACGCCGACCTG
AAATAGTTGCTTCTGGAAAA

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase 2; DXP synthase 2; DXPS 2 [H]

Number of amino acids: Translated: 624; Mature: 624

Protein sequence:

>624_residues
MYQYLNHIDSPDDLKKLKPEHLLDLAAEVRRFLLEKVSVTGGHLGSNLGTVELSIALLYCFDSPNDKIIWDVGHQAYTHK
ILTGRRDRFHTQRQYKGLSGFPKRSESEHDAFGVGHSSTSISAALGMAAAADLAGAKNHAIAVIGDGSLTGGMAFEALNQ
AGHLKKDLIVILNDNEMSISKNVGAFSSFISRKMTGRYFRDLKKEMQGLLRNIPAIGSDILHFARRAENSLKSFLTPGSL
FEALGFDYLGPLDGHDLPQLIEVFNNINQLDGPLLVHVMTTKGKGYKPAEENPDKFHGVGPFDIVTGKATSSTSARSYTE
LFGEAMVDLAEQDPRVVAITAAMRDGTGLKTFSERFPKRFFDVGIAEQHAMTFAAGLAADGFRPVTAIYSTFVQRAYDQV
FHDICLQKLPVTIAMDRAGLVGDDGPTHHGVMDYSFLRHIPGLALMAPKDENELRHMLKTAVTSGVPISLRYPRGAGMGV
ELDRDLKTLDIGRGELLMEGSDICLIAIGSTVYPALQAAHSLQGLGVRVGVVNARFIKPLDAELILSVAGSCGRIMTVEE
NLLQGGFGSAVLELLNDNNMQDVIVRRLGIPDRFVEHGSQARLRQDLGIDAEGIAAAALAFLKQ

Sequences:

>Translated_624_residues
MYQYLNHIDSPDDLKKLKPEHLLDLAAEVRRFLLEKVSVTGGHLGSNLGTVELSIALLYCFDSPNDKIIWDVGHQAYTHK
ILTGRRDRFHTQRQYKGLSGFPKRSESEHDAFGVGHSSTSISAALGMAAAADLAGAKNHAIAVIGDGSLTGGMAFEALNQ
AGHLKKDLIVILNDNEMSISKNVGAFSSFISRKMTGRYFRDLKKEMQGLLRNIPAIGSDILHFARRAENSLKSFLTPGSL
FEALGFDYLGPLDGHDLPQLIEVFNNINQLDGPLLVHVMTTKGKGYKPAEENPDKFHGVGPFDIVTGKATSSTSARSYTE
LFGEAMVDLAEQDPRVVAITAAMRDGTGLKTFSERFPKRFFDVGIAEQHAMTFAAGLAADGFRPVTAIYSTFVQRAYDQV
FHDICLQKLPVTIAMDRAGLVGDDGPTHHGVMDYSFLRHIPGLALMAPKDENELRHMLKTAVTSGVPISLRYPRGAGMGV
ELDRDLKTLDIGRGELLMEGSDICLIAIGSTVYPALQAAHSLQGLGVRVGVVNARFIKPLDAELILSVAGSCGRIMTVEE
NLLQGGFGSAVLELLNDNNMQDVIVRRLGIPDRFVEHGSQARLRQDLGIDAEGIAAAALAFLKQ
>Mature_624_residues
MYQYLNHIDSPDDLKKLKPEHLLDLAAEVRRFLLEKVSVTGGHLGSNLGTVELSIALLYCFDSPNDKIIWDVGHQAYTHK
ILTGRRDRFHTQRQYKGLSGFPKRSESEHDAFGVGHSSTSISAALGMAAAADLAGAKNHAIAVIGDGSLTGGMAFEALNQ
AGHLKKDLIVILNDNEMSISKNVGAFSSFISRKMTGRYFRDLKKEMQGLLRNIPAIGSDILHFARRAENSLKSFLTPGSL
FEALGFDYLGPLDGHDLPQLIEVFNNINQLDGPLLVHVMTTKGKGYKPAEENPDKFHGVGPFDIVTGKATSSTSARSYTE
LFGEAMVDLAEQDPRVVAITAAMRDGTGLKTFSERFPKRFFDVGIAEQHAMTFAAGLAADGFRPVTAIYSTFVQRAYDQV
FHDICLQKLPVTIAMDRAGLVGDDGPTHHGVMDYSFLRHIPGLALMAPKDENELRHMLKTAVTSGVPISLRYPRGAGMGV
ELDRDLKTLDIGRGELLMEGSDICLIAIGSTVYPALQAAHSLQGLGVRVGVVNARFIKPLDAELILSVAGSCGRIMTVEE
NLLQGGFGSAVLELLNDNNMQDVIVRRLGIPDRFVEHGSQARLRQDLGIDAEGIAAAALAFLKQ

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) [H]

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=666, Percent_Identity=22.3723723723724, Blast_Score=109, Evalue=7e-24,
Organism=Homo sapiens, GI4507521, Length=666, Percent_Identity=22.3723723723724, Blast_Score=109, Evalue=7e-24,
Organism=Homo sapiens, GI225637461, Length=428, Percent_Identity=26.6355140186916, Blast_Score=106, Evalue=6e-23,
Organism=Homo sapiens, GI225637463, Length=428, Percent_Identity=26.6355140186916, Blast_Score=106, Evalue=6e-23,
Organism=Homo sapiens, GI225637459, Length=428, Percent_Identity=26.6355140186916, Blast_Score=106, Evalue=8e-23,
Organism=Homo sapiens, GI133778974, Length=433, Percent_Identity=24.4803695150115, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI4557353, Length=270, Percent_Identity=24.0740740740741, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI34101272, Length=270, Percent_Identity=24.0740740740741, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI156564403, Length=229, Percent_Identity=25.3275109170306, Blast_Score=71, Evalue=3e-12,
Organism=Escherichia coli, GI1786622, Length=623, Percent_Identity=48.1540930979133, Blast_Score=590, Evalue=1e-170,
Organism=Escherichia coli, GI1788808, Length=292, Percent_Identity=28.0821917808219, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17539652, Length=413, Percent_Identity=25.6658595641646, Blast_Score=104, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17538422, Length=297, Percent_Identity=22.8956228956229, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24666278, Length=598, Percent_Identity=25.9197324414716, Blast_Score=127, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24645119, Length=626, Percent_Identity=24.7603833865815, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI45551847, Length=626, Percent_Identity=24.7603833865815, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI45550715, Length=626, Percent_Identity=24.7603833865815, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI21358145, Length=237, Percent_Identity=26.1603375527426, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24650940, Length=237, Percent_Identity=26.1603375527426, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF00676 E1_dh; PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.7 [H]

Molecular weight: Translated: 67808; Mature: 67808

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: PS00801 TRANSKETOLASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYQYLNHIDSPDDLKKLKPEHLLDLAAEVRRFLLEKVSVTGGHLGSNLGTVELSIALLYC
CCCHHHCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEEE
FDSPNDKIIWDVGHQAYTHKILTGRRDRFHTQRQYKGLSGFPKRSESEHDAFGVGHSSTS
ECCCCCCEEEECCCHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCH
ISAALGMAAAADLAGAKNHAIAVIGDGSLTGGMAFEALNQAGHLKKDLIVILNDNEMSIS
HHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHCCCCCCCEEEEECCCCEEHH
KNVGAFSSFISRKMTGRYFRDLKKEMQGLLRNIPAIGSDILHFARRAENSLKSFLTPGSL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCHHH
FEALGFDYLGPLDGHDLPQLIEVFNNINQLDGPLLVHVMTTKGKGYKPAEENPDKFHGVG
HHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCCCC
PFDIVTGKATSSTSARSYTELFGEAMVDLAEQDPRVVAITAAMRDGTGLKTFSERFPKRF
CCCEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCHHHHHHHHHHH
FDVGIAEQHAMTFAAGLAADGFRPVTAIYSTFVQRAYDQVFHDICLQKLPVTIAMDRAGL
HHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCC
VGDDGPTHHGVMDYSFLRHIPGLALMAPKDENELRHMLKTAVTSGVPISLRYPRGAGMGV
CCCCCCCCCCCHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCC
ELDRDLKTLDIGRGELLMEGSDICLIAIGSTVYPALQAAHSLQGLGVRVGVVNARFIKPL
EECCCCCEEECCCCCEEEECCCEEEEEECCHHHHHHHHHHHHCCCCEEEEEECHHHCCCC
DAELILSVAGSCGRIMTVEENLLQGGFGSAVLELLNDNNMQDVIVRRLGIPDRFVEHGSQ
CHHHHHHHHCCCCEEEEEHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHCCCH
ARLRQDLGIDAEGIAAAALAFLKQ
HHHHHHCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MYQYLNHIDSPDDLKKLKPEHLLDLAAEVRRFLLEKVSVTGGHLGSNLGTVELSIALLYC
CCCHHHCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEEE
FDSPNDKIIWDVGHQAYTHKILTGRRDRFHTQRQYKGLSGFPKRSESEHDAFGVGHSSTS
ECCCCCCEEEECCCHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCH
ISAALGMAAAADLAGAKNHAIAVIGDGSLTGGMAFEALNQAGHLKKDLIVILNDNEMSIS
HHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHCCCCCCCEEEEECCCCEEHH
KNVGAFSSFISRKMTGRYFRDLKKEMQGLLRNIPAIGSDILHFARRAENSLKSFLTPGSL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCHHH
FEALGFDYLGPLDGHDLPQLIEVFNNINQLDGPLLVHVMTTKGKGYKPAEENPDKFHGVG
HHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCCCC
PFDIVTGKATSSTSARSYTELFGEAMVDLAEQDPRVVAITAAMRDGTGLKTFSERFPKRF
CCCEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCHHHHHHHHHHH
FDVGIAEQHAMTFAAGLAADGFRPVTAIYSTFVQRAYDQVFHDICLQKLPVTIAMDRAGL
HHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCC
VGDDGPTHHGVMDYSFLRHIPGLALMAPKDENELRHMLKTAVTSGVPISLRYPRGAGMGV
CCCCCCCCCCCHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCC
ELDRDLKTLDIGRGELLMEGSDICLIAIGSTVYPALQAAHSLQGLGVRVGVVNARFIKPL
EECCCCCEEECCCCCEEEECCCEEEEEECCHHHHHHHHHHHHCCCCEEEEEECHHHCCCC
DAELILSVAGSCGRIMTVEENLLQGGFGSAVLELLNDNNMQDVIVRRLGIPDRFVEHGSQ
CHHHHHHHHCCCCEEEEEHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHCCCH
ARLRQDLGIDAEGIAAAALAFLKQ
HHHHHHCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA