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The map label for this gene is shc [H]

Identifier: 118579619

GI number: 118579619

Start: 1239584

End: 1241623

Strand: Direct

Name: shc [H]

Synonym: Ppro_1189

Alternate gene names: 118579619

Gene position: 1239584-1241623 (Clockwise)

Preceding gene: 118579609

Following gene: 118579620

Centisome position: 30.93

GC content: 62.5

Gene sequence:

>2040_bases
ATGAATCCAGCCAAATATAAGATTTCAAGCTCGTTGACGTCTCTCAACGCGGAGCCGGTGGAGCAGGCTCCCCTTCCCGC
GAAAAGAACCGGCTCGAAGGTGCACCGTCTTCCACCTTCCATCTGGAAGAAGATGGTTGCCGAGGCAAAAAGCCCCCTGG
ACAAGGGGATTGAGCGCACGCGGGACTTTTTCCTGCGCGAGCAGCTCCCCGACGGCTACTGGTGGGCGGAGCTGGAATCC
AACGTAACCATCAGCGCCGAATACGTTATGCTGTTCCACTTCCTGGGGATGGTTGACCGGGAGCGTGAGCGCAAACTGGC
CAACTACATCCTAGCCAAGCAGACCTCCGAGGGGTTCTGGTCCCTCTGGCACAACGGCCCCGGCGACCTCTCCACCACCA
TCGAAGCCTATTTTGCCCTCAAGCTGGCCGGCTATTCGGCCGACCATCCGGCCATGGCCAAGGCGCGGGCTTTCGTCCTG
GCTAACGGCGGCATCATCAAGGCCCGGGTCTTCACCAAGATCTTCCTGGCGCTGTTTGGCGAGTTCGCCTGGTTCGGCGT
CCCCTCCATGCCCATCGAGCTGATGCTGCTCCCCGACTGGGCCTATTTCAACATGTACGAATTCTCCAGCTGGTCCCGCG
CCACGATCATCCCGCTGTCGGTGGTCATGTCGGAACGGCCGGTGCGCAAGCTACCGCCGCGGGCCCAGGTCCAGGAACTC
TTTGTCCGGCCGCCGCGGCCCACCGATTACACCATCACCCGCGAGGACGGCCTCTTCACTTGGAAGAACTTCTTCATCGG
TGCCGACCATCTGATCAAGGTCTATGAGTCGTCGCCGATCCGTCCCTTCAAGAAGAGGGCGGTTGCCCTGGCCGAGAACT
GGATCCTGGAGCACCAGGAGCAGTCCGGCGACTGGGGCGGCATCCAGCCGGCCATGCTTAACTCCATCCTGGCCCTGCAC
TGTCTGGGATATGCCAACGACCACCCGGCGGTGGCCAAGGGGCTGGACGCACTGGCCAACTTCTGCATCGAGGACGACGA
CTGCATCGTGCTGCAGTCCTGCGTCTCGCCGGTGTGGGACACGGCTTTGGCGCTGGTGGCGCTGCAGGAGGCGGACGTGC
CCGCCGACCATCCCGCCCTGGTCAAGGCAGCCCAGTGGCTTCTGAACCTTGAGGTGCGGCGCAAGGGGGACTGGCAGGTG
AAGTGCCCCGAACTGGAGCCGGGCGGCTGGGCCTTCGAGTTCCTCAACGACTGGTATCCGGACGTGGACGACTCCGGGTT
TGTCATGCTGTCCATCAAGAACATCAAGGTTCGTGACCGCAAGCATCGGGAAGAAGCCATCAAGCGAGGCATCGCCTGGT
GCCTGGGCATGCAGAGCGAGAACGGCGGCTGGGGCGCCTTCGACCGGAACAACACCAAGTACCTGCTCAACAAGATCCCC
TTTGCCGACCTGGAAGCGTTGATCGATCCCCCTACGGCGGATCTGACCGGCCGCATGCTGGAGCTGATGGGCAATTTCGA
CTACCCCAAAAGCCACCCCGCAGCCGAGCGTGCCCTGGCCTTCCTCAAGAAGGAGCAGGAGTCGGAAGGACCCTGGTGGG
GGCGCTGGGGGGTCAACTACCTCTACGGCACCTGGTCGGTACTCTGCGGCCTGGAGGCCATCGGCGAGGATATGAACCAG
CCCTACATCAGGAAGGCGGTCAACTGGATCAAATCCCGCCAGAACAACGACGGCGGCTGGGGCGAGGTGTGCGAGTCCTA
CTTTGACCGTTCCCTGATGGGGAGCGGGCCGAGCACCGCCTCCCAGACCGGTTGGGCGCTGCTGGCCCTGATGGCGGCCG
GAGAGGCCAACTCCCGGGCAGCGGCCCAGGGTGTCAAGTACCTTCTGGAGACCCAGAACGAGGACGGCACCTGGGATGAG
GATGCTTTTACCGGAACCGGTTTTCCCAAGTTCTTCATGATCAAGTATCACATCTATCGCAACTGCTTTCCGCTGACCGC
GCTGGGCAGATACCGCAGGCTGACCGCCGCCAAGGGGTAA

Upstream 100 bases:

>100_bases
GGAAAATGATATACATCCATTGATGTTTATGCTATAAAAGCAAAATTTGGCAGTTGTGCAGTTTCCGCTGCCCAGGCAGC
GGCTAACAGGAGCTTTGTGA

Downstream 100 bases:

>100_bases
GGCCGCAGGGCAGCACATTCGGCATTTATTTGCAGGAGGCCCCGAGTTCGCCGCAATCCGGGGCTTTCCCCTTTTTTGAG
CGGCCTGTTTTGGTACTACC

Product: squalene-hopene cyclase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 679; Mature: 679

Protein sequence:

>679_residues
MNPAKYKISSSLTSLNAEPVEQAPLPAKRTGSKVHRLPPSIWKKMVAEAKSPLDKGIERTRDFFLREQLPDGYWWAELES
NVTISAEYVMLFHFLGMVDRERERKLANYILAKQTSEGFWSLWHNGPGDLSTTIEAYFALKLAGYSADHPAMAKARAFVL
ANGGIIKARVFTKIFLALFGEFAWFGVPSMPIELMLLPDWAYFNMYEFSSWSRATIIPLSVVMSERPVRKLPPRAQVQEL
FVRPPRPTDYTITREDGLFTWKNFFIGADHLIKVYESSPIRPFKKRAVALAENWILEHQEQSGDWGGIQPAMLNSILALH
CLGYANDHPAVAKGLDALANFCIEDDDCIVLQSCVSPVWDTALALVALQEADVPADHPALVKAAQWLLNLEVRRKGDWQV
KCPELEPGGWAFEFLNDWYPDVDDSGFVMLSIKNIKVRDRKHREEAIKRGIAWCLGMQSENGGWGAFDRNNTKYLLNKIP
FADLEALIDPPTADLTGRMLELMGNFDYPKSHPAAERALAFLKKEQESEGPWWGRWGVNYLYGTWSVLCGLEAIGEDMNQ
PYIRKAVNWIKSRQNNDGGWGEVCESYFDRSLMGSGPSTASQTGWALLALMAAGEANSRAAAQGVKYLLETQNEDGTWDE
DAFTGTGFPKFFMIKYHIYRNCFPLTALGRYRRLTAAKG

Sequences:

>Translated_679_residues
MNPAKYKISSSLTSLNAEPVEQAPLPAKRTGSKVHRLPPSIWKKMVAEAKSPLDKGIERTRDFFLREQLPDGYWWAELES
NVTISAEYVMLFHFLGMVDRERERKLANYILAKQTSEGFWSLWHNGPGDLSTTIEAYFALKLAGYSADHPAMAKARAFVL
ANGGIIKARVFTKIFLALFGEFAWFGVPSMPIELMLLPDWAYFNMYEFSSWSRATIIPLSVVMSERPVRKLPPRAQVQEL
FVRPPRPTDYTITREDGLFTWKNFFIGADHLIKVYESSPIRPFKKRAVALAENWILEHQEQSGDWGGIQPAMLNSILALH
CLGYANDHPAVAKGLDALANFCIEDDDCIVLQSCVSPVWDTALALVALQEADVPADHPALVKAAQWLLNLEVRRKGDWQV
KCPELEPGGWAFEFLNDWYPDVDDSGFVMLSIKNIKVRDRKHREEAIKRGIAWCLGMQSENGGWGAFDRNNTKYLLNKIP
FADLEALIDPPTADLTGRMLELMGNFDYPKSHPAAERALAFLKKEQESEGPWWGRWGVNYLYGTWSVLCGLEAIGEDMNQ
PYIRKAVNWIKSRQNNDGGWGEVCESYFDRSLMGSGPSTASQTGWALLALMAAGEANSRAAAQGVKYLLETQNEDGTWDE
DAFTGTGFPKFFMIKYHIYRNCFPLTALGRYRRLTAAKG
>Mature_679_residues
MNPAKYKISSSLTSLNAEPVEQAPLPAKRTGSKVHRLPPSIWKKMVAEAKSPLDKGIERTRDFFLREQLPDGYWWAELES
NVTISAEYVMLFHFLGMVDRERERKLANYILAKQTSEGFWSLWHNGPGDLSTTIEAYFALKLAGYSADHPAMAKARAFVL
ANGGIIKARVFTKIFLALFGEFAWFGVPSMPIELMLLPDWAYFNMYEFSSWSRATIIPLSVVMSERPVRKLPPRAQVQEL
FVRPPRPTDYTITREDGLFTWKNFFIGADHLIKVYESSPIRPFKKRAVALAENWILEHQEQSGDWGGIQPAMLNSILALH
CLGYANDHPAVAKGLDALANFCIEDDDCIVLQSCVSPVWDTALALVALQEADVPADHPALVKAAQWLLNLEVRRKGDWQV
KCPELEPGGWAFEFLNDWYPDVDDSGFVMLSIKNIKVRDRKHREEAIKRGIAWCLGMQSENGGWGAFDRNNTKYLLNKIP
FADLEALIDPPTADLTGRMLELMGNFDYPKSHPAAERALAFLKKEQESEGPWWGRWGVNYLYGTWSVLCGLEAIGEDMNQ
PYIRKAVNWIKSRQNNDGGWGEVCESYFDRSLMGSGPSTASQTGWALLALMAAGEANSRAAAQGVKYLLETQNEDGTWDE
DAFTGTGFPKFFMIKYHIYRNCFPLTALGRYRRLTAAKG

Specific function: Catalyzes the cyclization of squalene into hopene [H]

COG id: COG1657

COG function: function code I; Squalene cyclase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 7 PFTB repeats [H]

Homologues:

Organism=Homo sapiens, GI224177558, Length=649, Percent_Identity=26.3482280431433, Blast_Score=182, Evalue=7e-46,
Organism=Homo sapiens, GI47933395, Length=649, Percent_Identity=26.3482280431433, Blast_Score=182, Evalue=8e-46,
Organism=Homo sapiens, GI47933397, Length=649, Percent_Identity=26.3482280431433, Blast_Score=182, Evalue=8e-46,
Organism=Homo sapiens, GI224177556, Length=574, Percent_Identity=27.7003484320557, Blast_Score=174, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI6321863, Length=657, Percent_Identity=25.1141552511416, Blast_Score=144, Evalue=5e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006400
- InterPro:   IPR001330
- InterPro:   IPR018333
- InterPro:   IPR002365
- InterPro:   IPR008930 [H]

Pfam domain/function: PF00432 Prenyltrans [H]

EC number: =5.4.99.17 [H]

Molecular weight: Translated: 76655; Mature: 76655

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPAKYKISSSLTSLNAEPVEQAPLPAKRTGSKVHRLPPSIWKKMVAEAKSPLDKGIERT
CCCCCEEHHHHHHHCCCCCCCCCCCCCHHCCCHHHCCCHHHHHHHHHHHHCHHHHHHHHH
RDFFLREQLPDGYWWAELESNVTISAEYVMLFHFLGMVDRERERKLANYILAKQTSEGFW
HHHHHHHHCCCCEEEEEECCCEEEEHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCHH
SLWHNGPGDLSTTIEAYFALKLAGYSADHPAMAKARAFVLANGGIIKARVFTKIFLALFG
HHHCCCCCCHHHHHHHHHHHEEECCCCCCCHHHHHEEEEEECCCEEHHHHHHHHHHHHHH
EFAWFGVPSMPIELMLLPDWAYFNMYEFSSWSRATIIPLSVVMSERPVRKLPPRAQVQEL
HHHHCCCCCCCEEEEEECCCHHEEEEECCCCCCEEEEEHHHHHCCCCHHHCCCHHHHHHH
FVRPPRPTDYTITREDGLFTWKNFFIGADHLIKVYESSPIRPFKKRAVALAENWILEHQE
HCCCCCCCCEEEECCCCCEEHHHHHCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCC
QSGDWGGIQPAMLNSILALHCLGYANDHPAVAKGLDALANFCIEDDDCIVLQSCVSPVWD
CCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHH
TALALVALQEADVPADHPALVKAAQWLLNLEVRRKGDWQVKCPELEPGGWAFEFLNDWYP
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHEECCCCCEEECCCCCCCCCHHHHHHHCCC
DVDDSGFVMLSIKNIKVRDRKHREEAIKRGIAWCLGMQSENGGWGAFDRNNTKYLLNKIP
CCCCCCEEEEEEECEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHCCC
FADLEALIDPPTADLTGRMLELMGNFDYPKSHPAAERALAFLKKEQESEGPWWGRWGVNY
HHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEECCCCHH
LYGTWSVLCGLEAIGEDMNQPYIRKAVNWIKSRQNNDGGWGEVCESYFDRSLMGSGPSTA
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCC
SQTGWALLALMAAGEANSRAAAQGVKYLLETQNEDGTWDEDAFTGTGFPKFFMIKYHIYR
CHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEEHHHH
NCFPLTALGRYRRLTAAKG
CCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNPAKYKISSSLTSLNAEPVEQAPLPAKRTGSKVHRLPPSIWKKMVAEAKSPLDKGIERT
CCCCCEEHHHHHHHCCCCCCCCCCCCCHHCCCHHHCCCHHHHHHHHHHHHCHHHHHHHHH
RDFFLREQLPDGYWWAELESNVTISAEYVMLFHFLGMVDRERERKLANYILAKQTSEGFW
HHHHHHHHCCCCEEEEEECCCEEEEHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCHH
SLWHNGPGDLSTTIEAYFALKLAGYSADHPAMAKARAFVLANGGIIKARVFTKIFLALFG
HHHCCCCCCHHHHHHHHHHHEEECCCCCCCHHHHHEEEEEECCCEEHHHHHHHHHHHHHH
EFAWFGVPSMPIELMLLPDWAYFNMYEFSSWSRATIIPLSVVMSERPVRKLPPRAQVQEL
HHHHCCCCCCCEEEEEECCCHHEEEEECCCCCCEEEEEHHHHHCCCCHHHCCCHHHHHHH
FVRPPRPTDYTITREDGLFTWKNFFIGADHLIKVYESSPIRPFKKRAVALAENWILEHQE
HCCCCCCCCEEEECCCCCEEHHHHHCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCC
QSGDWGGIQPAMLNSILALHCLGYANDHPAVAKGLDALANFCIEDDDCIVLQSCVSPVWD
CCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHH
TALALVALQEADVPADHPALVKAAQWLLNLEVRRKGDWQVKCPELEPGGWAFEFLNDWYP
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHEECCCCCEEECCCCCCCCCHHHHHHHCCC
DVDDSGFVMLSIKNIKVRDRKHREEAIKRGIAWCLGMQSENGGWGAFDRNNTKYLLNKIP
CCCCCCEEEEEEECEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHCCC
FADLEALIDPPTADLTGRMLELMGNFDYPKSHPAAERALAFLKKEQESEGPWWGRWGVNY
HHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEECCCCHH
LYGTWSVLCGLEAIGEDMNQPYIRKAVNWIKSRQNNDGGWGEVCESYFDRSLMGSGPSTA
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCC
SQTGWALLALMAAGEANSRAAAQGVKYLLETQNEDGTWDEDAFTGTGFPKFFMIKYHIYR
CHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEEHHHH
NCFPLTALGRYRRLTAAKG
CCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1729216; 9532806; 2253626; 9295270; 9931258 [H]