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The map label for this gene is czcD [H]

Identifier: 118579305

GI number: 118579305

Start: 910782

End: 911711

Strand: Reverse

Name: czcD [H]

Synonym: Ppro_0868

Alternate gene names: 118579305

Gene position: 911711-910782 (Counterclockwise)

Preceding gene: 118579306

Following gene: 118579304

Centisome position: 22.75

GC content: 66.02

Gene sequence:

>930_bases
ATGACCGACCTTGACCAGAACATATCGCGACGCCTGCAGTTCGCCATCACCCTGACCGCCGTCACCCTGGTGGCGGAGAT
CATCGGCGGAATCTGGTCCAACTCCCTGGCGCTCCTCTCCGATGCGGGGCACGTGTTTCTGGACCTGTTCGCCCTGCTGC
TCTCCCTGGGCGCCATACGGCTGGCCTCCCGGGCGCCCAGCGAACGGCACTCCTTTGGCCTGCACCGGGCCGAGGTGCTG
GCCTCGTTGGTCAACGGCCTGACCGTGCTGCTCATGGCCATAGCCATCCTCTACGAGGGGGGCAAGCGGCTGATCGCGCC
GGAAGAGGTCAAGACCGTTCCCATGCTGGTCATCGCCGTGGTGGGACTGGTGGCCAACCTGTTGGCTGCCCGGGGATTGC
ACGGACACGCCCACGACGACCTGAACGTGCGCAGCGCCTTCCTGCACGTCCTGGGGGACGCGGCAGCCTCGGTGGGGGTC
ATCGCCGGCGCGCTGCTGATGCGCCTCACCGGCTGGTACCTGGCCGACCCGATCATCTCCATCGCCATCGGCCTGCTGAT
TCTCTGTGGTGCCGGCCGGGTGCTGCGGGACTCGCTGCACATCCTGATGGAGGGGGTGCCGCGGGGACTGTCGGTGGAGA
AGGTGGCTGAGCGGATACGGGAGATCGACGGCGTAAAGGACATCCACCACCTGAACATCTGGACGGTCTGTTCCCACATC
ATCGCCCTGTCGGTCCATGTGGAGGTACGTGAGGAATACACCGGACAACGGGGGGAACTGGTGCACGCCATCGAGCATGC
CCTGCACCACGACTTCCACATCACCCACACCACCATCCAGCTGGAGTGCTCCACCTGCAACGGCGGGCCGCTGATCAAGC
CCCTGCGCCACAGCGAACGCCACGCCGACTGCCAGGGGCATGGGCACTGA

Upstream 100 bases:

>100_bases
GCAAATCCCCCCCAGCCCCCCTTTTCCAAAGGGGGGAGCGGTTGAATTCAGCCCAGCCGAAGATTGCTCACTGGAGGAAA
AGCAGAGCAGAGAGGCAGCC

Downstream 100 bases:

>100_bases
CTGCCGGCCCACTCTTCTTCGCTGGTAGCGCATGCGAAGTGCCGCATGGGCTGACCGCCCGACGGCACGTCCCAAGAATC
TGCTCCATTCATCGCCGAAC

Product: cation diffusion facilitator family transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 309; Mature: 308

Protein sequence:

>309_residues
MTDLDQNISRRLQFAITLTAVTLVAEIIGGIWSNSLALLSDAGHVFLDLFALLLSLGAIRLASRAPSERHSFGLHRAEVL
ASLVNGLTVLLMAIAILYEGGKRLIAPEEVKTVPMLVIAVVGLVANLLAARGLHGHAHDDLNVRSAFLHVLGDAAASVGV
IAGALLMRLTGWYLADPIISIAIGLLILCGAGRVLRDSLHILMEGVPRGLSVEKVAERIREIDGVKDIHHLNIWTVCSHI
IALSVHVEVREEYTGQRGELVHAIEHALHHDFHITHTTIQLECSTCNGGPLIKPLRHSERHADCQGHGH

Sequences:

>Translated_309_residues
MTDLDQNISRRLQFAITLTAVTLVAEIIGGIWSNSLALLSDAGHVFLDLFALLLSLGAIRLASRAPSERHSFGLHRAEVL
ASLVNGLTVLLMAIAILYEGGKRLIAPEEVKTVPMLVIAVVGLVANLLAARGLHGHAHDDLNVRSAFLHVLGDAAASVGV
IAGALLMRLTGWYLADPIISIAIGLLILCGAGRVLRDSLHILMEGVPRGLSVEKVAERIREIDGVKDIHHLNIWTVCSHI
IALSVHVEVREEYTGQRGELVHAIEHALHHDFHITHTTIQLECSTCNGGPLIKPLRHSERHADCQGHGH
>Mature_308_residues
TDLDQNISRRLQFAITLTAVTLVAEIIGGIWSNSLALLSDAGHVFLDLFALLLSLGAIRLASRAPSERHSFGLHRAEVLA
SLVNGLTVLLMAIAILYEGGKRLIAPEEVKTVPMLVIAVVGLVANLLAARGLHGHAHDDLNVRSAFLHVLGDAAASVGVI
AGALLMRLTGWYLADPIISIAIGLLILCGAGRVLRDSLHILMEGVPRGLSVEKVAERIREIDGVKDIHHLNIWTVCSHII
ALSVHVEVREEYTGQRGELVHAIEHALHHDFHITHTTIQLECSTCNGGPLIKPLRHSERHADCQGHGH

Specific function: Involved in divalent cation and potassium homeostasis in the cell. Catalyzes the active efflux of zinc, cadmium and cobalt, in exchange for potassium and H(+) ions [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI21359890, Length=320, Percent_Identity=31.25, Blast_Score=158, Evalue=5e-39,
Organism=Homo sapiens, GI52352805, Length=301, Percent_Identity=29.9003322259136, Blast_Score=145, Evalue=5e-35,
Organism=Homo sapiens, GI289803013, Length=284, Percent_Identity=34.1549295774648, Blast_Score=144, Evalue=8e-35,
Organism=Homo sapiens, GI289803009, Length=284, Percent_Identity=34.1549295774648, Blast_Score=144, Evalue=8e-35,
Organism=Homo sapiens, GI289803007, Length=284, Percent_Identity=34.1549295774648, Blast_Score=144, Evalue=8e-35,
Organism=Homo sapiens, GI289803003, Length=284, Percent_Identity=34.1549295774648, Blast_Score=144, Evalue=8e-35,
Organism=Homo sapiens, GI64762489, Length=284, Percent_Identity=34.1549295774648, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI20070323, Length=320, Percent_Identity=27.5, Blast_Score=127, Evalue=9e-30,
Organism=Homo sapiens, GI21361112, Length=315, Percent_Identity=28.5714285714286, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI14210520, Length=232, Percent_Identity=29.3103448275862, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI222080086, Length=125, Percent_Identity=38.4, Blast_Score=88, Evalue=9e-18,
Organism=Homo sapiens, GI40255009, Length=125, Percent_Identity=38.4, Blast_Score=88, Evalue=9e-18,
Organism=Homo sapiens, GI301898545, Length=256, Percent_Identity=25.390625, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI21687224, Length=256, Percent_Identity=25.390625, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI52351208, Length=153, Percent_Identity=28.1045751633987, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1786966, Length=286, Percent_Identity=41.2587412587413, Blast_Score=177, Evalue=7e-46,
Organism=Caenorhabditis elegans, GI193210990, Length=314, Percent_Identity=30.8917197452229, Blast_Score=163, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17555796, Length=297, Percent_Identity=33.3333333333333, Blast_Score=155, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17555794, Length=297, Percent_Identity=33.3333333333333, Blast_Score=155, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI32564488, Length=307, Percent_Identity=30.6188925081433, Blast_Score=126, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17550442, Length=129, Percent_Identity=31.0077519379845, Blast_Score=66, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17550440, Length=129, Percent_Identity=31.0077519379845, Blast_Score=65, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6323899, Length=133, Percent_Identity=35.3383458646617, Blast_Score=83, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6320411, Length=181, Percent_Identity=34.8066298342541, Blast_Score=80, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6324892, Length=215, Percent_Identity=27.4418604651163, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24583858, Length=321, Percent_Identity=29.9065420560748, Blast_Score=136, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24656728, Length=340, Percent_Identity=29.4117647058824, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24656724, Length=340, Percent_Identity=29.4117647058824, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24656720, Length=340, Percent_Identity=29.4117647058824, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24656715, Length=340, Percent_Identity=29.4117647058824, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI21357035, Length=340, Percent_Identity=29.4117647058824, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24584409, Length=204, Percent_Identity=29.4117647058824, Blast_Score=91, Evalue=7e-19,
Organism=Drosophila melanogaster, GI28574430, Length=204, Percent_Identity=29.4117647058824, Blast_Score=91, Evalue=9e-19,
Organism=Drosophila melanogaster, GI24585900, Length=153, Percent_Identity=32.0261437908497, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24585898, Length=153, Percent_Identity=32.0261437908497, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24585896, Length=153, Percent_Identity=32.0261437908497, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI19921672, Length=153, Percent_Identity=32.0261437908497, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24645863, Length=109, Percent_Identity=42.2018348623853, Blast_Score=83, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 33390; Mature: 33258

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCCCCC
>Mature Secondary Structure 
TDLDQNISRRLQFAITLTAVTLVAEIIGGIWSNSLALLSDAGHVFLDLFALLLSLGAIR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHHHHHH
LASRAPSERHSFGLHRAEVLASLVNGLTVLLMAIAILYEGGKRLIAPEEVKTVPMLVIAV
HHHCCCCHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
VGLVANLLAARGLHGHAHDDLNVRSAFLHVLGDAAASVGVIAGALLMRLTGWYLADPIIS
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IAIGLLILCGAGRVLRDSLHILMEGVPRGLSVEKVAERIREIDGVKDIHHLNIWTVCSHI
HHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
IALSVHVEVREEYTGQRGELVHAIEHALHHDFHITHTTIQLECSTCNGGPLIKPLRHSER
HHHHHHEEEHHHHCCCCHHHHHHHHHHHHCCCEEEEEEEEEEEECCCCCCCCCHHHCCCC
HADCQGHGH
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377; 9099864 [H]