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The map label for this gene is cobD [H]

Identifier: 118579306

GI number: 118579306

Start: 912180

End: 913256

Strand: Reverse

Name: cobD [H]

Synonym: Ppro_0869

Alternate gene names: 118579306

Gene position: 913256-912180 (Counterclockwise)

Preceding gene: 118579307

Following gene: 118579305

Centisome position: 22.79

GC content: 63.05

Gene sequence:

>1077_bases
ATGTCACACAGCTATGAGCACGGCGGCAACCTGTTTTCCCTGGCCCGCCAGCGCGGCTTTTCCCCCGCCGATTCCATCGA
CTTCTCGGCCAGCATCAACCCGCTGGGCATCTCCCCCCGGGTCAGGGAGGCCATCACCCAGGCGCTGGACAGCCTGGTGC
ACTACCCGGACAACGATTGCGGCGAGCTGAGGCAGACCCTCTCCCAGGTCCACGGTGTCCCGCCGGAGTACTTCGCCATC
GCCAACGGCTCCACTGAGACCATCTACAACCTGCCTTCCCTGCTGCCGGGCAAGAGCGCCCTGATCGTCTCCCCCTCCTT
CAGCGAATACGCCTATGCCCTGTTGCAGCACCACTGCGAGGTGCGTCACCTGATCCTCTCGCCAAGCGACAACTTCTCCC
TGGATTTGGGTACATTGGCCAATGCACTGGCCGAGGATTACGACGCCCTCTACCTGTGCAACCCGGGCAACCCCAGCGGC
ACCCTCTACCCGCGGGAACTGGTGGAGCAGGTCTACGCCCTCTGTAAGGACACGGACACTTTCCTGGTGCTGGACGAGGC
CTTCATGGATTTCTGCGAGCAGGCCTCGGCCAAAGATATCATCATCGCCTCGGATCATGGCATCGTGCTGCGCTCCATGA
CCAAGTTCTACGGCATACCCGGCCTGCGGCTGGGATACGCCATGGCCGCGCCATCCCTGATCGAACGCCTGACCTCCATG
GGCGGCCCCTGGAGCGTCAACACCCTGGCCCAGGTGGCTGGCATAGCCGCCCTGAATGACGGGGAATATGCCCGACGCTC
CGTGGAGTATGTCACCGAACTGCGCCAGGCACTCGGCCAGGCGCTCTCCGACTTCCCCCAACTCACCGTCTACCCCTCCA
GCGCCAACTTCCTGCTGGTGGAGTTGGACGCCACCATCACCTCCAGTGAGCTGAAAGAGCGGCTGGTGGAAAAGCAGATC
CTGATCCGCGACTGCAGCAGCTTCGCTGGTCTCTCCAACCGCTTCTTCCGCGTGGCCGTGCGCACGGAAGCGGAAAACGC
TCGTCTGCTGGAATGCCTGGGCGAAATCCTCGCCTAA

Upstream 100 bases:

>100_bases
GACGGCCAGGCCTATCGCGGCATGATCAGACTGATGTACGCCACCACCCTTGCCATGGCCGTCATCTCCCTGGCAACGGC
CGCACTCCTGAGAGGTATCC

Downstream 100 bases:

>100_bases
CCGCATCACATGCCGCACACGAAAAAGGGGCGCCCCGCTGGCGCCCCTTTTTTCATTTCTGTCCCCCCTACAACATGAAG
TGTTCCACCAGCCGCCGCAC

Product: putative L-threonine-O-3-phosphate decarboxylase

Products: NA

Alternate protein names: L-threonine-O-3-phosphate decarboxylase [H]

Number of amino acids: Translated: 358; Mature: 357

Protein sequence:

>358_residues
MSHSYEHGGNLFSLARQRGFSPADSIDFSASINPLGISPRVREAITQALDSLVHYPDNDCGELRQTLSQVHGVPPEYFAI
ANGSTETIYNLPSLLPGKSALIVSPSFSEYAYALLQHHCEVRHLILSPSDNFSLDLGTLANALAEDYDALYLCNPGNPSG
TLYPRELVEQVYALCKDTDTFLVLDEAFMDFCEQASAKDIIIASDHGIVLRSMTKFYGIPGLRLGYAMAAPSLIERLTSM
GGPWSVNTLAQVAGIAALNDGEYARRSVEYVTELRQALGQALSDFPQLTVYPSSANFLLVELDATITSSELKERLVEKQI
LIRDCSSFAGLSNRFFRVAVRTEAENARLLECLGEILA

Sequences:

>Translated_358_residues
MSHSYEHGGNLFSLARQRGFSPADSIDFSASINPLGISPRVREAITQALDSLVHYPDNDCGELRQTLSQVHGVPPEYFAI
ANGSTETIYNLPSLLPGKSALIVSPSFSEYAYALLQHHCEVRHLILSPSDNFSLDLGTLANALAEDYDALYLCNPGNPSG
TLYPRELVEQVYALCKDTDTFLVLDEAFMDFCEQASAKDIIIASDHGIVLRSMTKFYGIPGLRLGYAMAAPSLIERLTSM
GGPWSVNTLAQVAGIAALNDGEYARRSVEYVTELRQALGQALSDFPQLTVYPSSANFLLVELDATITSSELKERLVEKQI
LIRDCSSFAGLSNRFFRVAVRTEAENARLLECLGEILA
>Mature_357_residues
SHSYEHGGNLFSLARQRGFSPADSIDFSASINPLGISPRVREAITQALDSLVHYPDNDCGELRQTLSQVHGVPPEYFAIA
NGSTETIYNLPSLLPGKSALIVSPSFSEYAYALLQHHCEVRHLILSPSDNFSLDLGTLANALAEDYDALYLCNPGNPSGT
LYPRELVEQVYALCKDTDTFLVLDEAFMDFCEQASAKDIIIASDHGIVLRSMTKFYGIPGLRLGYAMAAPSLIERLTSMG
GPWSVNTLAQVAGIAALNDGEYARRSVEYVTELRQALGQALSDFPQLTVYPSSANFLLVELDATITSSELKERLVEKQIL
IRDCSSFAGLSNRFFRVAVRTEAENARLLECLGEILA

Specific function: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1- amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin [H]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=310, Percent_Identity=28.3870967741935, Blast_Score=106, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6322075, Length=303, Percent_Identity=25.0825082508251, Blast_Score=86, Evalue=9e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005860
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.1.1.81 [H]

Molecular weight: Translated: 39185; Mature: 39054

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHSYEHGGNLFSLARQRGFSPADSIDFSASINPLGISPRVREAITQALDSLVHYPDNDC
CCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCH
GELRQTLSQVHGVPPEYFAIANGSTETIYNLPSLLPGKSALIVSPSFSEYAYALLQHHCE
HHHHHHHHHHHCCCCCCEEEECCCCHHHHCCCCCCCCCCEEEECCCHHHHHHHHHHHHHH
VRHLILSPSDNFSLDLGTLANALAEDYDALYLCNPGNPSGTLYPRELVEQVYALCKDTDT
HEEEEECCCCCCEEEHHHHHHHHHHCCCEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCC
FLVLDEAFMDFCEQASAKDIIIASDHGIVLRSMTKFYGIPGLRLGYAMAAPSLIERLTSM
EEEEHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHC
GGPWSVNTLAQVAGIAALNDGEYARRSVEYVTELRQALGQALSDFPQLTVYPSSANFLLV
CCCCCHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEE
ELDATITSSELKERLVEKQILIRDCSSFAGLSNRFFRVAVRTEAENARLLECLGEILA
EECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHC
>Mature Secondary Structure 
SHSYEHGGNLFSLARQRGFSPADSIDFSASINPLGISPRVREAITQALDSLVHYPDNDC
CCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCH
GELRQTLSQVHGVPPEYFAIANGSTETIYNLPSLLPGKSALIVSPSFSEYAYALLQHHCE
HHHHHHHHHHHCCCCCCEEEECCCCHHHHCCCCCCCCCCEEEECCCHHHHHHHHHHHHHH
VRHLILSPSDNFSLDLGTLANALAEDYDALYLCNPGNPSGTLYPRELVEQVYALCKDTDT
HEEEEECCCCCCEEEHHHHHHHHHHCCCEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCC
FLVLDEAFMDFCEQASAKDIIIASDHGIVLRSMTKFYGIPGLRLGYAMAAPSLIERLTSM
EEEEHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHC
GGPWSVNTLAQVAGIAALNDGEYARRSVEYVTELRQALGQALSDFPQLTVYPSSANFLLV
CCCCCHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEE
ELDATITSSELKERLVEKQILIRDCSSFAGLSNRFFRVAVRTEAENARLLECLGEILA
EECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]