Click here to switch to the map view.

The map label for this gene is serA [H]

Identifier: 118579173

GI number: 118579173

Start: 772422

End: 773594

Strand: Reverse

Name: serA [H]

Synonym: Ppro_0734

Alternate gene names: 118579173

Gene position: 773594-772422 (Counterclockwise)

Preceding gene: 118579174

Following gene: 118579172

Centisome position: 19.3

GC content: 62.15

Gene sequence:

>1173_bases
ATGTACAAGATACAGACACTTAACAAGATCGCGCGCTGCGGCCTGGACCAGCTGTCCCGCGACACGTACGAGGCCGCCAC
CGAGATACTCAACCCGGACGCCATCCTGGTGCGCTCGGCGGACATGCACTCCATGGAACTCCCCCCCAGCGTGCTGGCCA
TCGCCCGGGCAGGGGCTGGAGTCAACAACATCCCCATCCCTGCCTGCACCCAGCGGGGCATCGTCGTGTTCAACACCCCC
GGCGCAAATGCCAACGGCGTCAAGGAACTGGTCATCGCGTCCCTGTTCCTCTCCAGCCGCAACCTGTACGAGGGGATCAG
CTGGGCCAACAGCCTGGCGGGAACCGAAAACATCCCCGAGCAGATCGAGAAGGGGAAATCCCGCTTCGTGGGACCGGAGA
TCCAGGGCAAGACCCTGGGCGTGATCGGCCTGGGTGCAATCGGGGTAATGGTGGCCAATTCCGCCGCCAACCTGGGCATG
CGGGTGCTGGGGCTGGACCCCTTTATCAGCGTGGAAGCGGCCTGGAAACTCTCCCACGAGGTGATCAAGGCACCCAATCT
GGATATGCTGCTGGCCGAGTCGGACTACATCACCATCCACATTCCGCTCAAAGACGACACCAAGGGGCTGTTCAACGCCG
AGCGCATCTCCCGCATGAAGAAGGGGGCGCGCCTGCTCAACTTCAGCCGTTCCGGGCTGGTGGACAACACGGCCGTCAAG
ACGGCCATCGCCGAGGGACAGCTGGGGGGCTACGTGATCGACTTCCCCGAAGCCGAGCTGCTGGGGGTTGACAAGGTTCT
CTGCATCCCCCACCTGGGCGCTTCCACCCCCGAGAGCGAGGACAACTGCGCGATCATGGCGGCCGAGCAGCTCCGGGAAT
ACCTGGAGCGCGGCAACATCAAAAACTCGGTCAACTATCCCAACTGCGAGATGGCTCCCACCGGCAAGACCCGCATCACT
CTTTTGAATAGCAACGTGCCCAAGGTCATCAGCCGCATCACCTCCACCCTGGGCGAATACGGGCTGAACATCGACGAGAT
GCTCAACAAGAACAGGGGCGAAGTGGCCTACAACATCATCGATGTCTCCGACAGCGTACCCGACGAGCTGATTGAAAAGC
TCCGGCAGGTGGACGGGGTCGTTGCGGTGCGGCTGATCCCCGACTGCCAGTAA

Upstream 100 bases:

>100_bases
CCTCCGGGCATACCGGCTAGCCTCCACTGATTGTTCTTCACTTCTGTGGCTGACTCTCGTTTCAGGACAAAAAACTACCA
AAGCAGGTATGGACAGACCC

Downstream 100 bases:

>100_bases
CGGCACCCCATCCCCGTAAAGACCACAAGCCCCGCCGGCATCAATGCCGGCGGGGCTTGTGCCATTCCACGTCCGGCAGT
TTCAGGATACCGTTTCCAGG

Product: NAD-binding D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MYKIQTLNKIARCGLDQLSRDTYEAATEILNPDAILVRSADMHSMELPPSVLAIARAGAGVNNIPIPACTQRGIVVFNTP
GANANGVKELVIASLFLSSRNLYEGISWANSLAGTENIPEQIEKGKSRFVGPEIQGKTLGVIGLGAIGVMVANSAANLGM
RVLGLDPFISVEAAWKLSHEVIKAPNLDMLLAESDYITIHIPLKDDTKGLFNAERISRMKKGARLLNFSRSGLVDNTAVK
TAIAEGQLGGYVIDFPEAELLGVDKVLCIPHLGASTPESEDNCAIMAAEQLREYLERGNIKNSVNYPNCEMAPTGKTRIT
LLNSNVPKVISRITSTLGEYGLNIDEMLNKNRGEVAYNIIDVSDSVPDELIEKLRQVDGVVAVRLIPDCQ

Sequences:

>Translated_390_residues
MYKIQTLNKIARCGLDQLSRDTYEAATEILNPDAILVRSADMHSMELPPSVLAIARAGAGVNNIPIPACTQRGIVVFNTP
GANANGVKELVIASLFLSSRNLYEGISWANSLAGTENIPEQIEKGKSRFVGPEIQGKTLGVIGLGAIGVMVANSAANLGM
RVLGLDPFISVEAAWKLSHEVIKAPNLDMLLAESDYITIHIPLKDDTKGLFNAERISRMKKGARLLNFSRSGLVDNTAVK
TAIAEGQLGGYVIDFPEAELLGVDKVLCIPHLGASTPESEDNCAIMAAEQLREYLERGNIKNSVNYPNCEMAPTGKTRIT
LLNSNVPKVISRITSTLGEYGLNIDEMLNKNRGEVAYNIIDVSDSVPDELIEKLRQVDGVVAVRLIPDCQ
>Mature_390_residues
MYKIQTLNKIARCGLDQLSRDTYEAATEILNPDAILVRSADMHSMELPPSVLAIARAGAGVNNIPIPACTQRGIVVFNTP
GANANGVKELVIASLFLSSRNLYEGISWANSLAGTENIPEQIEKGKSRFVGPEIQGKTLGVIGLGAIGVMVANSAANLGM
RVLGLDPFISVEAAWKLSHEVIKAPNLDMLLAESDYITIHIPLKDDTKGLFNAERISRMKKGARLLNFSRSGLVDNTAVK
TAIAEGQLGGYVIDFPEAELLGVDKVLCIPHLGASTPESEDNCAIMAAEQLREYLERGNIKNSVNYPNCEMAPTGKTRIT
LLNSNVPKVISRITSTLGEYGLNIDEMLNKNRGEVAYNIIDVSDSVPDELIEKLRQVDGVVAVRLIPDCQ

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=294, Percent_Identity=31.9727891156463, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI61743967, Length=267, Percent_Identity=30.3370786516854, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI4557497, Length=267, Percent_Identity=30.3370786516854, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI145580578, Length=267, Percent_Identity=30.7116104868914, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI4557499, Length=267, Percent_Identity=30.7116104868914, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI145580575, Length=267, Percent_Identity=30.3370786516854, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI6912396, Length=246, Percent_Identity=26.4227642276423, Blast_Score=82, Evalue=1e-15,
Organism=Escherichia coli, GI1789279, Length=340, Percent_Identity=31.1764705882353, Blast_Score=149, Evalue=4e-37,
Organism=Escherichia coli, GI87082289, Length=275, Percent_Identity=28, Blast_Score=105, Evalue=5e-24,
Organism=Escherichia coli, GI1787645, Length=213, Percent_Identity=32.3943661971831, Blast_Score=91, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17532191, Length=272, Percent_Identity=33.4558823529412, Blast_Score=142, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI25147481, Length=252, Percent_Identity=25.3968253968254, Blast_Score=97, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6320925, Length=359, Percent_Identity=28.6908077994429, Blast_Score=147, Evalue=4e-36,
Organism=Saccharomyces cerevisiae, GI6322116, Length=359, Percent_Identity=28.4122562674095, Blast_Score=145, Evalue=9e-36,
Organism=Saccharomyces cerevisiae, GI6324055, Length=265, Percent_Identity=27.9245283018868, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6324964, Length=215, Percent_Identity=27.906976744186, Blast_Score=73, Evalue=6e-14,
Organism=Drosophila melanogaster, GI19921140, Length=288, Percent_Identity=35.4166666666667, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24646446, Length=277, Percent_Identity=30.6859205776173, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI24646448, Length=277, Percent_Identity=30.6859205776173, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI24646452, Length=277, Percent_Identity=30.6859205776173, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI24646450, Length=277, Percent_Identity=30.6859205776173, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI62472511, Length=277, Percent_Identity=30.6859205776173, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI45552429, Length=262, Percent_Identity=26.3358778625954, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24585514, Length=262, Percent_Identity=26.3358778625954, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI28574282, Length=262, Percent_Identity=26.3358778625954, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI45551003, Length=262, Percent_Identity=26.3358778625954, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI28574284, Length=262, Percent_Identity=26.3358778625954, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI28574286, Length=257, Percent_Identity=26.8482490272374, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24585516, Length=252, Percent_Identity=24.6031746031746, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI28571528, Length=255, Percent_Identity=25.8823529411765, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 42109; Mature: 42109

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYKIQTLNKIARCGLDQLSRDTYEAATEILNPDAILVRSADMHSMELPPSVLAIARAGAG
CCCCHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHCCCC
VNNIPIPACTQRGIVVFNTPGANANGVKELVIASLFLSSRNLYEGISWANSLAGTENIPE
CCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCHH
QIEKGKSRFVGPEIQGKTLGVIGLGAIGVMVANSAANLGMRVLGLDPFISVEAAWKLSHE
HHHHHHHHCCCCCCCCCEEEEEEHHHHHHHHCCCHHHCCEEEECCCCCEEHHHHHHHHHH
VIKAPNLDMLLAESDYITIHIPLKDDTKGLFNAERISRMKKGARLLNFSRSGLVDNTAVK
HHCCCCCCEEEECCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
TAIAEGQLGGYVIDFPEAELLGVDKVLCIPHLGASTPESEDNCAIMAAEQLREYLERGNI
HHHHCCCCCCEEEECCCHHHHCCCEEEEECCCCCCCCCCCCCEEEEEHHHHHHHHHHCCC
KNSVNYPNCEMAPTGKTRITLLNSNVPKVISRITSTLGEYGLNIDEMLNKNRGEVAYNII
CCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCHHHHHCCCCCCEEEEEE
DVSDSVPDELIEKLRQVDGVVAVRLIPDCQ
ECCCCCHHHHHHHHHHHCCEEEEEECCCCC
>Mature Secondary Structure
MYKIQTLNKIARCGLDQLSRDTYEAATEILNPDAILVRSADMHSMELPPSVLAIARAGAG
CCCCHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHCCCC
VNNIPIPACTQRGIVVFNTPGANANGVKELVIASLFLSSRNLYEGISWANSLAGTENIPE
CCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCHH
QIEKGKSRFVGPEIQGKTLGVIGLGAIGVMVANSAANLGMRVLGLDPFISVEAAWKLSHE
HHHHHHHHCCCCCCCCCEEEEEEHHHHHHHHCCCHHHCCEEEECCCCCEEHHHHHHHHHH
VIKAPNLDMLLAESDYITIHIPLKDDTKGLFNAERISRMKKGARLLNFSRSGLVDNTAVK
HHCCCCCCEEEECCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
TAIAEGQLGGYVIDFPEAELLGVDKVLCIPHLGASTPESEDNCAIMAAEQLREYLERGNI
HHHHCCCCCCEEEECCCHHHHCCCEEEEECCCCCCCCCCCCCEEEEEHHHHHHHHHHCCC
KNSVNYPNCEMAPTGKTRITLLNSNVPKVISRITSTLGEYGLNIDEMLNKNRGEVAYNII
CCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCHHHHHCCCCCCEEEEEE
DVSDSVPDELIEKLRQVDGVVAVRLIPDCQ
ECCCCCHHHHHHHHHHHCCEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]