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The map label for this gene is adk

Identifier: 118579140

GI number: 118579140

Start: 732632

End: 733294

Strand: Direct

Name: adk

Synonym: Ppro_0701

Alternate gene names: 118579140

Gene position: 732632-733294 (Clockwise)

Preceding gene: 118579139

Following gene: 118579141

Centisome position: 18.28

GC content: 45.7

Gene sequence:

>663_bases
ATGAACGTAATACTTTTTGGCCCTCCGGGGGCTGGTAAAGGCACTCAGGCTCAGTATGTTGTAGAACGATTTGGGATTCC
TCAAATATCTACCGGTGATATGCTGCGTGCTGCAGTAAAGAATTGTACTCCGCTTGGTCTTAAGGCCAAGGAGATAATGG
ATGCGGGCGGTCTTGTTTCTGATGAAATCGTACTCGGTATAGTCGCTGATAGGCTATCTTGTGAAGATTGTGGTACTGGT
TTTGTGCTGGACGGTTTTCCTCGGACAATACCTCAAGCTGAGGCATTGATTGAAATCCTTGCATGCTTAGGAAAACAAAC
TGATCATGTTATTTCTCTTGAAGTGTCAAATGACGAAATTACTCGACGCTTGTCTGGTCGTCGTACTTGTCCTTCTTGTG
GTAAAGGTTTTCATGTGCTTTTTGCTCCACCCAGAAAGGCGGGAGTTTGCGATTTCTGTGGTGCGGACTTGGTTCAGAGG
GGAGACGACCACCCTGAGTCCATATGTAACCGGTTGAGTGTATACGAAAAGCAGACATCACCTCTGAAAGCGTTTTATGC
ACAAAAAGGACTTTTGAGGGCTGTTGACGGTAGTCTGCCTGTAGAACAGATACAATTGCAGATTCGGAAGGTGTTGGAAG
GTTGCTCTAGTGATTGTGCTTAA

Upstream 100 bases:

>100_bases
TTGGCGTTGGGATGGATACTGTTTCGCAGATAGAATCTCATTTGATTACGCGAAGCTATGAAGGTTTTATGAAGGGTGTT
CGAATTCGAGGAAGAAGGTA

Downstream 100 bases:

>100_bases
ATCTCTCCGTGAGATTGAACGGATGAGAGTAGCTTGCAGATTGGTTGCCGAAGTCCTTGAGATGCTGAAAGAAGCTGTAA
GGCCGGGTGTATCGACTTGC

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 220; Mature: 220

Protein sequence:

>220_residues
MNVILFGPPGAGKGTQAQYVVERFGIPQISTGDMLRAAVKNCTPLGLKAKEIMDAGGLVSDEIVLGIVADRLSCEDCGTG
FVLDGFPRTIPQAEALIEILACLGKQTDHVISLEVSNDEITRRLSGRRTCPSCGKGFHVLFAPPRKAGVCDFCGADLVQR
GDDHPESICNRLSVYEKQTSPLKAFYAQKGLLRAVDGSLPVEQIQLQIRKVLEGCSSDCA

Sequences:

>Translated_220_residues
MNVILFGPPGAGKGTQAQYVVERFGIPQISTGDMLRAAVKNCTPLGLKAKEIMDAGGLVSDEIVLGIVADRLSCEDCGTG
FVLDGFPRTIPQAEALIEILACLGKQTDHVISLEVSNDEITRRLSGRRTCPSCGKGFHVLFAPPRKAGVCDFCGADLVQR
GDDHPESICNRLSVYEKQTSPLKAFYAQKGLLRAVDGSLPVEQIQLQIRKVLEGCSSDCA
>Mature_220_residues
MNVILFGPPGAGKGTQAQYVVERFGIPQISTGDMLRAAVKNCTPLGLKAKEIMDAGGLVSDEIVLGIVADRLSCEDCGTG
FVLDGFPRTIPQAEALIEILACLGKQTDHVISLEVSNDEITRRLSGRRTCPSCGKGFHVLFAPPRKAGVCDFCGADLVQR
GDDHPESICNRLSVYEKQTSPLKAFYAQKGLLRAVDGSLPVEQIQLQIRKVLEGCSSDCA

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI7524346, Length=198, Percent_Identity=41.4141414141414, Blast_Score=170, Evalue=1e-42,
Organism=Homo sapiens, GI4502013, Length=198, Percent_Identity=41.4141414141414, Blast_Score=169, Evalue=1e-42,
Organism=Homo sapiens, GI19923437, Length=198, Percent_Identity=36.3636363636364, Blast_Score=146, Evalue=1e-35,
Organism=Homo sapiens, GI310110345, Length=198, Percent_Identity=35.8585858585859, Blast_Score=132, Evalue=2e-31,
Organism=Homo sapiens, GI53832003, Length=198, Percent_Identity=35.8585858585859, Blast_Score=132, Evalue=2e-31,
Organism=Homo sapiens, GI8051579, Length=198, Percent_Identity=35.8585858585859, Blast_Score=132, Evalue=2e-31,
Organism=Homo sapiens, GI53832001, Length=198, Percent_Identity=35.8585858585859, Blast_Score=132, Evalue=2e-31,
Organism=Homo sapiens, GI4502011, Length=207, Percent_Identity=30.4347826086957, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI22749187, Length=185, Percent_Identity=28.6486486486486, Blast_Score=91, Evalue=8e-19,
Organism=Homo sapiens, GI28144897, Length=209, Percent_Identity=26.7942583732057, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI28144899, Length=209, Percent_Identity=26.7942583732057, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI1786680, Length=217, Percent_Identity=47.0046082949309, Blast_Score=209, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI17552384, Length=212, Percent_Identity=38.2075471698113, Blast_Score=162, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17537943, Length=192, Percent_Identity=30.7291666666667, Blast_Score=90, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI17567503, Length=203, Percent_Identity=27.5862068965517, Blast_Score=90, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6320432, Length=201, Percent_Identity=44.7761194029851, Blast_Score=188, Evalue=6e-49,
Organism=Saccharomyces cerevisiae, GI6321018, Length=197, Percent_Identity=34.5177664974619, Blast_Score=117, Evalue=2e-27,
Organism=Drosophila melanogaster, GI22026816, Length=198, Percent_Identity=42.9292929292929, Blast_Score=174, Evalue=3e-44,
Organism=Drosophila melanogaster, GI17737899, Length=195, Percent_Identity=37.4358974358974, Blast_Score=129, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24645822, Length=195, Percent_Identity=37.4358974358974, Blast_Score=129, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24663208, Length=212, Percent_Identity=27.3584905660377, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17647141, Length=212, Percent_Identity=27.3584905660377, Blast_Score=86, Evalue=2e-17,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_PELPD (A1ALW2)

Other databases:

- EMBL:   CP000482
- RefSeq:   YP_900390.1
- ProteinModelPortal:   A1ALW2
- SMR:   A1ALW2
- STRING:   A1ALW2
- GeneID:   4571500
- GenomeReviews:   CP000482_GR
- KEGG:   ppd:Ppro_0701
- eggNOG:   COG0563
- HOGENOM:   HBG630208
- OMA:   RTYHVKY
- PhylomeDB:   A1ALW2
- ProtClustDB:   PRK00279
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid; SSF57774 Adenylate_kinase_Znf_lid

EC number: =2.7.4.3

Molecular weight: Translated: 23578; Mature: 23578

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

5.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
5.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVILFGPPGAGKGTQAQYVVERFGIPQISTGDMLRAAVKNCTPLGLKAKEIMDAGGLVS
CCEEEECCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHCCCCCC
DEIVLGIVADRLSCEDCGTGFVLDGFPRTIPQAEALIEILACLGKQTDHVISLEVSNDEI
HHHHHHHHHHHCCHHHCCCCCEECCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCHHH
TRRLSGRRTCPSCGKGFHVLFAPPRKAGVCDFCGADLVQRGDDHPESICNRLSVYEKQTS
HHHHCCCCCCCCCCCCCEEEEECCCCCCCHHHHCHHHHHCCCCCHHHHHHHHHHHHHCCC
PLKAFYAQKGLLRAVDGSLPVEQIQLQIRKVLEGCSSDCA
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNVILFGPPGAGKGTQAQYVVERFGIPQISTGDMLRAAVKNCTPLGLKAKEIMDAGGLVS
CCEEEECCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHCCCCCC
DEIVLGIVADRLSCEDCGTGFVLDGFPRTIPQAEALIEILACLGKQTDHVISLEVSNDEI
HHHHHHHHHHHCCHHHCCCCCEECCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCHHH
TRRLSGRRTCPSCGKGFHVLFAPPRKAGVCDFCGADLVQRGDDHPESICNRLSVYEKQTS
HHHHCCCCCCCCCCCCCEEEEECCCCCCCHHHHCHHHHHCCCCCHHHHHHHHHHHHHCCC
PLKAFYAQKGLLRAVDGSLPVEQIQLQIRKVLEGCSSDCA
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA