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The map label for this gene is map [H]

Identifier: 118579141

GI number: 118579141

Start: 733281

End: 734030

Strand: Direct

Name: map [H]

Synonym: Ppro_0702

Alternate gene names: 118579141

Gene position: 733281-734030 (Clockwise)

Preceding gene: 118579140

Following gene: 118579142

Centisome position: 18.3

GC content: 45.6

Gene sequence:

>750_bases
GTGATTGTGCTTAAATCTCTCCGTGAGATTGAACGGATGAGAGTAGCTTGCAGATTGGTTGCCGAAGTCCTTGAGATGCT
GAAAGAAGCTGTAAGGCCGGGTGTATCGACTTGCGATCTTGAAGATATCGCTTTGAAACACACTCTGAAAAACAAAGCCA
AGCCGGCTTTTAAAGGTTATTGTAATTATCCTAGTGCTCTGTGCTGTTCACCTAATCAGCAGGTGGTGCATGGAGTGCCA
AATCGGGAGCCTCTTCGGGATGGTGACATCTTAAGCCTTGATTTTGGGGTTCTTTATGATGATTTCTACGGAGACGCAGC
AGTAACGCTTCCTGTCGGAATTGTTAGTGAAAAGGTGAAATCGCTTATTGCGACAACGGAGCAGTCTTTATATCGTGGTA
TTGAGAAGGCTATCCCTGGTAACCGTCTTACTGATATTTCGCATGCCATACAGGATTACGTTGAGAAACGGGGTTTTTCC
GTGGTTCGCGACTTTGTGGGGCATGGTATCGGTAGAGGGTTACACGAGGAACCTCAGATCCCTAATTATGGTGCGCCTGC
AAAAGGGGTAAAGCTCAAAGCGGGTATGGTCTTTGCTATTGAGCCAATGATAAACGAAAAATCGCATGAAGTGAAAATCC
TCGATGATGGTTGGACGGTTGTTACCTTGGATGGTGGTATGTCTGCGCATTTTGAGCACACCGTAGCGATTACGGATAAT
GGACCTGATATTTTAACTCGGCTTGTTTAA

Upstream 100 bases:

>100_bases
GCGTTTTATGCACAAAAAGGACTTTTGAGGGCTGTTGACGGTAGTCTGCCTGTAGAACAGATACAATTGCAGATTCGGAA
GGTGTTGGAAGGTTGCTCTA

Downstream 100 bases:

>100_bases
GCGTGAAGGGGAGTAGAGATGAAAGTGCGTGCTTCTGTAAAAAAAGTGTGTGACAAGTGTAAGATAATTAAACGTAAGGG
TGTTGTACGCGTTATTTGCG

Product: methionine aminopeptidase, type I

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 249; Mature: 249

Protein sequence:

>249_residues
MIVLKSLREIERMRVACRLVAEVLEMLKEAVRPGVSTCDLEDIALKHTLKNKAKPAFKGYCNYPSALCCSPNQQVVHGVP
NREPLRDGDILSLDFGVLYDDFYGDAAVTLPVGIVSEKVKSLIATTEQSLYRGIEKAIPGNRLTDISHAIQDYVEKRGFS
VVRDFVGHGIGRGLHEEPQIPNYGAPAKGVKLKAGMVFAIEPMINEKSHEVKILDDGWTVVTLDGGMSAHFEHTVAITDN
GPDILTRLV

Sequences:

>Translated_249_residues
MIVLKSLREIERMRVACRLVAEVLEMLKEAVRPGVSTCDLEDIALKHTLKNKAKPAFKGYCNYPSALCCSPNQQVVHGVP
NREPLRDGDILSLDFGVLYDDFYGDAAVTLPVGIVSEKVKSLIATTEQSLYRGIEKAIPGNRLTDISHAIQDYVEKRGFS
VVRDFVGHGIGRGLHEEPQIPNYGAPAKGVKLKAGMVFAIEPMINEKSHEVKILDDGWTVVTLDGGMSAHFEHTVAITDN
GPDILTRLV
>Mature_249_residues
MIVLKSLREIERMRVACRLVAEVLEMLKEAVRPGVSTCDLEDIALKHTLKNKAKPAFKGYCNYPSALCCSPNQQVVHGVP
NREPLRDGDILSLDFGVLYDDFYGDAAVTLPVGIVSEKVKSLIATTEQSLYRGIEKAIPGNRLTDISHAIQDYVEKRGFS
VVRDFVGHGIGRGLHEEPQIPNYGAPAKGVKLKAGMVFAIEPMINEKSHEVKILDDGWTVVTLDGGMSAHFEHTVAITDN
GPDILTRLV

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=247, Percent_Identity=38.4615384615385, Blast_Score=191, Evalue=6e-49,
Organism=Homo sapiens, GI40385867, Length=247, Percent_Identity=36.0323886639676, Blast_Score=167, Evalue=6e-42,
Organism=Escherichia coli, GI1786364, Length=247, Percent_Identity=46.1538461538462, Blast_Score=219, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI71996291, Length=240, Percent_Identity=36.25, Blast_Score=163, Evalue=7e-41,
Organism=Saccharomyces cerevisiae, GI6323273, Length=239, Percent_Identity=37.6569037656904, Blast_Score=175, Evalue=8e-45,
Organism=Drosophila melanogaster, GI21355531, Length=239, Percent_Identity=39.7489539748954, Blast_Score=182, Evalue=1e-46,
Organism=Drosophila melanogaster, GI24583427, Length=244, Percent_Identity=35.655737704918, Blast_Score=167, Evalue=6e-42,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 27350; Mature: 27350

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00680 MAP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVLKSLREIERMRVACRLVAEVLEMLKEAVRPGVSTCDLEDIALKHTLKNKAKPAFKGY
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCHHCC
CNYPSALCCSPNQQVVHGVPNREPLRDGDILSLDFGVLYDDFYGDAAVTLPVGIVSEKVK
CCCCCCEEECCCCHHEECCCCCCCCCCCCEEEEEHHHHHHHHCCCEEEEEHHHHHHHHHH
SLIATTEQSLYRGIEKAIPGNRLTDISHAIQDYVEKRGFSVVRDFVGHGIGRGLHEEPQI
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCC
PNYGAPAKGVKLKAGMVFAIEPMINEKSHEVKILDDGWTVVTLDGGMSAHFEHTVAITDN
CCCCCCCCCEEEECCEEEEEECCCCCCCCEEEEEECCEEEEEECCCCCCCEEEEEEEECC
GPDILTRLV
CHHHHHHCC
>Mature Secondary Structure
MIVLKSLREIERMRVACRLVAEVLEMLKEAVRPGVSTCDLEDIALKHTLKNKAKPAFKGY
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCHHCC
CNYPSALCCSPNQQVVHGVPNREPLRDGDILSLDFGVLYDDFYGDAAVTLPVGIVSEKVK
CCCCCCEEECCCCHHEECCCCCCCCCCCCEEEEEHHHHHHHHCCCEEEEEHHHHHHHHHH
SLIATTEQSLYRGIEKAIPGNRLTDISHAIQDYVEKRGFSVVRDFVGHGIGRGLHEEPQI
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCC
PNYGAPAKGVKLKAGMVFAIEPMINEKSHEVKILDDGWTVVTLDGGMSAHFEHTVAITDN
CCCCCCCCCEEEECCEEEEEECCCCCCCCEEEEEECCEEEEEECCCCCCCEEEEEEEECC
GPDILTRLV
CHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11792842; 7559358 [H]