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The map label for this gene is nuoH [H]

Identifier: 118579035

GI number: 118579035

Start: 634132

End: 635073

Strand: Direct

Name: nuoH [H]

Synonym: Ppro_0596

Alternate gene names: 118579035

Gene position: 634132-635073 (Clockwise)

Preceding gene: 118579034

Following gene: 118579036

Centisome position: 15.82

GC content: 58.92

Gene sequence:

>942_bases
ATGACACAATCACTGTTCGGCATGTTCGTGTTTCCCGGTTTTCTCTTTCTCTGCGCCATCGGTGTTTGCGCCGAGTACTT
CGACCGCATCTTCCATGCCCGCATGCAGAACCGCAAGGGTCCCCCCTGGTTCCAGCCGGTAGCGGATTTCATCAAACTCT
CCGCCAAGGAGGACATCATCCCGGAAGAGGCAGATGTGTTCATGTTCAAGGCCATGCCGATTGTTGCCGTTGCTTCGGCG
GTCACGGCGGTCCTCTATATCCCGCTTTGGGGAGGGCAGGCCCTGTACTCCTTCGAGGGGGATCTGATCATCGTGCTCTA
CCTGCTGACCATACCGACCATGACCTTCTTCCTGGCCGGATGGTATTCCACCTCGCTGTACGCGGCGATCGGTTCGGTGC
GCACCCTGACCCAGCTCTTCTCCTATGAGGTGCCGCTGTACATCGCGGTACTGGCGCCGGCGGTGCTGGCCAACAGCTGG
TCGTTGAGCGGTATGACCGCCTACTACGCCAGCCATCCCGGTTATTGGCTGTTCAACCTGCCCGGCCTGGCGGTGACCAT
GGTGATCCTGCTGGGCAAGCTGGAAAAGGTTCCCTTCGACATTCCCGAGGCCGAGACCGAGATCGTCGGCGGGGTATTCA
CCGAGTACACGGGGCGCTTCCTGGCCTTCTTCCGCATGGCAATCGATATCGAGACGGTGGTGGTGGCCTCACTGGTGTCG
AGCGTATTTCTCCCCTTTGGGTTGGGATTGCCTGTGGTGATCGGTTTCGTGCTCTACCTGGCCAAGATCGCGCTGGTGGT
CGCCGGGGTCTCGTTTCTGCGGACCATCTTCGCCAGGGCGCGCATCGATCAGATGGTTGTTTTCTGCTGGAAGTATCTGG
CTCCGGCCGCGATGGTCCAGATGCTGATCAATCTGATTCTGAAGGGAGTTTTACCGCAATGA

Upstream 100 bases:

>100_bases
CGCTCAGGCAGCACGGTATCGACTGGTACCGGAAGAACCATGGTATCGAGTTCGGGGCTCTGGCGAAAAAACTGCAAATG
ATGCGCGGGGAGCGGGCACT

Downstream 100 bases:

>100_bases
TAACCATACCGGGCAAGATGGCCAAAGAGGTGCTGCGACATTCGATCATGGCGCCGGCAACCCGCAACTACCCCTTCGAG
AAGCTGGAGATGCCGGACAA

Product: respiratory-chain NADH dehydrogenase, subunit 1

Products: NA

Alternate protein names: NADH dehydrogenase I subunit H; NDH-1 subunit H [H]

Number of amino acids: Translated: 313; Mature: 312

Protein sequence:

>313_residues
MTQSLFGMFVFPGFLFLCAIGVCAEYFDRIFHARMQNRKGPPWFQPVADFIKLSAKEDIIPEEADVFMFKAMPIVAVASA
VTAVLYIPLWGGQALYSFEGDLIIVLYLLTIPTMTFFLAGWYSTSLYAAIGSVRTLTQLFSYEVPLYIAVLAPAVLANSW
SLSGMTAYYASHPGYWLFNLPGLAVTMVILLGKLEKVPFDIPEAETEIVGGVFTEYTGRFLAFFRMAIDIETVVVASLVS
SVFLPFGLGLPVVIGFVLYLAKIALVVAGVSFLRTIFARARIDQMVVFCWKYLAPAAMVQMLINLILKGVLPQ

Sequences:

>Translated_313_residues
MTQSLFGMFVFPGFLFLCAIGVCAEYFDRIFHARMQNRKGPPWFQPVADFIKLSAKEDIIPEEADVFMFKAMPIVAVASA
VTAVLYIPLWGGQALYSFEGDLIIVLYLLTIPTMTFFLAGWYSTSLYAAIGSVRTLTQLFSYEVPLYIAVLAPAVLANSW
SLSGMTAYYASHPGYWLFNLPGLAVTMVILLGKLEKVPFDIPEAETEIVGGVFTEYTGRFLAFFRMAIDIETVVVASLVS
SVFLPFGLGLPVVIGFVLYLAKIALVVAGVSFLRTIFARARIDQMVVFCWKYLAPAAMVQMLINLILKGVLPQ
>Mature_312_residues
TQSLFGMFVFPGFLFLCAIGVCAEYFDRIFHARMQNRKGPPWFQPVADFIKLSAKEDIIPEEADVFMFKAMPIVAVASAV
TAVLYIPLWGGQALYSFEGDLIIVLYLLTIPTMTFFLAGWYSTSLYAAIGSVRTLTQLFSYEVPLYIAVLAPAVLANSWS
LSGMTAYYASHPGYWLFNLPGLAVTMVILLGKLEKVPFDIPEAETEIVGGVFTEYTGRFLAFFRMAIDIETVVVASLVSS
VFLPFGLGLPVVIGFVLYLAKIALVVAGVSFLRTIFARARIDQMVVFCWKYLAPAAMVQMLINLILKGVLPQ

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1005

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 1 (chain H)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 1 family [H]

Homologues:

Organism=Homo sapiens, GI251831107, Length=275, Percent_Identity=28.7272727272727, Blast_Score=93, Evalue=4e-19,
Organism=Escherichia coli, GI1788618, Length=303, Percent_Identity=27.0627062706271, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI87082115, Length=225, Percent_Identity=32, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1789077, Length=285, Percent_Identity=27.719298245614, Blast_Score=88, Evalue=6e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023020
- InterPro:   IPR001694
- InterPro:   IPR018086 [H]

Pfam domain/function: PF00146 NADHdh [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 34623; Mature: 34491

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: PS00668 COMPLEX1_ND1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQSLFGMFVFPGFLFLCAIGVCAEYFDRIFHARMQNRKGPPWFQPVADFIKLSAKEDII
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCC
PEEADVFMFKAMPIVAVASAVTAVLYIPLWGGQALYSFEGDLIIVLYLLTIPTMTFFLAG
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHH
WYSTSLYAAIGSVRTLTQLFSYEVPLYIAVLAPAVLANSWSLSGMTAYYASHPGYWLFNL
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCEEEEEC
PGLAVTMVILLGKLEKVPFDIPEAETEIVGGVFTEYTGRFLAFFRMAIDIETVVVASLVS
CHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SVFLPFGLGLPVVIGFVLYLAKIALVVAGVSFLRTIFARARIDQMVVFCWKYLAPAAMVQ
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MLINLILKGVLPQ
HHHHHHHHHCCCC
>Mature Secondary Structure 
TQSLFGMFVFPGFLFLCAIGVCAEYFDRIFHARMQNRKGPPWFQPVADFIKLSAKEDII
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCC
PEEADVFMFKAMPIVAVASAVTAVLYIPLWGGQALYSFEGDLIIVLYLLTIPTMTFFLAG
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHH
WYSTSLYAAIGSVRTLTQLFSYEVPLYIAVLAPAVLANSWSLSGMTAYYASHPGYWLFNL
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCEEEEEC
PGLAVTMVILLGKLEKVPFDIPEAETEIVGGVFTEYTGRFLAFFRMAIDIETVVVASLVS
CHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SVFLPFGLGLPVVIGFVLYLAKIALVVAGVSFLRTIFARARIDQMVVFCWKYLAPAAMVQ
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MLINLILKGVLPQ
HHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA