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The map label for this gene is lrgB [H]

Identifier: 118480468

GI number: 118480468

Start: 5207053

End: 5207751

Strand: Reverse

Name: lrgB [H]

Synonym: BALH_4942

Alternate gene names: 118480468

Gene position: 5207751-5207053 (Counterclockwise)

Preceding gene: 118480469

Following gene: 118480467

Centisome position: 99.06

GC content: 37.34

Gene sequence:

>699_bases
ATGAACATGGCAAGCACAATGACTCCATATTTCGGAATCGTCGTTTCATTAATCGCATACGGAATCGGAACATTATTGTT
TAAGCATTCAAAAGGCTTCTTCTTATTTACACCGTTATTCGTAGCAATGGTTTTAGGGATTGTCTTTCTAAAGGTAGGTA
ACTTCACTTTTGAAGAGTATAATACTGGCGGAAAAATGATTAGCTTCTTCTTAGAACCAGCAACTATCGCCTTTGCAATT
CCATTATATAAACAGGTTGATAAGTTAAAAAAATATTGGTGGCAAATTTTATCAGCTATCGTAGTTGGATCTATTTGCTC
AGTAATTGTCGTATTCATTGTTGCAAAAGCAATTGGTTTAGATACAGCAGTAATGAATTCAATGTTACCACAAGCAGCAA
CAACAGCAATTGCGTTACCAATCTCTGAAAGCATTGGTGGTATACCAGCAATTACATCGTTTGCAGTAATCTTTAACGCA
GTTATTGTATACGCATTAGGAGCATTATTCTTAAAAACATTTAGAGTGAAACATCCAATTGCAAAAGGTTTAGCACTTGG
AACAGCGGGTCACGCATTAGGAGTGGCAGTAGGAATTGAAATGGGTGAAGTAGAGGCAGCTATGGCAAGTATTGCTGTAA
CGGTAGTTGGGGTTGTAACTGTAGTTGTCATACCGATGTTTATGCCGTTTATTGGGTAG

Upstream 100 bases:

>100_bases
GAAAAAGAAACAGAAGATACAAAAGAATTGAAAGTAGTAAATAAAGGACGCAAGCACGGAAAAGTTGCGTAACCATTGTA
GTATATATTGTTAGGAGGTA

Downstream 100 bases:

>100_bases
GAAAACTTAATTAAAAAAATGAGAAAAGCAAGCTATTTGTAGGACAGATTTCTACTGATAGCTTGCTTTTTATGTTACAG
TAGTGGTAAGACCTCTTTTA

Product: antiholin-like protein LrgB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 232; Mature: 232

Protein sequence:

>232_residues
MNMASTMTPYFGIVVSLIAYGIGTLLFKHSKGFFLFTPLFVAMVLGIVFLKVGNFTFEEYNTGGKMISFFLEPATIAFAI
PLYKQVDKLKKYWWQILSAIVVGSICSVIVVFIVAKAIGLDTAVMNSMLPQAATTAIALPISESIGGIPAITSFAVIFNA
VIVYALGALFLKTFRVKHPIAKGLALGTAGHALGVAVGIEMGEVEAAMASIAVTVVGVVTVVVIPMFMPFIG

Sequences:

>Translated_232_residues
MNMASTMTPYFGIVVSLIAYGIGTLLFKHSKGFFLFTPLFVAMVLGIVFLKVGNFTFEEYNTGGKMISFFLEPATIAFAI
PLYKQVDKLKKYWWQILSAIVVGSICSVIVVFIVAKAIGLDTAVMNSMLPQAATTAIALPISESIGGIPAITSFAVIFNA
VIVYALGALFLKTFRVKHPIAKGLALGTAGHALGVAVGIEMGEVEAAMASIAVTVVGVVTVVVIPMFMPFIG
>Mature_232_residues
MNMASTMTPYFGIVVSLIAYGIGTLLFKHSKGFFLFTPLFVAMVLGIVFLKVGNFTFEEYNTGGKMISFFLEPATIAFAI
PLYKQVDKLKKYWWQILSAIVVGSICSVIVVFIVAKAIGLDTAVMNSMLPQAATTAIALPISESIGGIPAITSFAVIFNA
VIVYALGALFLKTFRVKHPIAKGLALGTAGHALGVAVGIEMGEVEAAMASIAVTVVGVVTVVVIPMFMPFIG

Specific function: Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgA, with the holin-like protein CidA. The LrgAB and CidA proteins may affect the proton motive force of the membrane. May be involved in programmed cell

COG id: COG1346

COG function: function code M; Putative effector of murein hydrolase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CidB/LrgB family. LrgB subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788464, Length=199, Percent_Identity=36.1809045226131, Blast_Score=135, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007300 [H]

Pfam domain/function: PF04172 LrgB [H]

EC number: NA

Molecular weight: Translated: 24595; Mature: 24595

Theoretical pI: Translated: 9.60; Mature: 9.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNMASTMTPYFGIVVSLIAYGIGTLLFKHSKGFFLFTPLFVAMVLGIVFLKVGNFTFEEY
CCCCHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCEEHHHH
NTGGKMISFFLEPATIAFAIPLYKQVDKLKKYWWQILSAIVVGSICSVIVVFIVAKAIGL
CCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DTAVMNSMLPQAATTAIALPISESIGGIPAITSFAVIFNAVIVYALGALFLKTFRVKHPI
HHHHHHHHCCHHHHHHHEEEHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKGLALGTAGHALGVAVGIEMGEVEAAMASIAVTVVGVVTVVVIPMFMPFIG
HHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNMASTMTPYFGIVVSLIAYGIGTLLFKHSKGFFLFTPLFVAMVLGIVFLKVGNFTFEEY
CCCCHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCEEHHHH
NTGGKMISFFLEPATIAFAIPLYKQVDKLKKYWWQILSAIVVGSICSVIVVFIVAKAIGL
CCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DTAVMNSMLPQAATTAIALPISESIGGIPAITSFAVIFNAVIVYALGALFLKTFRVKHPI
HHHHHHHHCCHHHHHHHEEEHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKGLALGTAGHALGVAVGIEMGEVEAAMASIAVTVVGVVTVVVIPMFMPFIG
HHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA