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The map label for this gene is lrgA [H]

Identifier: 118480469

GI number: 118480469

Start: 5207780

End: 5208292

Strand: Reverse

Name: lrgA [H]

Synonym: BALH_4945

Alternate gene names: 118480469

Gene position: 5208292-5207780 (Counterclockwise)

Preceding gene: 118480470

Following gene: 118480468

Centisome position: 99.07

GC content: 32.16

Gene sequence:

>513_bases
TTGACGTTCCGTTATGTAAACGCTTACTATAGCGGTTACATCATATACAATAAAGGTACCAAATCGAAAGAGGTGGCCAA
AATGAGTACGAAAAAAGTATATAGTTTCTTATCACAAGCATTCATATTCTCAGCTATTATGTTAATTTCTAATATTATTG
CAACACATTTACCAATTCCAATGCCCTCATCGGTAATCGGGTTAGTCATTTTATTTAGTCTATTATGCTTAAAGGTTATT
AAATTGGAACAAGTTGAATCACTTGGAACAGCTTTAACAGGTATTATCGGATTCCTTTTCGTCCCATCAGGTATTTCAGT
TATTAATTCCCTTGGTGTAATGGGACAATATTTTATACAAATCTTAACTGTAATTGTTGTCGCAACAGTTATTTTACTTG
CTGTAACAGGATTATTTGCACAATTTATTTTAGGAAAAGATGAAAAAGAAACAGAAGATACAAAAGAATTGAAAGTAGTA
AATAAAGGACGCAAGCACGGAAAAGTTGCGTAA

Upstream 100 bases:

>100_bases
TGTTAGTCGTACATATGCAAAAGAACTCAAGAAGCTGCTTCGTATTTAAGAAGCAGCTTTTGTATTTCATCCTTTTATAT
TTGTAACTGATTCTGTATAT

Downstream 100 bases:

>100_bases
CCATTGTAGTATATATTGTTAGGAGGTAATGAACATGGCAAGCACAATGACTCCATATTTCGGAATCGTCGTTTCATTAA
TCGCATACGGAATCGGAACA

Product: murein hydrolase regulator LrgA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 170; Mature: 169

Protein sequence:

>170_residues
MTFRYVNAYYSGYIIYNKGTKSKEVAKMSTKKVYSFLSQAFIFSAIMLISNIIATHLPIPMPSSVIGLVILFSLLCLKVI
KLEQVESLGTALTGIIGFLFVPSGISVINSLGVMGQYFIQILTVIVVATVILLAVTGLFAQFILGKDEKETEDTKELKVV
NKGRKHGKVA

Sequences:

>Translated_170_residues
MTFRYVNAYYSGYIIYNKGTKSKEVAKMSTKKVYSFLSQAFIFSAIMLISNIIATHLPIPMPSSVIGLVILFSLLCLKVI
KLEQVESLGTALTGIIGFLFVPSGISVINSLGVMGQYFIQILTVIVVATVILLAVTGLFAQFILGKDEKETEDTKELKVV
NKGRKHGKVA
>Mature_169_residues
TFRYVNAYYSGYIIYNKGTKSKEVAKMSTKKVYSFLSQAFIFSAIMLISNIIATHLPIPMPSSVIGLVILFSLLCLKVIK
LEQVESLGTALTGIIGFLFVPSGISVINSLGVMGQYFIQILTVIVVATVILLAVTGLFAQFILGKDEKETEDTKELKVVN
KGRKHGKVA

Specific function: Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgB, with the holin-like protein CidA. The LrgAB and CidA proteins may affect the proton motive force of the membrane. May be involved in programmed cell

COG id: COG1380

COG function: function code R; Putative effector of murein hydrolase LrgA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CidA/LrgA family. LrgA subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005538 [H]

Pfam domain/function: PF03788 LrgA [H]

EC number: NA

Molecular weight: Translated: 18616; Mature: 18484

Theoretical pI: Translated: 10.11; Mature: 10.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFRYVNAYYSGYIIYNKGTKSKEVAKMSTKKVYSFLSQAFIFSAIMLISNIIATHLPIP
CCEEEEEHHHCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
MPSSVIGLVILFSLLCLKVIKLEQVESLGTALTGIIGFLFVPSGISVINSLGVMGQYFIQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
ILTVIVVATVILLAVTGLFAQFILGKDEKETEDTKELKVVNKGRKHGKVA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
TFRYVNAYYSGYIIYNKGTKSKEVAKMSTKKVYSFLSQAFIFSAIMLISNIIATHLPIP
CEEEEEHHHCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
MPSSVIGLVILFSLLCLKVIKLEQVESLGTALTGIIGFLFVPSGISVINSLGVMGQYFIQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
ILTVIVVATVILLAVTGLFAQFILGKDEKETEDTKELKVVNKGRKHGKVA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12721630 [H]