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The map label for this gene is pyrE [H]

Identifier: 118479103

GI number: 118479103

Start: 3730182

End: 3730832

Strand: Reverse

Name: pyrE [H]

Synonym: BALH_3512

Alternate gene names: 118479103

Gene position: 3730832-3730182 (Counterclockwise)

Preceding gene: 118479104

Following gene: 118479096

Centisome position: 70.97

GC content: 39.78

Gene sequence:

>651_bases
GTGGGAAGGTGTAACAGTATGAAAAAAGAAATAGCATCGCATTTATTAGAAATTGGAGCAGTATTTTTACAACCAAATGA
TCCATTCACATGGTCTTCAGGTATGAAATCACCAATTTATTGTGATAACCGTTTAACTTTATCTTATCCGAAAGTACGTC
AAGCAATTGCAGCTGGATTAGAAGAGTTAATTAAAGAGCACTTCCCAACTGTAGAAGTTATTGCAGGAACAGCAACTGCT
GGTATTGCGCACGCTGCATGGGTAAGCGATCGTATGGATTTACCAATGTGCTACGTACGTAGTAAAGCAAAAGGTCACGG
TAAAGGGAACCAAATCGAAGGAAAAGCTGAAAAAGGTCAAAAAGTAGTAGTAGTAGAAGACTTAATTTCAACTGGCGGTA
GTGCTATTACATGTGTAGAAGCACTTCGCGAAGCTGGCTGTGAAGTATTAGGAATCGTATCAATCTTCACATACGAGCTT
GAAGCAGGAAAAGAAAAGTTAGAAGCAGCTAACGTAGCATCATACTCTTTAAGCGACTACAGTGCATTAACTGAAGTAGC
GGCAGAAAAAGGTATGATCGGACAAGCTGAAACGAAAAAATTACAAGAGTGGCGTAAAAATCCAGCTGACGAAGCTTGGA
TCACAGCGTAA

Upstream 100 bases:

>100_bases
CGAAACGTGCGAGGGAACTTGGCTCAAGCTATATCGTAGTTGGACGTAGTATTACAAAAGCAGAAAATCCGCTTGAAGCG
TATAAAACAGTAAAACAACA

Downstream 100 bases:

>100_bases
CACGAAAAAAGACGACTGCTGGTCTTATCCCTGTCAAGTAGACAGTATTAAAAAGACTAAGCAGCCATCGAGATTCGATA
TTCTATCGGAGCTCGATGGT

Product: orotate phosphoribosyltransferase

Products: NA

Alternate protein names: OPRT; OPRTase [H]

Number of amino acids: Translated: 216; Mature: 215

Protein sequence:

>216_residues
MGRCNSMKKEIASHLLEIGAVFLQPNDPFTWSSGMKSPIYCDNRLTLSYPKVRQAIAAGLEELIKEHFPTVEVIAGTATA
GIAHAAWVSDRMDLPMCYVRSKAKGHGKGNQIEGKAEKGQKVVVVEDLISTGGSAITCVEALREAGCEVLGIVSIFTYEL
EAGKEKLEAANVASYSLSDYSALTEVAAEKGMIGQAETKKLQEWRKNPADEAWITA

Sequences:

>Translated_216_residues
MGRCNSMKKEIASHLLEIGAVFLQPNDPFTWSSGMKSPIYCDNRLTLSYPKVRQAIAAGLEELIKEHFPTVEVIAGTATA
GIAHAAWVSDRMDLPMCYVRSKAKGHGKGNQIEGKAEKGQKVVVVEDLISTGGSAITCVEALREAGCEVLGIVSIFTYEL
EAGKEKLEAANVASYSLSDYSALTEVAAEKGMIGQAETKKLQEWRKNPADEAWITA
>Mature_215_residues
GRCNSMKKEIASHLLEIGAVFLQPNDPFTWSSGMKSPIYCDNRLTLSYPKVRQAIAAGLEELIKEHFPTVEVIAGTATAG
IAHAAWVSDRMDLPMCYVRSKAKGHGKGNQIEGKAEKGQKVVVVEDLISTGGSAITCVEALREAGCEVLGIVSIFTYELE
AGKEKLEAANVASYSLSDYSALTEVAAEKGMIGQAETKKLQEWRKNPADEAWITA

Specific function: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) [H]

COG id: COG0461

COG function: function code F; Orotate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily [H]

Homologues:

Organism=Homo sapiens, GI4507835, Length=170, Percent_Identity=25.8823529411765, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17508631, Length=180, Percent_Identity=30, Blast_Score=76, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17554964, Length=196, Percent_Identity=25, Blast_Score=70, Evalue=9e-13,
Organism=Drosophila melanogaster, GI17933654, Length=201, Percent_Identity=28.3582089552239, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004467
- InterPro:   IPR023031
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.10 [H]

Molecular weight: Translated: 23351; Mature: 23220

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGRCNSMKKEIASHLLEIGAVFLQPNDPFTWSSGMKSPIYCDNRLTLSYPKVRQAIAAGL
CCCCHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCEEECCEEEECCHHHHHHHHHHH
EELIKEHFPTVEVIAGTATAGIAHAAWVSDRMDLPMCYVRSKAKGHGKGNQIEGKAEKGQ
HHHHHHHCCCEEEEECCHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCCCCCHHCCCC
KVVVVEDLISTGGSAITCVEALREAGCEVLGIVSIFTYELEAGKEKLEAANVASYSLSDY
EEEEEHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHH
SALTEVAAEKGMIGQAETKKLQEWRKNPADEAWITA
HHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
GRCNSMKKEIASHLLEIGAVFLQPNDPFTWSSGMKSPIYCDNRLTLSYPKVRQAIAAGL
CCCHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCEEECCEEEECCHHHHHHHHHHH
EELIKEHFPTVEVIAGTATAGIAHAAWVSDRMDLPMCYVRSKAKGHGKGNQIEGKAEKGQ
HHHHHHHCCCEEEEECCHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCCCCCHHCCCC
KVVVVEDLISTGGSAITCVEALREAGCEVLGIVSIFTYELEAGKEKLEAANVASYSLSDY
EEEEEHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHH
SALTEVAAEKGMIGQAETKKLQEWRKNPADEAWITA
HHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA