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The map label for this gene is proC [H]

Identifier: 118478317

GI number: 118478317

Start: 2843524

End: 2844342

Strand: Direct

Name: proC [H]

Synonym: BALH_2680

Alternate gene names: 118478317

Gene position: 2843524-2844342 (Clockwise)

Preceding gene: 118478314

Following gene: 118478320

Centisome position: 54.09

GC content: 36.26

Gene sequence:

>819_bases
ATGGATAAACAAATTGGATTCATCGGATGCGGAAATATGGGGATGGCTATAATTGGCGGGATGCTAAATAAAAAGATAGT
GTCTTCAAATAAAATCATGTGTTCAGATTTAAACACGACGAATTTAGAAAATGCTAGTGAAAAGTACGGAATATCTATAA
CTACTGACAACAATGAAGTCGCTAAAAATGCTGATATTTTAATTTTATCAATTAAACCAGACTTATACGCATCAGTAATT
AACGAAATTAAAGAAGAGATCAAAAGCGATGTTATTGTCGTAACGATCGCTGCTGGAAAAAGTGTCAAAAGTACAGAGGA
TTCTTTTGATACAAAATTAAAAGTTGTACGAGTAATGCCTAATACCCCTGCCCTTGTTGGTGAAGGCATGTCTGCATTAT
GCCCGAATGAAATGGTGACAGAAAAAGATTTAGAAGATGTGCTAAACATTTTCAATAGCTTTGGTCAATCAGAGATTGTA
AGTGAAAAATTAATGGACGTTGTAACATCTGTAAGTGGTTCTTCACCTGCATACGTATATATGATTATAGAAGCGATGGC
AGATGCTGCTGTACTAGATGGTATGCCAAGAAATCAAGCATATAAATTCGCAGCTCAAGCTGTGTTAGGCTCTGCAAAAA
TGGTACTAGAAACAGGAATACATCCTGGTGAATTAAAAGATATGGTTTGTTCTCCTGGCGGAACAACGATAGAAGCTGTA
GCAACTTTAGAGGAAAAAGGCTTACGAACAGCCATCATTTCAGCTATGCAACGTTGTACACAAAAGTCTGTCGAACTATC
TGGTCAAACGAAAAAGTAA

Upstream 100 bases:

>100_bases
TAGAATGTTTCTTTATATTGCATGGAGATGTTATTGTTATTTTAAGATAACAATTTCAAAATGATATAATTTATTAAAAA
AGGAGCAAGATTGAGTTATT

Downstream 100 bases:

>100_bases
AACGATATAAGTAATCGCGTTAACTATGAATTTAATTAGAAACGCACTACATGATAAAAGGCTAAACTCGAATATACTTG
AGTTTAGCCTTTTTCATTTT

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 272; Mature: 272

Protein sequence:

>272_residues
MDKQIGFIGCGNMGMAIIGGMLNKKIVSSNKIMCSDLNTTNLENASEKYGISITTDNNEVAKNADILILSIKPDLYASVI
NEIKEEIKSDVIVVTIAAGKSVKSTEDSFDTKLKVVRVMPNTPALVGEGMSALCPNEMVTEKDLEDVLNIFNSFGQSEIV
SEKLMDVVTSVSGSSPAYVYMIIEAMADAAVLDGMPRNQAYKFAAQAVLGSAKMVLETGIHPGELKDMVCSPGGTTIEAV
ATLEEKGLRTAIISAMQRCTQKSVELSGQTKK

Sequences:

>Translated_272_residues
MDKQIGFIGCGNMGMAIIGGMLNKKIVSSNKIMCSDLNTTNLENASEKYGISITTDNNEVAKNADILILSIKPDLYASVI
NEIKEEIKSDVIVVTIAAGKSVKSTEDSFDTKLKVVRVMPNTPALVGEGMSALCPNEMVTEKDLEDVLNIFNSFGQSEIV
SEKLMDVVTSVSGSSPAYVYMIIEAMADAAVLDGMPRNQAYKFAAQAVLGSAKMVLETGIHPGELKDMVCSPGGTTIEAV
ATLEEKGLRTAIISAMQRCTQKSVELSGQTKK
>Mature_272_residues
MDKQIGFIGCGNMGMAIIGGMLNKKIVSSNKIMCSDLNTTNLENASEKYGISITTDNNEVAKNADILILSIKPDLYASVI
NEIKEEIKSDVIVVTIAAGKSVKSTEDSFDTKLKVVRVMPNTPALVGEGMSALCPNEMVTEKDLEDVLNIFNSFGQSEIV
SEKLMDVVTSVSGSSPAYVYMIIEAMADAAVLDGMPRNQAYKFAAQAVLGSAKMVLETGIHPGELKDMVCSPGGTTIEAV
ATLEEKGLRTAIISAMQRCTQKSVELSGQTKK

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI21361454, Length=267, Percent_Identity=37.8277153558052, Blast_Score=186, Evalue=1e-47,
Organism=Homo sapiens, GI24797095, Length=269, Percent_Identity=37.1747211895911, Blast_Score=182, Evalue=2e-46,
Organism=Homo sapiens, GI24797097, Length=269, Percent_Identity=37.1747211895911, Blast_Score=182, Evalue=3e-46,
Organism=Homo sapiens, GI198041662, Length=265, Percent_Identity=35.0943396226415, Blast_Score=175, Evalue=3e-44,
Organism=Escherichia coli, GI1786585, Length=267, Percent_Identity=53.9325842696629, Blast_Score=298, Evalue=3e-82,
Organism=Caenorhabditis elegans, GI17569021, Length=261, Percent_Identity=38.6973180076628, Blast_Score=187, Evalue=6e-48,
Organism=Caenorhabditis elegans, GI17540664, Length=281, Percent_Identity=33.0960854092527, Blast_Score=142, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6320861, Length=291, Percent_Identity=29.2096219931272, Blast_Score=122, Evalue=5e-29,
Organism=Drosophila melanogaster, GI24648116, Length=275, Percent_Identity=39.6363636363636, Blast_Score=202, Evalue=1e-52,
Organism=Drosophila melanogaster, GI21358587, Length=269, Percent_Identity=38.2899628252788, Blast_Score=197, Evalue=7e-51,
Organism=Drosophila melanogaster, GI24647700, Length=173, Percent_Identity=43.9306358381503, Blast_Score=154, Evalue=4e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 29044; Mature: 29044

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
7.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
5.5 %Met     (Mature Protein)
7.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKQIGFIGCGNMGMAIIGGMLNKKIVSSNKIMCSDLNTTNLENASEKYGISITTDNNEV
CCCCEEEEEECCCHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCHHCCEEEEECCCCH
AKNADILILSIKPDLYASVINEIKEEIKSDVIVVTIAAGKSVKSTEDSFDTKLKVVRVMP
HCCCCEEEEEECCHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCHHHCCEEEEEEECC
NTPALVGEGMSALCPNEMVTEKDLEDVLNIFNSFGQSEIVSEKLMDVVTSVSGSSPAYVY
CCCHHHHCCCHHCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCEEEE
MIIEAMADAAVLDGMPRNQAYKFAAQAVLGSAKMVLETGIHPGELKDMVCSPGGTTIEAV
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCEEHHH
ATLEEKGLRTAIISAMQRCTQKSVELSGQTKK
HHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MDKQIGFIGCGNMGMAIIGGMLNKKIVSSNKIMCSDLNTTNLENASEKYGISITTDNNEV
CCCCEEEEEECCCHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCHHCCEEEEECCCCH
AKNADILILSIKPDLYASVINEIKEEIKSDVIVVTIAAGKSVKSTEDSFDTKLKVVRVMP
HCCCCEEEEEECCHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCHHHCCEEEEEEECC
NTPALVGEGMSALCPNEMVTEKDLEDVLNIFNSFGQSEIVSEKLMDVVTSVSGSSPAYVY
CCCHHHHCCCHHCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCEEEE
MIIEAMADAAVLDGMPRNQAYKFAAQAVLGSAKMVLETGIHPGELKDMVCSPGGTTIEAV
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCEEHHH
ATLEEKGLRTAIISAMQRCTQKSVELSGQTKK
HHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6296787; 9278503 [H]