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The map label for this gene is czcD [H]

Identifier: 118477237

GI number: 118477237

Start: 1687435

End: 1688334

Strand: Direct

Name: czcD [H]

Synonym: BALH_1543

Alternate gene names: 118477237

Gene position: 1687435-1688334 (Clockwise)

Preceding gene: 118477235

Following gene: 118477241

Centisome position: 32.1

GC content: 35.89

Gene sequence:

>900_bases
ATGGGACATTCGCATGATCATGGGCATTCTAAAAATAAAAAAGCGTTGCTACTTGCATTCTTACTAACAACAAGTTTTAT
GATTGCTGAAGTTATTGGGGGATTTGTAACAAATAGTTTAGCACTACTATCTGACGCGGGGCATATGTTAAGTGATGCGG
TATCTTTAGCTTTAAGTTTACTTGCGTTTAAGCTAGGAGAAAAAACAGCAACAGCTGCGAAAACATACGGGTATAAGCGA
GTCGAAATGTTAGCGGCATTATGTAACGGTGTCGTTCTTATTGTCATTTCAGTATACATTTTTATTGAAGCAATTCGCCG
TTTTAAAGAACCAGTTGAGATTGCTAGTAATGGGATGCTCATTATTGCTGTACTTGGTCTGCTTATTAATGTTTTATCAG
CTTGGATATTAATGAGAGGCGGAGATGTAAAGGGGAATTTGAATGTAAGAAGTGCTTTCCTACACGTATTAGGCGATTTA
TTAGGATCCGTCGGAGCGATTATTGCTGCGTTACTTATTAAATTTTTCGGATGGACTGCTGCAGATGCGATTGCTAGTAT
TCTTGTGTCTATTTTAGTCATTATTAGTGGATGGCGTGTAACACGTGATACAGTCCATATATTAATGGAAGGTGCACCAC
AGCACATAAATGTTGAAGAGGTAAAAAGTACATTATTAAATATTACGGTTGTAAAAGAAGTTCATGATTTGCACATATGG
TCTGTTACATCTGATTTTCAAGTATTAACTTGCCATTTGATTATTAACGGAAATGAAACACAAAATGTATTAAAAGAGGC
TACGGATGTATTAAAGAAGAAGTTTCATGTAGAACATGTCACCATTCAAGTAGAAATAGATGGTGAATTTCATCATAGTG
AGACAACTTGCAAAGTATGA

Upstream 100 bases:

>100_bases
TTTGAAAAGTATCGAAGTGTGTATACAGAGGAAGCGGGATAAAGATAGGGAATTTGTTTCATACTAATGTACAGATATTG
CACTTAAAGGAGCATTTTGT

Downstream 100 bases:

>100_bases
AAGAAAAAGGATACGAAAAAGTGTCATAACATTTTTCGCGCGGCATACATATATATAATGTGGCCACAAATACTTTGTAA
GGTAAATATTTCATGAAATT

Product: cobalt-zinc-cadmium resistance protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 299; Mature: 298

Protein sequence:

>299_residues
MGHSHDHGHSKNKKALLLAFLLTTSFMIAEVIGGFVTNSLALLSDAGHMLSDAVSLALSLLAFKLGEKTATAAKTYGYKR
VEMLAALCNGVVLIVISVYIFIEAIRRFKEPVEIASNGMLIIAVLGLLINVLSAWILMRGGDVKGNLNVRSAFLHVLGDL
LGSVGAIIAALLIKFFGWTAADAIASILVSILVIISGWRVTRDTVHILMEGAPQHINVEEVKSTLLNITVVKEVHDLHIW
SVTSDFQVLTCHLIINGNETQNVLKEATDVLKKKFHVEHVTIQVEIDGEFHHSETTCKV

Sequences:

>Translated_299_residues
MGHSHDHGHSKNKKALLLAFLLTTSFMIAEVIGGFVTNSLALLSDAGHMLSDAVSLALSLLAFKLGEKTATAAKTYGYKR
VEMLAALCNGVVLIVISVYIFIEAIRRFKEPVEIASNGMLIIAVLGLLINVLSAWILMRGGDVKGNLNVRSAFLHVLGDL
LGSVGAIIAALLIKFFGWTAADAIASILVSILVIISGWRVTRDTVHILMEGAPQHINVEEVKSTLLNITVVKEVHDLHIW
SVTSDFQVLTCHLIINGNETQNVLKEATDVLKKKFHVEHVTIQVEIDGEFHHSETTCKV
>Mature_298_residues
GHSHDHGHSKNKKALLLAFLLTTSFMIAEVIGGFVTNSLALLSDAGHMLSDAVSLALSLLAFKLGEKTATAAKTYGYKRV
EMLAALCNGVVLIVISVYIFIEAIRRFKEPVEIASNGMLIIAVLGLLINVLSAWILMRGGDVKGNLNVRSAFLHVLGDLL
GSVGAIIAALLIKFFGWTAADAIASILVSILVIISGWRVTRDTVHILMEGAPQHINVEEVKSTLLNITVVKEVHDLHIWS
VTSDFQVLTCHLIINGNETQNVLKEATDVLKKKFHVEHVTIQVEIDGEFHHSETTCKV

Specific function: Involved in divalent cation and potassium homeostasis in the cell. Catalyzes the active efflux of zinc, cadmium and cobalt, in exchange for potassium and H(+) ions [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI21361112, Length=298, Percent_Identity=34.2281879194631, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI52352805, Length=305, Percent_Identity=32.4590163934426, Blast_Score=165, Evalue=4e-41,
Organism=Homo sapiens, GI21359890, Length=305, Percent_Identity=35.0819672131148, Blast_Score=164, Evalue=8e-41,
Organism=Homo sapiens, GI289803013, Length=303, Percent_Identity=33.3333333333333, Blast_Score=138, Evalue=6e-33,
Organism=Homo sapiens, GI289803009, Length=303, Percent_Identity=33.3333333333333, Blast_Score=138, Evalue=6e-33,
Organism=Homo sapiens, GI289803007, Length=303, Percent_Identity=33.3333333333333, Blast_Score=138, Evalue=6e-33,
Organism=Homo sapiens, GI289803003, Length=303, Percent_Identity=33.3333333333333, Blast_Score=138, Evalue=6e-33,
Organism=Homo sapiens, GI64762489, Length=303, Percent_Identity=33.3333333333333, Blast_Score=138, Evalue=6e-33,
Organism=Homo sapiens, GI20070323, Length=325, Percent_Identity=27.6923076923077, Blast_Score=136, Evalue=2e-32,
Organism=Homo sapiens, GI14210520, Length=230, Percent_Identity=32.1739130434783, Blast_Score=112, Evalue=6e-25,
Organism=Homo sapiens, GI52351208, Length=132, Percent_Identity=39.3939393939394, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI52352803, Length=124, Percent_Identity=41.9354838709677, Blast_Score=82, Evalue=8e-16,
Organism=Homo sapiens, GI222080086, Length=127, Percent_Identity=29.9212598425197, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI40255009, Length=127, Percent_Identity=29.9212598425197, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI1786966, Length=278, Percent_Identity=46.7625899280576, Blast_Score=204, Evalue=5e-54,
Organism=Caenorhabditis elegans, GI17555794, Length=318, Percent_Identity=36.4779874213836, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17555796, Length=314, Percent_Identity=35.6687898089172, Blast_Score=181, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI193210990, Length=326, Percent_Identity=33.7423312883436, Blast_Score=176, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI32564488, Length=296, Percent_Identity=30.0675675675676, Blast_Score=130, Evalue=8e-31,
Organism=Saccharomyces cerevisiae, GI6320411, Length=180, Percent_Identity=39.4444444444444, Blast_Score=105, Evalue=7e-24,
Organism=Saccharomyces cerevisiae, GI6323899, Length=132, Percent_Identity=40.1515151515151, Blast_Score=84, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6324892, Length=125, Percent_Identity=39.2, Blast_Score=77, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24583858, Length=338, Percent_Identity=31.6568047337278, Blast_Score=152, Evalue=3e-37,
Organism=Drosophila melanogaster, GI24656728, Length=339, Percent_Identity=30.9734513274336, Blast_Score=117, Evalue=6e-27,
Organism=Drosophila melanogaster, GI24656724, Length=339, Percent_Identity=30.9734513274336, Blast_Score=117, Evalue=6e-27,
Organism=Drosophila melanogaster, GI24656720, Length=339, Percent_Identity=30.9734513274336, Blast_Score=117, Evalue=6e-27,
Organism=Drosophila melanogaster, GI24656715, Length=339, Percent_Identity=30.9734513274336, Blast_Score=117, Evalue=6e-27,
Organism=Drosophila melanogaster, GI21357035, Length=339, Percent_Identity=30.9734513274336, Blast_Score=117, Evalue=6e-27,
Organism=Drosophila melanogaster, GI24585900, Length=150, Percent_Identity=37.3333333333333, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24585898, Length=150, Percent_Identity=37.3333333333333, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24585896, Length=150, Percent_Identity=37.3333333333333, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI19921672, Length=150, Percent_Identity=37.3333333333333, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24584409, Length=142, Percent_Identity=33.8028169014084, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI28574430, Length=142, Percent_Identity=33.8028169014084, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24645863, Length=125, Percent_Identity=36.8, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 32530; Mature: 32399

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGHSHDHGHSKNKKALLLAFLLTTSFMIAEVIGGFVTNSLALLSDAGHMLSDAVSLALSL
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAFKLGEKTATAAKTYGYKRVEMLAALCNGVVLIVISVYIFIEAIRRFKEPVEIASNGML
HHHHHCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
IIAVLGLLINVLSAWILMRGGDVKGNLNVRSAFLHVLGDLLGSVGAIIAALLIKFFGWTA
HHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHH
ADAIASILVSILVIISGWRVTRDTVHILMEGAPQHINVEEVKSTLLNITVVKEVHDLHIW
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEE
SVTSDFQVLTCHLIINGNETQNVLKEATDVLKKKFHVEHVTIQVEIDGEFHHSETTCKV
EECCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHCEEEEEEEEEECCCEECCCCCCCC
>Mature Secondary Structure 
GHSHDHGHSKNKKALLLAFLLTTSFMIAEVIGGFVTNSLALLSDAGHMLSDAVSLALSL
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAFKLGEKTATAAKTYGYKRVEMLAALCNGVVLIVISVYIFIEAIRRFKEPVEIASNGML
HHHHHCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
IIAVLGLLINVLSAWILMRGGDVKGNLNVRSAFLHVLGDLLGSVGAIIAALLIKFFGWTA
HHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHH
ADAIASILVSILVIISGWRVTRDTVHILMEGAPQHINVEEVKSTLLNITVVKEVHDLHIW
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEE
SVTSDFQVLTCHLIINGNETQNVLKEATDVLKKKFHVEHVTIQVEIDGEFHHSETTCKV
EECCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHCEEEEEEEEEECCCEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA