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The map label for this gene is ntdR [H]

Identifier: 118476688

GI number: 118476688

Start: 1113712

End: 1114794

Strand: Direct

Name: ntdR [H]

Synonym: BALH_0966

Alternate gene names: 118476688

Gene position: 1113712-1114794 (Clockwise)

Preceding gene: 118476682

Following gene: 118476689

Centisome position: 21.18

GC content: 38.41

Gene sequence:

>1083_bases
TTGCAGTTTCCAATAATATACTATATAATCAATTTAAGAAAACGTTTTCATGCAAAGGGGGAGAATTTCGTGTCGACTAT
AGAGGACGTGGCGAAATTAGCGGGGTTATCAAGGACAACGGTTTCTAGGGTGATTAATAATCATCCATATGTTTCAGATG
AGAAGAAAAAAAGGGTTCAATTAGCAATGAAGCATTTAGGCTTCGTTCCTAATTCTGCGGCGAGAAGGCTTCGTAAACAA
AAGACGGAAACAATTGCGGTGCTAGTTCCAAGGATTACAAATCCTTTCTTCAGTAGATTTATCGAAGCAATCGAGATTGC
TGCTTCTGAACATAAATATAAACTGATTATTTGTCAAACAAGATATTTACCGGAAAAAGAGATGGAGTATTTACAATTAT
TATCTACGAAACAAGTAGATGGGATTATTCTATGTTCACTAGAAAATCAATGGGAAGATGTAGAGCCATACTTACAGCAC
GGTCCAATCGTGTTATGTAATGAATATATTGAGGAAGCAAATGTTCCAACAGTGAAGTTTGATCATGCGCAAGGAGCATA
CATAGCTGCTAAGCATGTGTTAGAACAAGGATATCGTAATCTTATTTTTTGCCGTGGAAACGAAACCAAAGTCGTTAGTC
AACAGCGAAAAATGGGCTTTTTACGTGCCATAACGGAGAAGAGCCGCCAAGTAGAAGCGATTGACTTTCTTGAAAACGCT
TTCTCTTGGGAGGATGGAAAACGCATATTCCATGAAGTATTAAAGGACAAAAAAAATCCTACCGCGATTTTGGCAGGAGG
CGATGAAGTAGCAGCTGGAATTATTTCAGAGGCGAAACGCCATGACTGGAGCATTCCAGATGATCTAGCTGTTATCGGTT
TTGATAATCAAATTTTATCACAGATTACAGAGCCAGGTATTACGACAATTGAACAGCCAATCGATGAGATGGCCCGAAAA
GTTGTCGACCTGATGATGGATAAAATCCATACGAAAAATTATCGAAAAAAAGAATTGTATGAGTTTGAACTGGAGCTCTT
GGTGAAAGGTTCAACGATGAAGGATACGATGTTATTAGCCTAG

Upstream 100 bases:

>100_bases
ATGCCTCCTGTAAACTTCTAAAACTAATATAAATTTCCCTCCCATTAACATACTTTTCCCTATGTATAATATTAATATAG
TAAAATCATAACAACCGATA

Downstream 100 bases:

>100_bases
TAGACTATGTCTGCTAGGTTTTTTCTGTTCACAAACTACTACTCTTCGTGAACGCAGTCATCACATTTGTTATGGTATGC
TTCGTGCTGCTCATCAATTT

Product: LacI family transcription regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 360; Mature: 360

Protein sequence:

>360_residues
MQFPIIYYIINLRKRFHAKGENFVSTIEDVAKLAGLSRTTVSRVINNHPYVSDEKKKRVQLAMKHLGFVPNSAARRLRKQ
KTETIAVLVPRITNPFFSRFIEAIEIAASEHKYKLIICQTRYLPEKEMEYLQLLSTKQVDGIILCSLENQWEDVEPYLQH
GPIVLCNEYIEEANVPTVKFDHAQGAYIAAKHVLEQGYRNLIFCRGNETKVVSQQRKMGFLRAITEKSRQVEAIDFLENA
FSWEDGKRIFHEVLKDKKNPTAILAGGDEVAAGIISEAKRHDWSIPDDLAVIGFDNQILSQITEPGITTIEQPIDEMARK
VVDLMMDKIHTKNYRKKELYEFELELLVKGSTMKDTMLLA

Sequences:

>Translated_360_residues
MQFPIIYYIINLRKRFHAKGENFVSTIEDVAKLAGLSRTTVSRVINNHPYVSDEKKKRVQLAMKHLGFVPNSAARRLRKQ
KTETIAVLVPRITNPFFSRFIEAIEIAASEHKYKLIICQTRYLPEKEMEYLQLLSTKQVDGIILCSLENQWEDVEPYLQH
GPIVLCNEYIEEANVPTVKFDHAQGAYIAAKHVLEQGYRNLIFCRGNETKVVSQQRKMGFLRAITEKSRQVEAIDFLENA
FSWEDGKRIFHEVLKDKKNPTAILAGGDEVAAGIISEAKRHDWSIPDDLAVIGFDNQILSQITEPGITTIEQPIDEMARK
VVDLMMDKIHTKNYRKKELYEFELELLVKGSTMKDTMLLA
>Mature_360_residues
MQFPIIYYIINLRKRFHAKGENFVSTIEDVAKLAGLSRTTVSRVINNHPYVSDEKKKRVQLAMKHLGFVPNSAARRLRKQ
KTETIAVLVPRITNPFFSRFIEAIEIAASEHKYKLIICQTRYLPEKEMEYLQLLSTKQVDGIILCSLENQWEDVEPYLQH
GPIVLCNEYIEEANVPTVKFDHAQGAYIAAKHVLEQGYRNLIFCRGNETKVVSQQRKMGFLRAITEKSRQVEAIDFLENA
FSWEDGKRIFHEVLKDKKNPTAILAGGDEVAAGIISEAKRHDWSIPDDLAVIGFDNQILSQITEPGITTIEQPIDEMARK
VVDLMMDKIHTKNYRKKELYEFELELLVKGSTMKDTMLLA

Specific function: Positively regulates the ntdABC operon and negatively regulates its own transcription. Binds to NTD to induce ntdABC transcription [H]

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790369, Length=336, Percent_Identity=31.547619047619, Blast_Score=198, Evalue=4e-52,
Organism=Escherichia coli, GI1787948, Length=317, Percent_Identity=31.2302839116719, Blast_Score=165, Evalue=5e-42,
Organism=Escherichia coli, GI1790194, Length=318, Percent_Identity=27.0440251572327, Blast_Score=152, Evalue=4e-38,
Organism=Escherichia coli, GI1789202, Length=301, Percent_Identity=29.5681063122924, Blast_Score=141, Evalue=8e-35,
Organism=Escherichia coli, GI1788474, Length=302, Percent_Identity=27.8145695364238, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI48994940, Length=329, Percent_Identity=24.0121580547112, Blast_Score=118, Evalue=6e-28,
Organism=Escherichia coli, GI1789068, Length=328, Percent_Identity=23.1707317073171, Blast_Score=114, Evalue=9e-27,
Organism=Escherichia coli, GI1787580, Length=317, Percent_Identity=26.813880126183, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1790715, Length=319, Percent_Identity=22.884012539185, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI1786268, Length=335, Percent_Identity=24.1791044776119, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1790689, Length=312, Percent_Identity=23.7179487179487, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1786540, Length=322, Percent_Identity=23.9130434782609, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1787906, Length=324, Percent_Identity=20.9876543209877, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1789456, Length=329, Percent_Identity=21.8844984802432, Blast_Score=61, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 41384; Mature: 41384

Theoretical pI: Translated: 8.00; Mature: 8.00

Prosite motif: PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQFPIIYYIINLRKRFHAKGENFVSTIEDVAKLAGLSRTTVSRVINNHPYVSDEKKKRVQ
CCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHH
LAMKHLGFVPNSAARRLRKQKTETIAVLVPRITNPFFSRFIEAIEIAASEHKYKLIICQT
HHHHHHCCCCCHHHHHHHHHHHHEEEEEECHHCCHHHHHHHHHHHHHHCCCCEEEEEEEC
RYLPEKEMEYLQLLSTKQVDGIILCSLENQWEDVEPYLQHGPIVLCNEYIEEANVPTVKF
CCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHCCCEEEEHHHHHHCCCCEEEE
DHAQGAYIAAKHVLEQGYRNLIFCRGNETKVVSQQRKMGFLRAITEKSRQVEAIDFLENA
CCCCCHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FSWEDGKRIFHEVLKDKKNPTAILAGGDEVAAGIISEAKRHDWSIPDDLAVIGFDNQILS
CCCCHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHH
QITEPGITTIEQPIDEMARKVVDLMMDKIHTKNYRKKELYEFELELLVKGSTMKDTMLLA
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHEEEHEEECCCCCCCEECC
>Mature Secondary Structure
MQFPIIYYIINLRKRFHAKGENFVSTIEDVAKLAGLSRTTVSRVINNHPYVSDEKKKRVQ
CCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHH
LAMKHLGFVPNSAARRLRKQKTETIAVLVPRITNPFFSRFIEAIEIAASEHKYKLIICQT
HHHHHHCCCCCHHHHHHHHHHHHEEEEEECHHCCHHHHHHHHHHHHHHCCCCEEEEEEEC
RYLPEKEMEYLQLLSTKQVDGIILCSLENQWEDVEPYLQHGPIVLCNEYIEEANVPTVKF
CCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHCCCEEEEHHHHHHCCCCEEEE
DHAQGAYIAAKHVLEQGYRNLIFCRGNETKVVSQQRKMGFLRAITEKSRQVEAIDFLENA
CCCCCHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FSWEDGKRIFHEVLKDKKNPTAILAGGDEVAAGIISEAKRHDWSIPDDLAVIGFDNQILS
CCCCHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHH
QITEPGITTIEQPIDEMARKVVDLMMDKIHTKNYRKKELYEFELELLVKGSTMKDTMLLA
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHEEEHEEECCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]