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The map label for this gene is tetB [H]

Identifier: 118476650

GI number: 118476650

Start: 1059020

End: 1060411

Strand: Direct

Name: tetB [H]

Synonym: BALH_0927

Alternate gene names: 118476650

Gene position: 1059020-1060411 (Clockwise)

Preceding gene: 118476647

Following gene: 118476651

Centisome position: 20.14

GC content: 39.37

Gene sequence:

>1392_bases
ATGGTAGATCATTCATCACAAAATGCAGATAAATTACTAGGAGTTTTAGTAGTTACGCTAATATTTTCAGTTATGAACGG
TACGATGTTTAATGTAGCTCTTCCTGAAATCGGTAAAGAATTCAACCTTGTTCCTTCAGAGGTTAGTTGGATTATGACGA
GTTATATGGTCGTTTATGCTGTTGGTTCCATCGTAATGGGAAAACTGGCGGATAAATATCGGCTAAAAGATTTGTTAACG
TATGGATTACTTATTTTCGCTCTAGGTTCCTTGCTTGGCTTACTTGCTACTGAGTATTGGGTTATCATTTTAGGGCGTGT
TATTCAAGCAGCGGGAGCCTCTGTTCTTCCTGCGACAGCAATGATTATTCCGGTTAGATACTTTGTGCCAGAGAAAAGGG
GGCGTGCGCTTGGAACTTCAGCAGTTGGTTTAGCGCTTGGGAATGCTTTAGGGCCCGTTGCCGCTGGATTAATTACGAGT
TTTGGAAGCTGGAGACTCATGTTTGTTCTTTCATTACTACCGCTTCTAACGCTACCTTTCTTTAGAAAGTATTTAGACAA
TGCAAAAGGGAAGGCGGGTCGTATTGATATTCTTGGCGGAGGTCTATTAGCTGTATCAGTCGCGTTCTTCTTGCTTGCTA
TTACGCAAATGCAAGTGCTGTTATTCCTTGGTGGATTTGCTACGTTAGCTTTCTTCATTTTGCGGATTAGAAAAGCTAAA
GAGCCTTTTATTAAACCGATTCTGTTTAAAAATAAGAACTTTTCGATTGGGTTACTCCTTGCTTTTATGACGACAGCGAT
GAGCTTTAGCATGACATTCATGACGCCGCAATTTCTATCGGCAGTAAATGGATTGACTCCTTCGAATATTGGTTTTGTTT
TAGTTCCAGCTGCAATTGCCTCGGCAATTATGGGAAGAAAGGGAGGAAGGGTAGCTGATACTCGGGGCAATTTTGCACTC
GTTTTTATTGCCTCAGTATTCATATTCCTTGCTTTCTCATTATTATCTACTTTCATTGGGGTCTCGGCTTTTGTCATAGC
ATTGATTTTAATTTTCGGAAATGTAGGACAGACCTTTATGCAGATTTCAATGTCTAATACAATTTCACAAACACTGTCAA
AGGAAGAGACAGGTGTTGGAATGGGATTACTGTCGATGATTAATTTCATATCTGGCGCGATGGCTATGAGTGTAGTAGGG
AAATTGCTTGATAAAGGATCGACTTCACTAAAGCTAAATCCTTTTGTTGCAAATGAAGCTGCAAATATGTATAGTAATAT
CTTCGGCGTGATGTCATTATTGATCCTACTTGTAGTTGTGCTGTATCGTTTTCAATTTGGTACGGGCGTTTCTACGTTAA
ATATGACTAGCAAAGGTAATAAAAATTTATAA

Upstream 100 bases:

>100_bases
AATGATATCCTCATTATAATAAAATAGTGAGGATATTCATTATGTTGATACTCATTTAAATCTGAATAGATTACCGGAAA
AAGAAAAGGAGGTATGCACG

Downstream 100 bases:

>100_bases
AAGAATACAAGGAGGTTTATGTATGAATGCTCAAACAGCACCTGTTTCTTCACAGTCAAACGAGTTTGACAATGTGAAAA
GACTCCCCATTTTAATATCG

Product: major facilitator family transporter metal-tetracycline/H(+) antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 463; Mature: 463

Protein sequence:

>463_residues
MVDHSSQNADKLLGVLVVTLIFSVMNGTMFNVALPEIGKEFNLVPSEVSWIMTSYMVVYAVGSIVMGKLADKYRLKDLLT
YGLLIFALGSLLGLLATEYWVIILGRVIQAAGASVLPATAMIIPVRYFVPEKRGRALGTSAVGLALGNALGPVAAGLITS
FGSWRLMFVLSLLPLLTLPFFRKYLDNAKGKAGRIDILGGGLLAVSVAFFLLAITQMQVLLFLGGFATLAFFILRIRKAK
EPFIKPILFKNKNFSIGLLLAFMTTAMSFSMTFMTPQFLSAVNGLTPSNIGFVLVPAAIASAIMGRKGGRVADTRGNFAL
VFIASVFIFLAFSLLSTFIGVSAFVIALILIFGNVGQTFMQISMSNTISQTLSKEETGVGMGLLSMINFISGAMAMSVVG
KLLDKGSTSLKLNPFVANEAANMYSNIFGVMSLLILLVVVLYRFQFGTGVSTLNMTSKGNKNL

Sequences:

>Translated_463_residues
MVDHSSQNADKLLGVLVVTLIFSVMNGTMFNVALPEIGKEFNLVPSEVSWIMTSYMVVYAVGSIVMGKLADKYRLKDLLT
YGLLIFALGSLLGLLATEYWVIILGRVIQAAGASVLPATAMIIPVRYFVPEKRGRALGTSAVGLALGNALGPVAAGLITS
FGSWRLMFVLSLLPLLTLPFFRKYLDNAKGKAGRIDILGGGLLAVSVAFFLLAITQMQVLLFLGGFATLAFFILRIRKAK
EPFIKPILFKNKNFSIGLLLAFMTTAMSFSMTFMTPQFLSAVNGLTPSNIGFVLVPAAIASAIMGRKGGRVADTRGNFAL
VFIASVFIFLAFSLLSTFIGVSAFVIALILIFGNVGQTFMQISMSNTISQTLSKEETGVGMGLLSMINFISGAMAMSVVG
KLLDKGSTSLKLNPFVANEAANMYSNIFGVMSLLILLVVVLYRFQFGTGVSTLNMTSKGNKNL
>Mature_463_residues
MVDHSSQNADKLLGVLVVTLIFSVMNGTMFNVALPEIGKEFNLVPSEVSWIMTSYMVVYAVGSIVMGKLADKYRLKDLLT
YGLLIFALGSLLGLLATEYWVIILGRVIQAAGASVLPATAMIIPVRYFVPEKRGRALGTSAVGLALGNALGPVAAGLITS
FGSWRLMFVLSLLPLLTLPFFRKYLDNAKGKAGRIDILGGGLLAVSVAFFLLAITQMQVLLFLGGFATLAFFILRIRKAK
EPFIKPILFKNKNFSIGLLLAFMTTAMSFSMTFMTPQFLSAVNGLTPSNIGFVLVPAAIASAIMGRKGGRVADTRGNFAL
VFIASVFIFLAFSLLSTFIGVSAFVIALILIFGNVGQTFMQISMSNTISQTLSKEETGVGMGLLSMINFISGAMAMSVVG
KLLDKGSTSLKLNPFVANEAANMYSNIFGVMSLLILLVVVLYRFQFGTGVSTLNMTSKGNKNL

Specific function: Resistance to tetracycline by an active tetracycline efflux. This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. This protein functions as a metal-tetracycline/H(+) antiporter [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Escherichia coli, GI87081983, Length=410, Percent_Identity=23.9024390243902, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1790195, Length=313, Percent_Identity=24.9201277955272, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1789042, Length=439, Percent_Identity=23.9179954441913, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1788392, Length=403, Percent_Identity=25.5583126550869, Blast_Score=68, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6321663, Length=139, Percent_Identity=27.3381294964029, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 49653; Mature: 49653

Theoretical pI: Translated: 10.72; Mature: 10.72

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDHSSQNADKLLGVLVVTLIFSVMNGTMFNVALPEIGKEFNLVPSEVSWIMTSYMVVYA
CCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECHHCCCCCCCCHHHHHHHHHHHHHHHH
VGSIVMGKLADKYRLKDLLTYGLLIFALGSLLGLLATEYWVIILGRVIQAAGASVLPATA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
MIIPVRYFVPEKRGRALGTSAVGLALGNALGPVAAGLITSFGSWRLMFVLSLLPLLTLPF
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
FRKYLDNAKGKAGRIDILGGGLLAVSVAFFLLAITQMQVLLFLGGFATLAFFILRIRKAK
HHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
EPFIKPILFKNKNFSIGLLLAFMTTAMSFSMTFMTPQFLSAVNGLTPSNIGFVLVPAAIA
CCHHCHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCEEHHHHHH
SAIMGRKGGRVADTRGNFALVFIASVFIFLAFSLLSTFIGVSAFVIALILIFGNVGQTFM
HHHHCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
QISMSNTISQTLSKEETGVGMGLLSMINFISGAMAMSVVGKLLDKGSTSLKLNPFVANEA
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCHHHHHH
ANMYSNIFGVMSLLILLVVVLYRFQFGTGVSTLNMTSKGNKNL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCC
>Mature Secondary Structure
MVDHSSQNADKLLGVLVVTLIFSVMNGTMFNVALPEIGKEFNLVPSEVSWIMTSYMVVYA
CCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECHHCCCCCCCCHHHHHHHHHHHHHHHH
VGSIVMGKLADKYRLKDLLTYGLLIFALGSLLGLLATEYWVIILGRVIQAAGASVLPATA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
MIIPVRYFVPEKRGRALGTSAVGLALGNALGPVAAGLITSFGSWRLMFVLSLLPLLTLPF
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
FRKYLDNAKGKAGRIDILGGGLLAVSVAFFLLAITQMQVLLFLGGFATLAFFILRIRKAK
HHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
EPFIKPILFKNKNFSIGLLLAFMTTAMSFSMTFMTPQFLSAVNGLTPSNIGFVLVPAAIA
CCHHCHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCEEHHHHHH
SAIMGRKGGRVADTRGNFALVFIASVFIFLAFSLLSTFIGVSAFVIALILIFGNVGQTFM
HHHHCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
QISMSNTISQTLSKEETGVGMGLLSMINFISGAMAMSVVGKLLDKGSTSLKLNPFVANEA
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCHHHHHH
ANMYSNIFGVMSLLILLVVVLYRFQFGTGVSTLNMTSKGNKNL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2844262; 7584024; 9384377 [H]