Click here to switch to the map view.

The map label for this gene is serA [H]

Identifier: 117921853

GI number: 117921853

Start: 4086211

End: 4087440

Strand: Direct

Name: serA [H]

Synonym: Shewana3_3416

Alternate gene names: 117921853

Gene position: 4086211-4087440 (Clockwise)

Preceding gene: 117921850

Following gene: 117921854

Centisome position: 82.18

GC content: 50.0

Gene sequence:

>1230_bases
ATGGCGAAACATTCGCTGGACAAGGATAAGATCAAGATCCTGTTGTTGGAAGGCGTCCACCAATCTGCGGTCGATGTATT
TGAACGTGCTGGATACACCAATATCGAGTATCACAAAGCCTCCTTAGGTGATGAAGCCCTGCTCGAGTCCATCAAAGATG
CTCACTTTGTTGGTATTCGTTCCCGTACCCAATTAACGGCTGAGGTATTGAAGCGTGCCGAAAAACTGATTGCGATTGGT
TGTTTCTGTATCGGTACTAACCAAGTGGATCTGGCGACCGCCGAATTACTCGGTATCCCAGTATTTAACGCACCATTCTC
TAATACCCGCAGCGTGGCTGAACTGGTATTAGGCGAAATCATCATGCTGATGCGCGGCATTCCTGAACGTAATGCTATCG
CCCACCGTGGTGGCTGGATGAAGACGGCCGCCGGCAGTTACGAAGTCCGTGGCAAAACCTTAGGTGTGATAGGTTATGGT
CATATCGGTACACAGCTCGGGATCCTAGCTGAAACCTTAGGCATGCGCGTGGTGTTTTTCGATATCGAAGACAAACTGCC
ATTAGGCAATGCCCAGCAAATCCATTCGATGGAACAATTACTGGCACAGTCCGATGTGATCAGTTTGCACGTCCCTGAGA
CGGCGCAAACCAAAGATATGATCAGCACCGCCGAATTTGCCGCCATGCGTAAAGGCAGCATCTTTATCAACGCCTCACGC
GGCACTGTGGTCGATATCGATGCCCTAACGGTTGCCCTTAAAGAGCGTCACCTTGCGGGCGCGGCCATCGACGTATTCCC
CGTCGAGCCACAATCGAATGATGATGAATTTATCAGCCCATTACGTGGTTTAGATAACGTACTGCTGACTCCGCACGTGG
GTGGCAGTACTGCCGAAGCCCAAGAAAACATCGGTATCGAAGTTGCCGGTAAGTTAGCTAAATACTCTGACAACGGTTCG
ACCGTATCTGCGGTTAACTTCCCTGAAGTGTCGCTGCCAATGCACAAAGGCATTTCGCGCTTACTGCACATTCACCAAAA
CCGTCCTGGCGTGCTAATCAAAATCAACAAAGCCTTCTCTGAAAAAGGCATCAACATTGCCGCTCAGTACCTGCAAACCA
CTGCAGAAATCGGTTATGTGGTGATGGAAGTCGATACTCACCAAGCCGAAGAGGCACTGGTTGAACTTAAGGCCATTGAA
GGCACACTGCGCACCCGCGTATTGTTCTAA

Upstream 100 bases:

>100_bases
CTAGCCCTCCACAGTGAGCAAAAAAAGTGCTACTTTGGAAGGCCAAGGTTGTCAGCATATCACACAGAACTATTTCAATT
AATTAGAGGGTACCCATATC

Downstream 100 bases:

>100_bases
TGCTTTAAGCACTCAGCTTGAGTGAATTTATAAGGCGCACATTTCATTCAAGATATGTGCGCCTTATGCTTTTGAGCGCC
GCTTAATTCCGCTACAATCT

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 409; Mature: 408

Protein sequence:

>409_residues
MAKHSLDKDKIKILLLEGVHQSAVDVFERAGYTNIEYHKASLGDEALLESIKDAHFVGIRSRTQLTAEVLKRAEKLIAIG
CFCIGTNQVDLATAELLGIPVFNAPFSNTRSVAELVLGEIIMLMRGIPERNAIAHRGGWMKTAAGSYEVRGKTLGVIGYG
HIGTQLGILAETLGMRVVFFDIEDKLPLGNAQQIHSMEQLLAQSDVISLHVPETAQTKDMISTAEFAAMRKGSIFINASR
GTVVDIDALTVALKERHLAGAAIDVFPVEPQSNDDEFISPLRGLDNVLLTPHVGGSTAEAQENIGIEVAGKLAKYSDNGS
TVSAVNFPEVSLPMHKGISRLLHIHQNRPGVLIKINKAFSEKGINIAAQYLQTTAEIGYVVMEVDTHQAEEALVELKAIE
GTLRTRVLF

Sequences:

>Translated_409_residues
MAKHSLDKDKIKILLLEGVHQSAVDVFERAGYTNIEYHKASLGDEALLESIKDAHFVGIRSRTQLTAEVLKRAEKLIAIG
CFCIGTNQVDLATAELLGIPVFNAPFSNTRSVAELVLGEIIMLMRGIPERNAIAHRGGWMKTAAGSYEVRGKTLGVIGYG
HIGTQLGILAETLGMRVVFFDIEDKLPLGNAQQIHSMEQLLAQSDVISLHVPETAQTKDMISTAEFAAMRKGSIFINASR
GTVVDIDALTVALKERHLAGAAIDVFPVEPQSNDDEFISPLRGLDNVLLTPHVGGSTAEAQENIGIEVAGKLAKYSDNGS
TVSAVNFPEVSLPMHKGISRLLHIHQNRPGVLIKINKAFSEKGINIAAQYLQTTAEIGYVVMEVDTHQAEEALVELKAIE
GTLRTRVLF
>Mature_408_residues
AKHSLDKDKIKILLLEGVHQSAVDVFERAGYTNIEYHKASLGDEALLESIKDAHFVGIRSRTQLTAEVLKRAEKLIAIGC
FCIGTNQVDLATAELLGIPVFNAPFSNTRSVAELVLGEIIMLMRGIPERNAIAHRGGWMKTAAGSYEVRGKTLGVIGYGH
IGTQLGILAETLGMRVVFFDIEDKLPLGNAQQIHSMEQLLAQSDVISLHVPETAQTKDMISTAEFAAMRKGSIFINASRG
TVVDIDALTVALKERHLAGAAIDVFPVEPQSNDDEFISPLRGLDNVLLTPHVGGSTAEAQENIGIEVAGKLAKYSDNGST
VSAVNFPEVSLPMHKGISRLLHIHQNRPGVLIKINKAFSEKGINIAAQYLQTTAEIGYVVMEVDTHQAEEALVELKAIEG
TLRTRVLF

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=320, Percent_Identity=32.8125, Blast_Score=163, Evalue=3e-40,
Organism=Homo sapiens, GI145580578, Length=259, Percent_Identity=31.2741312741313, Blast_Score=116, Evalue=4e-26,
Organism=Homo sapiens, GI4557499, Length=259, Percent_Identity=31.2741312741313, Blast_Score=116, Evalue=4e-26,
Organism=Homo sapiens, GI145580575, Length=259, Percent_Identity=31.2741312741313, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI4557497, Length=263, Percent_Identity=30.0380228136882, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI61743967, Length=263, Percent_Identity=30.0380228136882, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI6912396, Length=243, Percent_Identity=27.9835390946502, Blast_Score=87, Evalue=4e-17,
Organism=Escherichia coli, GI1789279, Length=411, Percent_Identity=68.6131386861314, Blast_Score=578, Evalue=1e-166,
Organism=Escherichia coli, GI1787645, Length=264, Percent_Identity=31.4393939393939, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI87082289, Length=251, Percent_Identity=29.8804780876494, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1788660, Length=309, Percent_Identity=26.537216828479, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17532191, Length=322, Percent_Identity=33.5403726708075, Blast_Score=160, Evalue=8e-40,
Organism=Caenorhabditis elegans, GI25147481, Length=268, Percent_Identity=28.3582089552239, Blast_Score=106, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6320925, Length=414, Percent_Identity=49.2753623188406, Blast_Score=399, Evalue=1e-112,
Organism=Saccharomyces cerevisiae, GI6322116, Length=414, Percent_Identity=48.5507246376812, Blast_Score=392, Evalue=1e-110,
Organism=Saccharomyces cerevisiae, GI6324964, Length=256, Percent_Identity=26.171875, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6324055, Length=232, Percent_Identity=27.5862068965517, Blast_Score=84, Evalue=5e-17,
Organism=Drosophila melanogaster, GI19921140, Length=301, Percent_Identity=31.8936877076412, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI28574286, Length=263, Percent_Identity=30.4182509505703, Blast_Score=108, Evalue=8e-24,
Organism=Drosophila melanogaster, GI24646446, Length=260, Percent_Identity=30, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24646448, Length=260, Percent_Identity=30, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24646452, Length=260, Percent_Identity=30, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24646450, Length=260, Percent_Identity=30, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI62472511, Length=260, Percent_Identity=30, Blast_Score=105, Evalue=7e-23,
Organism=Drosophila melanogaster, GI24585514, Length=274, Percent_Identity=27.007299270073, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI28574282, Length=274, Percent_Identity=27.007299270073, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI28574284, Length=274, Percent_Identity=27.007299270073, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI45552429, Length=274, Percent_Identity=27.007299270073, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI45551003, Length=274, Percent_Identity=27.007299270073, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI28571528, Length=262, Percent_Identity=28.6259541984733, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24585516, Length=272, Percent_Identity=25.3676470588235, Blast_Score=78, Evalue=1e-14,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 44361; Mature: 44229

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKHSLDKDKIKILLLEGVHQSAVDVFERAGYTNIEYHKASLGDEALLESIKDAHFVGIR
CCCCCCCCCCEEEEEECCCCHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHCCCEEEECC
SRTQLTAEVLKRAEKLIAIGCFCIGTNQVDLATAELLGIPVFNAPFSNTRSVAELVLGEI
CHHHHHHHHHHHHHHEEEEEEEEEECCCCHHHHHHHHCCCEECCCCCCHHHHHHHHHHHH
IMLMRGIPERNAIAHRGGWMKTAAGSYEVRGKTLGVIGYGHIGTQLGILAETLGMRVVFF
HHHHCCCCCCCCHHHCCCCEEECCCCEEECCEEEEEEEECCHHHHHHHHHHHHCCEEEEE
DIEDKLPLGNAQQIHSMEQLLAQSDVISLHVPETAQTKDMISTAEFAAMRKGSIFINASR
ECCCCCCCCCHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEECCC
GTVVDIDALTVALKERHLAGAAIDVFPVEPQSNDDEFISPLRGLDNVLLTPHVGGSTAEA
CCEEEHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHCCCCEEECCCCCCCCCCH
QENIGIEVAGKLAKYSDNGSTVSAVNFPEVSLPMHKGISRLLHIHQNRPGVLIKINKAFS
HHCCCEEEECCHHEECCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEHHHC
EKGINIAAQYLQTTAEIGYVVMEVDTHQAEEALVELKAIEGTLRTRVLF
CCCCHHHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHHHHHHHHHEECC
>Mature Secondary Structure 
AKHSLDKDKIKILLLEGVHQSAVDVFERAGYTNIEYHKASLGDEALLESIKDAHFVGIR
CCCCCCCCCEEEEEECCCCHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHCCCEEEECC
SRTQLTAEVLKRAEKLIAIGCFCIGTNQVDLATAELLGIPVFNAPFSNTRSVAELVLGEI
CHHHHHHHHHHHHHHEEEEEEEEEECCCCHHHHHHHHCCCEECCCCCCHHHHHHHHHHHH
IMLMRGIPERNAIAHRGGWMKTAAGSYEVRGKTLGVIGYGHIGTQLGILAETLGMRVVFF
HHHHCCCCCCCCHHHCCCCEEECCCCEEECCEEEEEEEECCHHHHHHHHHHHHCCEEEEE
DIEDKLPLGNAQQIHSMEQLLAQSDVISLHVPETAQTKDMISTAEFAAMRKGSIFINASR
ECCCCCCCCCHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEECCC
GTVVDIDALTVALKERHLAGAAIDVFPVEPQSNDDEFISPLRGLDNVLLTPHVGGSTAEA
CCEEEHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHCCCCEEECCCCCCCCCCH
QENIGIEVAGKLAKYSDNGSTVSAVNFPEVSLPMHKGISRLLHIHQNRPGVLIKINKAFS
HHCCCEEEECCHHEECCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEHHHC
EKGINIAAQYLQTTAEIGYVVMEVDTHQAEEALVELKAIEGTLRTRVLF
CCCCHHHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHHHHHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]