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The map label for this gene is purK [H]

Identifier: 117921594

GI number: 117921594

Start: 3785115

End: 3786212

Strand: Direct

Name: purK [H]

Synonym: Shewana3_3156

Alternate gene names: 117921594

Gene position: 3785115-3786212 (Clockwise)

Preceding gene: 117921593

Following gene: 117921595

Centisome position: 76.13

GC content: 51.55

Gene sequence:

>1098_bases
ATGACTCAAGCAAGTGCAAAACCTAAGGTTTGGGTATTAGGTAATGGCCAACTTGGCGCCATGCTGACCCACGCGGGCGA
GCCTTTGGCGATTGATGTTCGCGCCGTCGATATCATGACGCCAACCGATGAAATCCTGCCGCTAGCGCCTCACGATATCA
TCACCGCCGAACGCGAGCAGTGGCCCGAATCCGCCTTAAGCTTACAACTCAGCACCCATCAGCATTTTGTTAACGGCCCA
GTATTTAGCCGTTTGGCCGATCGTTACAGCCAAAAAAGCTTACTCGATCAGATCCAAGTCCCAACGGCGCCTTGGACACT
TGTCGATGATAAAACCGACGTCGAAAATCTGTACCAAGCCTTTGGCCCGCGAGTGCTAATGAAGCGCCGCACAGGTGGTT
ACGACGGTAAGGGTCAACACTGGCTAAAACAAGCCGAAGCGGGAGAGATCCCCCAAGATTGGCGTAACTTGGCCATTGCC
GAACAAGCAATCAACTTCGATGAAGAAGTCTCCTTAGTCGGCGTACGTACCCGTGAAGGTCAATGCGTGTTTTATCCATT
AACACTCAACCTGCACCAAGACGGCATTTTGATGGCCTCAATTTCGCCACTGACTCGCCTGAATCACCTGCAAGCCCAAG
CGGAAGGCATGCTCAGCGCCATTATGCATGAGCTGGAATATGTCGGCGTGATGGCGATGGAGTGTTTCCGTGTTGGCGAT
AAGTTGCTGGTTAACGAGTTAGCACCGCGGGTGCACAACTCAGGCCATTGGACCCAAGCGGGCACCCATATGGATCAATT
CCAACTGCATTTAAGAGCCCTGTGCGGTATTGCGATTCCGCAGCCACAGGTGAACTTTCAATGCGTGATGGTCAATTTGA
TTGGTATCGAAAACGATCCCCGCTGGTTAAACCTGCCTAATGCCGAACTGTATTGGTACAACAAAGAGGTTCGTCCTGGC
CGTAAAGTCGGGCACTTAAACCTTTCTGTGCCGAATACTACCGTATTAAAAGACAGCATTAGCGCGCTGCAAACTTGGAT
GCCAAGCCAATACCAAGCGCCACTCGCGTGGATTTTAGCTGAGTTCGCTAAAGCCTAA

Upstream 100 bases:

>100_bases
TCTTAGCCAATAACGATGCTGAACTTGCCGCACGTTTAGAAGCCTTTAGAGAAGAACAAACCCGCGCAGTGCTGGACAAT
CCCGACCCGAGGGAAGCCTA

Downstream 100 bases:

>100_bases
CCGAGCCGCAGACCACTGATAAGGGAGCAAAATTGTTCCCTTATCCGTCATTTTTTTATCTTCGTTATATACTTATCCAT
ACTCAGCGTGAATGAGTTAG

Product: phosphoribosylaminoimidazole carboxylase ATPase subunit

Products: NA

Alternate protein names: N5-CAIR synthase; 5-(carboxyamino)imidazole ribonucleotide synthetase [H]

Number of amino acids: Translated: 365; Mature: 364

Protein sequence:

>365_residues
MTQASAKPKVWVLGNGQLGAMLTHAGEPLAIDVRAVDIMTPTDEILPLAPHDIITAEREQWPESALSLQLSTHQHFVNGP
VFSRLADRYSQKSLLDQIQVPTAPWTLVDDKTDVENLYQAFGPRVLMKRRTGGYDGKGQHWLKQAEAGEIPQDWRNLAIA
EQAINFDEEVSLVGVRTREGQCVFYPLTLNLHQDGILMASISPLTRLNHLQAQAEGMLSAIMHELEYVGVMAMECFRVGD
KLLVNELAPRVHNSGHWTQAGTHMDQFQLHLRALCGIAIPQPQVNFQCVMVNLIGIENDPRWLNLPNAELYWYNKEVRPG
RKVGHLNLSVPNTTVLKDSISALQTWMPSQYQAPLAWILAEFAKA

Sequences:

>Translated_365_residues
MTQASAKPKVWVLGNGQLGAMLTHAGEPLAIDVRAVDIMTPTDEILPLAPHDIITAEREQWPESALSLQLSTHQHFVNGP
VFSRLADRYSQKSLLDQIQVPTAPWTLVDDKTDVENLYQAFGPRVLMKRRTGGYDGKGQHWLKQAEAGEIPQDWRNLAIA
EQAINFDEEVSLVGVRTREGQCVFYPLTLNLHQDGILMASISPLTRLNHLQAQAEGMLSAIMHELEYVGVMAMECFRVGD
KLLVNELAPRVHNSGHWTQAGTHMDQFQLHLRALCGIAIPQPQVNFQCVMVNLIGIENDPRWLNLPNAELYWYNKEVRPG
RKVGHLNLSVPNTTVLKDSISALQTWMPSQYQAPLAWILAEFAKA
>Mature_364_residues
TQASAKPKVWVLGNGQLGAMLTHAGEPLAIDVRAVDIMTPTDEILPLAPHDIITAEREQWPESALSLQLSTHQHFVNGPV
FSRLADRYSQKSLLDQIQVPTAPWTLVDDKTDVENLYQAFGPRVLMKRRTGGYDGKGQHWLKQAEAGEIPQDWRNLAIAE
QAINFDEEVSLVGVRTREGQCVFYPLTLNLHQDGILMASISPLTRLNHLQAQAEGMLSAIMHELEYVGVMAMECFRVGDK
LLVNELAPRVHNSGHWTQAGTHMDQFQLHLRALCGIAIPQPQVNFQCVMVNLIGIENDPRWLNLPNAELYWYNKEVRPGR
KVGHLNLSVPNTTVLKDSISALQTWMPSQYQAPLAWILAEFAKA

Specific function: Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) [H]

COG id: COG0026

COG function: function code F; Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Escherichia coli, GI1786733, Length=355, Percent_Identity=51.2676056338028, Blast_Score=342, Evalue=2e-95,
Organism=Escherichia coli, GI1788155, Length=194, Percent_Identity=23.7113402061856, Blast_Score=63, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6324702, Length=361, Percent_Identity=27.7008310249307, Blast_Score=124, Evalue=3e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005875
- InterPro:   IPR011761
- InterPro:   IPR003135
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02222 ATP-grasp [H]

EC number: =6.3.4.18 [H]

Molecular weight: Translated: 40900; Mature: 40769

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQASAKPKVWVLGNGQLGAMLTHAGEPLAIDVRAVDIMTPTDEILPLAPHDIITAEREQ
CCCCCCCCEEEEEECCCCCCCEECCCCCEEEEEEEEEEECCCHHCCCCCCCHHEECCHHH
WPESALSLQLSTHQHFVNGPVFSRLADRYSQKSLLDQIQVPTAPWTLVDDKTDVENLYQA
CCHHHHEEEEEHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHH
FGPRVLMKRRTGGYDGKGQHWLKQAEAGEIPQDWRNLAIAEQAINFDEEVSLVGVRTREG
HCCCEEEECCCCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEEECCC
QCVFYPLTLNLHQDGILMASISPLTRLNHLQAQAEGMLSAIMHELEYVGVMAMECFRVGD
CEEEEEEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
KLLVNELAPRVHNSGHWTQAGTHMDQFQLHLRALCGIAIPQPQVNFQCVMVNLIGIENDP
HHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEEECCCCC
RWLNLPNAELYWYNKEVRPGRKVGHLNLSVPNTTVLKDSISALQTWMPSQYQAPLAWILA
CEEECCCCEEEEECCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCCCCHHHHHHH
EFAKA
HHHCC
>Mature Secondary Structure 
TQASAKPKVWVLGNGQLGAMLTHAGEPLAIDVRAVDIMTPTDEILPLAPHDIITAEREQ
CCCCCCCEEEEEECCCCCCCEECCCCCEEEEEEEEEEECCCHHCCCCCCCHHEECCHHH
WPESALSLQLSTHQHFVNGPVFSRLADRYSQKSLLDQIQVPTAPWTLVDDKTDVENLYQA
CCHHHHEEEEEHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHH
FGPRVLMKRRTGGYDGKGQHWLKQAEAGEIPQDWRNLAIAEQAINFDEEVSLVGVRTREG
HCCCEEEECCCCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEEECCC
QCVFYPLTLNLHQDGILMASISPLTRLNHLQAQAEGMLSAIMHELEYVGVMAMECFRVGD
CEEEEEEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
KLLVNELAPRVHNSGHWTQAGTHMDQFQLHLRALCGIAIPQPQVNFQCVMVNLIGIENDP
HHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEEECCCCC
RWLNLPNAELYWYNKEVRPGRKVGHLNLSVPNTTVLKDSISALQTWMPSQYQAPLAWILA
CEEECCCCEEEEECCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCCCCHHHHHHH
EFAKA
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]