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The map label for this gene is ispH [H]

Identifier: 117921571

GI number: 117921571

Start: 3758789

End: 3759745

Strand: Reverse

Name: ispH [H]

Synonym: Shewana3_3133

Alternate gene names: 117921571

Gene position: 3759745-3758789 (Counterclockwise)

Preceding gene: 117921572

Following gene: 117921570

Centisome position: 75.62

GC content: 47.65

Gene sequence:

>957_bases
ATGAAATTAGATCCTACCAGCCCAAGTTTAAATATTATGCTGGCCAATCCTCGCGGCTTTTGTGCTGGTGTGGATCGCGC
CATTAGTATTGTTGAGCGCGCACTTGAGTTATTTTCGCCGCCGATTTATGTTCGCCATGAAGTGGTGCATAACCGCTATG
TAGTGCAAAATCTGAAGGACCGCGGTGCCGTTTTTGTCGAAGAGTTAGACCAAGTACCGGATAACAATATTGTTATCTTC
AGTGCTCATGGAGTTTCTCAGGCTGTGCGTGCCGAGGCTAAGGCGCGTGGGTTGCGTGTTTTCGATGCGACTTGTCCATT
AGTCACCAAAGTGCATTTGCAGGTTACTCGAGCGAGCCGCAAGGGGATTGAATGTATTTTGATTGGCCATGAGGGACATC
CAGAGGTGGAAGGCACCATGGGGCAATACGATAACCCTAATGGTGGTGTTTATCTGATTGAATCTCCTGCGGATGTCGAA
ACTTTAGAAGTTCGTGATCCAAATAACCTCTGCTTCGTGACTCAAACAACGCTCTCGGTAGATGATACCCTCGATATTAT
CACCGCATTGCAAAAGCGTTTTCCTTCGATTGAAGGTCCGCGTAAGGATGATATTTGTTACGCGACGCAAAACCGTCAGG
ATGCAGTGCGGAACTTATCGGCCGATGTGGATCTGTTAATTGTGGTCGGCTCGAAAAACAGCTCTAACTCTAACCGCTTG
CGTGAATTGGCATTAAAGACGGGGACTCAATCTTATCTGGTTGATACCGCGGATGATATCGATTCATCTTGGTTTGAAAA
TGTGACTAAAGTTGCGGTGACCGCAGGCGCATCGGCACCAGAAGTGCTGGTTCAGCAAGTGGTTCAAGCGATTGCGAAAT
TAGCACCGAGTGTCGTTACCGAAGTTGAAGGACGTAAAGAAGATACCGTCTTTGCTGTACCAGCGGAATTACGCTAG

Upstream 100 bases:

>100_bases
GTGCGTGAGGTTGCGGGCGATTCGATTACGGTCGATCTCAATCACCCTCTGGCGGGACGCAAAGTGACATTTGAACTCGA
CGTGGTGAAGGTATTGTAAG

Downstream 100 bases:

>100_bases
TTCATTCGAATCAATATGATGAATAAAAAGAGGCCAATGGCCTCTTTTTTATTATCAAAATTCACCAAATACAAACAAGG
CATAATGGAATTAACGCTTA

Product: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 318; Mature: 318

Protein sequence:

>318_residues
MKLDPTSPSLNIMLANPRGFCAGVDRAISIVERALELFSPPIYVRHEVVHNRYVVQNLKDRGAVFVEELDQVPDNNIVIF
SAHGVSQAVRAEAKARGLRVFDATCPLVTKVHLQVTRASRKGIECILIGHEGHPEVEGTMGQYDNPNGGVYLIESPADVE
TLEVRDPNNLCFVTQTTLSVDDTLDIITALQKRFPSIEGPRKDDICYATQNRQDAVRNLSADVDLLIVVGSKNSSNSNRL
RELALKTGTQSYLVDTADDIDSSWFENVTKVAVTAGASAPEVLVQQVVQAIAKLAPSVVTEVEGRKEDTVFAVPAELR

Sequences:

>Translated_318_residues
MKLDPTSPSLNIMLANPRGFCAGVDRAISIVERALELFSPPIYVRHEVVHNRYVVQNLKDRGAVFVEELDQVPDNNIVIF
SAHGVSQAVRAEAKARGLRVFDATCPLVTKVHLQVTRASRKGIECILIGHEGHPEVEGTMGQYDNPNGGVYLIESPADVE
TLEVRDPNNLCFVTQTTLSVDDTLDIITALQKRFPSIEGPRKDDICYATQNRQDAVRNLSADVDLLIVVGSKNSSNSNRL
RELALKTGTQSYLVDTADDIDSSWFENVTKVAVTAGASAPEVLVQQVVQAIAKLAPSVVTEVEGRKEDTVFAVPAELR
>Mature_318_residues
MKLDPTSPSLNIMLANPRGFCAGVDRAISIVERALELFSPPIYVRHEVVHNRYVVQNLKDRGAVFVEELDQVPDNNIVIF
SAHGVSQAVRAEAKARGLRVFDATCPLVTKVHLQVTRASRKGIECILIGHEGHPEVEGTMGQYDNPNGGVYLIESPADVE
TLEVRDPNNLCFVTQTTLSVDDTLDIITALQKRFPSIEGPRKDDICYATQNRQDAVRNLSADVDLLIVVGSKNSSNSNRL
RELALKTGTQSYLVDTADDIDSSWFENVTKVAVTAGASAPEVLVQQVVQAIAKLAPSVVTEVEGRKEDTVFAVPAELR

Specific function: Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) [H]

COG id: COG0761

COG function: function code IM; Penicillin tolerance protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ispH family [H]

Homologues:

Organism=Escherichia coli, GI1786212, Length=309, Percent_Identity=65.6957928802589, Blast_Score=428, Evalue=1e-121,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003451 [H]

Pfam domain/function: PF02401 LYTB [H]

EC number: =1.17.1.2 [H]

Molecular weight: Translated: 34758; Mature: 34758

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLDPTSPSLNIMLANPRGFCAGVDRAISIVERALELFSPPIYVRHEVVHNRYVVQNLKD
CCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHC
RGAVFVEELDQVPDNNIVIFSAHGVSQAVRAEAKARGLRVFDATCPLVTKVHLQVTRASR
CCCHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHCCEEEEECCCCEEEEEEEEEEECCC
KGIECILIGHEGHPEVEGTMGQYDNPNGGVYLIESPADVETLEVRDPNNLCFVTQTTLSV
CCCEEEEECCCCCCCCCCCCCCCCCCCCCEEEEECCCCCEEEEEECCCCEEEEEEEEECC
DDTLDIITALQKRFPSIEGPRKDDICYATQNRQDAVRNLSADVDLLIVVGSKNSSNSNRL
CHHHHHHHHHHHHCCCCCCCCCCCEEEECCCHHHHHHHCCCCCEEEEEEECCCCCCHHHH
RELALKTGTQSYLVDTADDIDSSWFENVTKVAVTAGASAPEVLVQQVVQAIAKLAPSVVT
HHHHHHCCCCCEEEECHHHCCHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
EVEGRKEDTVFAVPAELR
HCCCCCCCEEEECCCCCC
>Mature Secondary Structure
MKLDPTSPSLNIMLANPRGFCAGVDRAISIVERALELFSPPIYVRHEVVHNRYVVQNLKD
CCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHC
RGAVFVEELDQVPDNNIVIFSAHGVSQAVRAEAKARGLRVFDATCPLVTKVHLQVTRASR
CCCHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHCCEEEEECCCCEEEEEEEEEEECCC
KGIECILIGHEGHPEVEGTMGQYDNPNGGVYLIESPADVETLEVRDPNNLCFVTQTTLSV
CCCEEEEECCCCCCCCCCCCCCCCCCCCCEEEEECCCCCEEEEEECCCCEEEEEEEEECC
DDTLDIITALQKRFPSIEGPRKDDICYATQNRQDAVRNLSADVDLLIVVGSKNSSNSNRL
CHHHHHHHHHHHHCCCCCCCCCCCEEEECCCHHHHHHHCCCCCEEEEEEECCCCCCHHHH
RELALKTGTQSYLVDTADDIDSSWFENVTKVAVTAGASAPEVLVQQVVQAIAKLAPSVVT
HHHHHHCCCCCEEEECHHHCCHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
EVEGRKEDTVFAVPAELR
HCCCCCCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]