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The map label for this gene is mutH [H]

Identifier: 117921483

GI number: 117921483

Start: 3649129

End: 3649800

Strand: Direct

Name: mutH [H]

Synonym: Shewana3_3044

Alternate gene names: 117921483

Gene position: 3649129-3649800 (Clockwise)

Preceding gene: 117921472

Following gene: 117921484

Centisome position: 73.39

GC content: 49.85

Gene sequence:

>672_bases
ATGAAACCGATAATCCCCCCTCAAAATCTGAGCGAACTGCTCGAACGTGCCAATATGATGGCCGGCATCTCTTTGGCTCA
AATTGCTGCTCACCGGGGGATTGCTGTGCCTAAGGATCTGAAACGAGATAAGGGCTGGGTCGGACAACTCATTGAAATGG
AGTTAGGTGCGACGGCCGGCTCAAAACCCGAGCAGGATTTTCTCCACCTCGGTGTAGAGCTAAAAACCATTCCCATCGAT
AGCAAAGGCAAACCACTGGAAACCACCTATGTGTGTGTGGCGCCGCTTACCAATATCGAAGGCTTAACCTGGCAGGACAG
CTTAGTGTGTCACAAGTTGCAGCGTGTACTCTGGGTACCCGTTGAGGGAGAGCGGCATATTCCTGTGGGAGATCGTAGAG
TCGGTACCCCCATATTGTGGGAACCTGATCTCCAAGAGCAAAGGTTACTGCAACAGGATTGGGAGGAGATAATGGAACTT
ATCGCCTTAGGTAAAGTGGAAAAACTCACTGCAAGGCATGGCGAAGTGTTGCAACTGCGCCCTAAAGCCGCCAACAGTAA
GGCGCTGACACAGAGCATTGCCGAGGACGGTAGCCTAAAAATGACCAATCCACGTGGTTTCTATTTAAAGACCGCTTTTA
CCGCCATGCTATTAAATAAGGTATTTGGTTAA

Upstream 100 bases:

>100_bases
ACACTTACAGATTTATCTGTGAGTACAATCTTATCCTTTTTTGAGTGCTTAATTTTTAACCTCTGTTGCTAAGCACCTAT
TTTCCAGTAAAATTCGCCTT

Downstream 100 bases:

>100_bases
ATTTTCGTAGCTATATAGCGTTGGATTGATCCAGATCACAAATATCACTGGCACTCTAGTGATGATTTTCTATAAACTAC
GGCATCCTGAAATATATGGT

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: Methyl-directed mismatch repair protein [H]

Number of amino acids: Translated: 223; Mature: 223

Protein sequence:

>223_residues
MKPIIPPQNLSELLERANMMAGISLAQIAAHRGIAVPKDLKRDKGWVGQLIEMELGATAGSKPEQDFLHLGVELKTIPID
SKGKPLETTYVCVAPLTNIEGLTWQDSLVCHKLQRVLWVPVEGERHIPVGDRRVGTPILWEPDLQEQRLLQQDWEEIMEL
IALGKVEKLTARHGEVLQLRPKAANSKALTQSIAEDGSLKMTNPRGFYLKTAFTAMLLNKVFG

Sequences:

>Translated_223_residues
MKPIIPPQNLSELLERANMMAGISLAQIAAHRGIAVPKDLKRDKGWVGQLIEMELGATAGSKPEQDFLHLGVELKTIPID
SKGKPLETTYVCVAPLTNIEGLTWQDSLVCHKLQRVLWVPVEGERHIPVGDRRVGTPILWEPDLQEQRLLQQDWEEIMEL
IALGKVEKLTARHGEVLQLRPKAANSKALTQSIAEDGSLKMTNPRGFYLKTAFTAMLLNKVFG
>Mature_223_residues
MKPIIPPQNLSELLERANMMAGISLAQIAAHRGIAVPKDLKRDKGWVGQLIEMELGATAGSKPEQDFLHLGVELKTIPID
SKGKPLETTYVCVAPLTNIEGLTWQDSLVCHKLQRVLWVPVEGERHIPVGDRRVGTPILWEPDLQEQRLLQQDWEEIMEL
IALGKVEKLTARHGEVLQLRPKAANSKALTQSIAEDGSLKMTNPRGFYLKTAFTAMLLNKVFG

Specific function: Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair [H]

COG id: COG3066

COG function: function code L; DNA mismatch repair protein

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mutH family [H]

Homologues:

Organism=Escherichia coli, GI1789196, Length=222, Percent_Identity=59.4594594594595, Blast_Score=281, Evalue=3e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004230
- InterPro:   IPR011337
- InterPro:   IPR011335 [H]

Pfam domain/function: PF02976 MutH [H]

EC number: NA

Molecular weight: Translated: 24840; Mature: 24840

Theoretical pI: Translated: 7.63; Mature: 7.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPIIPPQNLSELLERANMMAGISLAQIAAHRGIAVPKDLKRDKGWVGQLIEMELGATAG
CCCCCCCCCHHHHHHHHHHHHCHHHHHHHHHCCCCCCHHHHHCCCHHHHHHHHHHCCCCC
SKPEQDFLHLGVELKTIPIDSKGKPLETTYVCVAPLTNIEGLTWQDSLVCHKLQRVLWVP
CCCCHHHHHCCEEEEEEECCCCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHEEEC
VEGERHIPVGDRRVGTPILWEPDLQEQRLLQQDWEEIMELIALGKVEKLTARHGEVLQLR
CCCCCCCCCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCEEEEC
PKAANSKALTQSIAEDGSLKMTNPRGFYLKTAFTAMLLNKVFG
CCCCCHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKPIIPPQNLSELLERANMMAGISLAQIAAHRGIAVPKDLKRDKGWVGQLIEMELGATAG
CCCCCCCCCHHHHHHHHHHHHCHHHHHHHHHCCCCCCHHHHHCCCHHHHHHHHHHCCCCC
SKPEQDFLHLGVELKTIPIDSKGKPLETTYVCVAPLTNIEGLTWQDSLVCHKLQRVLWVP
CCCCHHHHHCCEEEEEEECCCCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHEEEC
VEGERHIPVGDRRVGTPILWEPDLQEQRLLQQDWEEIMELIALGKVEKLTARHGEVLQLR
CCCCCCCCCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCEEEEC
PKAANSKALTQSIAEDGSLKMTNPRGFYLKTAFTAMLLNKVFG
CCCCCHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]