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The map label for this gene is pgcA [H]

Identifier: 117921148

GI number: 117921148

Start: 3235137

End: 3236858

Strand: Reverse

Name: pgcA [H]

Synonym: Shewana3_2707

Alternate gene names: 117921148

Gene position: 3236858-3235137 (Counterclockwise)

Preceding gene: 117921149

Following gene: 117921147

Centisome position: 65.1

GC content: 52.96

Gene sequence:

>1722_bases
ATGAATACCCATTTGCAATTACAGGTTAAGCATTGGCTCGAAAATGACCCCGATCCCCGCACTCAGGCACAACTGCAAGC
CTTAATCGACGCCGGAAATGACGCCGAACTCGAGGCTCGTTTTGCGGGACGTTTAGAATTTGGTACCGCCGGATTACGCG
GTGTGGTGGGCGCTGGTCCTATGGGCATGAATCGCCTAGTGATCCGTCAAACATCTGCTGGGCTTGGTGCCTATTTACTC
GAACAAATTAAAGATGCCGCAGAACGTGGTGTCGTGATTGGTTACGATGGCCGCCATGATTCACGCACTTTCGCCCATGA
TACCGCCAGTGTGCTTACCGCGATGGGTATTAAGGTGCGCCTCACCGCCAAAGTGGCGCCAACGCCGCTGGTGGCCTTTG
GGGTTAAGCATTTTAATGCCGCTGCGGGCATTGTGGTGACCGCCAGCCATAACCCGCCACAATACAATGGCTACAAAGTG
TATTGGGAAAACGGCGCACAGATTATCCCGCCCCATGACTCTGGTATCGCCGCTAAGATTGAGCTGGCGGCAACTCAAGC
TATTCCGTTTATGGATCAGGTTGAGGCGACCAAACAGGGCAAGCTTATCTGGTTGCAGGACGATTATTACGAAACCTATC
GCCGCGGCGTGATGCACGCCAATGTGCTGCAAAATAACACTGCGCCCGAAAAAGTCAGCCTTGCCTATACCGCCATGCAC
GGTGTGGGCGCTGAAATGGCGGAAACTGTGCTCAAGGATGCGGGTTTTGCCCAAGTGTATTCGGTGGTGGCGCAGCGCGA
GCCCGATGGGGATTTCCCAACGGTTAACTTCCCTAATCCGGAAGAAAAGGGTGCGATGGACTTAGTCATTGCCGAAGCGA
AAAAGCATGGCGCCATGCTCGCCTGTGCCAATGACCCCGATGCGGACAGATTTGCGGTTGCAGTTCGTAAGGATGATGGC
GAGTATCAAATGCTAACGGGTGACCAAGTGGGTGTGCTCTTTGGTCATTATCTGTTAAGCCATGCGAGCAAGGAGCAGCG
TCTGGTGGGCACGACTATTGTCTCCTCCAGTCTATTATCTAAAATCGCTAAAGGCTTTGGCGTTGAAAGCTATACCACGC
TCACCGGTTTTAAGTGGCTGATGAATGTGGGAATTGCGCAGAGTCAGCCTGATAACCAATTCCTGTTTGCCTACGAAGAA
GCCCTGGGTTACACGGTCGGTAACATGGTGTGGGATAAGGACGGCTTGTCGGCTCTCGTCGCCTTTGCCCAATTAACCGC
CGAGCTTGCCGCTAAAGGGCAAACCATTTGGGATAGACTCGAGCAGATTTACCGCGAGCAGGGTTTCCATCTCAATGCTC
AAGTTAGCATTGCCTTAAAACCCGACACGCCTAATATTGGCGCGTATCTGCGTGAACATCCACCGCTGGCAATTGGTGAA
CATGCCTTGGTGTCGACCGATGATCTCAAGGCATTAGAGCGCCGTTTTGCCGATGGTAAGGTTGAGAAAATCAATCTGCC
CGCCAGTGATGTATTAACCTATCGCTTAGCCAATGGCGCGCGGGTTATAGTCAGGCCGTCAGGCACTGAGCCTAAAATCA
AGTGTTACTACGAGGTGGTCGAACCTATGACGGCGCAAGACACCTTAGCCAGCGCCCAAGCACGGGCAACTCTGGCGATG
GAGGCGTTTATTTCAGCCCATCAGGCGAGCCTGCCTAAATAA

Upstream 100 bases:

>100_bases
CCTCTTTACACTTAAATCCGTTGTGAAAAGTGCAAATTCGCTTGTTCTTCGGCATGGATTTTCCTAAGGTGATTGAAAAT
GATTTTCACTGAGGCCCCCT

Downstream 100 bases:

>100_bases
GCGCCTTGAGCGCACTCAATAAAATCGCTTCACTCAAAGGCTACTGACATGATGTTGTCAGTAGCCTTGTTTTATTCTTG
TTGTCGTCCGCTGGTGAACC

Product: phosphoglucomutase/phosphomannomutase alpha/beta/subunit

Products: NA

Alternate protein names: PGM; Alpha-phosphoglucomutase; Glucose phosphomutase [H]

Number of amino acids: Translated: 573; Mature: 573

Protein sequence:

>573_residues
MNTHLQLQVKHWLENDPDPRTQAQLQALIDAGNDAELEARFAGRLEFGTAGLRGVVGAGPMGMNRLVIRQTSAGLGAYLL
EQIKDAAERGVVIGYDGRHDSRTFAHDTASVLTAMGIKVRLTAKVAPTPLVAFGVKHFNAAAGIVVTASHNPPQYNGYKV
YWENGAQIIPPHDSGIAAKIELAATQAIPFMDQVEATKQGKLIWLQDDYYETYRRGVMHANVLQNNTAPEKVSLAYTAMH
GVGAEMAETVLKDAGFAQVYSVVAQREPDGDFPTVNFPNPEEKGAMDLVIAEAKKHGAMLACANDPDADRFAVAVRKDDG
EYQMLTGDQVGVLFGHYLLSHASKEQRLVGTTIVSSSLLSKIAKGFGVESYTTLTGFKWLMNVGIAQSQPDNQFLFAYEE
ALGYTVGNMVWDKDGLSALVAFAQLTAELAAKGQTIWDRLEQIYREQGFHLNAQVSIALKPDTPNIGAYLREHPPLAIGE
HALVSTDDLKALERRFADGKVEKINLPASDVLTYRLANGARVIVRPSGTEPKIKCYYEVVEPMTAQDTLASAQARATLAM
EAFISAHQASLPK

Sequences:

>Translated_573_residues
MNTHLQLQVKHWLENDPDPRTQAQLQALIDAGNDAELEARFAGRLEFGTAGLRGVVGAGPMGMNRLVIRQTSAGLGAYLL
EQIKDAAERGVVIGYDGRHDSRTFAHDTASVLTAMGIKVRLTAKVAPTPLVAFGVKHFNAAAGIVVTASHNPPQYNGYKV
YWENGAQIIPPHDSGIAAKIELAATQAIPFMDQVEATKQGKLIWLQDDYYETYRRGVMHANVLQNNTAPEKVSLAYTAMH
GVGAEMAETVLKDAGFAQVYSVVAQREPDGDFPTVNFPNPEEKGAMDLVIAEAKKHGAMLACANDPDADRFAVAVRKDDG
EYQMLTGDQVGVLFGHYLLSHASKEQRLVGTTIVSSSLLSKIAKGFGVESYTTLTGFKWLMNVGIAQSQPDNQFLFAYEE
ALGYTVGNMVWDKDGLSALVAFAQLTAELAAKGQTIWDRLEQIYREQGFHLNAQVSIALKPDTPNIGAYLREHPPLAIGE
HALVSTDDLKALERRFADGKVEKINLPASDVLTYRLANGARVIVRPSGTEPKIKCYYEVVEPMTAQDTLASAQARATLAM
EAFISAHQASLPK
>Mature_573_residues
MNTHLQLQVKHWLENDPDPRTQAQLQALIDAGNDAELEARFAGRLEFGTAGLRGVVGAGPMGMNRLVIRQTSAGLGAYLL
EQIKDAAERGVVIGYDGRHDSRTFAHDTASVLTAMGIKVRLTAKVAPTPLVAFGVKHFNAAAGIVVTASHNPPQYNGYKV
YWENGAQIIPPHDSGIAAKIELAATQAIPFMDQVEATKQGKLIWLQDDYYETYRRGVMHANVLQNNTAPEKVSLAYTAMH
GVGAEMAETVLKDAGFAQVYSVVAQREPDGDFPTVNFPNPEEKGAMDLVIAEAKKHGAMLACANDPDADRFAVAVRKDDG
EYQMLTGDQVGVLFGHYLLSHASKEQRLVGTTIVSSSLLSKIAKGFGVESYTTLTGFKWLMNVGIAQSQPDNQFLFAYEE
ALGYTVGNMVWDKDGLSALVAFAQLTAELAAKGQTIWDRLEQIYREQGFHLNAQVSIALKPDTPNIGAYLREHPPLAIGE
HALVSTDDLKALERRFADGKVEKINLPASDVLTYRLANGARVIVRPSGTEPKIKCYYEVVEPMTAQDTLASAQARATLAM
EAFISAHQASLPK

Specific function: Catalyzes the interconversion between glucose-6- phosphate and alpha-glucose-1-phosphate. This is the first step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i.e. the predominant glycolipid found in B.subtilis membrane, which is also used

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Homo sapiens, GI63055049, Length=578, Percent_Identity=36.5051903114187, Blast_Score=343, Evalue=2e-94,
Organism=Homo sapiens, GI31377548, Length=576, Percent_Identity=33.6805555555556, Blast_Score=299, Evalue=4e-81,
Organism=Escherichia coli, GI1789566, Length=320, Percent_Identity=26.5625, Blast_Score=69, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI71993870, Length=563, Percent_Identity=35.1687388987567, Blast_Score=305, Evalue=5e-83,
Organism=Caenorhabditis elegans, GI71993878, Length=318, Percent_Identity=36.4779874213836, Blast_Score=201, Evalue=8e-52,
Organism=Saccharomyces cerevisiae, GI6323934, Length=598, Percent_Identity=34.9498327759197, Blast_Score=289, Evalue=8e-79,
Organism=Drosophila melanogaster, GI20129809, Length=568, Percent_Identity=36.2676056338028, Blast_Score=328, Evalue=8e-90,
Organism=Drosophila melanogaster, GI24651977, Length=552, Percent_Identity=35.6884057971014, Blast_Score=310, Evalue=1e-84,
Organism=Drosophila melanogaster, GI24653722, Length=567, Percent_Identity=32.2751322751323, Blast_Score=265, Evalue=5e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2 [H]

Molecular weight: Translated: 62278; Mature: 62278

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTHLQLQVKHWLENDPDPRTQAQLQALIDAGNDAELEARFAGRLEFGTAGLRGVVGAGP
CCCEEEEEEHHHCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCEEEECCCCCCCCCCCCC
MGMNRLVIRQTSAGLGAYLLEQIKDAAERGVVIGYDGRHDSRTFAHDTASVLTAMGIKVR
CCCCEEEEEECCCCHHHHHHHHHHHHHHCCEEEEECCCCCCCCHHHHHHHHHHHCCEEEE
LTAKVAPTPLVAFGVKHFNAAAGIVVTASHNPPQYNGYKVYWENGAQIIPPHDSGIAAKI
EEEECCCCCHHHHHHHHCCCCCCEEEEECCCCCCCCCEEEEEECCCEEECCCCCCCEEEE
ELAATQAIPFMDQVEATKQGKLIWLQDDYYETYRRGVMHANVLQNNTAPEKVSLAYTAMH
EEEHHHCCCCHHHHHHCCCCCEEEEECHHHHHHHHCCEEHHHHCCCCCCCCEEEEEHHHH
GVGAEMAETVLKDAGFAQVYSVVAQREPDGDFPTVNFPNPEEKGAMDLVIAEAKKHGAML
CCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCEE
ACANDPDADRFAVAVRKDDGEYQMLTGDQVGVLFGHYLLSHASKEQRLVGTTIVSSSLLS
EECCCCCCCEEEEEEEECCCCEEEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
KIAKGFGVESYTTLTGFKWLMNVGIAQSQPDNQFLFAYEEALGYTVGNMVWDKDGLSALV
HHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEEEHHHHCCCHHCEEECCCHHHHHH
AFAQLTAELAAKGQTIWDRLEQIYREQGFHLNAQVSIALKPDTPNIGAYLREHPPLAIGE
HHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEEEEEEECCCCCCCCHHHHCCCCCEECC
HALVSTDDLKALERRFADGKVEKINLPASDVLTYRLANGARVIVRPSGTEPKIKCYYEVV
CEEECCHHHHHHHHHHCCCCEEEECCCHHHHEEEEECCCCEEEEECCCCCCCEEEEEEHH
EPMTAQDTLASAQARATLAMEAFISAHQASLPK
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNTHLQLQVKHWLENDPDPRTQAQLQALIDAGNDAELEARFAGRLEFGTAGLRGVVGAGP
CCCEEEEEEHHHCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCEEEECCCCCCCCCCCCC
MGMNRLVIRQTSAGLGAYLLEQIKDAAERGVVIGYDGRHDSRTFAHDTASVLTAMGIKVR
CCCCEEEEEECCCCHHHHHHHHHHHHHHCCEEEEECCCCCCCCHHHHHHHHHHHCCEEEE
LTAKVAPTPLVAFGVKHFNAAAGIVVTASHNPPQYNGYKVYWENGAQIIPPHDSGIAAKI
EEEECCCCCHHHHHHHHCCCCCCEEEEECCCCCCCCCEEEEEECCCEEECCCCCCCEEEE
ELAATQAIPFMDQVEATKQGKLIWLQDDYYETYRRGVMHANVLQNNTAPEKVSLAYTAMH
EEEHHHCCCCHHHHHHCCCCCEEEEECHHHHHHHHCCEEHHHHCCCCCCCCEEEEEHHHH
GVGAEMAETVLKDAGFAQVYSVVAQREPDGDFPTVNFPNPEEKGAMDLVIAEAKKHGAML
CCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCEE
ACANDPDADRFAVAVRKDDGEYQMLTGDQVGVLFGHYLLSHASKEQRLVGTTIVSSSLLS
EECCCCCCCEEEEEEEECCCCEEEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
KIAKGFGVESYTTLTGFKWLMNVGIAQSQPDNQFLFAYEEALGYTVGNMVWDKDGLSALV
HHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEEEHHHHCCCHHCEEECCCHHHHHH
AFAQLTAELAAKGQTIWDRLEQIYREQGFHLNAQVSIALKPDTPNIGAYLREHPPLAIGE
HHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEEEEEEECCCCCCCCHHHHCCCCCEECC
HALVSTDDLKALERRFADGKVEKINLPASDVLTYRLANGARVIVRPSGTEPKIKCYYEVV
CEEECCHHHHHHHHHHCCCCEEEECCCHHHHEEEEECCCCEEEEECCCCCCCEEEEEEHH
EPMTAQDTLASAQARATLAMEAFISAHQASLPK
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 2127799 [H]