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The map label for this gene is lon [H]

Identifier: 117921100

GI number: 117921100

Start: 3172975

End: 3175332

Strand: Reverse

Name: lon [H]

Synonym: Shewana3_2659

Alternate gene names: 117921100

Gene position: 3175332-3172975 (Counterclockwise)

Preceding gene: 117921101

Following gene: 117921099

Centisome position: 63.86

GC content: 49.62

Gene sequence:

>2358_bases
ATGACCTTAGAGCGTGAAGCGCATATCGAACTCCCCGTGCTACCACTGAGAGATGTGGTGGTCTATCCCCATATGGTAAT
TCCGTTGTTCGTTGGCCGAGAAAAATCGATTCGTTGTCTCGAAACGGCAATGGCCCAGGATAAGCAAATTATTTTAGTCG
CTCAGCGTGACGCTGAGTTAGACGAGCCGACCAAAGACGATATCTTTGAAGTCGGTACAGTGGCGTCTATTCTGCAACTG
CTTAAACTGCCTGACGGTACGGTAAAAGTACTGGTTGAAGGCGGTCGCCGCACTCGTATTACCCGTTATACCCAAGAAGC
GGATTTCTTTGTGGCTAAGGCGGAGTATCTTGAGTCTGAGCCTTTGGAAGACAAAGAAGAGGAAGTCTTAGTTCGTAGCG
CGATTGGCCAATTTGAAGGCTATATCAAGCTCAACAAGAAGATCCCTCCTGAAGTCTTAACCTCACTCTCTGGCATCGAT
GAAGCGGCGCGCCTTGCCGATACCATGGCGGCCCACATGCCACTCAAGCTTGAAGACAAGCAGTCCGTGCTGGAGATGAC
TAACGTCGGTGAGCGTCTGGAATATTTAATGGCGATGATGGAGTCGGAAATTGACCTGCTACAGGTCGAGAAACGCATCC
GTACCCGCGTTAAAAAGCAGATGGAAAAGAGCCAACGTGAGTATTATCTGAACGAGCAGATGAAAGCCATCCAAAAAGAA
TTGGGTGACTTAGACGAAGGCCACGACGAGTTTGAAGTCTTAAATCGTAAGATTGAAGAAGCTAACATGCCAAGCGATGC
TAAAGAGAAAGCCGTCGCCGAGCTGAATAAATTACGCATGATGTCGCCTATGTCTGCCGAAGCGACCGTTGTTCGCAGTT
ACGTGGATTGGATGACCTCAGTGCCTTGGAGCCAACGCTCTAAAATCAAACGCGATTTAGCCAAAGCCCAAGAAGTGCTA
GATACCGATCACTATGGCCTGGAAAAGGTCAAAGACCGTATTCTGGAATACTTGGCGGTGCAGAGCCGTGTGCGTCAACT
TAAAGGGCCTATCCTGTGCTTAGTCGGCCCACCAGGTGTGGGTAAAACCTCATTAGGCCAATCGATTGCGAAAGCAACTG
GTCGTAAGTATGTGCGTGTTGCCTTAGGCGGCGTGCGTGATGAAGCGGAAATCCGTGGTCATCGCCGTACTTACATTGGC
TCAATGCCGGGTAAAGTCATTCAAAAGATGGCGAAAGTGGGCGTGAAAAACCCCTTATTCTTGCTCGATGAAATCGACAA
AATGAGCTCGGATATGCGCGGCGACCCAGCGTCAGCACTGTTAGAGGTGCTTGATCCTGAACAAAACGCGACCTTTAACG
ACCATTATCTCGAAGTCGACTACGACTTATCCGATGTGATGTTCGTGGCGACCTCGAACTCGATGAATATTCCAGGCCCA
TTGCTGGACCGTATGGAAGTCATTCGCCTGTCGGGTTACACCGAAGATGAGAAGCTCAATATTGCTAAGCAGCATTTACT
GACCAAGCAAATCGAGCGTAACGGTCTTAAAGCGAACGAAATTCATATCGAAGACAGTGCGATAGTCGGCATTATCCGCT
ACTACACCCGTGAAGCCGGTGTTCGTGCACTAGAGCGTGAATTGTCGAAGATTTGCCGCAAGGTCGTGAAAATGATCCTG
CTGGATAAGTCCATCAAGTCAGTCACAGTGACCGCGGACAATCTCAAGTCTTTCCTTGGTGTACAGCGTTTTGACTACGG
TAAGGCGGAGTCGAACAACCAAATCGGTCAAGTTACAGGTTTGGCGTGGACCGAAGTGGGTGGCGATCTGCTTACCATTG
AAGCGACCTCTGTGCCAGGCAAAGGCAAGTTGACCTACACAGGCTCACTTGGCGATGTGATGCAAGAGTCGATTCAAGCG
GCAATGACGGTCGTGCGTGCCCGTGCGGAACAATTAGGTATCAACGGCGACTTTTATGAGAAGCGTGATATCCATGTTCA
CGTGCCAGAAGGGGCGACGCCAAAAGATGGTCCATCTGCGGGCGCGGCAATGTGTACTGCATTAGTGTCTAGCTTAACGG
GTAACCCAGTGCGCGCCGATGTGGCGATGACGGGTGAAATTACCTTACGCGGAGAAGTGTTACCGATCGGCGGTTTAAAA
GAAAAACTGCTCGCGGCACACCGTGGTGGCATTAAATTGGTACTTATTCCAAAAGAAAACGAGCGTGATCTGGAAGAAAT
TCCTGCCAATGTGATTGCCGATTTGGAAATTCGTCCCGTGCGTTGGGTCGACGAAGTGTTAAAACTGGCGCTAGAAAGAC
CGGTTGAAGGCTTCGAAGTGGTTAAAAACTTGGCATAA

Upstream 100 bases:

>100_bases
GAGTCCATCGGGCTCCTTTTTTTATTTTGCCCATTGAAACCCACTAAAGCGCCCCAATATACTCCTTAACTAATCCCTTT
CATCCAAACGGAATCGAACT

Downstream 100 bases:

>100_bases
CGCAAGAAAATGCGCTATCACGCTAAAAAAAATGAAAAAAGGGGCTTAACAAAGCGCAGACCTGTGGTAGCCTAGGTCTG
TGGAGAGTCGGTTGCTCCAA

Product: Lon-A peptidase

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 785; Mature: 784

Protein sequence:

>785_residues
MTLEREAHIELPVLPLRDVVVYPHMVIPLFVGREKSIRCLETAMAQDKQIILVAQRDAELDEPTKDDIFEVGTVASILQL
LKLPDGTVKVLVEGGRRTRITRYTQEADFFVAKAEYLESEPLEDKEEEVLVRSAIGQFEGYIKLNKKIPPEVLTSLSGID
EAARLADTMAAHMPLKLEDKQSVLEMTNVGERLEYLMAMMESEIDLLQVEKRIRTRVKKQMEKSQREYYLNEQMKAIQKE
LGDLDEGHDEFEVLNRKIEEANMPSDAKEKAVAELNKLRMMSPMSAEATVVRSYVDWMTSVPWSQRSKIKRDLAKAQEVL
DTDHYGLEKVKDRILEYLAVQSRVRQLKGPILCLVGPPGVGKTSLGQSIAKATGRKYVRVALGGVRDEAEIRGHRRTYIG
SMPGKVIQKMAKVGVKNPLFLLDEIDKMSSDMRGDPASALLEVLDPEQNATFNDHYLEVDYDLSDVMFVATSNSMNIPGP
LLDRMEVIRLSGYTEDEKLNIAKQHLLTKQIERNGLKANEIHIEDSAIVGIIRYYTREAGVRALERELSKICRKVVKMIL
LDKSIKSVTVTADNLKSFLGVQRFDYGKAESNNQIGQVTGLAWTEVGGDLLTIEATSVPGKGKLTYTGSLGDVMQESIQA
AMTVVRARAEQLGINGDFYEKRDIHVHVPEGATPKDGPSAGAAMCTALVSSLTGNPVRADVAMTGEITLRGEVLPIGGLK
EKLLAAHRGGIKLVLIPKENERDLEEIPANVIADLEIRPVRWVDEVLKLALERPVEGFEVVKNLA

Sequences:

>Translated_785_residues
MTLEREAHIELPVLPLRDVVVYPHMVIPLFVGREKSIRCLETAMAQDKQIILVAQRDAELDEPTKDDIFEVGTVASILQL
LKLPDGTVKVLVEGGRRTRITRYTQEADFFVAKAEYLESEPLEDKEEEVLVRSAIGQFEGYIKLNKKIPPEVLTSLSGID
EAARLADTMAAHMPLKLEDKQSVLEMTNVGERLEYLMAMMESEIDLLQVEKRIRTRVKKQMEKSQREYYLNEQMKAIQKE
LGDLDEGHDEFEVLNRKIEEANMPSDAKEKAVAELNKLRMMSPMSAEATVVRSYVDWMTSVPWSQRSKIKRDLAKAQEVL
DTDHYGLEKVKDRILEYLAVQSRVRQLKGPILCLVGPPGVGKTSLGQSIAKATGRKYVRVALGGVRDEAEIRGHRRTYIG
SMPGKVIQKMAKVGVKNPLFLLDEIDKMSSDMRGDPASALLEVLDPEQNATFNDHYLEVDYDLSDVMFVATSNSMNIPGP
LLDRMEVIRLSGYTEDEKLNIAKQHLLTKQIERNGLKANEIHIEDSAIVGIIRYYTREAGVRALERELSKICRKVVKMIL
LDKSIKSVTVTADNLKSFLGVQRFDYGKAESNNQIGQVTGLAWTEVGGDLLTIEATSVPGKGKLTYTGSLGDVMQESIQA
AMTVVRARAEQLGINGDFYEKRDIHVHVPEGATPKDGPSAGAAMCTALVSSLTGNPVRADVAMTGEITLRGEVLPIGGLK
EKLLAAHRGGIKLVLIPKENERDLEEIPANVIADLEIRPVRWVDEVLKLALERPVEGFEVVKNLA
>Mature_784_residues
TLEREAHIELPVLPLRDVVVYPHMVIPLFVGREKSIRCLETAMAQDKQIILVAQRDAELDEPTKDDIFEVGTVASILQLL
KLPDGTVKVLVEGGRRTRITRYTQEADFFVAKAEYLESEPLEDKEEEVLVRSAIGQFEGYIKLNKKIPPEVLTSLSGIDE
AARLADTMAAHMPLKLEDKQSVLEMTNVGERLEYLMAMMESEIDLLQVEKRIRTRVKKQMEKSQREYYLNEQMKAIQKEL
GDLDEGHDEFEVLNRKIEEANMPSDAKEKAVAELNKLRMMSPMSAEATVVRSYVDWMTSVPWSQRSKIKRDLAKAQEVLD
TDHYGLEKVKDRILEYLAVQSRVRQLKGPILCLVGPPGVGKTSLGQSIAKATGRKYVRVALGGVRDEAEIRGHRRTYIGS
MPGKVIQKMAKVGVKNPLFLLDEIDKMSSDMRGDPASALLEVLDPEQNATFNDHYLEVDYDLSDVMFVATSNSMNIPGPL
LDRMEVIRLSGYTEDEKLNIAKQHLLTKQIERNGLKANEIHIEDSAIVGIIRYYTREAGVRALERELSKICRKVVKMILL
DKSIKSVTVTADNLKSFLGVQRFDYGKAESNNQIGQVTGLAWTEVGGDLLTIEATSVPGKGKLTYTGSLGDVMQESIQAA
MTVVRARAEQLGINGDFYEKRDIHVHVPEGATPKDGPSAGAAMCTALVSSLTGNPVRADVAMTGEITLRGEVLPIGGLKE
KLLAAHRGGIKLVLIPKENERDLEEIPANVIADLEIRPVRWVDEVLKLALERPVEGFEVVKNLA

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=775, Percent_Identity=39.0967741935484, Blast_Score=530, Evalue=1e-150,
Organism=Homo sapiens, GI21396489, Length=830, Percent_Identity=36.3855421686747, Blast_Score=506, Evalue=1e-143,
Organism=Escherichia coli, GI1786643, Length=781, Percent_Identity=80.7938540332907, Blast_Score=1287, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=653, Percent_Identity=41.1944869831547, Blast_Score=495, Evalue=1e-140,
Organism=Caenorhabditis elegans, GI17556486, Length=792, Percent_Identity=33.3333333333333, Blast_Score=426, Evalue=1e-119,
Organism=Saccharomyces cerevisiae, GI6319449, Length=748, Percent_Identity=37.4331550802139, Blast_Score=492, Evalue=1e-140,
Organism=Drosophila melanogaster, GI221513036, Length=620, Percent_Identity=45, Blast_Score=524, Evalue=1e-148,
Organism=Drosophila melanogaster, GI24666867, Length=620, Percent_Identity=45, Blast_Score=523, Evalue=1e-148,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 87573; Mature: 87442

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLEREAHIELPVLPLRDVVVYPHMVIPLFVGREKSIRCLETAMAQDKQIILVAQRDAEL
CCCCCCCCCCCCCCCHHHHHHCCHHHHHHEECCCCHHHHHHHHHCCCCEEEEEEECCCCC
DEPTKDDIFEVGTVASILQLLKLPDGTVKVLVEGGRRTRITRYTQEADFFVAKAEYLESE
CCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEEEHHHHHHHHHHHHHHCCC
PLEDKEEEVLVRSAIGQFEGYIKLNKKIPPEVLTSLSGIDEAARLADTMAAHMPLKLEDK
CCCCHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHCHHHHHHHHHHHHHHCCCEECHH
QSVLEMTNVGERLEYLMAMMESEIDLLQVEKRIRTRVKKQMEKSQREYYLNEQMKAIQKE
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGDLDEGHDEFEVLNRKIEEANMPSDAKEKAVAELNKLRMMSPMSAEATVVRSYVDWMTS
HCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHC
VPWSQRSKIKRDLAKAQEVLDTDHYGLEKVKDRILEYLAVQSRVRQLKGPILCLVGPPGV
CCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCC
GKTSLGQSIAKATGRKYVRVALGGVRDEAEIRGHRRTYIGSMPGKVIQKMAKVGVKNPLF
CHHHHHHHHHHHCCCCEEEEECCCCCCHHHHCCCHHHHCCCCCHHHHHHHHHCCCCCCHH
LLDEIDKMSSDMRGDPASALLEVLDPEQNATFNDHYLEVDYDLSDVMFVATSNSMNIPGP
HHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCEEEEECCCCCEEEEEECCCCCCCCH
LLDRMEVIRLSGYTEDEKLNIAKQHLLTKQIERNGLKANEIHIEDSAIVGIIRYYTREAG
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHH
VRALERELSKICRKVVKMILLDKSIKSVTVTADNLKSFLGVQRFDYGKAESNNQIGQVTG
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHCCCCCCCCCCCCEEEEC
LAWTEVGGDLLTIEATSVPGKGKLTYTGSLGDVMQESIQAAMTVVRARAEQLGINGDFYE
EEHHHCCCCEEEEEEECCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
KRDIHVHVPEGATPKDGPSAGAAMCTALVSSLTGNPVRADVAMTGEITLRGEVLPIGGLK
CCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEECEEEEECEEEECCCHH
EKLLAAHRGGIKLVLIPKENERDLEEIPANVIADLEIRPVRWVDEVLKLALERPVEGFEV
HHHHHHHCCCEEEEEECCCCCCCHHHCCHHHEECCCCCCHHHHHHHHHHHHHCCCHHHHH
VKNLA
HHHCC
>Mature Secondary Structure 
TLEREAHIELPVLPLRDVVVYPHMVIPLFVGREKSIRCLETAMAQDKQIILVAQRDAEL
CCCCCCCCCCCCCCHHHHHHCCHHHHHHEECCCCHHHHHHHHHCCCCEEEEEEECCCCC
DEPTKDDIFEVGTVASILQLLKLPDGTVKVLVEGGRRTRITRYTQEADFFVAKAEYLESE
CCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEEEHHHHHHHHHHHHHHCCC
PLEDKEEEVLVRSAIGQFEGYIKLNKKIPPEVLTSLSGIDEAARLADTMAAHMPLKLEDK
CCCCHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHCHHHHHHHHHHHHHHCCCEECHH
QSVLEMTNVGERLEYLMAMMESEIDLLQVEKRIRTRVKKQMEKSQREYYLNEQMKAIQKE
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGDLDEGHDEFEVLNRKIEEANMPSDAKEKAVAELNKLRMMSPMSAEATVVRSYVDWMTS
HCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHC
VPWSQRSKIKRDLAKAQEVLDTDHYGLEKVKDRILEYLAVQSRVRQLKGPILCLVGPPGV
CCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCC
GKTSLGQSIAKATGRKYVRVALGGVRDEAEIRGHRRTYIGSMPGKVIQKMAKVGVKNPLF
CHHHHHHHHHHHCCCCEEEEECCCCCCHHHHCCCHHHHCCCCCHHHHHHHHHCCCCCCHH
LLDEIDKMSSDMRGDPASALLEVLDPEQNATFNDHYLEVDYDLSDVMFVATSNSMNIPGP
HHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCEEEEECCCCCEEEEEECCCCCCCCH
LLDRMEVIRLSGYTEDEKLNIAKQHLLTKQIERNGLKANEIHIEDSAIVGIIRYYTREAG
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHH
VRALERELSKICRKVVKMILLDKSIKSVTVTADNLKSFLGVQRFDYGKAESNNQIGQVTG
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHCCCCCCCCCCCCEEEEC
LAWTEVGGDLLTIEATSVPGKGKLTYTGSLGDVMQESIQAAMTVVRARAEQLGINGDFYE
EEHHHCCCCEEEEEEECCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
KRDIHVHVPEGATPKDGPSAGAAMCTALVSSLTGNPVRADVAMTGEITLRGEVLPIGGLK
CCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEECEEEEECEEEECCCHH
EKLLAAHRGGIKLVLIPKENERDLEEIPANVIADLEIRPVRWVDEVLKLALERPVEGFEV
HHHHHHHCCCEEEEEECCCCCCCHHHCCHHHEECCCCCCHHHHHHHHHHHHHCCCHHHHH
VKNLA
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8981986; 12620739 [H]