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The map label for this gene is lpxK

Identifier: 117921024

GI number: 117921024

Start: 3086434

End: 3087441

Strand: Reverse

Name: lpxK

Synonym: Shewana3_2583

Alternate gene names: 117921024

Gene position: 3087441-3086434 (Counterclockwise)

Preceding gene: 117921025

Following gene: 117921023

Centisome position: 62.09

GC content: 53.37

Gene sequence:

>1008_bases
ATGCAGGCGCTGGTAAATAAAATTTGGTACGAGGGCCACCCATTGCGGTGGCTCTTGCTGCCGTTTTCTGTGCTATTCGC
TTTAATCACCGCGATTCGTCGCAGCCTGTTTCGCTTAGGACTCAAATCCCAAACCGCATTACCCGTGCCCGTTATCGTCG
TCGGTAACATTACCGTTGGCGGCAGCGGTAAAACCCCCACAGTCATCTATTTAATTGAGTTGTTACGGCAACATGGGTTT
AATCCAGGTGTGATCAGCCGAGGTTATGGCGCGGATATTCAAGGGGTCAAAGTTGTTACTGCGGTGGATAGCGCGGCGGC
TGTGGGCGATGAGCCCGCCATGATAGTAGCGCGCACCAGTGTGCCTATGGTGGTGGGAGCCAAACGTGTCGATACCGCCA
AGGCATTGCTGGCAGAGTTTGCCGTGGATGTGATTATCTGTGACGATGGCTTGCAGCATTACGCCCTCGGCCGTGACATT
GAGCTGGTGGTGATTGATGGAAAGCGCGGTTTAGGGAATCGTCATTTGCTGCCCGCAGGGCCGCTACGGGAAGGGGCTTG
GCGCCTTAATCAAGTGGATTTTGTGGTGGTCAATGGTGGGCCCGCTCAGGCCAATCAATTTGAGATGCAGCTGAGTCCGA
GTGCAGTGTTACCAGTCAACCCTAAGGCTGAGGCCGTGTTTAACCCGACGCAGCCCGTGGTGGCAATGGCGGGTATTGGT
CATCCGGCGCGCTTTTTTGAGACGTTAACGCAGCAAGGCATTCAACTCGCGTTATCCCATGGTTTTGATGACCACCAAGC
CTACGATAAACACGTGTTATGCGAGCTTGCGGCATCTCGCCCGCTGATGATGACAGAAAAAGATGCGGTTAAATGTCGCG
ATTTTGCACAAGAAAACTGGTGGTATTTGGCTGTGGATGCCAAGCTATCGCCACAATTTGATCAACAGCTGCTGAGCCGT
GTGCGCTCTGTGGCTGCAGCTAAACAAGGAAAATCCCATGGCGTTTGA

Upstream 100 bases:

>100_bases
GGTCGATCAAGGTCGTATCGTTGAGCGCGGTACCCATAAATCCCTGCTGGAACTTGGCGGCATGTATGCCAAGTTATACC
AAATGCAGTTTGGTAGCTAA

Downstream 100 bases:

>100_bases
TAAAAAACTGTTAGACATAGTCGCTTGCCCTGTGTGCAAGGGAAAATTGGAATACGATAAAACAACGCAGCAATTGATTT
GTAAGGCAGACAAATTAGCC

Product: tetraacyldisaccharide 4'-kinase

Products: NA

Alternate protein names: Lipid A 4'-kinase

Number of amino acids: Translated: 335; Mature: 335

Protein sequence:

>335_residues
MQALVNKIWYEGHPLRWLLLPFSVLFALITAIRRSLFRLGLKSQTALPVPVIVVGNITVGGSGKTPTVIYLIELLRQHGF
NPGVISRGYGADIQGVKVVTAVDSAAAVGDEPAMIVARTSVPMVVGAKRVDTAKALLAEFAVDVIICDDGLQHYALGRDI
ELVVIDGKRGLGNRHLLPAGPLREGAWRLNQVDFVVVNGGPAQANQFEMQLSPSAVLPVNPKAEAVFNPTQPVVAMAGIG
HPARFFETLTQQGIQLALSHGFDDHQAYDKHVLCELAASRPLMMTEKDAVKCRDFAQENWWYLAVDAKLSPQFDQQLLSR
VRSVAAAKQGKSHGV

Sequences:

>Translated_335_residues
MQALVNKIWYEGHPLRWLLLPFSVLFALITAIRRSLFRLGLKSQTALPVPVIVVGNITVGGSGKTPTVIYLIELLRQHGF
NPGVISRGYGADIQGVKVVTAVDSAAAVGDEPAMIVARTSVPMVVGAKRVDTAKALLAEFAVDVIICDDGLQHYALGRDI
ELVVIDGKRGLGNRHLLPAGPLREGAWRLNQVDFVVVNGGPAQANQFEMQLSPSAVLPVNPKAEAVFNPTQPVVAMAGIG
HPARFFETLTQQGIQLALSHGFDDHQAYDKHVLCELAASRPLMMTEKDAVKCRDFAQENWWYLAVDAKLSPQFDQQLLSR
VRSVAAAKQGKSHGV
>Mature_335_residues
MQALVNKIWYEGHPLRWLLLPFSVLFALITAIRRSLFRLGLKSQTALPVPVIVVGNITVGGSGKTPTVIYLIELLRQHGF
NPGVISRGYGADIQGVKVVTAVDSAAAVGDEPAMIVARTSVPMVVGAKRVDTAKALLAEFAVDVIICDDGLQHYALGRDI
ELVVIDGKRGLGNRHLLPAGPLREGAWRLNQVDFVVVNGGPAQANQFEMQLSPSAVLPVNPKAEAVFNPTQPVVAMAGIG
HPARFFETLTQQGIQLALSHGFDDHQAYDKHVLCELAASRPLMMTEKDAVKCRDFAQENWWYLAVDAKLSPQFDQQLLSR
VRSVAAAKQGKSHGV

Specific function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)

COG id: COG1663

COG function: function code M; Tetraacyldisaccharide-1-P 4'-kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxK family

Homologues:

Organism=Escherichia coli, GI1787144, Length=328, Percent_Identity=46.0365853658537, Blast_Score=279, Evalue=2e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXK_SHESA (A0KYE1)

Other databases:

- EMBL:   CP000469
- RefSeq:   YP_870216.1
- STRING:   A0KYE1
- GeneID:   4479245
- GenomeReviews:   CP000469_GR
- KEGG:   shn:Shewana3_2583
- NMPDR:   fig|94122.5.peg.2627
- eggNOG:   COG1663
- HOGENOM:   HBG663914
- OMA:   DEPVLIH
- PhylomeDB:   A0KYE1
- ProtClustDB:   PRK00652
- BioCyc:   SSP94122:SHEWANA3_2583-MONOMER
- HAMAP:   MF_00409
- InterPro:   IPR003758
- TIGRFAMs:   TIGR00682

Pfam domain/function: PF02606 LpxK

EC number: =2.7.1.130

Molecular weight: Translated: 36306; Mature: 36306

Theoretical pI: Translated: 8.80; Mature: 8.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQALVNKIWYEGHPLRWLLLPFSVLFALITAIRRSLFRLGLKSQTALPVPVIVVGNITVG
CHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEC
GSGKTPTVIYLIELLRQHGFNPGVISRGYGADIQGVKVVTAVDSAAAVGDEPAMIVARTS
CCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEECHHHHCCCCCEEEEEECC
VPMVVGAKRVDTAKALLAEFAVDVIICDDGLQHYALGRDIELVVIDGKRGLGNRHLLPAG
CCEEECCCHHHHHHHHHHHHHEEEEEECCCCHHHHCCCCEEEEEEECCCCCCCCCCCCCC
PLREGAWRLNQVDFVVVNGGPAQANQFEMQLSPSAVLPVNPKAEAVFNPTQPVVAMAGIG
CCCCCCEEECCEEEEEECCCCCCCCEEEEEECCCEEECCCCCCCEEECCCCCEEEEECCC
HPARFFETLTQQGIQLALSHGFDDHQAYDKHVLCELAASRPLMMTEKDAVKCRDFAQENW
CHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHCCCC
WYLAVDAKLSPQFDQQLLSRVRSVAAAKQGKSHGV
EEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MQALVNKIWYEGHPLRWLLLPFSVLFALITAIRRSLFRLGLKSQTALPVPVIVVGNITVG
CHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEC
GSGKTPTVIYLIELLRQHGFNPGVISRGYGADIQGVKVVTAVDSAAAVGDEPAMIVARTS
CCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEECHHHHCCCCCEEEEEECC
VPMVVGAKRVDTAKALLAEFAVDVIICDDGLQHYALGRDIELVVIDGKRGLGNRHLLPAG
CCEEECCCHHHHHHHHHHHHHEEEEEECCCCHHHHCCCCEEEEEEECCCCCCCCCCCCCC
PLREGAWRLNQVDFVVVNGGPAQANQFEMQLSPSAVLPVNPKAEAVFNPTQPVVAMAGIG
CCCCCCEEECCEEEEEECCCCCCCCEEEEEECCCEEECCCCCCCEEECCCCCEEEEECCC
HPARFFETLTQQGIQLALSHGFDDHQAYDKHVLCELAASRPLMMTEKDAVKCRDFAQENW
CHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHCCCC
WYLAVDAKLSPQFDQQLLSRVRSVAAAKQGKSHGV
EEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA