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The map label for this gene is mdtE [H]

Identifier: 117920790

GI number: 117920790

Start: 2825448

End: 2826572

Strand: Reverse

Name: mdtE [H]

Synonym: Shewana3_2347

Alternate gene names: 117920790

Gene position: 2826572-2825448 (Counterclockwise)

Preceding gene: 117920791

Following gene: 117920789

Centisome position: 56.85

GC content: 41.51

Gene sequence:

>1125_bases
GTGAAAAAACCGTTGGTGTTAATAGTTGGAAGTACCTTTATTCTATTAATTGGGATAGTAGTTTGGGGTCTTAATTTTTC
CTCAAAAACACAAGATGCTGACAGTAAATTAACGGCAGAGATGATGGCTAAGTCAACGTCTAAAAAGTCACAACTACCTC
CTGCGGTTAGCCTTTTTAAAGTCACAAATCAAACGTTTAGCCAGTATATTGTATTGACCGGAACAATTGAGCCAACAAAA
GTGGCGAGTTTGGCCTCTCCGGCAGAAGGTCCGATTCTTAATCTTGTGGTGCGTGAGGGGGATACTGTTAATTTAGGACA
AGAGATTTTACGCATTGGTCGAACTCATGCGGCTGATTCTCTTCAAACATCTGCCGCTGAAGAAGTACGTAAACAAGTAT
TAAATTTAAAGCGTATTGAAACTTTAGTTAAGCAGCATACTTTACCTGAGGAGCAGTTAGACGAAGCACTATCATCATTA
GAAAAAGCGAAGGCGGCATTGAGCCAAGCAAAACAAGCCCTTAATGATTACATAGTGACCGTGCCTTGGTCAGGGATTAT
ATCTAAAGTCTTGGTTTCAGATGGTCATTTCGTTATACCCCGTAGTCCCTTGGTTGAAATGTATGATCCAGATAGTTTGG
TATTACGATTTAGCGTCGCAGAAGCCCAAGCTTTAGTTCTTAAGAAGGGGCATAAAGTTAAAGCGACTTTTGATGGGCTT
GCTGGGCAGGAATTTGAATTAGAGATTATTCGAGCTTATCCCGATTTAGATAGAAAGTTACGTACGCGTCTTTTTGAGGC
GTCGCTACCTGCAAATGAGTTTATTCCTGGTATGTTTGCGCGGATCCGAGTCGTACAGCAGGAGCACAAAAATACTCTTG
TCATACCGATTGATACGCTTCAAGTGCAAGGAAAAGACAAAAGTGTGTTTGTAGTGACAGATAATATTGTCACTCGACGA
TTAGTCGAAACCGGTTTAGAGCAGGATGATCAAATTGAAGTGTTATCGGGACTGAAAGCGGGTGAGATAATCGTTCTAAC
TGGCATTGAAAGGGTGAAAAATGGCTCCGCAGTGAGAGTATTGGAGCAACCCGCTGAAAACAATAGCACGGGTGTTGAAA
AATGA

Upstream 100 bases:

>100_bases
TCATCATTGGCGCCTATTACGCTTGGGTGAATATTTTCGTTCCATCTTTGTTTTAGCCTAATTTTATTCCTAACAATGCT
TTTCTTGTGAGGTCCTTTCT

Downstream 100 bases:

>100_bases
TTATTAAAGCCGCGATTTCTCGTCGAATTTCAACGGCTGTATTGGCTTTCGGTTTAGCTATTTTCGGGGCGCTAAATCTG
AATATGCTACCTGTCGATTT

Product: RND family efflux transporter MFP subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 374; Mature: 374

Protein sequence:

>374_residues
MKKPLVLIVGSTFILLIGIVVWGLNFSSKTQDADSKLTAEMMAKSTSKKSQLPPAVSLFKVTNQTFSQYIVLTGTIEPTK
VASLASPAEGPILNLVVREGDTVNLGQEILRIGRTHAADSLQTSAAEEVRKQVLNLKRIETLVKQHTLPEEQLDEALSSL
EKAKAALSQAKQALNDYIVTVPWSGIISKVLVSDGHFVIPRSPLVEMYDPDSLVLRFSVAEAQALVLKKGHKVKATFDGL
AGQEFELEIIRAYPDLDRKLRTRLFEASLPANEFIPGMFARIRVVQQEHKNTLVIPIDTLQVQGKDKSVFVVTDNIVTRR
LVETGLEQDDQIEVLSGLKAGEIIVLTGIERVKNGSAVRVLEQPAENNSTGVEK

Sequences:

>Translated_374_residues
MKKPLVLIVGSTFILLIGIVVWGLNFSSKTQDADSKLTAEMMAKSTSKKSQLPPAVSLFKVTNQTFSQYIVLTGTIEPTK
VASLASPAEGPILNLVVREGDTVNLGQEILRIGRTHAADSLQTSAAEEVRKQVLNLKRIETLVKQHTLPEEQLDEALSSL
EKAKAALSQAKQALNDYIVTVPWSGIISKVLVSDGHFVIPRSPLVEMYDPDSLVLRFSVAEAQALVLKKGHKVKATFDGL
AGQEFELEIIRAYPDLDRKLRTRLFEASLPANEFIPGMFARIRVVQQEHKNTLVIPIDTLQVQGKDKSVFVVTDNIVTRR
LVETGLEQDDQIEVLSGLKAGEIIVLTGIERVKNGSAVRVLEQPAENNSTGVEK
>Mature_374_residues
MKKPLVLIVGSTFILLIGIVVWGLNFSSKTQDADSKLTAEMMAKSTSKKSQLPPAVSLFKVTNQTFSQYIVLTGTIEPTK
VASLASPAEGPILNLVVREGDTVNLGQEILRIGRTHAADSLQTSAAEEVRKQVLNLKRIETLVKQHTLPEEQLDEALSSL
EKAKAALSQAKQALNDYIVTVPWSGIISKVLVSDGHFVIPRSPLVEMYDPDSLVLRFSVAEAQALVLKKGHKVKATFDGL
AGQEFELEIIRAYPDLDRKLRTRLFEASLPANEFIPGMFARIRVVQQEHKNTLVIPIDTLQVQGKDKSVFVVTDNIVTRR
LVETGLEQDDQIEVLSGLKAGEIIVLTGIERVKNGSAVRVLEQPAENNSTGVEK

Specific function: Part of a multidrug resistance efflux system that confers resistance to compounds such as rhodamine 6G, erythromycin, doxorubicin, ethidium bromide, TPP, SDS, deoxycholate, crystal violet and benzalkonium [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789929, Length=360, Percent_Identity=24.4444444444444, Blast_Score=77, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 41036; Mature: 41036

Theoretical pI: Translated: 7.10; Mature: 7.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKPLVLIVGSTFILLIGIVVWGLNFSSKTQDADSKLTAEMMAKSTSKKSQLPPAVSLFK
CCCCEEEEECHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCHHHCCCCHHHHHH
VTNQTFSQYIVLTGTIEPTKVASLASPAEGPILNLVVREGDTVNLGQEILRIGRTHAADS
HHHHHCCCEEEEEECCCHHHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHCCHHCHHH
LQTSAAEEVRKQVLNLKRIETLVKQHTLPEEQLDEALSSLEKAKAALSQAKQALNDYIVT
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEE
VPWSGIISKVLVSDGHFVIPRSPLVEMYDPDSLVLRFSVAEAQALVLKKGHKVKATFDGL
ECHHHHHHHHHHCCCCEEECCCCCEEEECCCCEEEEEEHHHHHHHHHHCCCEEEEEECCC
AGQEFELEIIRAYPDLDRKLRTRLFEASLPANEFIPGMFARIRVVQQEHKNTLVIPIDTL
CCCCEEEEEEECCCCHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHHHHCCCEEEEEEEEE
QVQGKDKSVFVVTDNIVTRRLVETGLEQDDQIEVLSGLKAGEIIVLTGIERVKNGSAVRV
EECCCCCEEEEEECHHHHHHHHHHCCCCCCCHHHHHCCCCCCEEEEECHHHHCCCCEEEE
LEQPAENNSTGVEK
EECCCCCCCCCCCC
>Mature Secondary Structure
MKKPLVLIVGSTFILLIGIVVWGLNFSSKTQDADSKLTAEMMAKSTSKKSQLPPAVSLFK
CCCCEEEEECHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCHHHCCCCHHHHHH
VTNQTFSQYIVLTGTIEPTKVASLASPAEGPILNLVVREGDTVNLGQEILRIGRTHAADS
HHHHHCCCEEEEEECCCHHHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHCCHHCHHH
LQTSAAEEVRKQVLNLKRIETLVKQHTLPEEQLDEALSSLEKAKAALSQAKQALNDYIVT
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEE
VPWSGIISKVLVSDGHFVIPRSPLVEMYDPDSLVLRFSVAEAQALVLKKGHKVKATFDGL
ECHHHHHHHHHHCCCCEEECCCCCEEEECCCCEEEEEEHHHHHHHHHHCCCEEEEEECCC
AGQEFELEIIRAYPDLDRKLRTRLFEASLPANEFIPGMFARIRVVQQEHKNTLVIPIDTL
CCCCEEEEEEECCCCHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHHHHCCCEEEEEEEEE
QVQGKDKSVFVVTDNIVTRRLVETGLEQDDQIEVLSGLKAGEIIVLTGIERVKNGSAVRV
EECCCCCEEEEEECHHHHHHHHHHCCCCCCCHHHHHCCCCCCEEEEECHHHHCCCCEEEE
LEQPAENNSTGVEK
EECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]