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The map label for this gene is zwf [H]

Identifier: 117920595

GI number: 117920595

Start: 2576498

End: 2577970

Strand: Reverse

Name: zwf [H]

Synonym: Shewana3_2151

Alternate gene names: 117920595

Gene position: 2577970-2576498 (Counterclockwise)

Preceding gene: 117920598

Following gene: 117920594

Centisome position: 51.85

GC content: 48.68

Gene sequence:

>1473_bases
ATGGGCAAAACAACATCAGGCGCCAAAGCTTGTGACTTCGTACTCTTTGGTACTAAAGGCGACTTGGCACGACGCAAGTT
GTTACCTTCTTTATACCAGCTAGATAAAGCTGAACTTCTGGATAAAAACACCAAAGTCATTGGGGTTGCCAAAGATGAGT
TCAGTCAGGATGAATTTAGAGAACTCGTCATCCTTGCGTTAAAAACCTTCGTAAAAGAAGCCCTCTGCGAAGAGACTGTC
CAACGCTTCTTGTCCCGCTGCCATTATGTCGGCACGAATTTCACCGAATCTGCAGGCTACAGCGCCTTCCATGAATTGCT
CAAACCAGAAGAGCGCGTCATGGTCAGTTATTTTGCCACCCCTCCTGCGATTTTTGGCGATATCTGCCGCTGTTTACACG
AACAAAATCTTATCCATAGCGATTCTCGCGTGGTACTCGAAAAGCCCATTGGCTCTGACCTCGCTTCTTCCCGTGTGATT
AACGATCAAGTTTCTGCCTACTTCAAAGAAAACCAAGTTTATCGTATCGACCATTACTTAGGTAAAGAGACAGTCCAAAA
CCTGATTGCGCTGCGTTTCGCTAACTCGTTATTCGCGTCTAAGTGGGACAACCGGACCATTGACCATGTCCAGATCACCG
TTGCTGAAGAAGTGGGTATCGAAGGCCGTTGGGGTTACTTCGATAAAGCCGGTCAGATGCGCGATATGATCCAAAACCAC
TTACTGCAAGTGTTGACACTGGTTGCCATGGATCCACCAGTTAACTTAGATGCTGACAGTATTCGCGATGAAAAAGTGAA
AGTACTGAAGTCGCTGCGCCCAATCAATGCCGACAATGTCTATGAGAACACTGTCCGTGGTCAGTACAGTGCCGGCTTCC
TAAAAGGCAGTCCTGTTCCTGGCTATTTAGAGGAAGAGGGCGCTAACCTTCAGTCCCATACTGAAACCTTTGTGGCGCTG
CGTGTCGATATCGACAACTGGCGTTGGGCTGGCGTGCCATTTTATCTGCGTAGCGGTAAACGCATGCCGTTCAAGAGCTC
TGAAATTGTGGTGTATTTTAAAAACCCACCCCACAACTTGTATCGCTCAAGCTACCGTAACTTGCCACCTAACAAGTTAA
CCATCCGTCTGCAACCACATGAAGGGGTTGAGATCCAGATGATGAACAAGGTGCCGGGGCTAGAGCAGAAACAACGTTTA
CAAACCACCAAACTCGACTTGAGTTTCTCGGATACCTTTAAAAACGAGCGTATCGCCGATGCTTACGAGCGTCTGTTGCT
CGAAGCCATGCTCGGTAACCAAGCCCTGTTCGTTCGCCGTGACGAAGTAGAGCAGGCTTGGACTTGGGTGGATGGCATCA
TCCAATCATGGGAACAAAGTAACGAGAAACCGAAACCTTATCCTGCGGGCACTTGGGGACCTGTTGCGTCGGTCGCGCTG
ATCACCAAAGACGGCCGTTCGTGGGATGAATAG

Upstream 100 bases:

>100_bases
AATAGATGCATTTAACAAATTCTGTTGTTATATTACAACAAAAGTGTGGATTTCTTCATTGGCTTGAAGGGACACAACAT
ACAAAGGAGAGCGTAACGCA

Downstream 100 bases:

>100_bases
GGGGCTTTTATGATTAAAGAAACCGTATTTAAATCCTTTGATACACCCGCAGCGCTCGAGCAACAGTTGGCGAATAAGAT
CGCCAGTCAGTTGCAAGAGG

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 490; Mature: 489

Protein sequence:

>490_residues
MGKTTSGAKACDFVLFGTKGDLARRKLLPSLYQLDKAELLDKNTKVIGVAKDEFSQDEFRELVILALKTFVKEALCEETV
QRFLSRCHYVGTNFTESAGYSAFHELLKPEERVMVSYFATPPAIFGDICRCLHEQNLIHSDSRVVLEKPIGSDLASSRVI
NDQVSAYFKENQVYRIDHYLGKETVQNLIALRFANSLFASKWDNRTIDHVQITVAEEVGIEGRWGYFDKAGQMRDMIQNH
LLQVLTLVAMDPPVNLDADSIRDEKVKVLKSLRPINADNVYENTVRGQYSAGFLKGSPVPGYLEEEGANLQSHTETFVAL
RVDIDNWRWAGVPFYLRSGKRMPFKSSEIVVYFKNPPHNLYRSSYRNLPPNKLTIRLQPHEGVEIQMMNKVPGLEQKQRL
QTTKLDLSFSDTFKNERIADAYERLLLEAMLGNQALFVRRDEVEQAWTWVDGIIQSWEQSNEKPKPYPAGTWGPVASVAL
ITKDGRSWDE

Sequences:

>Translated_490_residues
MGKTTSGAKACDFVLFGTKGDLARRKLLPSLYQLDKAELLDKNTKVIGVAKDEFSQDEFRELVILALKTFVKEALCEETV
QRFLSRCHYVGTNFTESAGYSAFHELLKPEERVMVSYFATPPAIFGDICRCLHEQNLIHSDSRVVLEKPIGSDLASSRVI
NDQVSAYFKENQVYRIDHYLGKETVQNLIALRFANSLFASKWDNRTIDHVQITVAEEVGIEGRWGYFDKAGQMRDMIQNH
LLQVLTLVAMDPPVNLDADSIRDEKVKVLKSLRPINADNVYENTVRGQYSAGFLKGSPVPGYLEEEGANLQSHTETFVAL
RVDIDNWRWAGVPFYLRSGKRMPFKSSEIVVYFKNPPHNLYRSSYRNLPPNKLTIRLQPHEGVEIQMMNKVPGLEQKQRL
QTTKLDLSFSDTFKNERIADAYERLLLEAMLGNQALFVRRDEVEQAWTWVDGIIQSWEQSNEKPKPYPAGTWGPVASVAL
ITKDGRSWDE
>Mature_489_residues
GKTTSGAKACDFVLFGTKGDLARRKLLPSLYQLDKAELLDKNTKVIGVAKDEFSQDEFRELVILALKTFVKEALCEETVQ
RFLSRCHYVGTNFTESAGYSAFHELLKPEERVMVSYFATPPAIFGDICRCLHEQNLIHSDSRVVLEKPIGSDLASSRVIN
DQVSAYFKENQVYRIDHYLGKETVQNLIALRFANSLFASKWDNRTIDHVQITVAEEVGIEGRWGYFDKAGQMRDMIQNHL
LQVLTLVAMDPPVNLDADSIRDEKVKVLKSLRPINADNVYENTVRGQYSAGFLKGSPVPGYLEEEGANLQSHTETFVALR
VDIDNWRWAGVPFYLRSGKRMPFKSSEIVVYFKNPPHNLYRSSYRNLPPNKLTIRLQPHEGVEIQMMNKVPGLEQKQRLQ
TTKLDLSFSDTFKNERIADAYERLLLEAMLGNQALFVRRDEVEQAWTWVDGIIQSWEQSNEKPKPYPAGTWGPVASVALI
TKDGRSWDE

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI109389365, Length=483, Percent_Identity=36.6459627329193, Blast_Score=320, Evalue=2e-87,
Organism=Homo sapiens, GI108773793, Length=483, Percent_Identity=36.6459627329193, Blast_Score=320, Evalue=2e-87,
Organism=Homo sapiens, GI52145310, Length=507, Percent_Identity=28.5996055226824, Blast_Score=161, Evalue=1e-39,
Organism=Escherichia coli, GI1788158, Length=486, Percent_Identity=64.8148148148148, Blast_Score=669, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17538218, Length=488, Percent_Identity=38.7295081967213, Blast_Score=328, Evalue=5e-90,
Organism=Saccharomyces cerevisiae, GI6324088, Length=470, Percent_Identity=35.9574468085106, Blast_Score=302, Evalue=7e-83,
Organism=Drosophila melanogaster, GI24643350, Length=485, Percent_Identity=36.9072164948454, Blast_Score=313, Evalue=1e-85,
Organism=Drosophila melanogaster, GI24643352, Length=485, Percent_Identity=36.9072164948454, Blast_Score=313, Evalue=2e-85,
Organism=Drosophila melanogaster, GI221513548, Length=477, Percent_Identity=27.8825995807128, Blast_Score=187, Evalue=2e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 55881; Mature: 55750

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKTTSGAKACDFVLFGTKGDLARRKLLPSLYQLDKAELLDKNTKVIGVAKDEFSQDEFR
CCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHCCHHHHHCCCCEEEEEEHHHCCHHHHH
ELVILALKTFVKEALCEETVQRFLSRCHYVGTNFTESAGYSAFHELLKPEERVMVSYFAT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCHHHEEEEEECC
PPAIFGDICRCLHEQNLIHSDSRVVLEKPIGSDLASSRVINDQVSAYFKENQVYRIDHYL
CHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCCEEEHHHHH
GKETVQNLIALRFANSLFASKWDNRTIDHVQITVAEEVGIEGRWGYFDKAGQMRDMIQNH
CHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEHHHCCCCCCCCCCCCCHHHHHHHHHH
LLQVLTLVAMDPPVNLDADSIRDEKVKVLKSLRPINADNVYENTVRGQYSAGFLKGSPVP
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCCCCCCCCC
GYLEEEGANLQSHTETFVALRVDIDNWRWAGVPFYLRSGKRMPFKSSEIVVYFKNPPHNL
CCHHHCCCCCHHCCCEEEEEEEECCCCEECCCCCEECCCCCCCCCCCCEEEEECCCCHHH
YRSSYRNLPPNKLTIRLQPHEGVEIQMMNKVPGLEQKQRLQTTKLDLSFSDTFKNERIAD
HHHHHCCCCCCEEEEEECCCCCCEEEEECCCCCCCHHHHHHHHHEEEEEHHHHCCCHHHH
AYERLLLEAMLGNQALFVRRDEVEQAWTWVDGIIQSWEQSNEKPKPYPAGTWGPVASVAL
HHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHEEEE
ITKDGRSWDE
EEECCCCCCC
>Mature Secondary Structure 
GKTTSGAKACDFVLFGTKGDLARRKLLPSLYQLDKAELLDKNTKVIGVAKDEFSQDEFR
CCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHCCHHHHHCCCCEEEEEEHHHCCHHHHH
ELVILALKTFVKEALCEETVQRFLSRCHYVGTNFTESAGYSAFHELLKPEERVMVSYFAT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCHHHEEEEEECC
PPAIFGDICRCLHEQNLIHSDSRVVLEKPIGSDLASSRVINDQVSAYFKENQVYRIDHYL
CHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCCEEEHHHHH
GKETVQNLIALRFANSLFASKWDNRTIDHVQITVAEEVGIEGRWGYFDKAGQMRDMIQNH
CHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEHHHCCCCCCCCCCCCCHHHHHHHHHH
LLQVLTLVAMDPPVNLDADSIRDEKVKVLKSLRPINADNVYENTVRGQYSAGFLKGSPVP
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCCCCCCCCC
GYLEEEGANLQSHTETFVALRVDIDNWRWAGVPFYLRSGKRMPFKSSEIVVYFKNPPHNL
CCHHHCCCCCHHCCCEEEEEEEECCCCEECCCCCEECCCCCCCCCCCCEEEEECCCCHHH
YRSSYRNLPPNKLTIRLQPHEGVEIQMMNKVPGLEQKQRLQTTKLDLSFSDTFKNERIAD
HHHHHCCCCCCEEEEEECCCCCCEEEEECCCCCCCHHHHHHHHHEEEEEHHHHCCCHHHH
AYERLLLEAMLGNQALFVRRDEVEQAWTWVDGIIQSWEQSNEKPKPYPAGTWGPVASVAL
HHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHEEEE
ITKDGRSWDE
EEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8145647 [H]